| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Orlando Torres-Rodríguez, Yesenia Rivera-Escobales, Yesenia Castillo-Ocampo, Bethzaly Velazquez, María Colón, James T Porte. Purinergic P2X7 Receptor-mediated inflammation precedes PTSD-related Behaviors in Rats. Brain, behavior, and immunity. 2023-02-23. PMID:36822379. |
three days after sps exposure, increased inflammatory cytokines were found in the blood and hippocampal microglia showed increased expression of the p2x7r, il-1β, and tnf-α, suggesting increased peripheral and central inflammation before the onset of impaired fear extinction. |
2023-02-23 |
2023-08-14 |
rat |
| Orlando Torres-Rodríguez, Yesenia Rivera-Escobales, Yesenia Castillo-Ocampo, Bethzaly Velazquez, María Colón, James T Porte. Purinergic P2X7 Receptor-mediated inflammation precedes PTSD-related Behaviors in Rats. Brain, behavior, and immunity. 2023-02-23. PMID:36822379. |
in addition, sps-exposed animals with impaired fear extinction recall also had more iba1-positive microglia expressing the p2x7r in the ventral hippocampus. |
2023-02-23 |
2023-08-14 |
rat |
| Xiaolin Zhong, Yajuan Wang, Dandan Liu, Yue Liang, WenJia Liu, Yanmei Huang, Lihua Xie, Wenyu Cao, Yang Xu, Ling Che. HC067047 Ameliorates SAE by Suppressing Endoplasmic Reticulum Stress and Oxidative Stress-Induced Pyroptosis in the Hippocampi of Mice. Neuroscience. 2023-02-22. PMID:36805006. |
additionally, we found that hc067047 selectively prevented pyroptosis in hippocampal cells, mainly the neurons, oligodendrocytes and the resident microglia. |
2023-02-22 |
2023-08-14 |
mouse |
| Yingbiao Yue, Lei Zou, Hong Li, Yu Xia, Zhouyang Ren, Fazhen Yang, Deshenyue Kong, Guofen Re, Huayou Luo, Zunyue Zhang, Kunhua Wang, Mei Zh. Therapeutic effect of implanted and non-invasive vagus nerve stimulation on heroin-induced anxiety. Biochemical and biophysical research communications. vol 652. 2023-02-22. PMID:36809704. |
using immunofluorescence, we observed the proliferation and activation of microglia in the hippocampus. |
2023-02-22 |
2023-08-14 |
mouse |
| Yingbiao Yue, Lei Zou, Hong Li, Yu Xia, Zhouyang Ren, Fazhen Yang, Deshenyue Kong, Guofen Re, Huayou Luo, Zunyue Zhang, Kunhua Wang, Mei Zh. Therapeutic effect of implanted and non-invasive vagus nerve stimulation on heroin-induced anxiety. Biochemical and biophysical research communications. vol 652. 2023-02-22. PMID:36809704. |
the anxiety level of heroin-treated mice was significantly increased, microglia in the hippocampus was significantly proliferated and activated, and the proinflammatory factors (il-1β, il-6, tnf-α) in the hippocampus were significantly up-regulated. |
2023-02-22 |
2023-08-14 |
mouse |
| Jing Zhu, Soojin Park, Chul Hoon Kim, Kyoung Hoon Jeong, Won-Joo Ki. Eugenol alleviates neuronal damage via inhibiting inflammatory process against pilocarpine-induced status epilepticus. Experimental biology and medicine (Maywood, N.J.). 2023-02-21. PMID:36802956. |
our results showed that eugenol reduced se-induced apoptotic neuronal cell death, mitigated the activation of astrocytes and microglia, and attenuated the expression of interleukin-1β and tumor necrosis factor α in the hippocampus after se onset. |
2023-02-21 |
2023-08-14 |
Not clear |
| Chie Hisada, Kyoko Kajimoto, Hiroko Tsugane, Iinuma Mitsuo, Kagaku Azuma, Kin-Ya Kub. Maternal chewing alleviates prenatal stress-related neuroinflammation mediated by microglia in the hippocampus of the mouse offspring. Journal of prosthodontic research. 2023-02-15. PMID:36792221. |
