| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wataru Nagata, Mari Gotoh, Akiho Koizumi, Keiko Fukasawa, Keiichi Nakagawa, Yasushi Satoh, Toshiaki Ishizuk. Two-carba cyclic phosphatidic acid treatment promotes phenotypic switch from M1 to M2 microglia and prevents behavioral abnormalities in a mouse model of neuropsychiatric systemic lupus erythematosus. Human cell. 2023-08-04. PMID:37540445. |
the expression of cd68, an m1 phenotypic marker of microglia, was significantly elevated in the prefrontal cortex and hippocampus of mrl/lpr mice, which was significantly suppressed by 2ccpa treatment. |
2023-08-04 |
2023-08-14 |
mouse |
| Tao Zhu, Bingran Chen, Han Han, Xu Lu, Zhuo Chen, Ting Ye, Hui Zhao, Meng Zheng, Chao Huan. Zymosan A produces a rapid and sustained antidepressant effect in chronically stressed mice by stimulating hippocampal microglia. Behavioural pharmacology. vol 34. issue 6. 2023-08-02. PMID:37530136. |
zymosan a produces a rapid and sustained antidepressant effect in chronically stressed mice by stimulating hippocampal microglia. |
2023-08-02 |
2023-08-14 |
mouse |
| Nina E Baumgartner, Mandy C Biraud, Elizabeth K Luca. Sex differences in socioemotional behavior and changes in ventral hippocampal transcription across aging in C57Bl/6J mice. Neurobiology of aging. vol 130. 2023-07-31. PMID:37524006. |
to investigate potential neural mechanisms underlying these behavioral changes, we analyzed transcriptional neuropathology markers in the ventral hippocampus and found age-related changes in genes related to activated microglia, angiogenesis, and cytokines. |
2023-07-31 |
2023-08-14 |
mouse |
| Jemi Feiona Vergil Andrews, Divya Bharathi Selvaraj, Akshay Kumar, Syed Aasish Roshan, Muthuswamy Anusuyadevi, Mahesh Kandasam. A Mild Dose of Aspirin Promotes Hippocampal Neurogenesis and Working Memory in Experimental Ageing Mice. Brain sciences. vol 13. issue 7. 2023-07-29. PMID:37509038. |
this study investigated the effect of aspirin on spatial memory in correlation with the regulation of hippocampal neurogenesis and microglia in the brains of ageing experimental mice. |
2023-07-29 |
2023-08-14 |
mouse |
| Yan Cheng, Rachael Elizabeth Dempsey, Soheil Kazemi Roodsari, Dorela D Shuboni-Mulligan, Olivier George, Larry D Sanford, Ming-Lei Gu. Cocaine Regulates NLRP3 Inflammasome Activity and CRF Signaling in a Region- and Sex-Dependent Manner in Rat Brain. Biomedicines. vol 11. issue 7. 2023-07-29. PMID:37509440. |
to further characterize the effects of cocaine on microglia and neuroimmune signaling in vivo, we utilized the brains from both sexes of outbred rats with cocaine self-administration to explore the activation status of microglia, nod-, lrr-, and pyrin domain-containing protein 3 (nlrp3) inflammasome activity, corticotropin-releasing factor (crf) signaling, and nf-κb levels in the striatum and hippocampus (hp). |
2023-07-29 |
2023-08-14 |
mouse |
| Keiichi Hiramoto, Masashi Imai, Shota Tanaka, Kazuya Oo. Dementia Is Induced via the AGEs/Iba1/iNOS Pathway in Aged KK-Ay/Tajcl Mice. Life (Basel, Switzerland). vol 13. issue 7. 2023-07-29. PMID:37511915. |
hippocampal levels of cc-chemokine receptor 7 and inducible nitric oxide synthase, which are from m1-type macrophages that shift from microglia, were higher in kk-ay/tajcl mice than in control mice. |
2023-07-29 |
2023-08-14 |
mouse |
| Lulu Xie, Jiaxin Qin, Tingting Wang, Shuai Zhang, Mingcui Luo, Xuelei Cheng, Xinrui Cao, Hui Wang, Baozhen Yao, Dan Xu, Biwen Pen. Impact of Prenatal Acetaminophen Exposure for Hippocampal Development Disorder on Mice. Molecular neurobiology. 2023-07-29. PMID:37516664. |
