All Relations between microglial cell and hippocampus

Publication Sentence Publish Date Extraction Date Species
Ji-Hye Kwak, Kyungmin Le. Forebrain glutamatergic neuron-specific Ctcf deletion induces reactive microgliosis and astrogliosis with neuronal loss in adult mouse hippocampus. BMB reports. vol 54. issue 6. 2021-07-13. PMID:33612151. however, little is known about the long-term effect of ctcf deficiency on postnatal neurons, astrocytes, or microglia in the hippocampus of adult mice. 2021-07-13 2023-08-13 mouse
Ji-Hye Kwak, Kyungmin Le. Forebrain glutamatergic neuron-specific Ctcf deletion induces reactive microgliosis and astrogliosis with neuronal loss in adult mouse hippocampus. BMB reports. vol 54. issue 6. 2021-07-13. PMID:33612151. prominent rod-shaped microglia that participate in immune surveillance were observed in the stratum pyramidale and radiatum layer, indicating a potential increase in inflammatory mediators released by hippocampal neurons. 2021-07-13 2023-08-13 mouse
Masaki Kajimoto, Muhammad Nuri, Justin R Sleasman, Kevin A Charette, Branden R Nelson, Michael A Portma. Inhaled nitric oxide reduces injury and microglia activation in porcine hippocampus after deep hypothermic circulatory arrest. The Journal of thoracic and cardiovascular surgery. vol 161. issue 6. 2021-07-12. PMID:32037238. inhaled nitric oxide reduces injury and microglia activation in porcine hippocampus after deep hypothermic circulatory arrest. 2021-07-12 2023-08-13 Not clear
Maren Richter, Natascha Vidovic, Knut Biber, Amalia Dolga, Carsten Culmsee, Richard Dode. The neuroprotective role of microglial cells against amyloid beta-mediated toxicity in organotypic hippocampal slice cultures. Brain pathology (Zurich, Switzerland). vol 30. issue 3. 2021-07-08. PMID:31769564. here, we used organotypic hippocampal slice cultures (ohscs) to investigate the impact of microglia on amyloid beta (aβ)-mediated toxicity. 2021-07-08 2023-08-13 Not clear
E P G Vazi, F Holanda, N A Santos, C V Cardoso, M F M Martins, E F Bonda. Short-term systemic methotrexate administration in rats induces astrogliosis and microgliosis. Research in veterinary science. vol 138. 2021-07-08. PMID:34091228. on the 5th day, brain samples were collected for hematoxylin-eosin and luxol fast blue staining techniques, as well as for immunohistochemical staining for glial fibrillary acidic protein (gfap) expression in astrocytes and iba1 (ionized calcium binding adaptor molecule 1) for microglia in the frontal cortex, hippocampus, hypothalamus and molecular/granular layers of the cerebellum. 2021-07-08 2023-08-13 rat
Chun Wang, Xu Cao, Jing Yin, Wen-Rui Gao, Wei-Ran Li, Jin-Shun Qi, Mei-Na W. [Chronic sleep deprivation exacerbates cognitive and pathological impairments in APP/PS1/tau triple transgenic Alzheimer's disease model mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 3. 2021-07-08. PMID:34230948. these results indicate that chronic sleep deprivation exacerbates the impairments of recognition memory, working memory and conditioned fear memory in 3xtg-ad mice by aggravating aβ deposition and the excessive activation of microglia in the hippocampus. 2021-07-08 2023-08-13 mouse
Ileana Marinescu, Dragoş Marinescu, Laurenţiu Mogoantă, Ion Cristian Efrem, Puiu Olivian Stovice. SARS-CoV-2 infection in patients with serious mental illness and possible benefits of prophylaxis with Memantine and Amantadine. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 61. issue 4. 2021-07-07. PMID:34171050. activation of m1-type microglia has an important role in pathogenesis of major psychiatric disorders, such as major depression, schizophrenia or bipolar disorder, and may associate hippocampal atrophy and disconnection of cognitive structures. 2021-07-07 2023-08-13 Not clear
