| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Xiang Tan, Hong-Yu Dai, Juan Yao, Jia-Jia Wang, Yu-Chen Dai, Tian-Hao Zhang, Li-Li Qiu, Jie Su. Hippocampal estrogens rescued the decline of synaptic plasticity after surgery and anesthesia by inhibiting microglia overactivation. Behavioural brain research. 2023-12-06. PMID:38056710. |
this study aimed to determine whether suppressing microglia overactivation by hippocampal estrogens can rescue the decrease of synaptic plasticity after surgery and anesthesia. |
2023-12-06 |
2023-12-10 |
Not clear |
| R De Simone, M A Ajmone-Cat, A M Tartaglione, G Calamandrei, L Minghett. Maternal suboptimal selenium intake and low-level lead exposure affect offspring's microglial immune profile and its reactivity to a subsequent inflammatory hit. Scientific reports. vol 13. issue 1. 2023-12-05. PMID:38052845. |
we found an overall higher basal expression of inflammatory markers in neonatal brains, as well as in purified microglia and organotypic hippocampal slice cultures, from the subopt se offspring. |
2023-12-05 |
2023-12-10 |
rat |
| Heliana de Barros Fernandes, Bruna da Silva Oliveira, Caroline Amaral Machado, Brener Cunha Carvalho, Eliana Cristina de Brito Toscano, Maria Carolina M da Silva, Érica Leandro Marciano Vieira, Antônio Carlos Pinheiro de Oliveira, Antônio Lúcio Teixeira, Aline Silva de Miranda, Aristóbolo Mendes da Silv. Behavioral, neurochemical and neuroimmune features of RasGEF1b deficient mice. Progress in neuro-psychopharmacology & biological psychiatry. 2023-12-04. PMID:38048936. |
in addition, morphological alterations were observed in rasgef1b deficient microglia along with decreased levels of hippocampal bdnf. |
2023-12-04 |
2023-12-10 |
mouse |
| Wenrong Wen, Jingsheng Zhou, Chang'an Zhan, Jun Wan. Microglia as a Game Changer in Epilepsy Comorbid Depression. Molecular neurobiology. 2023-12-04. PMID:38048030. |
activated microglia released cytokines like il-6 and il-1β, orchestrating neuroinflammation especially in the hippocampus, worsening both depression and epilepsy. |
2023-12-04 |
2023-12-10 |
Not clear |
| Yuan Qi, Xuehang Wang, Yaoxin Zhang, Yue Leng, Xiaoting Liu, Xiyan Wang, Dan Wu, Ji Wang, Weihong Mi. Walnut-Derived Peptide Improves Cognitive Impairment in Colitis Mice Induced by Dextran Sodium Sulfate via the Microbiota-Gut-Brain Axis (MGBA). Journal of agricultural and food chemistry. 2023-12-01. PMID:38039336. |
furthermore, lp-5 ameliorated hippocampal neuron damage and protected blood-brain barrier (bbb) integrity by downregulating microglia marker protein iba-1, increasing tj protein expression, and restoring the deterioration of synaptic proteins. |
2023-12-01 |
2023-12-10 |
mouse |
| Yongri Hong, Caichuan Wei, Miaoying Fu, Xinyang Li, Haiju Zhang, Baozhen Ya. MCC950 alleviates seizure severity and angiogenesis by inhibiting NLRP3/ IL-1β signaling pathway-mediated pyroptosis in mouse model of epilepsy. International immunopharmacology. vol 126. 2023-12-01. PMID:38039716. |
in addition, immunofluorescence staining, rt-qpcr, and western blot demonstrated that mcc950 inhibited the expression of the nlrp3 inflammasome and its related proteins in microglia, whereas microangiogenesis was found to be increased in the cerebral cortex and hippocampus of epileptic mice, and these effects could be reversed by mcc950. |
2023-12-01 |
2023-12-10 |
mouse |
| Antara Rao, Nuo Chen, Min Joo Kim, Jessica Blumenfeld, Oscar Yip, Yanxia Hao, Zherui Liang, Maxine R Nelson, Nicole Koutsodendris, Brian Grone, Leo Ding, Seo Yeon Yoon, Patrick Arriola, Yadong Huan. Microglia Depletion Reduces Human Neuronal APOE4-Driven Pathologies in a Chimeric Alzheimer's Disease Model. bioRxiv : the preprint server for biology. 2023-11-28. PMID:38014339. |
specifically, we transplanted homozygous apoe4, isogenic apoe3, and apoe-knockout (apoe-ko) induced pluripotent stem cell (ipsc)-derived human neurons into the hippocampus of human apoe3 or apoe4 knock-in mice, and depleted microglia in half the chimeric mice. |