maternal chewing alleviates prenatal stress-related neuroinflammation mediated by microglia in the hippocampus of the mouse offspring. |
2023-02-15 |
2023-08-14 |
mouse |
| Suresh B Rangasamy, Jit Poddar, Kalipada Paha. Protection of Mice from Controlled Cortical Impact Injury by Food Additive Glyceryl Tribenzoate. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36768402. |
oral administration of gtb decreased the activation of microglia and astrocytes to inhibit the expression of inducible nitric oxide synthase (inos) in hippocampus and cortex of tbi mice. |
2023-02-11 |
2023-08-14 |
mouse |
| Yeon Joo Choi, Min Jea Shin, Gi Soo Youn, Jung Hwan Park, Hyeon Ji Yeo, Eun Ji Yeo, Hyun Jung Kwon, Lee Re Lee, Na Yeon Kim, Su Yeon Kwon, Hyo Young Jung, Yong-Jun Cho, Dae Won Kim, Jinseu Park, Kyu Hyung Han, Keun Wook Lee, Jong Kook Park, Chan Hee Lee, Won Sik Eum, Soo Young Cho. Protective Effects of PEP-1-GSTA2 Protein in Hippocampal Neuronal Cell Damage Induced by Oxidative Stress. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36769090. |
an in vivo ischemic animal model, pep-1-gsta2, markedly prevented the loss of hippocampal neurons and reduced the activation of microglia and astrocytes. |
2023-02-11 |
2023-08-14 |
Not clear |
| Anqi Kong, Tianyao Liu, Shilong Deng, Shiyao Xu, Yi Luo, Jianghui Li, Zhulin Du, Liuyongwei Wang, Xingshun Xu, Xiaotang Fa. Novel antidepressant-like properties of the fullerenol in an LPS-induced depressive mouse model. International immunopharmacology. vol 116. 2023-02-04. PMID:36738679. |
we found that fullerenol treatment mitigated lps-induced hippocampal microglia activation and released proinflammatory cytokines. |
2023-02-04 |
2023-08-14 |
mouse |
| Dan Gao, Ceng-Ceng Zheng, Jin-Ping Hao, Cui-Cui Yang, Chao-Ying H. Icariin Ameliorates Behavioral Deficits and Neuropathology in a Mouse Model of Multiple Sclerosis. Brain research. 2023-02-02. PMID:36731819. |
meanwhile, it was observed that the activation of microglia in cerebral cortex and hippocampus were inhibited followed by the neuroinflammatory cytokines downregulation such as il-1β, il-6 and tnf-α after ica treatment, which was probably attributable to the suppression of microglial nlrp3 inflammasome activation. |
2023-02-02 |
2023-08-14 |
mouse |
| Xintong Wang, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Che. Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation. Microbiome. vol 11. issue 1. 2023-02-01. PMID:36721179. |
here, we established fecal microbiota transplantation, aeromonas colonization and lps or butyrate supplementation tests to evaluate the role of the intestinal microbiota and its metabolites in melatonin in alleviating sd-induced memory impairment. results: transplantation of the sd-gut microbiota into normal mice induced microglia overactivation and neuronal apoptosis in the hippocampus, cognitive decline, and colonic microbiota disorder, manifesting as increased levels of aeromonas and lps and decreased levels of lachnospiraceae_nk4a136 and butyrate. |
2023-02-01 |
2023-08-14 |
mouse |
| Kathryn A McNaughton, Lauren L Williamso. EFFECTS OF SEX AND PRO-INFLAMMATORY CYTOKINES ON CONTEXT DISCRIMINATION MEMORY. Behavioural brain research. 2023-01-31. PMID:36720350. |
inflammation alone did not alter microglia morphology, but il-1ra did in certain sub-regions of the hippocampus. |
2023-01-31 |
2023-08-14 |
rat |
| Dusica Maysinger, Issan Zhang, Pei You Wu, Marten Kagelmacher, Haiming Daniel Luo, Jayachandran N Kizhakkedathu, Jens Dernedde, Matthias Ballauf, Rainer Haag, Adeola Shobo, Gerhard Multhaup, R Anne McKinne. Sulfated Hyperbranched and Linear Polyglycerols Modulate HMGB1 and Morphological Plasticity in Neural Cells. ACS chemical neuroscience. 2023-01-30. PMID:36717083. |
