| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ming-Hong Lin, Po-Ching Cheng, Pi-Jung Hsiao, Szu-Chia Chen, Chih-Hsing Hung, Chao-Hung Kuo, Shau-Ku Huang, Hsin-Ying Clair Chio. The GLP-1 receptor agonist exenatide ameliorates neuroinflammation, locomotor activity, and anxiety-like behavior in mice with diet-induced obesity through the modulation of microglial M2 polarization and downregulation of SR-A4. International immunopharmacology. vol 115. 2023-01-01. PMID:36587502. |
moreover, exenatide increased phosphor-erk and m2-type microglia marker arginase-1 expression in the hippocampus and cortex. |
2023-01-01 |
2023-08-14 |
mouse |
| Regina T Vontell, Juan Pablo de Rivero Vaccari, Xiaoyan Sun, Sakir Humayun Gultekin, Helen M Bramlett, W Dalton Dietrich, Robert W Kean. Identification of inflammasome signaling proteins in neurons and microglia in early and intermediate stages of Alzheimer's disease. Brain pathology (Zurich, Switzerland). 2022-12-29. PMID:36579934. |
there was a significant increase of asc in neurons labeled by ic100, whereas microglia in the hippocampus and subiculum were labeled with the commercial anti-asc antibody. |
2022-12-29 |
2023-08-14 |
Not clear |
| Wenshu Zou, Kai Zhang, Zhengying Qiu, Ruihua Xin, Guibo Wang, Jingyan Zhang, Jianxi L. Asiatic acid and andrographolide reduce hippocampal injury through suppressing neuroinflammation caused by Salmonella typhimurium infection. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-12-29. PMID:36581090. |
aa and ad attenuated s. typhimurium -induced hippocampal injury by reducing the inflammatory response on microglia. |
2022-12-29 |
2023-08-14 |
mouse |
| Diego Bulcão Visco, Raul Manhães-de-Castro, Márcia Maria da Silva, Bárbara J R Costa-de-Santana, Joaci Pereira Dos Santos Junior, Luís Miguel Saavedra, Maria Daniele Teixeira Beltrão de Lemos, Juan José Valdéz-Alarcón, Claudia Jacques Lagranha, Omar Guzman-Quevedo, Luz Torner, Ana Elisa Toscan. Neonatal kaempferol exposure attenuates impact of cerebral palsy model on neuromotor development, cell proliferation, microglia activation, and antioxidant enzyme expression in the hippocampus of rats. Nutritional neuroscience. 2022-12-28. PMID:36576161. |
neonatal kaempferol exposure attenuates impact of cerebral palsy model on neuromotor development, cell proliferation, microglia activation, and antioxidant enzyme expression in the hippocampus of rats. |
2022-12-28 |
2023-08-14 |
rat |
| Diego Bulcão Visco, Raul Manhães-de-Castro, Márcia Maria da Silva, Bárbara J R Costa-de-Santana, Joaci Pereira Dos Santos Junior, Luís Miguel Saavedra, Maria Daniele Teixeira Beltrão de Lemos, Juan José Valdéz-Alarcón, Claudia Jacques Lagranha, Omar Guzman-Quevedo, Luz Torner, Ana Elisa Toscan. Neonatal kaempferol exposure attenuates impact of cerebral palsy model on neuromotor development, cell proliferation, microglia activation, and antioxidant enzyme expression in the hippocampus of rats. Nutritional neuroscience. 2022-12-28. PMID:36576161. |
this study aims to assess the effect of neonatal treatment with kaempferol on neuromotor development, proliferation of neural precursor cells, the microglia profile, and antioxidant enzyme gene expression in the hippocampus. |
2022-12-28 |
2023-08-14 |
rat |
| Anika Neuschulz, Olga Bakina, Victor Badillo-Lisakowski, Pedro Olivares-Chauvet, Thomas Conrad, Michael Gotthardt, Helmut Kettenmann, Jan Philipp Junke. A single-cell RNA labeling strategy for measuring stress response upon tissue dissociation. Molecular systems biology. 2022-12-27. PMID:36573354. |
finally, we showed that dissociation of the mouse hippocampus can lead to the artificial activation of microglia. |
