| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paula Ortiz-Romero, Alejandro González-Simón, Gustavo Egea, Luis A Pérez-Jurado, Victoria Campuzan. Co-Treatment With Verapamil and Curcumin Attenuates the Behavioral Alterations Observed in Williams-Beuren Syndrome Mice by Regulation of MAPK Pathway and Microglia Overexpression. Frontiers in pharmacology. vol 12. 2021-08-21. PMID:34413771. |
cd mice showed an increased density of activated microglia in the motor cortex and ca1 hippocampal region, which was prevented by co-treatment. |
2021-08-21 |
2023-08-13 |
mouse |
| Fenghua Chen, Jibrin Danladi, Maryam Ardalan, Jens R Nyengaard, Connie Sanchez, Gregers Wegene. The rat hippocampal gliovascular system following one week vortioxetine and fluoxetine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 42. 2021-08-20. PMID:33199100. |
as a continuation of this line of research, and given the putative role of brain glial cells in mediating antidepressant responses the present study investigated early effects of vortioxetine on hippocampal microvasculature and vascular endothelial growth factor (vegf) and astrocytes and microglia cells. |
2021-08-20 |
2023-08-13 |
rat |
| Fenghua Chen, Jibrin Danladi, Maryam Ardalan, Jens R Nyengaard, Connie Sanchez, Gregers Wegene. The rat hippocampal gliovascular system following one week vortioxetine and fluoxetine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 42. 2021-08-20. PMID:33199100. |
stereological principles were used to estimate the number of aldh1l1 positive astrocytes and iba1 positive microglia cells, and the length of microvessels in subregions of hippocampus. |
2021-08-20 |
2023-08-13 |
rat |
| Feng Zhang, Keqing Zhao, Tao Tang, Yan Deng, Yun Zhang, Shuo Feng, Pu Feng, Mengyuan Guo, Xiaohui Li, Juan Ce. Bisindole compound 4ae ameliorated cognitive impairment in rats with vascular dementia by anti-inflammation effect via microglia cells. European journal of pharmacology. vol 908. 2021-08-20. PMID:34284012. |
our results showed that 4ae treatment effectively reduced iba-1 positive microglia cells in cerebral cortex and hippocampus after cerebral ischemia. |
2021-08-20 |
2023-08-13 |
rat |
| Sayna Bagheri, Kamyar Moradi, Elnaz Ehghaghi, Abolfazl Badripour, Mohammad Keykhaei, Amir Ashraf-Ganjouei, Mana Moassefi, Shahriar Faghani, Ahmad Reza Dehpou. Melatonin improves learning and memory of mice with chronic social isolation stress via an interaction between microglia polarization and BDNF/TrkB/CREB signaling pathway. European journal of pharmacology. vol 908. 2021-08-20. PMID:34289399. |
hippocampus samples were obtained and the expressions of bdnf, trkb, phosphorylated trkb (ptrkb), creb, phosphorylated creb (pcreb), as well as m1 and m2 microglia were assessed. |
2021-08-20 |
2023-08-13 |
mouse |
| Emanuele Mocciaro, Auston Grant, Rinat O Esenaliev, Irene Y Petrov, Yuriy Petrov, Stacy L Sell, Nicole L Hausser, Jutatip Guptarak, Elizabeth Bishop, Margaret A Parsley, Ian J Bolding, Kathia M Johnson, Maxwell Lidstone, Donald S Prough, Maria-Adelaide Micc. Non-Invasive Transcranial Nano-Pulsed Laser Therapy Ameliorates Cognitive Function and Prevents Aberrant Migration of Neural Progenitor Cells in the Hippocampus of Rats Subjected to Traumatic Brain Injury. Journal of neurotrauma. vol 37. issue 8. 2021-08-18. PMID:31856661. |
nplt did not significantly reduce tbi-induced microglia activation in the hippocampus. |
2021-08-18 |
2023-08-13 |
rat |
