| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ye Wang, Amy K Y Fu, Nancy Y I. IL-33/ST2 Signaling Regulates Synaptic Plasticity and Homeostasis in the Adult Hippocampal Circuitry. DNA and cell biology. vol 40. issue 9. 2021-09-23. PMID:34297618. |
glial cells, including astrocytes and microglia, actively regulate hippocampal synaptic plasticity by coordinating the neuronal activity-induced synaptic changes at the circuit level. |
2021-09-23 |
2023-08-13 |
Not clear |
| Maheedhar Kodali, Vikas Mishra, Bharathi Hattiangady, Sahithi Attaluri, Jenny Jaimes Gonzalez, Bing Shuai, Ashok K Shett. Moderate, intermittent voluntary exercise in a model of Gulf War Illness improves cognitive and mood function with alleviation of activated microglia and astrocytes, and enhanced neurogenesis in the hippocampus. Brain, behavior, and immunity. vol 97. 2021-09-22. PMID:34245811. |
moderate, intermittent voluntary exercise in a model of gulf war illness improves cognitive and mood function with alleviation of activated microglia and astrocytes, and enhanced neurogenesis in the hippocampus. |
2021-09-22 |
2023-08-13 |
rat |
| Katherine Picard, Kanchan Bisht, Silvia Poggini, Stefano Garofalo, Maria Teresa Golia, Bernadette Basilico, Fatima Abdallah, Naomi Ciano Albanese, Irmgard Amrein, Nathalie Vernoux, Kaushik Sharma, Chin Wai Hui, Julie C Savage, Cristina Limatola, Davide Ragozzino, Laura Maggi, Igor Branchi, Marie-Ève Trembla. Microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice. Brain, behavior, and immunity. vol 97. 2021-09-22. PMID:34343616. |
microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice. |
2021-09-22 |
2023-08-13 |
mouse |
| Katherine Picard, Kanchan Bisht, Silvia Poggini, Stefano Garofalo, Maria Teresa Golia, Bernadette Basilico, Fatima Abdallah, Naomi Ciano Albanese, Irmgard Amrein, Nathalie Vernoux, Kaushik Sharma, Chin Wai Hui, Julie C Savage, Cristina Limatola, Davide Ragozzino, Laura Maggi, Igor Branchi, Marie-Ève Trembla. Microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice. Brain, behavior, and immunity. vol 97. 2021-09-22. PMID:34343616. |
we first confirmed that microglia were depleted in gr in our model in males and females among the cingulate cortex and the hippocampus, both stress-sensitive brain regions. |
2021-09-22 |
2023-08-13 |
mouse |
| Lourdes Fernández de Cossío, Chloé Lacabanne, Maude Bordeleau, Garance Castino, Phillip Kyriakakis, Marie-Ève Trembla. Lipopolysaccharide-induced maternal immune activation modulates microglial CX3CR1 protein expression and morphological phenotype in the hippocampus and dentate gyrus, resulting in cognitive inflexibility during late adolescence. Brain, behavior, and immunity. vol 97. 2021-09-22. PMID:34343619. |
the current study sought to evaluate the origin and impact of this reduced hippocampal cx3cr1 mrna expression on microglia and cognition. |
2021-09-22 |
2023-08-13 |
Not clear |
| Caner Günaydin, Z Betül Çelik, S Sırrı Bilge, Bahattin Avci, Nurten Kar. SAHA attenuates rotenone-induced toxicity in primary microglia and HT-22 cells. Toxicology and industrial health. vol 37. issue 1. 2021-09-21. PMID:33300458. |
therefore, we here investigated the effects of histone acetylation on rotenone-induced inflammation and oxidative stress in both primary mouse microglia and hippocampal ht-22 cells using the pan-histone deacetylase (hdac) inhibitor, suberoylanilide hydroxamic acid (saha). |
2021-09-21 |
2023-08-13 |
mouse |
| Di Wu, Jay Prakash P Kumal, Xiaodi Lu, Yixuan Li, Dongsheng Mao, Xudong Tang, Meitong Nie, Xin Liu, Liang Sun, Bin Liu, Yafang Zhan. Traumatic Brain Injury Accelerates the Onset of Cognitive Dysfunction and Aggravates Alzheimer's-Like Pathology in the Hippocampus by Altering the Phenotype of Microglia in the APP/PS1 Mouse Model. Frontiers in neurology. vol 12. 2021-09-21. PMID:34539542. |
