All Relations between microglial cell and hippocampus

Publication Sentence Publish Date Extraction Date Species
Ming Wang, Yangmei Xie, Yiye Shao, Yinghui Che. LncRNA Snhg5 Attenuates Status Epilepticus Induced Inflammation through Regulating NF-κΒ Signaling Pathway. Biological & pharmaceutical bulletin. vol 45. issue 1. 2022-01-04. PMID:34980782. the nissl stain and immunohistochemical stain were performed to observe hippocampal damage and microglia proliferation. 2022-01-04 2023-08-13 rat
Ming Wang, Yangmei Xie, Yiye Shao, Yinghui Che. LncRNA Snhg5 Attenuates Status Epilepticus Induced Inflammation through Regulating NF-κΒ Signaling Pathway. Biological & pharmaceutical bulletin. vol 45. issue 1. 2022-01-04. PMID:34980782. moreover, down-regulation of snhg5 attenuated se-induced inflammation and reduced the number of microglia in hippocampus. 2022-01-04 2023-08-13 rat
Daria Zamolodchikov, Michael Duffield, Lynn E Macdonald, Nicole Alessandri-Habe. Accumulation of high molecular weight kininogen in the brains of Alzheimer's disease patients may affect microglial function by altering phagocytosis and lysosomal cathepsin activity. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-01-03. PMID:34978145. we show increased levels of hk in the hippocampus of ad patients, which colocalized with amyloid beta (aβ) deposits and activated microglia. 2022-01-03 2023-08-13 Not clear
Daria Zamolodchikov, Michael Duffield, Lynn E Macdonald, Nicole Alessandri-Habe. Accumulation of high molecular weight kininogen in the brains of Alzheimer's disease patients may affect microglial function by altering phagocytosis and lysosomal cathepsin activity. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-01-03. PMID:34978145. we demonstrate that microglia internalize hk and traffic it to lysosomes, which is accompanied by reduced activity of lysosomal cathepsins l and s. our results suggest that hk accumulation in the ad hippocampus may alter microglial uptake and degradation of aβ fibrils, possibly contributing to microglial dysfunction in ad. 2022-01-03 2023-08-13 Not clear
Francesca Logiacco, Pengfei Xia, Svilen Veselinov Georgiev, Celeste Franconi, Yi-Jen Chang, Bilge Ugursu, Anje Sporbert, Ralf Kühn, Helmut Kettenmann, Marcus Semtne. Microglia sense neuronal activity via GABA in the early postnatal hippocampus. Cell reports. vol 37. issue 13. 2021-12-29. PMID:34965412. microglia sense neuronal activity via gaba in the early postnatal hippocampus. 2021-12-29 2023-08-13 Not clear
Qian Li, Hong Li, Xiuting Yao, Conghui Wang, Haiqing Liu, Dan Xu, Chenxi Yang, Hong Zhuang, Yu Xiao, Rui Liu, Sinuo Shen, Shaoyang Zhou, Chenge Fu, Yifan Wang, Gaojun Teng, Lijie Li. Stress Response and Hearing Loss Differentially Contribute to Dynamic Alterations in Hippocampal Neurogenesis and Microglial Reactivity in Mice Exposed to Acute Noise Exposure. Frontiers in neuroscience. vol 15. 2021-12-27. PMID:34955715. these findings provide evidence that both the stress response and hearing loss contribute to the dynamic alterations of microglia and hippocampal neurogenesis following noise exposure; moreover, noise-induced permanent hearing loss rather than noise-induced transient stress is more likely to be responsible for perpetuating the neurodegenerative process associated with many neurological diseases. 2021-12-27 2023-08-13 mouse
Yin Yuxiong, Xiang Xujin, Tang Yi, Chen Ya, Li Yujuan, Hu Shanshan, Wang Huiwe. Brain-specific TRAF7 deletion ameliorates traumatic brain injury by suppressing MEKK3-regulated glial inflammation and neuronal death. International immunopharmacology. vol 103. 2021-12-25. PMID:34953447. moreover, the aberrant activation of astrocyte and microglia in cortex and hippocampus of tbi mice was significantly restrained by traf7 conditional knockout in brain, as indicated by the increased expression of gfap and iba1. 2021-12-25 2023-08-13 mouse
