| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francesca Sciarretta, Fabio Zaccaria, Andrea Ninni, Veronica Ceci, Riccardo Turchi, Savina Apolloni, Martina Milani, Ilaria Della Valle, Marta Tiberi, Valerio Chiurchiù, Nadia D'Ambrosi, Silvia Pedretti, Nico Mitro, Cinzia Volontè, Susanna Amadio, Katia Aquilano, Daniele Lettieri-Barbat. Frataxin deficiency shifts metabolism to promote reactive microglia via glucose catabolism. Life science alliance. vol 7. issue 7. 2024-04-17. PMID:38631900. |
in conclusion, our findings elucidate the role of disrupted homeostatic function in cerebellar microglia in the pathogenesis of frda. |
2024-04-17 |
2024-04-20 |
mouse |
| Aïda Padilla-Ferrer, Alex Carrete, Anne Simon, Delphine Meffre, Mehrnaz Jafarian-Tehran. A disintegrin and Metalloprotease 10 expression within the murine central nervous system. Brain research. 2024-03-28. PMID:38548249. |
here, we described the regional and cellular adam10 protein expression in c57bl/6 mice examined by immunofluorescence 1) throughout the adult mouse brain, cerebellum and spinal cord in vivo and 2) in different cell types as neurons, astrocytes, oligodendrocytes and microglia in vitro. |
2024-03-28 |
2024-03-31 |
mouse |
| MaKenna Y Cealie, James C Douglas, Hannah K Swan, Erik D Vonkaenel, Matthew N McCall, Paul D Drew, Ania K Majewsk. Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum. Cells. vol 13. issue 5. 2024-03-13. PMID:38474350. |
developmental ethanol exposure impacts purkinje cells but not microglia in the young adult cerebellum. |
2024-03-13 |
2024-03-15 |
mouse |
| MaKenna Y Cealie, James C Douglas, Hannah K Swan, Erik D Vonkaenel, Matthew N McCall, Paul D Drew, Ania K Majewsk. Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum. Cells. vol 13. issue 5. 2024-03-13. PMID:38474350. |
to determine how developmental ethanol exposure affects adult cerebellar microglia and purkinje cells, we used a human third-trimester binge exposure model in which mice received ethanol or saline from postnatal (p) days 4-9. |
2024-03-13 |
2024-03-15 |
mouse |
| MaKenna Y Cealie, James C Douglas, Hannah K Swan, Erik D Vonkaenel, Matthew N McCall, Paul D Drew, Ania K Majewsk. Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum. Cells. vol 13. issue 5. 2024-03-13. PMID:38474350. |
in adolescence, cerebellar cranial windows were implanted and mice were aged to young adulthood for examination of microglia and purkinje cells in vivo with two-photon imaging or in fixed tissue. |
2024-03-13 |
2024-03-15 |
mouse |
| MaKenna Y Cealie, James C Douglas, Hannah K Swan, Erik D Vonkaenel, Matthew N McCall, Paul D Drew, Ania K Majewsk. Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum. Cells. vol 13. issue 5. 2024-03-13. PMID:38474350. |
overall, developmental ethanol exposure had few effects on cerebellar microglia in young adulthood and purkinje cells appeared to be more susceptible to its effects. |
2024-03-13 |
2024-03-15 |
mouse |
| Zhongbin An, Qiong He, Ling Jiang, Yuan Wang, Yongyue Zhang, Yang Sun, Mengxin Wang, Shiyuan Yang, Lijie Huang, Huiwen Li, Yu Hao, Xiaolong Liang, Shumin Wan. A One-Stone-Two-Birds Strategy of Targeting Microbubbles with "Dual" Anti-Inflammatory and Blood-Brain Barrier "Switch" Function for Ischemic Stroke Treatment. ACS biomaterials science & engineering. 2024-02-29. PMID:38420991. |
in the treatment of stroke inflammation, it was found that hydrocortisone itself has anti-inflammatory effects and can also change the polarization of microglia from the harmful pro-inflammatory m1 phenotype to the beneficial anti-inflammatory m2 phenotype, thus achieving dual anti-inflammatory effects and enhancing the anti-inflammatory effects in ischemic areas after stroke, well reducing the cerebellar infarction volume by inhibiting the inflammatory response after cerebral ischemia. |