in addition, pace significantly decreased the expression of genes related to synaptic development in fetal hippocampal neurons and hippocampal astrocyte and microglia were also damaged to varying degrees. |
2023-07-29 |
2023-08-14 |
mouse |
| Juan M Tamayo, Hadley C Osman, Jared J Schwartzer, Kent Pinkerton, Paul Ashwoo. Characterizing the Neuroimmune Environment of Offspring in a Novel Model of Maternal Allergic Asthma and Particulate Matter Exposure. Research square. 2023-07-28. PMID:37503062. |
the combination of maa and uis exposure (maa-uis) during pregnancy resulted in an increase in microglia density in the hippocampus of offspring, as identified by iba-1 staining. |
2023-07-28 |
2023-08-14 |
mouse |
| Liming Dong, Ning Jiang, Jie Bai, Yiman Li, Zhihui Song, Xinmin Liu, Chao Zhan. Neuroprotective Effects of Dammarane Sapogenins Against lipopolysaccharide-induced Cognitive Impairment, Neuroinflammation and Synaptic Dysfunction. Neurochemical research. 2023-07-25. PMID:37490197. |
ds also remarkably inhibited lps-induced neuroinflammation by suppressing microglia overactivation, pro-inflammatory cytok ine release (tnf-α and il-1β) and reducing neuronal loss in the ca1 and dg regions of the hippocampus. |
2023-07-25 |
2023-08-14 |
rat |
| Zhiwei Xue, Lei Ye, Jianwei Ge, Zhen Lan, Xinxin Zou, Chenglu Mao, Xinyu Bao, Linjie Yu, Yun Xu, Xiaolei Zh. Wwl70-induced ABHD6 inhibition attenuates memory deficits and pathological phenotypes in APPswe/PS1dE9 mice. Pharmacological research. 2023-07-22. PMID:37480972. |
furthermore, wwl70 significantly decreased the aβ levels and neuroinflammation in the hippocampus of ad mice, and enhanced aβ phagocytized by microglia. |
2023-07-22 |
2023-08-14 |
mouse |
| Inez Koopman, Bart J van Dijk, Nicolaas P A Zuithoff, Jacqueline A Sluijs, Marije J van der Kamp, Zelonna A V Baldew, Catharina J M Frijns, Gabriel J E Rinkel, Elly M Hol, Mervyn D I Vergouwe. Glial cell response and microthrombosis in aneurysmal subarachnoid hemorrhage patients: An autopsy study. Journal of neuropathology and experimental neurology. 2023-07-21. PMID:37478478. |
in a second study, we investigated the correlation between microthrombosis and microglia by studying the microglial surface area around vessels with and without microthrombosis in the frontal cortex and hippocampus of 8 other asah patients. |
2023-07-21 |
2023-08-14 |
Not clear |
| Miao Sun, Yang Li, Min Liu, Qingxiao Li, Likai Shi, Xianghan Ruan, Yuting Huo, Zhikang Zhou, Xiaoying Zhang, Yulong Ma, Weidong M. Insulin alleviates lipopolysaccharide-induced cognitive impairment via inhibiting neuroinflammation and ferroptosis. European journal of pharmacology. 2023-07-21. PMID:37479016. |
insulin treatment could also inhibit the lps-induced activation of microglia and astrocytes, and the release of tumor necrosis factor-α (tnf-α) and interleukin-1β (il-1β) in the hippocampus. |
2023-07-21 |
2023-08-14 |
Not clear |
| Ziyang Yu, Huize Pang, Yifan Yang, Doudou Luo, Haiping Zheng, Zicheng Huang, Mingxia Zhang, Ke Re. Microglia dysfunction drives disrupted hippocampal amplitude of low frequency after acute kidney injury. CNS neuroscience & therapeutics. 2023-07-20. PMID:37469216. |
microglia dysfunction drives disrupted hippocampal amplitude of low frequency after acute kidney injury. |
2023-07-20 |
2023-08-14 |
Not clear |
| Ying He, Man-Shu Zou, Ting-Ting Ren, Ping Li, Yang Liu, Yuan-Shan Ha. [Therapeutic effect and mechanism of Xiaoyao Kangai Jieyu Recipe on mice with breast cancer related depression through regulating COX pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 14. 2023-07-20. PMID:37475079. |
immunofluorescence was performed to detect the mean fluorescence intensity of cd11b, a marker of hippocampal microglia activation. |
2023-07-20 |
2023-08-14 |
mouse |