(ii) dpgs can normalize hmgb1 compartmentalization in microglia exposed to lps and prevent dendritic spine loss in the excitatory hippocampal neurons. |
2023-01-30 |
2023-08-14 |
Not clear |
| Iván Ballasch, Esther García-García, Cristina Vila, Anna Pérez-González, Anna Sancho-Balsells, Jéssica Fernández, David Soto, Mar Puigdellívol, Xavier Gasull, Jordi Alberch, Manuel J Rodríguez, Josep M Canals, Albert Giral. Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration. Brain, behavior, and immunity. 2023-01-26. PMID:36702234. |
using genetic tools, here we describe that ikzf1 is specifically expressed in the adult microglia in brain regions such as cortex and hippocampus. |
2023-01-26 |
2023-08-14 |
mouse |
| Iván Ballasch, Esther García-García, Cristina Vila, Anna Pérez-González, Anna Sancho-Balsells, Jéssica Fernández, David Soto, Mar Puigdellívol, Xavier Gasull, Jordi Alberch, Manuel J Rodríguez, Josep M Canals, Albert Giral. Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration. Brain, behavior, and immunity. 2023-01-26. PMID:36702234. |
by characterizing the ikzf1 deficient mice, we observed that these mice displayed spatial learning deficits, impaired hippocampal ca3-ca1 long-term potentiation, and decreased spine density in pyramidal neurons of the ca1, which correlates with an increased expression of synaptic markers within microglia. |
2023-01-26 |
2023-08-14 |
mouse |
| Iván Ballasch, Esther García-García, Cristina Vila, Anna Pérez-González, Anna Sancho-Balsells, Jéssica Fernández, David Soto, Mar Puigdellívol, Xavier Gasull, Jordi Alberch, Manuel J Rodríguez, Josep M Canals, Albert Giral. Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration. Brain, behavior, and immunity. 2023-01-26. PMID:36702234. |
additionally, these ikzf1 deficient microglia exhibited a severe abnormal morphology in the hippocampus, which is accompanied by astrogliosis, an aberrant composition of the inflammasome, and an altered expression of disease-associated microglia molecules. |
2023-01-26 |
2023-08-14 |
mouse |
| Iván Ballasch, Esther García-García, Cristina Vila, Anna Pérez-González, Anna Sancho-Balsells, Jéssica Fernández, David Soto, Mar Puigdellívol, Xavier Gasull, Jordi Alberch, Manuel J Rodríguez, Josep M Canals, Albert Giral. Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration. Brain, behavior, and immunity. 2023-01-26. PMID:36702234. |
since the lack of ikzf1 in mice appears to induce the internalization of synaptic markers within microglia, and severe gliosis we then analyzed hippocampal ikzf1 levels in several models of neurological disorders. |
2023-01-26 |
2023-08-14 |
mouse |
| Du Zheng, Hongwei Wang, Youfa Zhou, Yeru Chen, Gang Che. Ac-YVAD-cmk ameliorated sevoflurane-induced cognitive dysfunction and revised mitophagy impairment. PloS one. vol 18. issue 1. 2023-01-25. PMID:36696410. |
the cleaved caspase-1 was demonstrated in microglia of hippocampus. |
2023-01-25 |
2023-08-14 |
mouse |
| Xiaorong Wu, Shiqi Li, Meijia Zhang, Shengjun Bai, Yangyue Ni, Qiaoqiao Xu, Yun Fan, Chuncheng Lu, Zhipeng Xu, Chenbo Ji, Guizhen Du, Yufeng Qi. Early-life bisphenol AP exposure impacted neurobehaviors in adulthood through microglial activation in mice. Chemosphere. 2023-01-25. PMID:36696922. |
besides, single-nucleus rna-sequencing (snrna-seq) showed bpap exposure altered the transcriptome of microglia in hippocampus. |
2023-01-25 |
2023-08-14 |
mouse |