| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lulu Ren, Huazheng Liang, Li Zhu, Xiao Yang, Hong Zhang, Nianyi Sun, Dunbing Huang, Jing Feng, Yufeng Wu, Lize Xiong, Xiaohua Ke, Min Li, Anren Zhan. Dietary restriction improves perioperative neurocognitive disorders by inhibiting neuroinflammation and gut microbial dysbiosis. Neuroscience. 2024-01-25. PMID:38272300. |
this effect is achieved through the modulation of gut microbiota, suppression of inflammatory responses in hippocampal microglia, and facilitation of neuronal repair and regeneration. |
2024-01-25 |
2024-01-28 |
mouse |
| Santosh Kumar Samal, Madhav Sharma, Jayasri Das Sarm. Isolation and Enrichment of Major Primary Neuroglial Cells from Neonatal Mouse Brain. Bio-protocol. vol 14. issue 2. 2024-01-25. PMID:38268978. |
our current protocol overcomes these drawbacks by utilizing the brain from day-0 pups to isolate cns resident neuroglial cells including astrocytes, microglia, oligodendrocytes [oligodendrocyte precursor cells (opcs) and differentiated oligodendrocytes], and meningeal fibroblasts, as well as hippocampal neurons, avoiding sacrificing pregnant mice, which makes this procedure efficient and cost effective. |
2024-01-25 |
2024-01-27 |
mouse |
| Daniela M Magalhães, Myrthe Mampay, Ana M Sebastião, Graham K Sheridan, Cláudia A Valent. Age-related impact of social isolation in mice: Young vs middle-aged. Neurochemistry international. 2024-01-24. PMID:38266657. |
increased iba-1 expression and nlrp3 priming were both observed in the hippocampus of socially isolated middle-aged mice, suggesting a role for microglia and nlrp3 pathway in the detrimental effects of social isolation on cognition and behaviour. |
2024-01-24 |
2024-01-27 |
mouse |
| Haitao Qian, Andi Chen, Daoyi Lin, Jianhui Deng, Fei Gao, Jianjie Wei, Xuyang Wu, Yongxin Huang, Dingliang Cai, Xiaohui Chen, Xiaochun Zhen. Activation of the CD200/CD200R1 axis improves cognitive impairment by enhancing hippocampal neurogenesis via suppression of M1 microglial polarization and neuroinflammation in hypoxic-ischemic neonatal rats. International immunopharmacology. vol 128. 2024-01-18. PMID:38237226. |
additionally, cd200fc inhibited m1 polarization of microglia, reduced neuroinflammation, improved hippocampal neurogenesis, and mitigated cognitive impairment caused by hibd in neonatal rats. |
2024-01-18 |
2024-01-21 |
rat |
| Haitao Qian, Andi Chen, Daoyi Lin, Jianhui Deng, Fei Gao, Jianjie Wei, Xuyang Wu, Yongxin Huang, Dingliang Cai, Xiaohui Chen, Xiaochun Zhen. Activation of the CD200/CD200R1 axis improves cognitive impairment by enhancing hippocampal neurogenesis via suppression of M1 microglial polarization and neuroinflammation in hypoxic-ischemic neonatal rats. International immunopharmacology. vol 128. 2024-01-18. PMID:38237226. |
it also inhibited m1 polarization of microglia, reduced neuroinflammation, and improved hippocampal neurogenesis and cognitive function in neonatal rats with hibd. |
2024-01-18 |
2024-01-21 |
rat |
| Haitao Qian, Andi Chen, Daoyi Lin, Jianhui Deng, Fei Gao, Jianjie Wei, Xuyang Wu, Yongxin Huang, Dingliang Cai, Xiaohui Chen, Xiaochun Zhen. Activation of the CD200/CD200R1 axis improves cognitive impairment by enhancing hippocampal neurogenesis via suppression of M1 microglial polarization and neuroinflammation in hypoxic-ischemic neonatal rats. International immunopharmacology. vol 128. 2024-01-18. PMID:38237226. |
our findings illustrate that activation of the cd200/cd200r1 axis inhibits the nf-κb-mediated m1 polarization of microglia to improve hibd-induced cognitive impairment and hippocampal neurogenesis disorder via the pi3k/akt signaling pathway. |