| Ying He, Man-Shu Zou, Ting-Ting Ren, Ping Li, Yang Liu, Yuan-Shan Ha. [Therapeutic effect and mechanism of Xiaoyao Kangai Jieyu Recipe on mice with breast cancer related depression through regulating COX pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 14. 2023-07-20. PMID:37475079. |
the experimental results indicated that compared with the normal group, the model group had reduced glucose consumption and lowered number of total activities in open field test(p<0.05, p<0.01), prolonged first feeding latency in no-velty-suppressed feeding test(p<0.01), and significant depression-like behavior; the contents of il-1β, il-18, cox-2, and eprs in hippocampus were increased(p<0.05, p<0.01), with hippocampal microglia activation and obvious neuronal damage. |
2023-07-20 |
2023-08-14 |
mouse |
| Ying He, Man-Shu Zou, Ting-Ting Ren, Ping Li, Yang Liu, Yuan-Shan Ha. [Therapeutic effect and mechanism of Xiaoyao Kangai Jieyu Recipe on mice with breast cancer related depression through regulating COX pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 14. 2023-07-20. PMID:37475079. |
compared with the model group, the positive drug group and the xkjr group presented an improvement in depressive behaviors, a decrease in the contents of il-1β, il-18, cox-2 and eprs in hippocampus, and an alleviation in the activation of hippocampal microglia and neuronal damage; the tumor suppression rates of positive drug and xkjr were 40.32% and 48.83%, respectively, suggesting a lower tumor growth rate than that of the model group. |
2023-07-20 |
2023-08-14 |
mouse |
| Ying He, Man-Shu Zou, Ting-Ting Ren, Ping Li, Yang Liu, Yuan-Shan Ha. [Therapeutic effect and mechanism of Xiaoyao Kangai Jieyu Recipe on mice with breast cancer related depression through regulating COX pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 14. 2023-07-20. PMID:37475079. |
in summary, xkjr may improve hippocampal microglia activation and neuronal damage in mice with breast cancer related depression through activating cox signaling pathway. |
2023-07-20 |
2023-08-14 |
mouse |
| Masato Kobayashi, Nobuhiro Moro, Atsuo Yoshino, Takahiro Kumagawa, Katsunori Shijo, Takeshi Maeda, Hideki Oshim. Inhibition of P2X4 and P2X7 receptors improves histological and behavioral outcomes after experimental traumatic brain injury in rats. Experimental and therapeutic medicine. vol 26. issue 2. 2023-07-17. PMID:37456165. |
in the cci-5-bdbd, cci-az11645373, and cci-5-bdbd + az11645373 groups, expression of activated microglia was suppressed in the ipsilateral cortex and hippocampus 3 days after the cci. |
2023-07-17 |
2023-08-14 |
rat |
| Amanda Moya-Gómez, Lena Pérez Font, Andreea Burlacu, Yeranddy A Alpizar, Miriam Marañón Cardonne, Bert Brône, Annelies Bronckaer. Extremely Low-Frequency Electromagnetic Stimulation (ELF-EMS) Improves Neurological Outcome and Reduces Microglial Reactivity in a Rodent Model of Global Transient Stroke. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446295. |
next, we studied microglial cells migration and, in organotypic hippocampal brain slices, we assessed neuronal survival and microglia reactivity. |
2023-07-14 |
2023-08-14 |
Not clear |
| Amanda Moya-Gómez, Lena Pérez Font, Andreea Burlacu, Yeranddy A Alpizar, Miriam Marañón Cardonne, Bert Brône, Annelies Bronckaer. Extremely Low-Frequency Electromagnetic Stimulation (ELF-EMS) Improves Neurological Outcome and Reduces Microglial Reactivity in a Rodent Model of Global Transient Stroke. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446295. |
it also improved neuronal survival and decreased glia reactivity in the hippocampus, with microglia showing the first signs of treatment effect. |
2023-07-14 |
2023-08-14 |
Not clear |