2023-11-28 |
2023-11-29 |
mouse |
| Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Sing. S1PR2 inhibition mitigates cognitive deficit in diabetic mice by modulating microglial activation via Akt-p53-TIGAR pathway. International immunopharmacology. vol 126. 2023-11-27. PMID:38011768. |
it further enhanced anti-inflammatory microglia in the hippocampus and prefrontal cortex (pfc), as evidenced by increased arg-1, cd206, and ym-1 levels and decreased inos, cd16, and mhcii levels. |
2023-11-27 |
2023-11-29 |
mouse |
| Qian Xiao, Jiaojiao Wang, Qiuyun Tian, Na Tian, Qi Tian, Xin He, Yutian Wang, Zhifang Don. Uric Acid Mitigates Cognitive Deficits via TFEB-Mediated Microglial Autophagy in Mice Models of Alzheimer's Disease. Molecular neurobiology. 2023-11-26. PMID:38008888. |
furthermore, ua activated microglia and upregulated the autophagy-related proteins such as lc3ii/i ratio, beclin-1, and lamp1 in the hippocampus of ad model mice. |
2023-11-26 |
2023-11-28 |
mouse |
| Caio Matheus Santos da Silva Calado, Raul Manhães-de-Castro, Sabrina da Conceição Pereira, Vanessa da Silva Souza, Leticia Nicoly Ferreira Barbosa, Osmar Henrique Dos Santos Junior, Claudia Jacques Lagranha, Pedro Alberto Romero Juárez, Luz Torner, Omar Guzmán-Quevedo, Ana Elisa Toscan. Resveratrol Reduces Neuroinflammation and Hippocampal Microglia Activation and Protects Against Impairment of Memory and Anxiety-Like Behavior in Experimental Cerebral Palsy. Molecular neurobiology. 2023-11-24. PMID:38001357. |
resveratrol reduces neuroinflammation and hippocampal microglia activation and protects against impairment of memory and anxiety-like behavior in experimental cerebral palsy. |
2023-11-24 |
2023-11-28 |
rat |
| Caio Matheus Santos da Silva Calado, Raul Manhães-de-Castro, Sabrina da Conceição Pereira, Vanessa da Silva Souza, Leticia Nicoly Ferreira Barbosa, Osmar Henrique Dos Santos Junior, Claudia Jacques Lagranha, Pedro Alberto Romero Juárez, Luz Torner, Omar Guzmán-Quevedo, Ana Elisa Toscan. Resveratrol Reduces Neuroinflammation and Hippocampal Microglia Activation and Protects Against Impairment of Memory and Anxiety-Like Behavior in Experimental Cerebral Palsy. Molecular neurobiology. 2023-11-24. PMID:38001357. |
the cps group showed an increase in the activated microglia and a reduction in cell proliferation in the hippocampus, while cpr animals showed a reduction of activated microglia and an increase in cell proliferation. |
2023-11-24 |
2023-11-28 |
rat |
| Jie Gao, Huiping Zhang, Leiying Zhou, Jiaqi Liu, Enba Zhuo, Yujun Shen, Xuesheng Liu, Qiying She. MANF Alleviates Sevoflurane-Induced Cognitive Impairment in Neonatal Mice by Modulating Microglial Activation and Polarization. Molecular neurobiology. 2023-11-22. PMID:37989984. |
finally, the recombinant human manf (rhmanf, 20 μg) protein was intraperitoneally administrated to neonatal mice before the sevoflurane anesthesia and the cognitive function, levels of pro-inflammatory cytokine and synapse-associated protein psd95, the status of neural apoptosis, microglia activation and oxidative stress in hippocampus of the mice were investigated. |
2023-11-22 |
2023-11-29 |
mouse |
| Jie Gao, Huiping Zhang, Leiying Zhou, Jiaqi Liu, Enba Zhuo, Yujun Shen, Xuesheng Liu, Qiying She. MANF Alleviates Sevoflurane-Induced Cognitive Impairment in Neonatal Mice by Modulating Microglial Activation and Polarization. Molecular neurobiology. 2023-11-22. PMID:37989984. |
the sevoflurane anesthesia increased the expression of endogenous manf in the hippocampus, especially in microglia. |
2023-11-22 |
2023-11-29 |
mouse |
| Jie Gao, Huiping Zhang, Leiying Zhou, Jiaqi Liu, Enba Zhuo, Yujun Shen, Xuesheng Liu, Qiying She. MANF Alleviates Sevoflurane-Induced Cognitive Impairment in Neonatal Mice by Modulating Microglial Activation and Polarization. Molecular neurobiology. 2023-11-22. PMID:37989984. |
