| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giusy Pizzirusso, Efthalia Preka, Julen Goikolea, Celia Aguilar-Ruiz, Patricia Rodriguez Rodriguez, Guillermo Vazquez Cabrera, Simona Laterza, Maria Latorre Leal, Francesca Eroli, Klas Blomgren, Silvia Maioli, Per Nilsson, Adamantia Fragkopoulou, André Fisahn, Luis Enrique Arroyo-Garcí. Dynamic microglia alterations associate with hippocampal network impairments: A turning point in amyloid pathology progression. Brain, behavior, and immunity. 2024-04-12. PMID:38608739. |
dynamic microglia alterations associate with hippocampal network impairments: a turning point in amyloid pathology progression. |
2024-04-12 |
2024-04-15 |
Not clear |
| Xiuting Yao, Chenxi Yang, Xirui Jia, Zhehao Yu, Conghui Wang, Jingyi Zhao, Yuxi Chen, Bingjie Xie, Hong Zhuang, Congli Sun, Qian Li, Xiaomin Kang, Yu Xiao, Lijie Li. High-fat diet consumption promotes adolescent neurobehavioral abnormalities and hippocampal structural alterations via microglial overactivation accompanied by an elevated serum free fatty acid concentration. Brain, behavior, and immunity. 2024-04-11. PMID:38604269. |
additionally, we showed that hippocampal microglia in hfd-fed mice assumed a hyperactive state concomitant with increased psd95-positive and myelin basic protein (mbp)-positive inclusions, implicating microglia in hippocampal structural alterations induced by hfd consumption. |
2024-04-11 |
2024-04-14 |
mouse |
| Xiuting Yao, Chenxi Yang, Xirui Jia, Zhehao Yu, Conghui Wang, Jingyi Zhao, Yuxi Chen, Bingjie Xie, Hong Zhuang, Congli Sun, Qian Li, Xiaomin Kang, Yu Xiao, Lijie Li. High-fat diet consumption promotes adolescent neurobehavioral abnormalities and hippocampal structural alterations via microglial overactivation accompanied by an elevated serum free fatty acid concentration. Brain, behavior, and immunity. 2024-04-11. PMID:38604269. |
along with increased levels of serum free fatty acids (ffas), abnormal deposition of lipid droplets and increased levels of hif-1α protein (a transcription factor that has been reported to facilitate cellular lipid accumulation) within hippocampal microglia were observed in hfd-fed mice. |
2024-04-11 |
2024-04-14 |
mouse |
| Xiuting Yao, Chenxi Yang, Xirui Jia, Zhehao Yu, Conghui Wang, Jingyi Zhao, Yuxi Chen, Bingjie Xie, Hong Zhuang, Congli Sun, Qian Li, Xiaomin Kang, Yu Xiao, Lijie Li. High-fat diet consumption promotes adolescent neurobehavioral abnormalities and hippocampal structural alterations via microglial overactivation accompanied by an elevated serum free fatty acid concentration. Brain, behavior, and immunity. 2024-04-11. PMID:38604269. |
the use of minocycline, a pharmacological suppressor of microglial overactivation, effectively attenuated neurobehavioral abnormalities and hippocampal structural alterations but barely altered lipid droplet accumulation in the hippocampal microglia of hfd-fed mice. |
2024-04-11 |
2024-04-14 |
mouse |
| Yizhen Zhu, Xue Zhao, Ruojing Liu, Dan Yang, Guo G. Effect of Oxygen-Glucose Deprivation of Microglia-Derived Exosomes on Hippocampal Neurons: A Study on miR-124 and Inflammatory Cytokines. Journal of molecular histology. 2024-04-10. PMID:38598045. |
we incubated hippocampal neurons with exosomes secreted by oxygen-glucose deprivation/ reoxygenation (ogd/r) microglia. |
2024-04-10 |
2024-04-12 |
human |
| Michael Surala, Luna Soso-Zdravkovic, David Munro, Ali Rifat, Koliane Ouk, Imre Vida, Josef Priller, Christian Madr. Lifelong absence of microglia alters hippocampal glutamatergic networks but not synapse and spine density. EMBO reports. 2024-04-08. PMID:38589666. |