| Tomohiro Ohgomori, Kyoko Iinuma, Jun Yamada, Shozo Jinn. A unique subtype of ramified microglia associated with synapses in the rat hippocampus. The European journal of neuroscience. vol 54. issue 3. 2021-08-18. PMID:34110047. |
a unique subtype of ramified microglia associated with synapses in the rat hippocampus. |
2021-08-18 |
2023-08-13 |
rat |
| Rose Chesworth, Rashmi Gamage, Faheem Ullah, Sandra Sonego, Christopher Millington, Amanda Fernandez, Huazheng Liang, Tim Karl, Gerald Münch, Garry Niedermayer, Erika Gyenges. Spatial Memory and Microglia Activation in a Mouse Model of Chronic Neuroinflammation and the Anti-inflammatory Effects of Apigenin. Frontiers in neuroscience. vol 15. 2021-08-17. PMID:34393713. |
we investigated whether chronic treatment with the natural flavonoid, apigenin, could reduce microglia activation in the hippocampus and improve spatial memory. |
2021-08-17 |
2023-08-13 |
mouse |
| Yu-Qin Li, Ji-Xiang Chen, Quan-Wei Li, Zheng-Jun Xiao, Tao Yuan, Zhao-Hui Xi. Targeting NLRP3 inflammasome improved the neurogenesis and post-stroke cognition in a mouse model of photothrombotic stroke. Neuroreport. vol 31. issue 11. 2021-08-16. PMID:32576768. |
intraperitoneal injection of mcc950 inhibited the nlrp3 activation, decreased the number of microglia, increased the number of neurons and promoted the hippocampal neurogenesis, eventually improved psci. |
2021-08-16 |
2023-08-13 |
mouse |
| Liping Li, Yisha Qiu, Miao Miao, Zhitao Liu, Wanyi Li, Yiyi Zhu, Qinwen Wan. Reduction of Tet2 exacerbates early stage Alzheimer's pathology and cognitive impairments in 2×Tg-AD mice. Human molecular genetics. vol 29. issue 11. 2021-08-13. PMID:31943063. |
on this basis, we examined the reduction of tet2 expression in the hippocampus at early disease stages, which caused a decline of 5hmc levels and led young 2×tg-ad mice to present with advanced stages of ad-related pathological hallmarks, including aβ accumulation, gfap-positive astrogliosis and iba1-positive microglia overgrowth as well as the overproduction of pro-inflammatory factors. |
2021-08-13 |
2023-08-13 |
mouse |
| Tomohiro Ohgomori, Shozo Jinn. Modulation of neuropathology and cognitive deficits by lipopolysaccharide preconditioning in a mouse pilocarpine model of status epilepticus. Neuropharmacology. vol 176. 2021-08-13. PMID:32634527. |
gene profile analysis of hippocampal microglia at 15 days after se showed that the expression level of interleukin-1β was increased by se induction but decreased by lps preconditioning. |
2021-08-13 |
2023-08-13 |
mouse |
| Tomohiro Ohgomori, Shozo Jinn. Modulation of neuropathology and cognitive deficits by lipopolysaccharide preconditioning in a mouse pilocarpine model of status epilepticus. Neuropharmacology. vol 176. 2021-08-13. PMID:32634527. |
interestingly, lps preconditioning increased the numerical density of hippocampal microglia expressing the 5d4 keratan sulfate epitope, a population of cells known to be involved in phagocytosis. |
2021-08-13 |
2023-08-13 |
mouse |
| Elisa M York, Jingfei Zhang, Hyun B Choi, Brian A MacVica. Neuroinflammatory inhibition of synaptic long-term potentiation requires immunometabolic reprogramming of microglia. Glia. vol 69. issue 3. 2021-08-13. PMID:32946147. |
here, using fluorescence lifetime imaging of endogenous nad(p)h, we measure the metabolic activity of individual microglia within acute hippocampal slices. |
2021-08-13 |
2023-08-13 |
Not clear |