2022-12-27 |
2023-08-14 |
mouse |
| Jie Wu, Ziwen Hao, Ying Wang, Dongying Yan, Jia Meng, Honglin M. Melatonin alleviates BDE-209-induced cognitive impairment and hippocampal neuroinflammation by modulating microglia polarization via SIRT1-mediated HMGB1/TLR4/NF-κB pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-12-25. PMID:36566971. |
melatonin alleviates bde-209-induced cognitive impairment and hippocampal neuroinflammation by modulating microglia polarization via sirt1-mediated hmgb1/tlr4/nf-κb pathway. |
2022-12-25 |
2023-08-14 |
rat |
| Lei Gao, Daryl L Davies, Liana Asatrya. Sodium Butyrate Supplementation Modulates Neuroinflammatory Response Aggravated by Antibiotic Treatment in a Mouse Model of Binge-like Ethanol Drinking. International journal of molecular sciences. vol 23. issue 24. 2022-12-23. PMID:36555338. |
pro- and anti-inflammatory cytokines, as well as changes in microglia and astrocytes were analyzed in hippocampus tissues from abx-, sb-, abx+sb-treated mice subjected to 4-week did. |
2022-12-23 |
2023-08-14 |
mouse |
| Yi-Fang Wu, Kai-Yan Jin, Da-Peng Wang, Qi Lin, Jun Sun, Shao-Hua Su, Jian Ha. VEGF loaded nanofiber membranes inhibit chronic cerebral hypoperfusion-induced cognitive dysfunction by promoting HIF-1a/VEGF mediated angiogenesis. Nanomedicine : nanotechnology, biology, and medicine. 2022-12-22. PMID:36549557. |
vegf-nfms sticking decreased the number of tunel-positive cells in surgical temporal cortex, ameliorated impaired synaptic plasticity, and inhibited the release of pro-inflammatory cytokines and the activation of microglia and astrocytes in surgical temporal cortex and hippocampus. |
2022-12-22 |
2023-08-14 |
rat |
| Alia O Alia, Sohee Jeon, Jelena Popovic, Miranda A Salvo, Katherine R Sadleir, Robert Vassar, Leah K Cudd. Aberrant glial activation and synaptic defects in CaMKIIα-iCre and nestin-Cre transgenic mouse models. Scientific reports. vol 12. issue 1. 2022-12-21. PMID:36543864. |
neuroinflammation in camkiiα-icre mice was characterized by the activation and proliferation of microglia and astrocytes in synaptic layers of the hippocampus. |
2022-12-21 |
2023-08-14 |
mouse |
| Yuping Zhang, Kun Liu, Yunpeng Li, Yujie Ma, Yu Wang, Zihan Fan, Yanning Li, Jinsheng Q. D-beta-hydroxybutyrate protects against microglial activation in lipopolysaccharide-treated mice and BV-2 cells. Metabolic brain disease. 2022-12-21. PMID:36543978. |
bhb treatments attenuated behavioral abnormalities, reduced the number of iba-1-positive cells and the intensity of il-6 fluorescence in the hippocampus, with amelioration of microglia morphological changes in the lps-treated mice. |
2022-12-21 |
2023-08-14 |
mouse |
| Wei Sun, Min Wen, Min Liu, Qingpeng Wang, Quiqin Liu, Lanjie Li, Hans-Christian Siebert, Gabriele Loers, Ruiyan Zhang, Ning Zhan. Effect of β-hydroxybutyrate on behavioral alterations, molecular and morphological changes in CNS of multiple sclerosis mouse model. Frontiers in aging neuroscience. vol 14. 2022-12-19. PMID:36533180. |
the results showed that bhb treatment improved behavioral performance, prevented myelin loss, decreased the activation of astrocyte as well as microglia, and up-regulated the neurotrophin brain-derived neurotrophic factor in both the corpus callosum and hippocampus. |
2022-12-19 |
2023-08-14 |
mouse |
| Zheng Xie, Xuan Wang, Xiaoxiao Luo, Jing Yan, Jie Zhang, Rao Sun, Ailin Luo, Shiyong L. Activated AMPK mitigates diabetes-related cognitive dysfunction by inhibiting hippocampal ferroptosis. Biochemical pharmacology. 2022-12-12. PMID:36502872. |
we found that ferroptosis was mainly activated in hippocampal neurons but not in microglia or astrocytes. |