lifelong absence of microglia alters hippocampal glutamatergic networks but not synapse and spine density. |
2024-04-08 |
2024-04-11 |
mouse |
| Bin Fan, Junbin Lin, Qihang Luo, Weijing Liao, Chizi Ha. Enriched Environment Inhibits Neurotoxic Reactive Astrocytes via JAK2-STAT3 to Promote Glutamatergic Synaptogenesis and Cognitive Improvement in Chronic Cerebral Hypoperfusion Rats. Neurotoxicity research. vol 42. issue 2. 2024-04-02. PMID:38564082. |
immunofluorescence was used to detect glutamatergic synapses, neurotoxic reactive astrocytes, and reactive microglia, as well as the expression of p-stat3 in astrocytes in the hippocampus. |
2024-04-02 |
2024-04-04 |
rat |
| Shunfeng Liu, Bei Zhang, Haowei Guo, Zhanghua Ding, Wenhui Hou, Xiaoli Hu, Yuchu Wang, Wupeng Tan, Shouhong Zho. The antidepressant effects of protein arginine methyltransferase 2 involve neuroinflammation. Neurochemistry international. 2024-04-01. PMID:38561150. |
hippocampal microglia and prmt2 were stained using immunofluorescence techniques. |
2024-04-01 |
2024-04-04 |
rat |
| Shunfeng Liu, Bei Zhang, Haowei Guo, Zhanghua Ding, Wenhui Hou, Xiaoli Hu, Yuchu Wang, Wupeng Tan, Shouhong Zho. The antidepressant effects of protein arginine methyltransferase 2 involve neuroinflammation. Neurochemistry international. 2024-04-01. PMID:38561150. |
prmt2 overexpression in the hippocampus reduced the proportion of activated microglia in the hippocampus, upregulated arg1 and h3r8me2a expression, and downregulated inos expression. |
2024-04-01 |
2024-04-04 |
rat |
| Shunfeng Liu, Bei Zhang, Haowei Guo, Zhanghua Ding, Wenhui Hou, Xiaoli Hu, Yuchu Wang, Wupeng Tan, Shouhong Zho. The antidepressant effects of protein arginine methyltransferase 2 involve neuroinflammation. Neurochemistry international. 2024-04-01. PMID:38561150. |
in summary, prmt2 overexpression in the hippocampus promoted the conversion of microglia from the m1 to m2 type, resulting in an antidepressant effect. |
2024-04-01 |
2024-04-04 |
rat |
| Hai Duc Nguyen, Huong Huong V. Molecular mechanisms implicated in protein changes in the Alzheimer's disease human hippocampus. Mechanisms of ageing and development. 2024-03-30. PMID:38554950. |
the presence of modified proteins was discovered to trigger the activation of microglia and decrease the functioning of ribosomes and mitochondria in the hippocampus. |
2024-03-30 |
2024-04-02 |
human |
| Sharif Ahmed, Ning Ma, Jun Kawanokuchi, Keiya Matsuoka, Shinji Oikawa, Hatasu Kobayashi, Yusuke Hiraku, Mariko Murat. Taurine reduces microglia activation in the brain of aged senescence-accelerated mice by increasing the level of TREM2. Scientific reports. vol 14. issue 1. 2024-03-29. PMID:38548872. |
immunohistochemical and western blot analyses revealed that taurine significantly reduced the number of activated microglia, levels of phospho-tau and aβ deposit in the hippocampus and cortex. |
2024-03-29 |
2024-03-31 |
mouse |
| Zhicheng Gao, Kangxin Luo, Yulin Hu, Yunqian Niu, Xinchao Zhu, Shoujun Li, Haiyang Zhan. Melatonin alleviates chronic stress-induced hippocampal microglia pyroptosis and subsequent depression-like behaviors by inhibiting Cathepsin B/NLRP3 signaling pathway in rats. Translational psychiatry. vol 14. issue 1. 2024-03-28. PMID:38538614. |
melatonin alleviates chronic stress-induced hippocampal microglia pyroptosis and subsequent depression-like behaviors by inhibiting cathepsin b/nlrp3 signaling pathway in rats. |
2024-03-28 |
2024-03-30 |
rat |