traumatic brain injury accelerates the onset of cognitive dysfunction and aggravates alzheimer's-like pathology in the hippocampus by altering the phenotype of microglia in the app/ps1 mouse model. |
2021-09-21 |
2023-08-13 |
mouse |
| Junya Onodera, Hidetaka Nagata, Ai Nakashima, Yuji Ikegaya, Ryuta Koyam. Neuronal brain-derived neurotrophic factor manipulates microglial dynamics. Glia. vol 69. issue 4. 2021-09-20. PMID:33119934. |
here, we examined the effects of bdnf on the properties of microglia in the ca3 region of the hippocampus. |
2021-09-20 |
2023-08-13 |
mouse |
| Junya Onodera, Hidetaka Nagata, Ai Nakashima, Yuji Ikegaya, Ryuta Koyam. Neuronal brain-derived neurotrophic factor manipulates microglial dynamics. Glia. vol 69. issue 4. 2021-09-20. PMID:33119934. |
thus, neuronal bdnf prevents microglia from engulfing mossy fiber synapses in the hippocampus. |
2021-09-20 |
2023-08-13 |
mouse |
| Viktoriya Maystrenko, Irina Ivleva, Darya Krytskaya, Alexander Zubov, Andrey Ivlev, Marina Karpenk. Changes in activity of µ- and m-calpains and signs of neuroinflammation in the hippocampus and striatum of rats after single intraperitoneal injection of subseptic dose of endotoxin. Metabolic brain disease. vol 36. issue 7. 2021-09-20. PMID:34014442. |
we showed, that in the hippocampus the day after lps administration an increase in production of il-1β and tnf-α mrna, followed by elevated mrna expression and activity of µ- and m-calpains without signs of microglia activation is observed. |
2021-09-20 |
2023-08-13 |
rat |
| Marcia G Honig, Conor C Dorian, John D Worthen, Anthony C Micetich, Isabelle A Mulder, Katelyn B Sanchez, William F Pierce, Nobel A Del Mar, Anton Reine. Progressive long-term spatial memory loss following repeat concussive and subconcussive brain injury in mice, associated with dorsal hippocampal neuron loss, microglial phenotype shift, and vascular abnormalities. The European journal of neuroscience. vol 54. issue 5. 2021-09-17. PMID:32090401. |
hierarchical cluster analysis of dorsal hippocampal microglia across the three groups based on morphology and expression of mhcii, cx3cr1, cd68 and iba1 revealed five distinct phenotypes. |
2021-09-17 |
2023-08-13 |
mouse |
| Andrea Lewen, Thuy-Truc Ta, Tiziana Cesetti, Jan-Oliver Hollnagel, Ismini E Papageorgiou, Bruno Chausse, Oliver Kan. Neuronal gamma oscillations and activity-dependent potassium transients remain regular after depletion of microglia in postnatal cortex tissue. Journal of neuroscience research. vol 98. issue 10. 2021-09-17. PMID:32638411. |
the slice cultures featured well-preserved hippocampal cytoarchitecture and parvalbumin-positive interneuron networks, microglia with ramified morphology, and low basal levels of il-6, tnf-α, and nitric oxide (no). |
2021-09-17 |
2023-08-13 |
rat |
| Kazuki Nakanishi, Harutoshi Sakakima, Kosuke Norimatsu, Shotaro Otsuka, Seiya Takada, Akira Tani, Kiyoshi Kikuch. Effect of low-intensity motor balance and coordination exercise on cognitive functions, hippocampal Aβ deposition, neuronal loss, neuroinflammation, and oxidative stress in a mouse model of Alzheimer's disease. Experimental neurology. vol 337. 2021-09-13. PMID:33388314. |
our findings suggest that low-intensity motor balance and coordination exercise prevented age-related cognitive decline in the early stage of ad progression, possibly through the suppression of hippocampal aβ deposition, neuronal loss, oxidative stress, and neuroinflammation, including reduced m1 and a1 phenotypes microglia and astrocytes. |