2024-01-18 |
2024-01-21 |
rat |
| Max Gentenaar, Fleur L Meulmeester, Ximaine R van der Burg, Anna T Hoekstra, Hazel Hunt, Jan Kroon, Willeke M C van Roon-Mom, Onno C Meije. Glucocorticoid receptor antagonist CORT113176 attenuates motor and neuropathological symptoms of Huntington's disease in R6/2 mice. Experimental neurology. 2024-01-12. PMID:38216109. |
it also restored hd-related parameters including astrocyte markers in both the dorsolateral striatum and the hippocampus, and microglia markers in the hippocampus. |
2024-01-12 |
2024-01-15 |
mouse |
| Fen Zhuge, Liujie Zheng, Yuxiang Pan, Liyang Ni, Zhengwei Fu, Junping Shi, Yinhua N. DPP-4 inhibition by linagliptin ameliorates age-related mild cognitive impairment by regulating microglia polarization in mice. Experimental neurology. 2024-01-10. PMID:38199510. |
we found that dpp-4 activity increased in the hippocampus of middle-aged mice, and dpp-4 was mainly expressed by microglia rather than astrocytes and oligodendrocytes. |
2024-01-10 |
2024-01-13 |
mouse |
| Fen Zhuge, Liujie Zheng, Yuxiang Pan, Liyang Ni, Zhengwei Fu, Junping Shi, Yinhua N. DPP-4 inhibition by linagliptin ameliorates age-related mild cognitive impairment by regulating microglia polarization in mice. Experimental neurology. 2024-01-10. PMID:38199510. |
both linagliptin and metformin enhanced cognitive ability, increased hippocampal synaptic plasticity and neurogenesis, and decreased age-related oxidative stress and inflammation by regulating microglia polarization in the hippocampus of middle-aged mice. |
2024-01-10 |
2024-01-13 |
mouse |
| Sana Chintamen, Pallavi Gaur, Nicole Vo, Elizabeth M Bradshaw, Vilas Menon, Steven G Kerni. Distinct microglial transcriptomic signatures within the hippocampus. PloS one. vol 19. issue 1. 2024-01-05. PMID:38180982. |
recent evidence demonstrates that microglia modulate adult hippocampal neurogenesis by inhibiting cell proliferation of neural precursors and survival both in vitro and in vivo, thus maintaining a balance between cell division and cell death in the neural stem cell pool. |
2024-01-05 |
2024-01-08 |
Not clear |
| Sana Chintamen, Pallavi Gaur, Nicole Vo, Elizabeth M Bradshaw, Vilas Menon, Steven G Kerni. Distinct microglial transcriptomic signatures within the hippocampus. PloS one. vol 19. issue 1. 2024-01-05. PMID:38180982. |
here, we present evidence that hippocampal microglia exhibit transcriptomic heterogeneity, with some cells expressing genes associated with neurogenesis. |
2024-01-05 |
2024-01-08 |
Not clear |
| Sana Chintamen, Pallavi Gaur, Nicole Vo, Elizabeth M Bradshaw, Vilas Menon, Steven G Kerni. Distinct microglial transcriptomic signatures within the hippocampus. PloS one. vol 19. issue 1. 2024-01-05. PMID:38180982. |
by comprehensively profiling myeloid lineage cells in the hippocampus using single cell rna-sequencing, we have uncovered a small, yet distinct population of microglia which exhibit depletion in genes associated with homeostatic microglia and enrichment of genes associated with phagocytosis. |
2024-01-05 |
2024-01-08 |
Not clear |
| Xiaohui Li, Yifu Jia, Mengyuan Xiong, Yan Gao, Xueqin Xu, Changbin K. MHC-I in the hippocampus promotes comorbid depressive symptoms in bone cancer pain via the upregulation of microglial TREM2/DAP12 signaling. Behavioural brain research. 2024-01-04. PMID:38176616. |
these results suggested that hippocampal mhc-i was involved in bcp and depression comorbidity via upregulating the signals mediated by trem2/dap12 in microglia. |
2024-01-04 |
