| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria-Leonor López-Meraz, Dulce-Mariely Álvarez-Crod. Microglia and Status Epilepticus in the Immature Brain. Epilepsia open. 2022-05-09. PMID:35531942. |
in the developing brain, status epilepticus (se) promotes microglia activation that is associated with neuronal injury in some areas of the brain, such as the hippocampus, thalamus and amygdala. |
2022-05-09 |
2023-08-13 |
Not clear |
| Hua-Xiang Shi, Meng-Wei Zhou, Hu Zhou, Jing-Xin Zhang, Wei-Guo Shi, Li-Yun Wan. [Time-dependent injury of mouse cerebral cortex and hippocampus by acute hypoxia]. Sheng li xue bao : [Acta physiologica Sinica]. vol 74. issue 2. 2022-05-03. PMID:35503062. |
immunofluorescent staining was used to detect neuroinflammatory response of microglia in the cerebral cortex and hippocampus. |
2022-05-03 |
2023-08-13 |
mouse |
| Jie Luo, Jing-Qiong Wang, Li-Na Xie, An-Na Meng, Si-Si Zheng, Shou-Hong Zho. [Voluntary wheel running exercise regulates microglia polarization in hippocampus through STAT3 signal pathway to inhibit depression-like behavior induced by chronic stress in rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 74. issue 2. 2022-05-03. PMID:35503065. |
[voluntary wheel running exercise regulates microglia polarization in hippocampus through stat3 signal pathway to inhibit depression-like behavior induced by chronic stress in rats]. |
2022-05-03 |
2023-08-13 |
rat |
| Jie Luo, Jing-Qiong Wang, Li-Na Xie, An-Na Meng, Si-Si Zheng, Shou-Hong Zho. [Voluntary wheel running exercise regulates microglia polarization in hippocampus through STAT3 signal pathway to inhibit depression-like behavior induced by chronic stress in rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 74. issue 2. 2022-05-03. PMID:35503065. |
these results suggest that voluntary wheel running ameliorates the depression-like behavior induced by cwirs in rats, and the mechanism may be related to regulating hippocampal microglia polarization via stat3 signaling pathway. |
2022-05-03 |
2023-08-13 |
rat |
| Li Lu, Xuan Liu, Juanhua Fu, Jun Liang, Yayi Hou, Huan Do. sTREM-1 promotes the phagocytic function of microglia to induce hippocampus damage via the PI3K-AKT signaling pathway. Scientific reports. vol 12. issue 1. 2022-04-29. PMID:35487953. |
strem-1 promotes the phagocytic function of microglia to induce hippocampus damage via the pi3k-akt signaling pathway. |
2022-04-29 |
2023-08-13 |
mouse |
| Li Lu, Xuan Liu, Juanhua Fu, Jun Liang, Yayi Hou, Huan Do. sTREM-1 promotes the phagocytic function of microglia to induce hippocampus damage via the PI3K-AKT signaling pathway. Scientific reports. vol 12. issue 1. 2022-04-29. PMID:35487953. |
after intracerebroventricular (icv) injection, the damage in hippocampal neurons increased, and the loss of neuronal synapses and activation of microglia increased compared to the control mice (treated with saline). |
2022-04-29 |
2023-08-13 |
mouse |
| Li Lu, Xuan Liu, Juanhua Fu, Jun Liang, Yayi Hou, Huan Do. sTREM-1 promotes the phagocytic function of microglia to induce hippocampus damage via the PI3K-AKT signaling pathway. Scientific reports. vol 12. issue 1. 2022-04-29. PMID:35487953. |
pi3k-akt pathway inhibitor ly294002 reversed the excessive activation and phagocytosis of microglia caused by strem-1 in vivo and in vitro, which in turn improved the hippocampus damage. |
2022-04-29 |
2023-08-13 |
mouse |
| Jeimmy Cerón, Julieta Troncos. Facial nerve injury-associated hippocampal microglial activation Biomedica : revista del Instituto Nacional de Salud. vol 42. issue 1. 2022-04-28. PMID:35471181. |
the animals were sacrificed at specific times after injury to evaluate hippocampal microglial cell proliferation (cell density) and activation (cell area); sham-operated animals were compared to lesioned animals sacrificed 1, 3, 7, 21, or 35 days after injury.results: facial nerve-injured rats’ hippocampal microglial cells proliferated and adopted an activated phenotype 3- to 21-days post-lesion. |
2022-04-28 |
2023-08-16 |
rat |
| Ying-Ying Wang, Yu-Sen Deng, Shang-Kun Dai, Ting-Wei Mi, Rui-Yang Li, Pei-Pei Liu, Cong Liu, Bao-Dong He, Xuan-Cheng He, Hong-Zhen Du, Han-Chen Yang, Yi Tang, Chang-Mei Liu, Zhao-Qian Ten. Loss of microglial EED impairs synapse density, learning, and memory. Molecular psychiatry. 2022-04-28. PMID:35484239. |
the absence of microglial eed at early postnatal stages resulted in reduced spines and impaired synapse density in the hippocampus at adulthood, accompanied by upregulated expression of phagocytosis-related genes in microglia. |
2022-04-28 |
2023-08-13 |
mouse |
| T A McCorkle, Z L Romm, R Raghupath. Repeated mild TBI in adolescent rats reveals sex differences in acute and chronic behavioral deficits. Neuroscience. 2022-04-26. PMID:35469970. |
histological analysis at 6 weeks after injury revealed that repeated mild tbi in male and female adolescent rats resulted in increased reactivity of astrocytes and microglia within the corpus callosum below the impact site and in the stratum oriens and stratum pyramidale of the ca2 region of the dorsal hippocampus. |