2024-02-29 |
2024-03-02 |
Not clear |
| Kai Wang, Jin Liu, Jialin Xie, Zhongtian Yong, Han Li, Liyan Wang, Na Xia, Tao Bai, Hongxing Wang, Li Wan. Sleep deprivation from mid-gestation leads to impaired of motor coordination in young offspring mice with microglia activation in the cerebellar vermis. Sleep medicine. vol 115. 2024-02-17. PMID:38367362. |
sleep deprivation from mid-gestation leads to impaired of motor coordination in young offspring mice with microglia activation in the cerebellar vermis. |
2024-02-17 |
2024-02-20 |
mouse |
| Kai Wang, Jin Liu, Jialin Xie, Zhongtian Yong, Han Li, Liyan Wang, Na Xia, Tao Bai, Hongxing Wang, Li Wan. Sleep deprivation from mid-gestation leads to impaired of motor coordination in young offspring mice with microglia activation in the cerebellar vermis. Sleep medicine. vol 115. 2024-02-17. PMID:38367362. |
to investigate the effects of mid-pregnancy sleep deprivation (sd) in c57bl/6 j mice on the motor coordination of the offspring and to explore the potential mechanism of microglia activation in the cerebellar vermis of the offspring involved in the induction of impaired motor coordination development. |
2024-02-17 |
2024-02-20 |
mouse |
| Jenny Lai, Didem Demirbas, Junho Kim, Ailsa M Jeffries, Allie Tolles, Junseok Park, Thomas W Chittenden, Patrick G Buckley, Timothy W Yu, Michael A Lodato, Eunjung Alice Le. ATM-deficiency-induced microglial activation promotes neurodegeneration in ataxia-telangiectasia. Cell reports. vol 43. issue 1. 2023-12-30. PMID:38159274. |
atm expression is enriched in microglia throughout cerebellar development and adulthood. |
2023-12-30 |
2024-01-05 |
Not clear |
| Anna M Fiorito, Eric Fakra, Guillaume Sescousse, El Chérif Ibrahim, Romain Re. Molecular mapping of a core transcriptional signature of microglia-specific genes in schizophrenia. Translational psychiatry. vol 13. issue 1. 2023-12-13. PMID:38092734. |
we report evidence of a widespread transcriptional alteration of microglia genes both in brain tissues (we observed a decreased expression in the cerebellum, associative striatum, hippocampus, and parietal cortex of individuals with schizophrenia compared with healthy controls) and whole blood (characterized by a mixed altered expression pattern). |
2023-12-13 |
2023-12-17 |
human |
| Joana R Guedes, Pedro A Ferreira, Jéssica Costa, Mariana Laranjo, Maria J Pinto, Tiago Reis, Ana Maria Cardoso, Carolina Lebre, Maria Casquinha, Marcos Gomes, Viktoriya Shkatova, Marta Pereira, Nuno Beltrão, Nicholas Hanuscheck, Andrew D Greenhalgh, Christina Francisca Vogelaar, Ana Luísa Carvalho, Frauke Zipp, Ana Luísa Cardoso, João Peç. IL-4 shapes microglia-dependent pruning of the cerebellum during postnatal development. Neuron. vol 111. issue 21. 2023-11-02. PMID:37918358. |
here, we show that low levels of il-4 in the early postnatal stage delineate a critical period in which microglia extensively prune cerebellar neurons. |
2023-11-02 |
2023-11-08 |
mouse |
| Sumit S Rathod, Yogeeta O Agrawal, Kartik T Nakhate, M F Nagoor Meeran, Shreesh Ojha, Sameer N Goya. Neuroinflammation in the Central Nervous System: Exploring the Evolving Influence of Endocannabinoid System. Biomedicines. vol 11. issue 10. 2023-10-30. PMID:37893016. |
the presence of cb2 receptors in certain brain components, like cultured cerebellar granular cells, purkinje fibers, and microglia, as well as in the areas like the cerebral cortex, hippocampus, and cerebellum is also evidenced by immunoblotting assays, radioligand binding, and autoradiography studies. |
2023-10-30 |
2023-11-08 |
Not clear |