2021-09-13 |
2023-08-13 |
mouse |
| Xiaoyue Qiao, Hailin Wang, Li Lu, Jinglei Chen, Qinpei Cheng, Meng Guo, Yayi Hou, Huan Do. Hippocampal microglia CD40 mediates NPSLE cognitive dysfunction in mice. Journal of neuroimmunology. vol 357. 2021-09-13. PMID:34062352. |
hippocampal microglia cd40 mediates npsle cognitive dysfunction in mice. |
2021-09-13 |
2023-08-13 |
mouse |
| Xiaoyue Qiao, Hailin Wang, Li Lu, Jinglei Chen, Qinpei Cheng, Meng Guo, Yayi Hou, Huan Do. Hippocampal microglia CD40 mediates NPSLE cognitive dysfunction in mice. Journal of neuroimmunology. vol 357. 2021-09-13. PMID:34062352. |
this study aimed to investigate whether hippocampal microglia cd40 of mrl/mpj-fas |
2021-09-13 |
2023-08-13 |
mouse |
| Yunpeng Liu, Danya Sanderson, M Firoz Mian, Karen-Anne McVey Neufeld, Paul Forsyth. Loss of vagal integrity disrupts immune components of the microbiota-gut-brain axis and inhibits the effect of Lactobacillus rhamnosus on behavior and the corticosterone stress response. Neuropharmacology. vol 195. 2021-09-13. PMID:34175326. |
these effects were associated with an increase in splenic t regulatory cells and a decrease in activated microglia in the hippocampus. |
2021-09-13 |
2023-08-13 |
mouse |
| Yunpeng Liu, Danya Sanderson, M Firoz Mian, Karen-Anne McVey Neufeld, Paul Forsyth. Loss of vagal integrity disrupts immune components of the microbiota-gut-brain axis and inhibits the effect of Lactobacillus rhamnosus on behavior and the corticosterone stress response. Neuropharmacology. vol 195. 2021-09-13. PMID:34175326. |
the anxiolytic effects, hpa modulation and increase in t regulatory cells were prevented by vagotomy, whereas vagotomy alone led to a significant increase in activated microglia in the hippocampus that was not altered with l.rhamnosus treatment. |
2021-09-13 |
2023-08-13 |
mouse |
| Yasuhisa Ano, Rena Ohya, Akihiko Takashima, Kazuyuki Uchida, Hiroyuki Nakayam. β-Lactolin Reduces Age-Related Inflammation and Cognitive Decline. Frontiers in nutrition. vol 8. 2021-09-10. PMID:34497823. |
additionally, the number of activated microglia in the hippocampus and cortex and the production of cytokines (tumor necrosis factor-α, macrophage inflammatory protein-1α, and macrophage chemoattractant protein-1) were increased in aged mice compared with those in young mice but were reduced in aged mice fed β-lactolin. |
2021-09-10 |
2023-08-13 |
mouse |
| Zhijun He, Xiaoqian Li, Shuangxue Han, Bingyu Ren, Xia Hu, Nan Li, Xiubo Du, Jiazuan Ni, Xiaogai Yang, Qiong Li. Bis(ethylmaltolato)oxidovanadium (IV) attenuates amyloid-beta-mediated neuroinflammation by inhibiting NF-κB signaling pathway via a PPARγ-dependent mechanism. Metallomics : integrated biometal science. vol 13. issue 7. 2021-09-09. PMID:34124763. |
beov administration significantly decreased the levels of tumor necrosis factor-α, interleukin-6, interleukin-1β, inducible nitric oxide synthase, and cyclooxygenase-2 both in the hippocampus of appswe/ps1e9 mice and in the aβ-stimulated bv2 microglia. |
2021-09-09 |
2023-08-13 |
mouse |
| Jindan He, Taotao Liu, Yue Li, Xinning Mi, Dengyang Han, Ning Yang, Lei Chen, Yitong Li, Jingshu Hong, Chongshen Kuang, Yi Yuan, Yiyun Cao, Yongzheng Han, Chengmei Shi, Zhengqian Li, Xiangyang Gu. JNK inhibition alleviates delayed neurocognitive recovery after surgery by limiting microglia pyroptosis. International immunopharmacology. vol 99. 2021-09-08. PMID:34298396. |
in vivo, we observed surgery-induced upregulation of phosphorylated (p)-c-jun n-terminal kinases (jnk) in microglia and subsequently nlrp3 inflammasome activation, pyroptosis, and inflammatory cytokines release in mice hippocampus. |
2021-09-08 |
2023-08-13 |
mouse |