All Relations between microglial cell and hippocampus

Publication Sentence Publish Date Extraction Date Species
Dan Gao, Jin-Ping Hao, Bo-Ya Li, Ceng-Ceng Zheng, Bei-Bei Miao, Li Zhang, Ya-Li Li, Lin Li, Xing-Jie Li, Lan Zhan. Tetrahydroxy stilbene glycoside ameliorates neuroinflammation for Alzheimer's disease via cGAS-STING. European journal of pharmacology. 2023-06-16. PMID:37328043. meanwhile, it was observed that the expressions of serum inflammatory cytokines and the activation of microglia in cerebral cortex and hippocampus were suppressed after tsg treatment, which was probably attributable to the decrease of cyclic gmp-amp synthase (cgas) and stimulator of interferon genes (sting) triggered immune response and nlrp3 inflammasome activation. 2023-06-16 2023-08-14 mouse
Osamu Nakagawasai, Kohei Takahashi, Taisei Koyama, Ryota Yamagata, Wataru Nemoto, Koichi Tan-N. Activation of angiotensin-converting enzyme 2 produces an antidepressant-like effect via MAS receptors in mice. Molecular brain. vol 16. issue 1. 2023-06-13. PMID:37312182. next, we measured the levels of ace2 activation in the cerebral cortex, prefrontal cortex, hippocampus, and amygdala after dize injection, and examined which cell types, including neurons, microglia, and astrocytes, express ace2 in the hippocampus using immunofluorescence. 2023-06-13 2023-08-14 mouse
Osamu Nakagawasai, Kohei Takahashi, Taisei Koyama, Ryota Yamagata, Wataru Nemoto, Koichi Tan-N. Activation of angiotensin-converting enzyme 2 produces an antidepressant-like effect via MAS receptors in mice. Molecular brain. vol 16. issue 1. 2023-06-13. PMID:37312182. ace2 was localized to neurons, astrocytes, and microglia in the hippocampus. 2023-06-13 2023-08-14 mouse
Zhihong Zhuo, Yao Wang, Huimin Kong, Tianjiao F. GKLF, a transcriptional activator of Txnip, drives microglia activation in kainic acid-induced murine models of epileptic seizures. International immunopharmacology. vol 121. 2023-06-09. PMID:37295029. results showed that gklf enhanced ka-induced neuronal loss, pro-inflammatory cytokine secretion, activation of nod-like receptor protein-3 (nlrp3) inflammasomes and microglia, and txnip expression in the hippocampus. 2023-06-09 2023-08-14 Not clear
Kolsoum Dehdar, Morteza Salimi, Farhad Tabasi, Samaneh Dehghan, Akira Sumiyoshi, Mani Garousi, Hamidreza Jamaati, Mohammad Javan, Mohammad Reza Raouf. Allergen induces depression-like behavior in association with altered prefrontal-hippocampal circuit in male rats. Neuroscience. 2023-06-07. PMID:37286161. we found that allergen-induced depressive-like behavior was associated with more activated microglia and astrocytes in mpfc and vhipp, as well as reduced hippocampus volume. 2023-06-07 2023-08-14 rat
Chao Huang, Ting Ye, Bingran Chen, Zhuo Chen, Ying Ye, Huijun Li. Intranasal administration of lipopolysaccharide reverses chronic stress-induced depression-like behavior in mice by microglial stimulation. International immunopharmacology. vol 120. 2023-06-04. PMID:37270930. we recently reported that intraperitoneal injection of a low dose of lipopolysaccharide (lps) reversed depression-like behavior in mice induced by chronic stress by stimulating microglia in the hippocampus. 2023-06-04 2023-08-14 mouse
Chen-Meng Qiao, Wei Quan, Yu Zhou, Gu-Yu Niu, Hui Hong, Jian Wu, Li-Ping Zhao, Ting Li, Chun Cui, Wei-Jiang Zhao, Yan-Qin She. Orally Induced High Serum Level of Trimethylamine N-oxide Worsened Glial Reaction and Neuroinflammation on MPTP-Induced Acute Parkinson's Disease Model Mice. Molecular neurobiology. 2023-06-02. PMID:37266763. furthermore, immunofluorescence, elisa, and rt-qpcr results of the hippocampus also showed that high serum tmao significantly promoted the activation of microglia and astrocytes in the dentate gyrus, increased the levels of tnf-α and il-1β, and upregulated gene expression of m1 microglia-related markers (including cd16, cd32, and inos) and a2 astrocyte-related markers (including s100a10, ptx3, and emp1) in mrna levels. 2023-06-02 2023-08-14 mouse