Jiayu Wang, Ying Zhou, Ke Li, Xiaofeng Li, Meimei Guo, Mian Pen. A Noradrenergic Lesion Attenuates Surgery-Induced Cognitive Impairment in Rats by Suppressing Neuroinflammation. Frontiers in molecular neuroscience. vol 14. 2021-12-17. PMID:34916906. in addition, dsp-4 treatment attenuated hippocampal-dependent learning and memory impairment in rats with pocd, with a downregulation of the activation of microglia and astrocytes in the prefrontal cortex and hippocampus. 2021-12-17 2023-08-13 rat
Étienne Gervais, Parisa Iloun, Ekaterina Martianova, Ana Claudia Gonçalves Bessa, Serge Rivest, Lisa Topolni. Structural analysis of the microglia-interneuron interactions in the CA1 hippocampal area of the APP/PS1 mouse model of Alzheimer's disease. The Journal of comparative neurology. 2021-12-17. PMID:34919273. here, we compared the interactions between microglia and parvalbumin (pv+) and somatostatin (som+) expressing interneurons in the ca1 hippocampal area of app/ps1 transgenic mice that mimic certain aspects of the alzheimer's disease (ad). 2021-12-17 2023-08-13 mouse
Yukitoshi Izumi, Anil G Cashikar, Kathiresan Krishnan, Steven M Paul, Douglas F Covey, Steven J Mennerick, Charles F Zorumsk. A Proinflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 49. 2021-12-12. PMID:34725187. here, we examined the effects of lipopolysaccharide (lps), an activator of innate immunity, on 25hc production in microglia, and the effects of lps and 25hc on ca1 hippocampal synaptic plasticity and learning. 2021-12-12 2023-08-13 Not clear
Kata Tóth, Tamás Oroszi, Eddy A van der Zee, Csaba Nyakas, Regien G Schoemake. Effects of exercise training on behavior and brain function after high dose isoproterenol-induced cardiac damage. Scientific reports. vol 11. issue 1. 2021-12-12. PMID:34880374. however, iso reduced anxiety, coinciding with locally reduced microglia (processes) size in the hippocampus. 2021-12-12 2023-08-13 rat
Gürsel Çalışkan, Timothy French, Sara Enrile Lacalle, Miguel Del Angel, Johannes Steffen, Markus M Heimesaat, Ildiko Rita Dunay, Oliver Stor. Antibiotic-induced gut dysbiosis leads to activation of microglia and impairment of cholinergic gamma oscillations in the hippocampus. Brain, behavior, and immunity. vol 99. 2021-12-11. PMID:34673174. antibiotic-induced gut dysbiosis leads to activation of microglia and impairment of cholinergic gamma oscillations in the hippocampus. 2021-12-11 2023-08-13 mouse
Janace J Gifford, Pooja Deshpande, Priyanka Mehta, George C Wagner, Alexander W Kusneco. The Effect of Valproic Acid Exposure throughout Development on Microglia Number in the Prefrontal Cortex, Hippocampus and Cerebellum. Neuroscience. 2021-12-11. PMID:34780921. the effect of valproic acid exposure throughout development on microglia number in the prefrontal cortex, hippocampus and cerebellum. 2021-12-11 2023-08-13 Not clear
João Paulo Brás, Isabelle Guillot de Suduiraut, Olivia Zanoletti, Silvia Monari, Mandy Meijer, Jocelyn Grosse, Mário Adolfo Barbosa, Susana Gomes Santos, Carmen Sandi, Maria Inês Almeid. Stress-induced depressive-like behavior in male rats is associated with microglial activation and inflammation dysregulation in the hippocampus in adulthood. Brain, behavior, and immunity. vol 99. 2021-12-11. PMID:34793941. in addition, pps caused long-term effects on hippocampal microglia, particularly in h-csr rats, with increased hippocampal iba-1 expression and morphological alterations compatible with a higher degree of activation. 2021-12-11 2023-08-13 rat
