| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E De Felice, E Gonçalves de Andrade, M T Golia, F González Ibáñez, M Khakpour, M A Di Castro, S Garofalo, E Di Pietro, C Benatti, N Brunello, F Tascedda, B Kaminska, C Limatola, D Ragozzino, M E Tremblay, S Alboni, L Magg. Microglial diversity along the hippocampal longitudinal axis impacts synaptic plasticity in adult male mice under homeostatic conditions. Journal of neuroinflammation. vol 19. issue 1. 2022-12-09. PMID:36482444. |
we characterized in depth the features of microglia in the two hippocampal poles and investigated their contribution to ca1 plasticity under physiological conditions. |
2022-12-09 |
2023-08-14 |
mouse |
| Corena V Grant, Kyle A Sullivan, Kylie Wentworth, Lauren D Otto, Lindsay D Strehle, Jose J Otero, Leah M Pyte. Microglia are implicated in the development of paclitaxel chemotherapy-associated cognitive impairment in female mice. Brain, behavior, and immunity. 2022-12-09. PMID:36494047. |
moreover, using a machine learning random forest classifier we identified immunohistochemical features of reactive microglia in multiple hippocampal subregions that were distinct between vehicle- and paclitaxel-treated mice. |
2022-12-09 |
2023-08-14 |
mouse |
| Corena V Grant, Kyle A Sullivan, Kylie Wentworth, Lauren D Otto, Lindsay D Strehle, Jose J Otero, Leah M Pyte. Microglia are implicated in the development of paclitaxel chemotherapy-associated cognitive impairment in female mice. Brain, behavior, and immunity. 2022-12-09. PMID:36494047. |
plx5622 significantly reduced hippocampal gene expression of paclitaxel-induced proinflammatory cytokines and restored memory, suggesting that microglia play a critical role in the development of chemotherapy-associated neuroinflammation and cognitive impairments. |
2022-12-09 |
2023-08-14 |
mouse |
| Zhangbi Wu, Jialin Huang, Xiaojie Bai, Qunan Wang, Fen Wang, Jun Xu, Huiping Tang, Chunying Yin, Yu Wang, Feng Yu, Hong Zhan. Ginsenoside-Rg1 mitigates cardiac arrest-induced cognitive damage by modulating neuroinflammation and hippocampal plasticity. European journal of pharmacology. 2022-12-04. PMID:36463944. |
next, we found that ginsenoside-rg1 inhibited hippocampal neuroinflammation by alleviating the ca/cpr-induced hippocampal activation of microglia and astrocytes and the overexpression of related proinflammatory cytokines interleukin-1β (il-1β) and tumour necrosis factor-α (tnf-α). |
2022-12-04 |
2023-08-14 |
rat |
| Liang Shen, Dan-Yang Chen, Qian-Qian Lou, Peng Cao, Rui Hu, Yan Jin, Di Wang, Shan-Shan H. Angiotensin Type 2 Receptor Pharmacological Agonist Relieves Neurocognitive Deficits via Reducing Neuroinflammation and Microglial Engulfment of Dendritic Spines. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2022-12-04. PMID:36464726. |
brain hippocampus and prefrontal cortex tissues were collected for immunofluorescence staining and western blotting to evaluate the resulting impacts on microglia, including morphological traits, functional markers, synaptic engulfment, superoxide production, and signaling molecules. |
2022-12-04 |
2023-08-14 |
mouse |
| Li-Qiang Chen, Xue-Jing Lv, Qing-Huan Guo, Su-Su Lv, Ning Lv, Wen-Dong Xu, Jin Yu, Yu-Qiu Zhan. Asymmetric activation of microglia in the hippocampus drives anxiodepressive consequences of trigeminal neuralgia in rodents. British journal of pharmacology. 2022-11-29. PMID:36443951. |
asymmetric activation of microglia in the hippocampus drives anxiodepressive consequences of trigeminal neuralgia in rodents. |
2022-11-29 |
2023-08-14 |
Not clear |