Zengyu Zhang, Zimin Guo, Pengpeng Jin, Hualan Yang, Mengting Hu, Yuan Zhang, Zhilan Tu, Shuangxing Ho. Transcriptome Profiling of Hippocampus After Cerebral Hypoperfusion in Mice. Journal of molecular neuroscience : MN. 2023-06-02. PMID:37266840. increased inflammatory cells, particularly microglia, often parallel hypoperfusion-induced gray matter damage such as hippocampal lesions, but the exact mechanism remains largely unknown. 2023-06-02 2023-08-14 mouse
David J Braun, Hilaree N Frazier, Verda A Davis, Meggie J Coleman, Colin B Rogers, Linda J Van Eldi. Early chronic suppression of microglial p38α in a model of Alzheimer's disease does not significantly alter amyloid-associated neuropathology. PloS one. vol 18. issue 5. 2023-06-01. PMID:37256881. however, this manipulation did significantly increase hippocampal levels of soluble aβ42 and reduce colocalization of iba1 and 6e10 in a subset of microglia in close proximity to plaques. 2023-06-01 2023-08-14 mouse
Kevin Sanchez, Sienna L Wu, Reha Kakkar, Jeffrey S Darling, Claire S Harper, Laura K Fonke. Ovariectomy in mice primes hippocampal microglia to exacerbate behavioral sickness responses. Brain, behavior, & immunity - health. vol 30. 2023-05-31. PMID:37256192. ovariectomy in mice primes hippocampal microglia to exacerbate behavioral sickness responses. 2023-05-31 2023-08-14 mouse
Zhourui Wu, Ran Zhu, Yan Yu, Jianjie Wang, Xiao Hu, Wei Xu, Yilong Ren, Chen Li, Zhili Zeng, Bin Ma, Ning Xie, Gufa Lin, Bei Ma, Rongrong Zhu, Keqiang Ye, Liming Chen. Spinal cord injury-activated C/EBPβ-AEP axis mediates cognitive impairment through APP C586/Tau N368 fragments spreading. Progress in neurobiology. 2023-05-31. PMID:37257680. elevated c/ebpβ level, as well as microglia population and inflammatory cytokines were also noticed in the cortex and hippocampus of sci mice. 2023-05-31 2023-08-14 mouse
Arielle J D Hay, Amanda S Latham, Genova Mumford, Amelia D Hines, Sydney Risen, Elizabeth Gordon, Connor Siebenaler, Vincenzo S Gilberto, Mark D Zabel, Julie A Moren. Intranasally delivered mesenchymal stromal cells decrease glial inflammation early in prion disease. Frontiers in neuroscience. vol 17. 2023-05-30. PMID:37250395. admsc treatment promoted a quiescent state in hippocampal microglia by inducing changes in both number and morphology. 2023-05-30 2023-08-14 mouse
Giacomo Gravina, Maryam Ardalan, Tetyana Chumak, Halfdan Rydbeck, Xiaoyang Wang, Carl Joakim Ek, Carina Mallar. Transcriptome network analysis links perinatal Staphylococcus epidermidis infection to microglia reprogramming in the immature hippocampus. Glia. 2023-05-29. PMID:37246946. transcriptome network analysis links perinatal staphylococcus epidermidis infection to microglia reprogramming in the immature hippocampus. 2023-05-29 2023-08-14 mouse
Giacomo Gravina, Maryam Ardalan, Tetyana Chumak, Halfdan Rydbeck, Xiaoyang Wang, Carl Joakim Ek, Carina Mallar. Transcriptome network analysis links perinatal Staphylococcus epidermidis infection to microglia reprogramming in the immature hippocampus. Glia. 2023-05-29. PMID:37246946. we employed morphological, transcriptomic and physiological methods to extensively characterize microglia in the immature hippocampus following s. epidermidis infection. 2023-05-29 2023-08-14 mouse