Chen Chen, Junfeng Lu, Weijia Peng, Marvin Sh Mak, Yang Yang, Zeyu Zhu, Shuyi Wang, Jiawei Hou, Xin Zhou, Wenjun Xin, Yafang Hu, Karl Wah Keung Tsim, Yifan Han, Qinyu Liu, Rongbiao P. Acrolein, an endogenous aldehyde induces Alzheimer's disease-like pathologies in mice: A new sporadic AD animal model. Pharmacological research. vol 175. 2021-12-11. PMID:34838693. 1) olfactory dysfunctions, cognitive impairments and psychological symptoms in c57bl/6 mice; 2) increased levels of aβ1-42 and tau phosphorylation (s396/t231) in cortex and hippocampus; 3) astrocytes and microglia proliferation; 4) reduced levels of postsynaptic density 95(psd95) and synapsin1, as well as the density of dendritic spines in the ca1 and dg neurons of the hippocampus; 5) high-frequency stimulation failed to induce the long-term potentiation (ltp) in the hippocampus after exposure to acrolein for 4 weeks; 6) decreased blood oxygen level-dependent (bold) signal in the olfactory bulb and induced high t2 signals in the hippocampus, which matched to the clinical observation in the brain of ad patients, and 7) activated rhoa/rock2/ p-cofilin-associated pathway in hippocampus of acrolein-treated mice, which may be the causes of synaptic damage and neuroinflammation in acrolein mice model. 2021-12-11 2023-08-13 mouse
Hong Zhuang, Xiuting Yao, Hong Li, Qian Li, Chenxi Yang, Conghui Wang, Dan Xu, Yu Xiao, Yuan Gao, Jiayi Gao, Mingze Bi, Rui Liu, Gaojun Teng, Lijie Li. Long-term high-fat diet consumption by mice throughout adulthood induces neurobehavioral alterations and hippocampal neuronal remodeling accompanied by augmented microglial lipid accumulation. Brain, behavior, and immunity. vol 100. 2021-12-11. PMID:34848340. hippocampal microglia in mice in the hfd group generally had a more activated phenotype evidenced by a smaller microglial territory area and increased cluster of differentiation 68 (cd68, a marker of phagocytic activity) immunoreactivity, while the microglial density in the dentate gyrus (dg) was decreased, indicating microglial decline. 2021-12-11 2023-08-13 mouse
Adeel Ahmed, Afzal Misrani, Sidra Tabassum, Li Yang, Cheng Lon. Minocycline inhibits sleep deprivation-induced aberrant microglial activation and Keap1-Nrf2 expression in mouse hippocampus. Brain research bulletin. vol 174. 2021-12-10. PMID:34087360. we found that sd animals exhibit activated microglia and decreased levels of keap1 and nrf2 (antioxidant and anti-inflammatory factors) in the hippocampus. 2021-12-10 2023-08-13 mouse
Nicola Lopizzo, Moira Marizzoni, Veronica Begni, Monica Mazzelli, Stefania Provasi, Luigimaria Borruso, Marco Andrea Riva, Annamaria Cattane. Social isolation in adolescence and long-term changes in the gut microbiota composition and in the hippocampal inflammation: Implications for psychiatric disorders - Dirk Hellhammer Award Paper 2021. Psychoneuroendocrinology. vol 133. 2021-12-10. PMID:34593267. we collected fecal samples at different post-natal days to investigate the short- and long-lasting effects of social isolation on gut microbiota composition and we collected brain areas (dorsal and ventral hippocampus) samples at killing to measure a panel of inflammatory and microglia activation markers. 2021-12-10 2023-08-13 rat
Anna Tyrtyshnaia, Anatoly Bondar, Sophia Konovalova, Igor Manzhul. Synaptamide Improves Cognitive Functions and Neuronal Plasticity in Neuropathic Pain. International journal of molecular sciences. vol 22. issue 23. 2021-12-10. PMID:34884587. nerve ligation caused microglia activation predominantly in the contralateral hippocampus, while synaptamide inhibited this effect. 2021-12-10 2023-08-13 mouse
Francesca Romana Rizzo, Livia Guadalupi, Krizia Sanna, Valentina Vanni, Diego Fresegna, Francesca De Vito, Alessandra Musella, Silvia Caioli, Sara Balletta, Silvia Bullitta, Antonio Bruno, Ettore Dolcetti, Mario Stampanoni Bassi, Fabio Buttari, Luana Gilio, Georgia Mandolesi, Diego Centonze, Antonietta Gentil. Exercise protects from hippocampal inflammation and neurodegeneration in experimental autoimmune encephalomyelitis. Brain, behavior, and immunity. vol 98. 2021-12-09. PMID:34391817. indeed, exercise significantly reduced microgliosis in the ca1 area, the expression of tumour necrosis factor (tnf) in microglia and, to a lesser extent, the hippocampal level of interleukin 1 beta (il-1β), previously shown to contribute to aberrant synaptic plasticity in the eae hippocampus. 2021-12-09 2023-08-13 mouse