| Shuming Li, Huan Liu, Yue Qian, Linhao Jiang, Shuai Liu, Yanling Liu, Cihang Liu, Xiaoping G. IL-33/ST2 axis promotes remodeling of the extracellular matrix and drives protective microglial responses in the mouse model of perioperative neurocognitive disorders. International immunopharmacology. vol 114. 2022-11-29. PMID:36446234. |
we showed that il-33 and st2 were downregulated in the hippocampus after anesthesia and surgery, and the expression of aggrecan, remodeling by microglia, was upregulated. |
2022-11-29 |
2023-08-14 |
mouse |
| Shuming Li, Huan Liu, Yue Qian, Linhao Jiang, Shuai Liu, Yanling Liu, Cihang Liu, Xiaoping G. IL-33/ST2 axis promotes remodeling of the extracellular matrix and drives protective microglial responses in the mouse model of perioperative neurocognitive disorders. International immunopharmacology. vol 114. 2022-11-29. PMID:36446234. |
notably, the administration of il-33 attenuated neuroinflammation and shifted the polarization of microglia in the hippocampus after anesthesia and surgery. |
2022-11-29 |
2023-08-14 |
mouse |
| Bina Lee, Ingabire Ines, Jihyun Je, Eun Jung Park, Hyemin Seong, Min Gi Jo, Hwajin Kim, Seon-Hee Kim, Seong Jae Kim, Hye Jung Kim, Minkyeong Kim, Sang Won Park, Seung Pil Yu. Effect of Renal Ischemia Reperfusion on Brain Neuroinflammation. Biomedicines. vol 10. issue 11. 2022-11-26. PMID:36428560. |
the activation of astrocytes and microglia in the hippocampus and cerebral cortex, which are responsible for important functions, including memory, learning, concentration, and language, can trigger nerve cell apoptosis. |
2022-11-26 |
2023-08-14 |
Not clear |
| Bina Lee, Ingabire Ines, Jihyun Je, Eun Jung Park, Hyemin Seong, Min Gi Jo, Hwajin Kim, Seon-Hee Kim, Seong Jae Kim, Hye Jung Kim, Minkyeong Kim, Sang Won Park, Seung Pil Yu. Effect of Renal Ischemia Reperfusion on Brain Neuroinflammation. Biomedicines. vol 10. issue 11. 2022-11-26. PMID:36428560. |
in the situation of kidney ischemia reperfusion (ir)-induced aki, activation of microglia and astrocytes were observed in the striatum, ventral midbrain, hippocampus, and cortex. |
2022-11-26 |
2023-08-14 |
Not clear |
| Nini Li, Dongdong Zhang, Hena Guo, Qian Yang, Peng Li, Yifan H. Inhibition of circ_0004381 improves cognitive function via miR-647/PSEN1 axis in an Alzheimer disease mouse model. Journal of neuropathology and experimental neurology. 2022-11-21. PMID:36409993. |
in conclusion, knockdown of circ_0004381 attenuated hippocampal neuronal damage and promoted microglia m2-type polarization through the mir-647/psen1 axis, ultimately improving cognitive function in ad model mice. |
2022-11-21 |
2023-08-14 |
mouse |
| Younghun Jung, Jonathan Lopez-Benitez, Christina M Tognoni, Isabel Carreras, Alpaslan Dedeogl. Dysregulation of Sphingosine-1-Phosphate (S1P) and S1P Receptor 1 Signaling in the 5xFAD Mouse Model of Alzheimer's Disease. Brain research. 2022-11-21. PMID:36410428. |
our recent studies have shown that treatment with fingolimod, an analog of sphingosine, provides neuroprotective effects in five familiar alzheimer disease (5xfad) transgenic mice, resulting in the reduction of amyloid-β (aβ) neurotoxicity, inhibition of activation of microglia and astrocytes, increased hippocampal neurogenesis, and improved learning and memory. |
2022-11-21 |
2023-08-14 |
mouse |
| Yu Wang, Yi-Jie Liu, Man-Man Zhang, Han Zhou, Yi-Han Gao, Wen-Jing Cheng, Zi-Wei Ye, Zhong-Yu Yuan, Guang-Hui Xu, Cheng-Fu Li, Li-Tao Y. CY-09 Alleviates the Depression-like Behaviors via Inhibiting NLRP3 Inflammasome-Mediated Neuroinflammation in Lipopolysaccharide-Induced Mice. ACS chemical neuroscience. 2022-11-18. PMID:36399525. |
moreover, cy-09 increased the brain-derived neurotrophic factor (bdnf) only in microglia but not in the whole hippocampus. |
