| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shengliang Peng, Yun Yu, Juan Li, Danling Jiang, Guohai Xu, Lidong Wu, Jialing H. Hsp22 pretreatment protection against LPS-induced hippocampal injury by alleviating neuroinflammation and apoptosis by regulating the NLRP3/Caspase1/IL-1β signaling pathway in mice. Aging. vol 15. 2023-03-19. PMID:36934348. |
preconditioning with the hsp22-overexpressing lentivirus attenuated lps-induced activation of hippocampal microglia, the expression of inflammatory factors and pathway proteins, and apoptosis, and improved cognitive impairment in mice. |
2023-03-19 |
2023-08-14 |
mouse |
| Jiangnan Wu, Yanjing Guo, Wei Li, Zihao Zhang, Xinlei Li, Qidi Zhang, Qihang Du, Xinhuan Niu, Xijiang Liu, Gongming Wan. Microglial priming induced by loss of Mef2C contributes to postoperative cognitive dysfunction in aged mice. Experimental neurology. 2023-03-17. PMID:36931617. |
we found here that exploratory laparotomy induced cognitive function decline in aged mice but not in young mice and that this decline was accompanied by inflammatory activation of microglia in the hippocampus. |
2023-03-17 |
2023-08-14 |
mouse |
| Alex P Vu, David Lam, Cayla Denney, Kelly V Lee, Jason R Plemel, Jesse Jackso. Social isolation produces a sex and brain-region specific alteration of microglia state. The European journal of neuroscience. 2023-03-15. PMID:36918398. |
our results show that the dorsomedial hypothalamus and hippocampal ca2 region of adult male mice undergo increased microglia volume, territory, and endpoints following social isolation, whereas females exhibit this increase in the hypothalamus only. |
2023-03-15 |
2023-08-14 |
mouse |
| Benjamin B Tournier, Christophe Snoeijs, Stergios Tsartsalis, Quentin Amossé, Ramzi Farchoukh, Eniko Kövari, Kelly Ceyzériat, Philippe Mille. The 18 kDa translocator protein is associated with microglia in the hippocampus of non-demented elderly subjects. Aging brain. vol 2. 2023-03-13. PMID:36908874. |
the 18 kda translocator protein is associated with microglia in the hippocampus of non-demented elderly subjects. |
2023-03-13 |
2023-08-14 |
human |
| Benjamin B Tournier, Christophe Snoeijs, Stergios Tsartsalis, Quentin Amossé, Ramzi Farchoukh, Eniko Kövari, Kelly Ceyzériat, Philippe Mille. The 18 kDa translocator protein is associated with microglia in the hippocampus of non-demented elderly subjects. Aging brain. vol 2. 2023-03-13. PMID:36908874. |
this study sustains the hypothesis that tspo is mainly associated with microglia and in aβ42-rich subdivisions in the hippocampus of non-demented elderly individuals. |
2023-03-13 |
2023-08-14 |
human |
| Eunbi Cho, Se Jin Jeon, Jieun Jeon, Jee Hyun Yi, Huiyoung Kwon, Hyun-Ji Kwon, Kyoung Ja Kwon, Minho Moon, Chan Young Shin, Dong Hyun Ki. Phyllodulcin improves hippocampal long-term potentiation in 5XFAD mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 161. 2023-03-13. PMID:36913892. |
oral administration of phyllodulcin improved aβ-induced memory impairments in normal mice, reduced aβ deposition in the hippocampus, inhibited the activation of microglia and astrocytes, and improved synaptic plasticity in 5xfad mice. |
2023-03-13 |
2023-08-14 |
mouse |
| Danielle Guez-Barber, Lorianna M Colon, Dana Raphael, Max A Wragan, Sanghee Yun, Amelia J Eisc. Female and male microglia are not different in the dentate gyrus of postnatal day 10 mice. Neuroscience letters. 2023-03-10. PMID:36898652. |
indeed, postnatal day (p)-dependent sex differences in number, density, and morphology of microglia have been reported in certain hippocampal subregions at specific ages. |
2023-03-10 |
2023-08-14 |
mouse |
| Dionysis Nikolopoulos, Theodora Manolakou, Alexia Polissidis, Anastasia Filia, George Bertsias, Yassemi Koutmani, Dimitrios T Boumpa. Microglia activation in the presence of intact blood-brain barrier and disruption of hippocampal neurogenesis via IL-6 and IL-18 mediate early diffuse neuropsychiatric lupus. Annals of the rheumatic diseases. 2023-03-10. PMID:36898766. |