| Xiaoming Zhang, Yang Heng, Susanne M Kooistra, Hilmar R J van Weering, Maaike L Brummer, Emma Gerrits, Evelyn M Wesseling, Nieske Brouwer, Tjalling W Nijboer, Marissa L Dubbelaar, Erik W G M Boddeke, Bart J L Egge. Intrinsic DNA damage repair deficiency results in progressive microglia loss and replacement. Glia. vol 69. issue 3. 2021-08-13. PMID:33068332. |
larger and more ramified microglia were observed following ercc1 deletion both in vivo and in organotypic hippocampal slice cultures. |
2021-08-13 |
2023-08-13 |
mouse |
| Lijuan Zhang, Minmin Tang, Xiaofang Xie, Qiuying Zhao, Nan Hu, Hui He, Gangcai Liu, Shiqi Huang, Cheng Peng, Ying Xiao, Zili Yo. Ginsenoside Rb1 induces a pro-neurogenic microglial phenotype via PPARγ activation in male mice exposed to chronic mild stress. Journal of neuroinflammation. vol 18. issue 1. 2021-08-13. PMID:34372875. |
microglia can promote or inhibit adult hippocampal neurogenesis according to their functional phenotypes. |
2021-08-13 |
2023-08-13 |
mouse |
| Lei Wu, Shuang Li, Shulan Pang, Bo Zhang, Jierui Wang, Bin He, Linyi Lv, Weixuan Wang, Na Zhao, Yanshu Zhan. Effects of lead exposure on the activation of microglia in mice fed with high-fat diets. Environmental toxicology. vol 36. issue 9. 2021-08-12. PMID:34156151. |
pb exposure could promote microglia activation and increase the expression of m1 microglia marker and decrease the expression of m2 microglia marker in the hippocampus of mice with hfd. |
2021-08-12 |
2023-08-13 |
mouse |
| Lei Wu, Shuang Li, Shulan Pang, Bo Zhang, Jierui Wang, Bin He, Linyi Lv, Weixuan Wang, Na Zhao, Yanshu Zhan. Effects of lead exposure on the activation of microglia in mice fed with high-fat diets. Environmental toxicology. vol 36. issue 9. 2021-08-12. PMID:34156151. |
our finding suggested that pb exposure may aggravate cns damage by promoting m1 polarization and inhibiting m2 polarization of hippocampal microglia in hfd mice. |
2021-08-12 |
2023-08-13 |
mouse |
| Kelly M Bakulski, John F Dou, Robert C Thompson, Christopher Lee, Lauren Y Middleton, Bambarendage P U Perera, Sean P Ferris, Tamara R Jones, Kari Neier, Xiang Zhou, Maureen A Sartor, Saher S Hammoud, Dana C Dolinoy, Justin A Colacin. Single-Cell Analysis of the Gene Expression Effects of Developmental Lead (Pb) Exposure on the Mouse Hippocampus. Toxicological sciences : an official journal of the Society of Toxicology. vol 176. issue 2. 2021-08-11. PMID:32458983. |
gene expression patterns revealed 12 hippocampus cell clusters, mapping to major expected cell types (eg, microglia, astrocytes, neurons, and oligodendrocytes). |
2021-08-11 |
2023-08-13 |
mouse |
| Guangwei Zhang, Yujiao Lu, Luodan Yang, Yan Dong, Jin Wen, Jianguo Xu, Quanguang Zhan. Methylene blue post-treatment improves hypoxia-ischemic recovery in a neonatal rat model. Neurochemistry international. vol 139. 2021-08-11. PMID:32628986. |
in addition, mb profoundly inhibited microglia and astrocyte activation and the pro-inflammatory cytokines production in neonatal cortex and hippocampus after hi. |
2021-08-11 |
2023-08-13 |
rat |
| Qingmei Sun, Hongdan Yan, Falong Chen, Fen Jiang, Wenjuan Chen, Dongliang Li, Yongmin Gu. Restoration of Proresolution Pathway with Exogenous Resolvin D1 Prevents Sevoflurane-Induced Cognitive Decline by Attenuating Neuroinflammation in the Hippocampus in Rats with Type 2 Diabetes Mellitus. Frontiers in pharmacology. vol 12. 2021-08-10. PMID:34366871. |
compared with gk control rats, gk rats received sev exhibited shorter freezing times in trace fear conditioning task, which was accompanied by increased microglia activity and pro-inflammatory cytokine expression in the hippocampus. |
2021-08-10 |
2023-08-13 |
rat |