Ana Catarina Rodrigues-Neves, Rafael Carecho, Sónia Catarina Correia, Cristina Carvalho, Elisa Julião Campos, Filipa Isabel Baptista, Paula Isabel Moreira, António Francisco Ambrósi. Retina and Brain Display Early and Differential Molecular and Cellular Changes in the 3xTg-AD Mouse Model of Alzheimer's Disease. Molecular neurobiology. vol 58. issue 7. 2021-07-06. PMID:33606195. however, we detected a few differential changes in the retina and brain regions, and particularly a different profile in microglia branching in the retina and hippocampus, only at 4 months, where the number and length of the processes decreased in the retina and increased in the hippocampus. 2021-07-06 2023-08-13 mouse
Leelavathi N Madhu, Maheedhar Kodali, Sahithi Attaluri, Bing Shuai, Laila Melissari, Xiaolan Rao, Ashok K Shett. Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus. Redox biology. vol 43. 2021-07-05. PMID:33933884. behavioral tests revealed cognitive and mood dysfunction in gwi rats receiving vehicle, which were associated with elevated oxidative stress, reduced nrf2, catalase and mitochondrial complex proteins, astrocyte hypertrophy, activated microglia with nlrp3 inflammasomes, elevated proinflammatory cytokines, waned neurogenesis, and synapse loss in the hippocampus. 2021-07-05 2023-08-13 rat
Tomohiro Ohgomori, Shozo Jinn. The expression of keratan sulfate reveals a unique subset of microglia in the mouse hippocampus after pilocarpine-induced status epileptics. The Journal of comparative neurology. vol 528. issue 1. 2021-07-01. PMID:31237692. the expression of keratan sulfate reveals a unique subset of microglia in the mouse hippocampus after pilocarpine-induced status epileptics. 2021-07-01 2023-08-13 mouse
Tomohiro Ohgomori, Shozo Jinn. The expression of keratan sulfate reveals a unique subset of microglia in the mouse hippocampus after pilocarpine-induced status epileptics. The Journal of comparative neurology. vol 528. issue 1. 2021-07-01. PMID:31237692. to address this issue, we analyzed the characteristics of microglia labeled by the 5d4 epitope, a marker of high-sulfated keratan sulfate, in the mouse hippocampus during the latent period after pilocarpine-induced status epilepticus (se). 2021-07-01 2023-08-13 mouse
Season K Wyatt-Johnson, Alexandra L Sommer, Kevin Y Shim, Amy L Brewste. Suppression of Microgliosis With the Colony-Stimulating Factor 1 Receptor Inhibitor PLX3397 Does Not Attenuate Memory Defects During Epileptogenesis in the Rat. Frontiers in neurology. vol 12. 2021-06-29. PMID:34149593. our previous studies revealed extensive hippocampal microgliosis that peaked between 2 and 3 weeks after se and paralleled the development of cognitive impairments, suggesting a role for reactive microglia in this pathophysiology. 2021-06-29 2023-08-13 rat
Season K Wyatt-Johnson, Alexandra L Sommer, Kevin Y Shim, Amy L Brewste. Suppression of Microgliosis With the Colony-Stimulating Factor 1 Receptor Inhibitor PLX3397 Does Not Attenuate Memory Defects During Epileptogenesis in the Rat. Frontiers in neurology. vol 12. 2021-06-29. PMID:34149593. both plx3397-treated control and se groups had significantly decreased numbers of microglia in the hippocampus (60%) compared to those in sc. 2021-06-29 2023-08-13 rat
Season K Wyatt-Johnson, Alexandra L Sommer, Kevin Y Shim, Amy L Brewste. Suppression of Microgliosis With the Colony-Stimulating Factor 1 Receptor Inhibitor PLX3397 Does Not Attenuate Memory Defects During Epileptogenesis in the Rat. Frontiers in neurology. vol 12. 2021-06-29. PMID:34149593. thus, despite drastic reductions in microglial cells, memory was unaffected in the plx3397-treated groups compared to those in sc, suggesting that remaining microglia may be sufficient to help maintain hippocampal functions. 2021-06-29 2023-08-13 rat