microglia activation in the presence of intact blood-brain barrier and disruption of hippocampal neurogenesis via il-6 and il-18 mediate early diffuse neuropsychiatric lupus. |
2023-03-10 |
2023-08-14 |
Not clear |
| Peiyan Jiang, Lianyu Zhou, Zhulin Du, Linyang Zhao, Yexi Tang, Xinghang Fei, Lian Wang, Dabing Li, Song Li, Hui Yang, Xiaotang Fan, Huiling Lia. Icariin alleviates autistic-like behavior, hippocampal inflammation and vGlut1 expression in adult BTBR mice. Behavioural brain research. 2023-03-08. PMID:36889463. |
furthermore, ica treatment inhibited neuroinflammation via decreasing microglia number and the soma size in the ca1 region of the hippocampus, as well as the protein levels of proinflammatory cytokines in the hippocampus of btbr mice. |
2023-03-08 |
2023-08-14 |
mouse |
| Yi-Ying Wang, Yu-Ning Zhou, Lin Jiang, Shun Wang, Lin Zhu, Shan-Shan Zhang, Hao Yang, Qi He, Li Liu, Yu-Han Xie, Xin Liang, Jing Tang, Feng-Lei Chao, Yong Tan. Long-term voluntary exercise inhibited AGE/RAGE and microglial activation and reduced the loss of dendritic spines in the hippocampi of APP/PS1 transgenic mice. Experimental neurology. 2023-03-05. PMID:36871860. |
however, further studies are needed to determine whether running exercise reduces synapse loss in the hippocampus in an ad model by regulating microglia. |
2023-03-05 |
2023-08-14 |
mouse |
| Li-Ping Huang, Long-Hui Lu, Xi-Yang Yang, Yong-Yan Xie, Zi-Wei Xu, Xu-Dong Zhu, Jing-Jing Wang, Zhi-Xin Wu, Jian-Fu Tang, Yi Wu, Yao-Hui Che. [Effect of Erjing Pills on alleviating neuroinflammation of AD rats based on TLR4/NF-κB/NLRP3 pathway and its mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 3. 2023-03-05. PMID:36872241. |
the results showed that as compared with the sham group, the new object recognition index of rats in the model control group decreased significantly, the deposition of aβ_(1-42) and p-tau~(404) positive protein in the hippocampus increased significantly, and the levels of microglia activation increased significantly in the dentate gyrus. |
2023-03-05 |
2023-08-14 |
rat |
| Li-Ping Huang, Long-Hui Lu, Xi-Yang Yang, Yong-Yan Xie, Zi-Wei Xu, Xu-Dong Zhu, Jing-Jing Wang, Zhi-Xin Wu, Jian-Fu Tang, Yi Wu, Yao-Hui Che. [Effect of Erjing Pills on alleviating neuroinflammation of AD rats based on TLR4/NF-κB/NLRP3 pathway and its mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 3. 2023-03-05. PMID:36872241. |
compared with the model control group, the erjing pill groups enhanced the new object recognition index of rats, decreased the deposition of aβ_(1-42) and the expression of p-tau~(404) positive protein in the hippocampus, inhibited the activation of microglia in the dentate gyrus, reduced the levels of inflammatory factors il-1β, tnf-α, and il-6 in the hippocampus, and down-regulated the expression levels of tlr4, p-nf-κb p65/nf-κb p65, p-iκbα/iκbα, and nlrp3 proteins in the hippocampus. |
2023-03-05 |
2023-08-14 |
rat |
| Li-Ping Huang, Long-Hui Lu, Xi-Yang Yang, Yong-Yan Xie, Zi-Wei Xu, Xu-Dong Zhu, Jing-Jing Wang, Zhi-Xin Wu, Jian-Fu Tang, Yi Wu, Yao-Hui Che. [Effect of Erjing Pills on alleviating neuroinflammation of AD rats based on TLR4/NF-κB/NLRP3 pathway and its mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 3. 2023-03-05. PMID:36872241. |
in conclusion, erjing pills can improve the learning and memory ability of the rat model of ad presumably by improving the activation of microglia, reducing the expression levels of neuroinflammatory factors il-1β, tnf-α, and il-6, inhibiting the tlr4/nf-κb/nlrp3 neuroinflammation pathway, and decreasing hippocampal deposition of aβ and expression of p-tau, thereby restoring the hippocampal morphological structure. |
2023-03-05 |
2023-08-14 |
rat |