2022-12-12 |
2023-08-14 |
mouse |
| Nevin Varghese, Barclay Morriso. Partial Depletion of Microglia Attenuates Long-Term Potentiation Deficits following Repeated Blast Traumatic Brain Injury in Organotypic Hippocampal Slice Cultures. Journal of neurotrauma. 2022-12-12. PMID:36508265. |
partial depletion of microglia attenuates long-term potentiation deficits following repeated blast traumatic brain injury in organotypic hippocampal slice cultures. |
2022-12-12 |
2023-08-14 |
Not clear |
| Yanxia Guo, Min Yan, Li Li, Li Zhao, Yan L. Treadmill Exercise Prevents Cognitive Impairments in Adolescent Intermittent Ethanol Rats by Reducing the Excessive Activation of Microglia Cell in the Hippocampus. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499029. |
treadmill exercise prevents cognitive impairments in adolescent intermittent ethanol rats by reducing the excessive activation of microglia cell in the hippocampus. |
2022-12-11 |
2023-08-14 |
rat |
| Yanxia Guo, Min Yan, Li Li, Li Zhao, Yan L. Treadmill Exercise Prevents Cognitive Impairments in Adolescent Intermittent Ethanol Rats by Reducing the Excessive Activation of Microglia Cell in the Hippocampus. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499029. |
the excessive activation of microglia cell induced by adolescent intermittent ethanol (aie) leads to neuroinflammation in the hippocampus. |
2022-12-11 |
2023-08-14 |
rat |
| Yanxia Guo, Min Yan, Li Li, Li Zhao, Yan L. Treadmill Exercise Prevents Cognitive Impairments in Adolescent Intermittent Ethanol Rats by Reducing the Excessive Activation of Microglia Cell in the Hippocampus. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499029. |
the purpose of this study was to explore the effects of treadmill exercise intervention on the cognitive performance, activation of microglia cells and the expression of monoacylglycerol lipase (magl), cannabinoid receptor type 1 (cb1r) and cannabinoid receptor type 2 (cb2r) in the hippocampus of aie rats. |
2022-12-11 |
2023-08-14 |
rat |
| Yanxia Guo, Min Yan, Li Li, Li Zhao, Yan L. Treadmill Exercise Prevents Cognitive Impairments in Adolescent Intermittent Ethanol Rats by Reducing the Excessive Activation of Microglia Cell in the Hippocampus. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499029. |
in addition, we found that treadmill exercise reduced the excessive activation of the microglia cell in the hippocampus of aie rats. |
2022-12-11 |
2023-08-14 |
rat |
| Kitty Reemst, Laura Kracht, Janssen M Kotah, Reza Rahimian, Astrid A S van Irsen, Gonzalo Congrains Sotomayor, Laura N Verboon, Nieske Brouwer, Sophie Simard, Gustavo Turecki, Naguib Mechawar, Susanne M Kooistra, Bart J L Eggen, Aniko Koros. Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions. Translational psychiatry. vol 12. issue 1. 2022-12-09. PMID:36481769. |
the hippocampus of els-exposed adult mice displayed altered proportions of morphological subtypes of microglia, as well as microglial transcriptomic changes related to the tumor necrosis factor response and protein ubiquitination. |
2022-12-09 |
2023-08-14 |
mouse |
| Sebastiaan Moonen, Marta J Koper, Evelien Van Schoor, Jolien M Schaeverbeke, Rik Vandenberghe, Christine A F von Arnim, Thomas Tousseyn, Bart De Strooper, Dietmar Rudolf Tha. Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons. Acta neuropathologica. 2022-12-09. PMID:36481964. |
cleaved gsdmd was detected in microglia, but also in astrocytes and in few pyramidal neurons in the first sector of the cornu ammonis (ca1) of the hippocampus and the temporal cortex of brodmann area 36. |
2022-12-09 |
2023-08-14 |
human |