2024-01-07 |
mouse |
| Kohei Takahashi, Kazuhiro Kurokawa, Lihua Hong, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuj. Hippocampal and gut AMPK activation attenuates enterocolitis-like symptoms and co-occurring depressive-like behavior in ulcerative colitis model mice: Involvement of brain-gut autophagy. Experimental neurology. 2023-12-31. PMID:38160982. |
moreover, nlrp3 staining was observed in the neurons and microglia, and cleaved gsdmd staining in neurons in the hippocampus of dss-treated mice. |
2023-12-31 |
2024-01-05 |
mouse |
| Hong-Ying Li, Yuan Shen, Lu-Shuang Xie, Qiao-Feng Wu, Shu-Guang Y. Moxibustion influences hippocampal microglia polarization via IL-33/ST2 pathway in Alzheimer's disease mice. Zhen ci yan jiu = Acupuncture research. vol 48. issue 12. 2023-12-26. PMID:38146242. |
moxibustion influences hippocampal microglia polarization via il-33/st2 pathway in alzheimer's disease mice. |
2023-12-26 |
2023-12-28 |
mouse |
| Sadegh Izadi, Maryam Abdolrezaei, Roksana Soukhaklari, Maryam Moosav. Memory impairment induced by aluminum nanoparticles is associated with hippocampal IL-1 and IBA-1 upregulation in mice. Neurological research. 2023-12-25. PMID:38145565. |
therefore, in the present study, the hippocampal levels of ionized calcium-binding adaptor molecule 1 (iba-1), as the marker of microglia activation, and il-1β were assessed. |
2023-12-25 |
2023-12-28 |
mouse |
| Yu-Han Xie, Lin Jiang, Yi Zhang, Yu-Hui Deng, Hao Yang, Qi He, Yu-Ning Zhou, Chun-Ni Zhou, Yan-Min Luo, Xin Liang, Jin Wang, Du-Juan Huang, Lin Zhu, Yong Tang, Feng-Lei Cha. Antagonizing LINGO-1 reduces activated microglia and alleviates dendritic spine loss in the hippocampus of APP/PS1 transgenic mice. Neuroscience letters. 2023-12-24. PMID:38142924. |
antagonizing lingo-1 reduces activated microglia and alleviates dendritic spine loss in the hippocampus of app/ps1 transgenic mice. |
2023-12-24 |
2023-12-27 |
mouse |
| Yu-Han Xie, Lin Jiang, Yi Zhang, Yu-Hui Deng, Hao Yang, Qi He, Yu-Ning Zhou, Chun-Ni Zhou, Yan-Min Luo, Xin Liang, Jin Wang, Du-Juan Huang, Lin Zhu, Yong Tang, Feng-Lei Cha. Antagonizing LINGO-1 reduces activated microglia and alleviates dendritic spine loss in the hippocampus of APP/PS1 transgenic mice. Neuroscience letters. 2023-12-24. PMID:38142924. |
lingo-1 is a negative regulator of nerve growth, and whether antagonizing lingo-1 can attenuate synaptic pruning by microglia and rescue dendritic spines in the hippocampus in ad is still unclear. |
2023-12-24 |
2023-12-27 |
mouse |
| Yu-Han Xie, Lin Jiang, Yi Zhang, Yu-Hui Deng, Hao Yang, Qi He, Yu-Ning Zhou, Chun-Ni Zhou, Yan-Min Luo, Xin Liang, Jin Wang, Du-Juan Huang, Lin Zhu, Yong Tang, Feng-Lei Cha. Antagonizing LINGO-1 reduces activated microglia and alleviates dendritic spine loss in the hippocampus of APP/PS1 transgenic mice. Neuroscience letters. 2023-12-24. PMID:38142924. |
compared to wild-type mice, app/ps1 transgenic mice had worse performance on behavioral tests, fewer dendritic spines but more microglia in the hippocampus. |
2023-12-24 |
2023-12-27 |
mouse |
| Yu-Han Xie, Lin Jiang, Yi Zhang, Yu-Hui Deng, Hao Yang, Qi He, Yu-Ning Zhou, Chun-Ni Zhou, Yan-Min Luo, Xin Liang, Jin Wang, Du-Juan Huang, Lin Zhu, Yong Tang, Feng-Lei Cha. Antagonizing LINGO-1 reduces activated microglia and alleviates dendritic spine loss in the hippocampus of APP/PS1 transgenic mice. Neuroscience letters. 2023-12-24. PMID:38142924. |
moreover, app/ps1 transgenic mice had more postsynaptic termini colocalized with microglia in the hippocampus than wild-type mice. |
2023-12-24 |
2023-12-27 |
mouse |