| Sepideh Ghazvineh, Morteza Salimi, Samaneh Dehghan, Azam Asemi-Rad, Kolsoum Dehdar, Alireza Salimi, Hamidreza Jamaati, Mohammad Reza Raouf. Stimulating olfactory epithelium mitigates mechanical ventilation-induced hippocampal inflammation and apoptosis. Hippocampus. 2023-03-03. PMID:36864704. |
we found that stimulating olfactory epithelium through applying rhythmic nasal ap, in association with reviving respiration-coupled brain rhythm, mitigates mv-induced hippocampal apoptosis and inflammation involving microglia and astrocytes. |
2023-03-03 |
2023-08-14 |
rat |
| Lior Naggan, Elad Robinson, Eyal Dinur, Hagar Goldenberg, Ewa Kozela, Raz Yirmiy. Suicide in bipolar disorder patients is associated with hippocampal microglia activation and reduction of lymphocytes-activation gene 3 (LAG3) microglial checkpoint expression. Brain, behavior, and immunity. 2023-03-02. PMID:36863492. |
suicide in bipolar disorder patients is associated with hippocampal microglia activation and reduction of lymphocytes-activation gene 3 (lag3) microglial checkpoint expression. |
2023-03-02 |
2023-08-14 |
Not clear |
| Sara Merlo, Grazia Ilaria Caruso, Dhwani Sunil Korde, Alla Khodorovska, Christian Humpel, Maria Angela Sortin. Melatonin Activates Anti-Inflammatory Features in Microglia in a Multicellular Context: Evidence from Organotypic Brain Slices and HMC3 Cells. Biomolecules. vol 13. issue 2. 2023-02-25. PMID:36830742. |
in the present study, we exploited the highly preserved cytoarchitecture of organotypic brain cultures (oc) to explore the effects of mel on hippocampal microglia in a 3d context as compared to a single cell type context represented by the human hmc3 cell line. |
2023-02-25 |
2023-08-14 |
human |
| Xinlin Li, Rong Zhou, Hui Peng, Jing Peng, Qiaoling Li, Meng Me. Microglia PKM2 Mediates Neuroinflammation and Neuron Loss in Mice Epilepsy through the Astrocyte C3-Neuron C3R Signaling Pathway. Brain sciences. vol 13. issue 2. 2023-02-25. PMID:36831807. |
we knocked down microglia pkm2 in the hippocampus using a stereotaxic adeno-associated virus (aav) microinjection and established a pilocarpine-induced status epilepticus (pise) model. |
2023-02-25 |
2023-08-14 |
mouse |
| Divya Bharathi Selvaraj, Jemi Feiona Vergil Andrews, Muthuswamy Anusuyadevi, Mahesh Kandasam. Ranitidine Alleviates Anxiety-like Behaviors and Improves the Density of Pyramidal Neurons upon Deactivation of Microglia in the CA3 Region of the Hippocampus in a Cysteamine HCl-Induced Mouse Model of Gastrointestinal Disorder. Brain sciences. vol 13. issue 2. 2023-02-25. PMID:36831809. |
ranitidine alleviates anxiety-like behaviors and improves the density of pyramidal neurons upon deactivation of microglia in the ca3 region of the hippocampus in a cysteamine hcl-induced mouse model of gastrointestinal disorder. |
2023-02-25 |
2023-08-14 |
mouse |
| Divya Bharathi Selvaraj, Jemi Feiona Vergil Andrews, Muthuswamy Anusuyadevi, Mahesh Kandasam. Ranitidine Alleviates Anxiety-like Behaviors and Improves the Density of Pyramidal Neurons upon Deactivation of Microglia in the CA3 Region of the Hippocampus in a Cysteamine HCl-Induced Mouse Model of Gastrointestinal Disorder. Brain sciences. vol 13. issue 2. 2023-02-25. PMID:36831809. |
nissl staining and immunohistochemical assessment of ionized calcium-binding adapter molecule (iba)-1 positive microglia in cryosectioned brains indicated enhanced density of pyramidal neurons and reduced activation of microglia in the hippocampal ca-3 region of brains of ranitidine-treated experimental mice. |
2023-02-25 |
2023-08-14 |
mouse |
| Chouhui Xuan, Haixia Cui, Zhengyong Jin, Yuyang Yue, Shuxia Cao, Songbiao Cui, Dongyuan X. Glutamine ameliorates hyperoxia-induced hippocampal damage by attenuating inflammation and apoptosis Frontiers in pharmacology. vol 14. 2023-02-23. PMID:36817145. |
gln treatment significantly reduced brain tissue water content, oxidative stress levels, microglia activation and inflammatory factor expression, and attenuated tissue damage and apoptosis in the hippocampal region. |
2023-02-23 |
2023-08-14 |
rat |