mko upregulated the expression of tumor necrosis factor-α (tnf-α), accelerated the neural apoptosis and the activation of microglia in hippocampus in young mice. |
2023-11-22 |
2023-11-29 |
mouse |
| Zhen Mei, Jiaqi Liu, Jason P Schroeder, David Weinshenker, Duc M Duong, Nicholas T Seyfried, Yujing Li, Peng Jin, Aliza P Wingo, Thomas S Wing. Lowering Hippocampal miR-29a Expression Slows Cognitive Decline and Reduces Beta-Amyloid Deposition in 5×FAD Mice. Molecular neurobiology. 2023-11-22. PMID:37989983. |
mir-29a sponge significantly reduced hippocampal beta-amyloid deposition in 5×fad mice and lowered astrocyte and microglia activation in both 5×fad and wt mice. |
2023-11-22 |
2023-11-29 |
mouse |
| Jian Jing Siew, Hui-Mei Chen, Feng-Lan Chiu, Chia-Wei Lee, Yao-Ming Chang, Hung-Lin Chen, Thi Ngoc Anh Nguyen, Hung-Ting Liao, Mengyu Liu, Hsiao-Tien Hagar, Yung-Chen Sun, Hsing-Lin Lai, Min-Hao Kuo, David Blum, Luc Buée, Lee-Way Jin, Shih-Yu Chen, Tai-Ming Ko, Jie-Rong Huang, Hung-Chih Kuo, Fu-Tong Liu, Yijuang Cher. Galectin-3 aggravates microglial activation and tau transmission in tauopathy. The Journal of clinical investigation. 2023-11-21. PMID:37988169. |
single-cell rna-seq analysis of the hippocampus of a mouse model of tauopathy (thy-tau22) revealed a group of pathogenic tau-evoked, gal3-associated microglia (gam) with altered cellular machineries implicated in neurodegeneration, including enhanced immune and inflammatory responses. |
2023-11-21 |
2023-11-29 |
mouse |
| Dore Loef, Indira Tendolkar, Philip F P van Eijndhoven, Jeroen J M Hoozemans, Mardien L Oudega, Annemieke J M Rozemuller, Paul J Lucassen, Annemiek Dols, Anke A Dijkstr. Electroconvulsive therapy is associated with increased immunoreactivity of neuroplasticity markers in the hippocampus of depressed patients. Translational psychiatry. vol 13. issue 1. 2023-11-20. PMID:37981649. |
upon histopathological examination, no indications were observed for major hippocampal cell loss, overt cytoarchitectural changes or classic neuropathology in these 3 groups, nor were obvious differences present in inflammatory markers for astrocytes or microglia. |
2023-11-20 |
2023-11-29 |
human |
| Wen-Yuan Zhang, Cui-Mei Zhao, Chang-Shui Wang, Xin Xie, Yu-Qi Li, Bei-Bei Chen, Lei Feng, Pei Jian. Methylglyoxal accumulation contributes to accelerated brain aging in spontaneously hypertensive rats. Free radical biology & medicine. 2023-11-20. PMID:37984752. |
age methylglyoxal-hydro imidazoline-1 (mg-h1) is primarily localized in astrocytes, while its presence was not observed in neurons and microglia within the hypertensive hippocampus. |
2023-11-20 |
2023-11-29 |
rat |
| Tanveer Singh, Sreevidhya Ramakrishnan, Xin Wu, Doodipala Samba Redd. The Journal of pharmacology and experimental therapeutics. 2023-11-17. PMID:37977810. |
neuropathological analysis showed substantially fewer principal neurons and inhibitory interneurons with a marked increase in reactive microglia and neuroinflammation in the hippocampus and other brain regions. |
2023-11-17 |
2023-11-20 |
rat |
| Xiaomeng Han, Peter H Li, Shuohong Wang, Morgan Sanchez, Sneha Aggarwal, Tim Blakely, Richard Schalek, Yaron Meirovitch, Zudi Lin, Daniel Berger, Yuelong Wu, Fatima Aly, Sylvie Bay, Benoît Delatour, Pierre LaFaye, Hanspeter Pfister, Donglai Wei, Viren Jain, Hidde Ploegh, Jeff Lichtma. A large-scale volumetric correlated light and electron microscopy study localizes Alzheimer's disease-related molecules in the hippocampus. bioRxiv : the preprint server for biology. 2023-11-14. PMID:37961104. |
three molecules (ptau, aβ, and a marker for activated microglia (cd11b)) were labeled without the need for detergents by three nanobody probes in a sample of the hippocampus of the 3xtg alzheimer's disease model mouse. |
2023-11-14 |
2023-11-20 |
mouse |