| Seth A Ament, Marcia Cortes-Gutierrez, Brian R Herb, Evelina Mocci, Carlo Colantuoni, Margaret M McCarth. A single-cell genomic atlas for maturation of the human cerebellum during early childhood. Science translational medicine. 2023-10-12. PMID:37824600. |
immunohistochemical analysis of a subset of these postmortem cerebellar samples revealed no change to purkinje neuron soma size but evidence for increased activation of microglia in those children who had experienced inflammation. |
2023-10-12 |
2023-10-15 |
human |
| Shinji Yamamoto, Kensuke Iwasa, Anzu Yamagishi, Chikara Haruta, Kei Maruyama, Keisuke Yoshikaw. Microglial depletion exacerbates axonal damage and motor dysfunction in mice with cuprizone-induced demyelination. Journal of pharmacological sciences. vol 153. issue 3. 2023-09-28. PMID:37770161. |
plx treatment removed microglia from the superior cerebellar peduncle (scp), but not from the corpus callosum (cc). |
2023-09-28 |
2023-10-07 |
mouse |
| Lara-Jasmin Schröder, Hauke Thiesler, Lina Gretenkort, Thiemo Malte Möllenkamp, Martin Stangel, Viktoria Gudi, Herbert Hildebrand. Corrigendum: Polysialic acid promotes remyelination in cerebellar slice cultures by Siglec-E-dependent modulation of microglia polarization. Frontiers in cellular neuroscience. vol 17. 2023-09-08. PMID:37680864. |
corrigendum: polysialic acid promotes remyelination in cerebellar slice cultures by siglec-e-dependent modulation of microglia polarization. |
2023-09-08 |
2023-10-07 |
Not clear |
| Lara-Jasmin Schröder, Hauke Thiesler, Lina Gretenkort, Thiemo Malte Möllenkamp, Martin Stangel, Viktoria Gudi, Herbert Hildebrand. Polysialic acid promotes remyelination in cerebellar slice cultures by Siglec-E-dependent modulation of microglia polarization. Frontiers in cellular neuroscience. vol 17. 2023-07-26. PMID:37492129. |
polysialic acid promotes remyelination in cerebellar slice cultures by siglec-e-dependent modulation of microglia polarization. |
2023-07-26 |
2023-08-14 |
Not clear |
| Bárbara Juacy Rodrigues Costa-de-Santana, Raul Manhães-de-Castro, Henrique José Cavalcanti Bezerra Gouveia, Eliesly Roberto Silva, Marcos Antônio da Silva Araújo, Diego Cabral Lacerda, Omar Guzmán-Quevedo, Luz Torner, Ana Elisa Toscan. Motor deficits are associated with increased glial cell activation in the hypothalamus and cerebellum of young rats subjected to cerebral palsy. Brain research. 2023-06-10. PMID:37301423. |
there was also found to be an increase in astrocyte and microglia activation in the cerebellum and hypothalamus (arcuate nucleus, arc) of animals subjected to cp. |
2023-06-10 |
2023-08-14 |
rat |
| MaKenna Y Cealie, James C Douglas, Linh H D Le, Erik D Vonkaenel, Matthew N McCall, Paul D Drew, Ania K Majewsk. Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence. Frontiers in neuroscience. vol 17. 2023-05-23. PMID:37214408. |
to better understand these mechanisms, we examined the cerebellum on a cellular level by studying microglia, the principal immune cells of the central nervous system, and purkinje cells, the sole output of the cerebellum. |
2023-05-23 |
2023-08-14 |
Not clear |
| Naserddine Hamadi, Sumaya Beegam, Nur Elena Zaaba, Ozaz Elzaki, Mariam Abdulla Altamimi, Abderrahim Nemma. Neuroinflammation, Oxidative Stress, Apoptosis, Microgliosis and Astrogliosis in the Cerebellum of Mice Chronically Exposed to Waterpipe Smoke. Biomedicines. vol 11. issue 4. 2023-05-16. PMID:37189722. |
immunofluorescence analysis of the cerebellum showed that wps exposure significantly augmented the number of ionized calcium-binding adaptor molecule 1 and glial fibrillary acidic protein-positive microglia and astroglia, respectively. |
2023-05-16 |
2023-08-14 |
mouse |