2022-11-18 |
2023-08-14 |
mouse |
| Yu Wang, Yi-Jie Liu, Man-Man Zhang, Han Zhou, Yi-Han Gao, Wen-Jing Cheng, Zi-Wei Ye, Zhong-Yu Yuan, Guang-Hui Xu, Cheng-Fu Li, Li-Tao Y. CY-09 Alleviates the Depression-like Behaviors via Inhibiting NLRP3 Inflammasome-Mediated Neuroinflammation in Lipopolysaccharide-Induced Mice. ACS chemical neuroscience. 2022-11-18. PMID:36399525. |
in conclusion, the results of the study showed that the antidepressant-like effects of nlrp3 inhibitor cy-09 were mediated by alleviating neuroinflammation in microglia and independent of the neurotrophic function in the hippocampus. |
2022-11-18 |
2023-08-14 |
mouse |
| Laifa Wang, Xueqin Wang, Ling Deng, Hui Zhang, Binsheng He, Wenyu Cao, Yanhui Cu. Pexidartinib (PLX3397) through restoring hippocampal synaptic plasticity ameliorates social isolation-induced mood disorders. International immunopharmacology. vol 113. issue Pt B. 2022-11-17. PMID:36395673. |
these findings suggest that inhibition of microglia in the hippocampus could ameliorate mood disorders in mice, providing a new perspective for the treatment of psychiatric disorders such as depression. |
2022-11-17 |
2023-08-14 |
mouse |
| Jinxuan Zhang, Junyu Hao, Ran Liu, Tao Wu, Rui Liu, Wenjie Sui, Min Zhan. Hawthorn flavonoid ameliorates cognitive deficit in mice with Alzheimer's disease by increasing the levels of Food & function. 2022-11-14. PMID:36373486. |
hf also effectively ameliorated β-amyloid (aβ) accumulation and abnormal activation of hippocampal microglia. |
2022-11-14 |
2023-08-14 |
mouse |
| Xingying Wu, Bowen Chen, Zhong Di, Shuo Jiang, Haipeng Xu, Mengting Shi, Rong Hu, Shaopeng Sun, Zhujin Song, Jiapeng Liu, Ruijie Ma, Qin Gu. Involvement of kynurenine pathway between inflammation and glutamate in the underlying etiopathology of CUMS-induced depression mouse model. BMC neuroscience. vol 23. issue 1. 2022-11-11. PMID:36357867. |
kyn is a precursor for qa in microglia, which could activate the n-methyl-d-aspartate receptor (nmdar), increasing the glu release, mirrored by increased ido activity, quinolinic acid and glu levels in the hippocampus, prefrontal cortex and serum. |
2022-11-11 |
2023-08-14 |
mouse |
| Linda Rubinstein, Frederico Kiffer, Stephanie Puukila, Moniece G Lowe, Brie Goo, Amalia Luthens, Ann-Sofie Schreurs, Samantha M Torres, Sonette Steczina, Candice G T Tahimic, Antiño R Alle. Mitochondria-Targeted Human Catalase in the Mouse Longevity MCAT Model Mitigates Head-Tilt Bedrest-Induced Neuro-Inflammation in the Hippocampus. Life (Basel, Switzerland). vol 12. issue 11. 2022-11-11. PMID:36362993. |
indeed, we saw an elevation of the activated microglia cd68 marker following hu in the hippocampus, and this pathology was mitigated in mcat mice. |
2022-11-11 |
2023-08-14 |
mouse |
| Yingjuan Xu, Jiling Zhang, Zeman Fang, Handi Zhan. The effects of social defeat stress on hippocampal glial cells and interleukin-6 in adolescence and adulthood. Neuroreport. vol 33. issue 18. 2022-11-11. PMID:36367792. |
the purpose of this study is to investigate the dynamic changes of the hippocampal neuroinflammatory mediators, including microglia, astrocyte, and interleukin-6 (il-6) levels in mice experiencing social defeat stress during adolescence. |
2022-11-11 |
2023-08-14 |
mouse |
| Yingjuan Xu, Jiling Zhang, Zeman Fang, Handi Zhan. The effects of social defeat stress on hippocampal glial cells and interleukin-6 in adolescence and adulthood. Neuroreport. vol 33. issue 18. 2022-11-11. PMID:36367792. |
the hippocampal microglia, astrocyte, and il-6 levels were measured 24 h and 3 weeks after the end of stress exposure. |
2022-11-11 |
2023-08-14 |
mouse |