Ha-Yeun Chung, Jonathan Wickel, Nina Hahn, Nils Mein, Meike Schwarzbrunn, Philipp Koch, Mihai Ceanga, Holger Haselmann, Carolin Baade-Büttner, Nikolai von Stackelberg, Nina Hempel, Lars Schmidl, Marco Groth, Nico Andreas, Juliane Götze, Sina M Coldewey, Michael Bauer, Christian Mawrin, Justina Dargvainiene, Frank Leypoldt, Stephan Steinke, Zhao-Qi Wang, Michael Hust, Christian Gei. Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in sepsis-associated encephalopathy. Science advances. vol 9. issue 21. 2023-05-26. PMID:37235660. we identified microglia and c1q complement activation in hippocampal autopsy tissue of patients with sepsis and increased c1q-mediated synaptic pruning in a murine polymicrobial sepsis model. 2023-05-26 2023-08-14 mouse
Ha-Yeun Chung, Jonathan Wickel, Nina Hahn, Nils Mein, Meike Schwarzbrunn, Philipp Koch, Mihai Ceanga, Holger Haselmann, Carolin Baade-Büttner, Nikolai von Stackelberg, Nina Hempel, Lars Schmidl, Marco Groth, Nico Andreas, Juliane Götze, Sina M Coldewey, Michael Bauer, Christian Mawrin, Justina Dargvainiene, Frank Leypoldt, Stephan Steinke, Zhao-Qi Wang, Michael Hust, Christian Gei. Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in sepsis-associated encephalopathy. Science advances. vol 9. issue 21. 2023-05-26. PMID:37235660. unbiased transcriptomics of hippocampal tissue and isolated microglia derived from septic mice revealed an involvement of the innate immune system, complement activation, and up-regulation of lysosomal pathways during sae in parallel to neuronal and synaptic damage. 2023-05-26 2023-08-14 mouse
Ali Nouraeineja. The functional and structural changes in the hippocampus of COVID-19 patients. Acta neurologica Belgica. 2023-05-24. PMID:37226033. covid-19 activates microglia in the hippocampus and induces a cns cytokine storm, leading to loss of hippocampal neurogenesis. 2023-05-24 2023-08-14 human
Yulong Wu, Zhouyan Dong, Xinze Jiang, Lei Qu, Wei Zhou, Xu Sun, Jiangshan Hou, Hongmei Xu, Mei Chen. Gut Microbiota Taxon-Dependent Transformation of Microglial M1/M2 Phenotypes Underlying Mechanisms of Spatial Learning and Memory Impairment after Chronic Methamphetamine Exposure. Microbiology spectrum. 2023-05-22. PMID:37212669. here, we investigated the impact of the gut microbiota on the phenotype status of microglia (microglial phenotypes m1 and microglial m2) and their secreting factors, the subsequent hippocampal neural processes, and the resulting influence on spatial learning and memory of chronically meth-exposed mice. 2023-05-22 2023-08-14 mouse
Hyun Joo Shin, Kyung Eun Kim, Eun Ae Jeong, Hyeong Seok An, So Jeong Lee, Jaewoong Lee, Gu Seob Ro. Amyloid β oligomer promotes microglial galectin-3 and astrocytic lipocalin-2 levels in the hippocampus of mice fed a high-fat diet. Biochemical and biophysical research communications. vol 667. 2023-05-18. PMID:37201358. sholl analysis of iba-1-positive microglia showed retraction of microglial ramifications in the hippocampus of hfd-fed diabetic mice. 2023-05-18 2023-08-14 mouse
Song-Ji Li, Min-Hui Ma, Jun-Mei Li, Xiao-Yu Lu, Cheng-Biao Lu, Shi-Fen Zhou, Lin-Xuan Zhang, Meng-Qing Li, Tong-Ze Shao, Su-Ping Bai, Xiao-Xin Yan, Fang Li, Chang-Qi L. CNTN1 Aggravates Neuroinflammation and Triggers Cognitive Deficits in Male Mice by Boosting Crosstalk between Microglia and Astrocytes. Aging and disease. 2023-05-17. PMID:37196127. the mechanisms underlying these cognitive deficits could be attributed to hippocampal microglia and astrocyte activation, which led to aberrant expression of excitatory amino acid transporters (eaat)1/eaat2. 2023-05-17 2023-08-14 mouse