| Zhicheng Gao, Kangxin Luo, Yulin Hu, Yunqian Niu, Xinchao Zhu, Shoujun Li, Haiyang Zhan. Melatonin alleviates chronic stress-induced hippocampal microglia pyroptosis and subsequent depression-like behaviors by inhibiting Cathepsin B/NLRP3 signaling pathway in rats. Translational psychiatry. vol 14. issue 1. 2024-03-28. PMID:38538614. |
in vivo studies, melatonin inhibited chronic restraint stress (crs)-induced activation of cathepsin b/nlrp3 signaling pathway and alleviated hippocampal microglia pyroptosis in rats. |
2024-03-28 |
2024-03-30 |
rat |
| Zhicheng Gao, Kangxin Luo, Yulin Hu, Yunqian Niu, Xinchao Zhu, Shoujun Li, Haiyang Zhan. Melatonin alleviates chronic stress-induced hippocampal microglia pyroptosis and subsequent depression-like behaviors by inhibiting Cathepsin B/NLRP3 signaling pathway in rats. Translational psychiatry. vol 14. issue 1. 2024-03-28. PMID:38538614. |
these results demonstrated that melatonin could alleviate crs-induced hippocampal microglia pyroptosis by inhibiting cathepsin b/nlrp3 signaling pathway, thereby improving depression-like behaviors in rats. |
2024-03-28 |
2024-03-30 |
rat |
| Qi-Cheng Lin, Jiao Wang, Xin-Lin Wang, Chi Pan, Shao-Wu Jin, Steven Char, Yuan-Xiang Tao, Hong Cao, Jun L. Hippocampal HDAC6 promotes POCD by regulating NLRP3-induced microglia pyroptosis via HSP90/HSP70 in aged mice. Biochimica et biophysica acta. Molecular basis of disease. 2024-03-25. PMID:38527593. |
hippocampal hdac6 promotes pocd by regulating nlrp3-induced microglia pyroptosis via hsp90/hsp70 in aged mice. |
2024-03-25 |
2024-03-28 |
mouse |
| Takuya Oshima, Mandy S J Kater, Christiaan F M Huffels, Evelyn M Wesseling, Jinte Middeldorp, Elly M Hol, Mark H G Verheijen, August B Smit, Erik W G M Boddeke, Bart J L Egge. Early amyloid-induced changes in microglia gene expression in male APP/PS1 mice. Journal of neuroscience research. vol 102. issue 3. 2024-03-22. PMID:38515329. |
here, to determine early changes in microglia gene expression, hippocampal microglia from male appswe/ps1de9 (app/ps1) mice and wild-type littermates were isolated and analyzed by rna sequencing (rna-seq). |
2024-03-22 |
2024-03-24 |
mouse |
| Takuya Oshima, Mandy S J Kater, Christiaan F M Huffels, Evelyn M Wesseling, Jinte Middeldorp, Elly M Hol, Mark H G Verheijen, August B Smit, Erik W G M Boddeke, Bart J L Egge. Early amyloid-induced changes in microglia gene expression in male APP/PS1 mice. Journal of neuroscience research. vol 102. issue 3. 2024-03-22. PMID:38515329. |
by bulk rna-seq, transcriptomic changes were detected in hippocampal microglia from 6-months-old app/ps1 mice. |
2024-03-22 |
2024-03-24 |
mouse |
| Heng-Cai Wang, Wei Yang, Ling Xu, Yong-Hui Han, Yi Lin, Cui-Tao Lu, Kwonseop Kim, Ying-Zheng Zhao, Xi-Chong Y. BV2 Membrane-coated PEGylated-liposomes Delivered hFGF21 to Cortical and Hippocampal Microglia for Alzheimer's Disease Therapy. Advanced healthcare materials. 2024-03-21. PMID:38513154. |
bv2 membrane-coated pegylated-liposomes delivered hfgf21 to cortical and hippocampal microglia for alzheimer's disease therapy. |
2024-03-21 |
2024-03-24 |
Not clear |
| Elena Di Martino, Anoop Ambikan, Daniel Ramsköld, Takashi Umekawa, Sarantis Giatrellis, Davide Vacondio, Alejandro Lastra Romero, Marta Gómez Galán, Rickard Sandberg, Ulrika Ådén, Volker M Lauschke, Ujjwal Neogi, Klas Blomgren, Julianna Kel. Inflammatory, metabolic, and sex-dependent gene-regulatory dynamics of microglia and macrophages in neonatal hippocampus after hypoxia-ischemia. iScience. vol 27. issue 4. 2024-03-19. PMID:38500830. |
inflammatory, metabolic, and sex-dependent gene-regulatory dynamics of microglia and macrophages in neonatal hippocampus after hypoxia-ischemia. |
2024-03-19 |
2024-03-21 |
Not clear |