Jinqiang Zhang, Peijing Rong, Lijuan Zhang, Hui He, Tao Zhou, Yonghua Fan, Li Mo, Qiuying Zhao, Yue Han, Shaoyuan Li, Yifei Wang, Wan Yan, Huafu Chen, Zili Yo. IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis. Science advances. vol 7. issue 12. 2021-06-25. PMID:33731342. adult neurogenesis in the dentate gyrus of the hippocampus is regulated by specific microglia groups and functionally implicated in behavioral responses to stress. 2021-06-25 2023-08-13 Not clear
Jinqiang Zhang, Peijing Rong, Lijuan Zhang, Hui He, Tao Zhou, Yonghua Fan, Li Mo, Qiuying Zhao, Yue Han, Shaoyuan Li, Yifei Wang, Wan Yan, Huafu Chen, Zili Yo. IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis. Science advances. vol 7. issue 12. 2021-06-25. PMID:33731342. however, the role of microglia in hippocampal neurogenesis and stress resilience remains unclear. 2021-06-25 2023-08-13 Not clear
Jinqiang Zhang, Peijing Rong, Lijuan Zhang, Hui He, Tao Zhou, Yonghua Fan, Li Mo, Qiuying Zhao, Yue Han, Shaoyuan Li, Yifei Wang, Wan Yan, Huafu Chen, Zili Yo. IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis. Science advances. vol 7. issue 12. 2021-06-25. PMID:33731342. we identified interleukin 4 (il4)-driven microglia characterized by high expression of arg1, which is critical in maintaining hippocampal neurogenesis and stress resistance. 2021-06-25 2023-08-13 Not clear
Mandakh Bekhbat, Deepika Mukhara, Mikhail G Dozmorov, John C Stansfield, Savannah D Benusa, Molly M Hyer, Sydney A Rowson, Sean D Kelly, Zhaohui Qin, Jeffrey L Dupree, Gregory K Tharp, Malú G Tansey, Gretchen N Neig. Adolescent stress sensitizes the adult neuroimmune transcriptome and leads to sex-specific microglial and behavioral phenotypes. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 5. 2021-06-23. PMID:33558677. here we hypothesized that biological sex would dictate differential induction of inflammation-related transcriptomic pathways and immune cell involvement (microglia activation and leukocyte presence) in the hippocampus of male and female rats with a history of cas. 2021-06-23 2023-08-13 rat
Songji Li, Wenyu Cao, Shifen Zhou, Minhui Ma, Wenjuan Zhang, Fang Li, Changqi L. Expression of Cntn1 is regulated by stress and associated with anxiety and depression phenotypes. Brain, behavior, and immunity. vol 95. 2021-06-23. PMID:33737174. using an adeno-associated virus-based approach to directly overexpress cntn1 via stereotactic injection, we demonstrated that cntn1 overexpression in the hippocampus triggered anxiety- and depression-like phenotypes in addition to microglia activation or phagocytosis in the hippocampus, resulting in upregulation of pro-inflammatory cytokine (il1α, il6, and ccl2) mrna expression and downregulation of anti-inflammatory cytokine (il4 and cd206) mrna expression, determined using real-time quantitative pcr, thus impairing hippocampal immature neurons in the dentate gyrus, determined using immunohistochemical staining for doublecortin, a specific marker for immature neurons. 2021-06-23 2023-08-13 mouse
Zuotian Wu, Lin Zhou, Limin Sun, Yumeng Xie, Ling Xiao, Huiling Wang, Gaohua Wan. Brief postpartum separation from offspring promotes resilience to lipopolysaccharide challenge-induced anxiety and depressive-like behaviors and inhibits neuroinflammation in C57BL/6J dams. Brain, behavior, and immunity. vol 95. 2021-06-23. PMID:33766700. lpsresulted in anxiety and depressive-like behaviors in nps dams and activated ionized calcium-binding adaptor molecule (iba1), an important biomarker of microglia, in the hippocampus. 2021-06-23 2023-08-13 mouse