2022-04-26 |
2023-08-13 |
rat |
| Yu Ren, Qing Wang, Zexian Yang, Linyin Feng, Yu Zhan. MCC950 ameliorates the dementia symptom at the early age of line M83 mouse and reduces hippocampal α-synuclein accumulation. Biochemical and biophysical research communications. vol 611. 2022-04-26. PMID:35472607. |
furthermore, immunostaining or immunoblotting experiments on the hippocampal tissue were performed, and the results suggested that mcc950 not only inhibited the expression of nlrp3, and suppressed the activation of astrocytes and microglia, but also promoted the mtor-mediated autophagy pathway to reduce human α-synuclein accumulation. |
2022-04-26 |
2023-08-13 |
mouse |
| Woo-Ju Song, Jeongtae Kim, Taekyun Shin, Myeong-Seon Jeong, Kil-Nam Kim, Jang-Hyuk Yun, Myung-Bok Wi. Esculetin and Fucoidan Attenuate Autophagy and Apoptosis Induced by Zinc Oxide Nanoparticles through Modulating Reactive Astrocyte and Proinflammatory Cytokines in the Rat Brain. Toxics. vol 10. issue 4. 2022-04-21. PMID:35448455. |
serum and brain homogenates were examined by enzyme-linked immunosorbent assay (elisa), and neurons, microglia, and astrocytes in the hippocampal region were examined with immunohistochemical analysis. |
2022-04-21 |
2023-08-13 |
rat |
| Yao Zhao, Jiawei Zhang, Yaxuan Zhang, Yueqi Zhang, Xiaojie Zhang, Yaling Zheng, Hongmei Wang, Xiuzhe Wang, Jianliang F. Network pharmacology-based strategy to investigate pharmacological mechanisms of Andrographolide for treatment of vascular cognitive impairment. International immunopharmacology. vol 108. 2022-04-09. PMID:35397390. |
immunohistochemistry study revealed that andro could reduce neuronal damage and activation of microglia in the cortex and hippocampus in bccao rats. |
2022-04-09 |
2023-08-13 |
rat |
| Yixing Du, Faith H Brennan, Phillip G Popovich, Min Zho. Microglia maintain the normal structure and function of the hippocampal astrocyte network. Glia. 2022-04-08. PMID:35394085. |
microglia maintain the normal structure and function of the hippocampal astrocyte network. |
2022-04-08 |
2023-08-13 |
mouse |
| Yixing Du, Faith H Brennan, Phillip G Popovich, Min Zho. Microglia maintain the normal structure and function of the hippocampal astrocyte network. Glia. 2022-04-08. PMID:35394085. |
here, we explored a role for microglia in regulating the structure and function of the astrocyte syncytium in mouse hippocampus. |
2022-04-08 |
2023-08-13 |
mouse |
| Yixing Du, Faith H Brennan, Phillip G Popovich, Min Zho. Microglia maintain the normal structure and function of the hippocampal astrocyte network. Glia. 2022-04-08. PMID:35394085. |
because neuronal function requires intact astrocyte coupling, we also evaluated the effects of microglia depletion on synaptic transmission in the hippocampus. |
2022-04-08 |
2023-08-13 |
mouse |
| Jada L-B Davis, Mara O'Connor, Hannah Erlbacher, Sarah L Schlichte, Hanna E Steven. The Impact of Maternal Antioxidants on Prenatal Stress Effects on Offspring Neurobiology and Behavior. The Yale journal of biology and medicine. vol 95. issue 1. 2022-04-04. PMID:35370489. |
cell types in the brain sensitive to oxidative stress-cortical microglia and cortical and hippocampal interneurons-may be altered by oxidative stress generated during prenatal stress and may be neurobiological substrates for altered behavior. |
2022-04-04 |
2023-08-13 |
mouse |
| Xiaomi Ding, Jing Zhou, Li Zhao, Mingyue Chen, Shenglin Wang, Ming Zhang, Xiaodong Zhang, Guohui Jian. Intestinal Flora Composition Determines Microglia Activation and Improves Epileptic Episode Progress. Frontiers in cellular and infection microbiology. vol 12. 2022-03-31. PMID:35356535. |
the seizure grade, duration, latency, hippocampal potential, and energy density were used to evaluate seizures, and the changes in the polarization of microglia were detected by western blot. |
2022-03-31 |
2023-08-13 |
mouse |
| Canelif Yilmaz, Thanasis Rogdakis, Alessia Latorrata, Evangelia Thanou, Eleftheria Karadima, Eleni Papadimitriou, Eleni Siapi, Ka Wan Li, Theodora Katsila, Theodora Calogeropoulou, Ioannis Charalampopoulos, Vasileia Ismini Alexak. ENT-A010, a Novel Steroid Derivative, Displays Neuroprotective Functions and Modulates Microglial Responses. Biomolecules. vol 12. issue 3. 2022-03-25. PMID:35327616. |
in addition, ent-a010 pretreatment partially restored homeostatic features of microglia in the hippocampus of lipopolysaccharide (lps)-treated mice, enhanced aβ phagocytosis, and increased |
2022-03-25 |
2023-08-13 |
mouse |
| Urszula Hohmann, Chalid Ghadban, Tim Hohmann, Joshua Kleine, Miriam Schmidt, Christian Scheller, Christian Strauss, Faramarz Dehghan. Nimodipine Exerts Time-Dependent Neuroprotective Effect after Excitotoxical Damage in Organotypic Slice Cultures. International journal of molecular sciences. vol 23. issue 6. 2022-03-25. PMID:35328753. |
direct effects of nimodipine on neurons amongst others were observed in the hippocampus as well as its influence on both microglia and astrocytes. |
2022-03-25 |
2023-08-13 |
Not clear |