| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cheng Zhao, Zhuo Chen, Xu Lu, Wenfeng Hu, Rongrong Yang, Qun Lu, Bingran Chen, Chao Huan. Microglia-Dependent Reversal of Depression-Like Behaviors in Chronically Stressed Mice by Administration of a Specific Immuno-stimulant β-Glucan. Neurochemical research. 2023-11-14. PMID:37962706. |
in recent years, the decline of microglia in the hippocampus has been shown to play a role in the development of depression, and its reversal shows marked antidepressant-like effects. |
2023-11-14 |
2023-11-20 |
mouse |
| Kozo Saito, Eiji Shigetomi, Youichi Shinozaki, Kenji Kobayashi, Bijay Parajuli, Yuto Kubota, Kent Sakai, Miho Miyakawa, Hiroshi Horiuchi, Junichi Nabekura, Schuichi Koizum. Microglia sense astrocyte dysfunction and prevent disease progression in an Alexander disease model. Brain : a journal of neurology. 2023-11-13. PMID:37955589. |
functional changes in microglia were assessed by ca2+ imaging using hippocampal brain slices from iba1-gcamp6-60tm mice and two-photon microscopy. |
2023-11-13 |
2023-11-20 |
mouse |
| Tamires Cabral-França, Fernanda Ferreira Cruz, Paulo Cesar Silva, Vera Lucia Nunes Pannain, Arlete Fernandes, José Marcus Raso Eulálio, Maurício Magalhães Paiva, Hugo Macedo-Ramos, Jose Eduardo Ferreira Manso, Wagner Baetas-da-Cru. Hippocampal Microglia Activation Induced by Acute Pancreatic Injury in Rats. Digestive diseases and sciences. 2023-11-13. PMID:37957410. |
hippocampal microglia activation induced by acute pancreatic injury in rats. |
2023-11-13 |
2023-11-20 |
rat |
| Kinga Tylek, Ewa Trojan, Monika Leśkiewicz, Imane Ghafir El Idrissi, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kai. Microglia Depletion Attenuates the Pro-Resolving Activity of the Formyl Peptide Receptor 2 Agonist AMS21 Related to Inhibition of Inflammasome NLRP3 Signalling Pathway: A Study of Organotypic Hippocampal Cultures. Cells. vol 12. issue 21. 2023-11-10. PMID:37947648. |
microglia depletion attenuates the pro-resolving activity of the formyl peptide receptor 2 agonist ams21 related to inhibition of inflammasome nlrp3 signalling pathway: a study of organotypic hippocampal cultures. |
2023-11-10 |
2023-11-20 |
Not clear |
| Seungun Yeo, Jaemyung Jang, Hyun Jin Jung, Hyeyoung Lee, Youngshik Cho. Primary cilia-mediated regulation of microglial secretion in Alzheimer's disease. Frontiers in molecular biosciences. vol 10. 2023-11-09. PMID:37942288. |
these lateral septum (ls)-enriched microglia were associated with dense axonal bundles originating from the hippocampus. |
2023-11-09 |
2023-11-20 |
mouse |
| Seungun Yeo, Jaemyung Jang, Hyun Jin Jung, Hyeyoung Lee, Youngshik Cho. Primary cilia-mediated regulation of microglial secretion in Alzheimer's disease. Frontiers in molecular biosciences. vol 10. 2023-11-09. PMID:37942288. |
these results indicate that dam-like microglia are present in the ls, a critical target region for hippocampal nerve bundles, and that the primary ciliary signaling system regulates microglial secretion, affecting extracellular proteostasis. |
2023-11-09 |
2023-11-20 |
mouse |
| Bingran Chen, Cheng Zhao, Haojie Zhu, Xu Lu, Huijun Liu, Qun Lu, Tao Zhu, Chao Huan. β-glucan, a specific immuno-stimulant, produces rapid antidepressant effects by stimulating ERK1/2-dependent synthesis of BDNF in the hippocampus. European journal of pharmacology. 2023-11-08. PMID:37939990. |
a decline in microglia in the dentate gyrus of the hippocampus has recently been described as an important mechanism for the progression of depression. |
2023-11-08 |
2023-11-20 |
mouse |
| Tingting Wang, Beidi Chen, Mingcui Luo, Lulu Xie, Mengxi Lu, Xiaoqian Lu, Shuai Zhang, Liyi Wei, Xinli Zhou, Baozhen Yao, Hui Wang, Dan X. Microbiota-indole 3-propionic acid-brain axis mediates abnormal synaptic pruning of hippocampal microglia and susceptibility to ASD in IUGR offspring. Microbiome. vol 11. issue 1. 2023-11-07. PMID:37932832. |
microbiota-indole 3-propionic acid-brain axis mediates abnormal synaptic pruning of hippocampal microglia and susceptibility to asd in iugr offspring. |
2023-11-07 |
2023-11-08 |
Not clear |
| Ye Yuan, Yamei Liu, Li Hao, Jinlian Ma, Simai Shao, Ziyang Yu, Ming Shi, Zhenqiang Zhang, Zijuan Zhan. The neuroprotective effects of Liuwei Dihuang medicine in the APP/PS1 mouse model are dependent on the PI3K/Akt signaling pathway. Frontiers in pharmacology. vol 14. 2023-11-03. PMID:37920210. |
at the same time, lwd can increase the expression of hippocampal autophagy biomarkers, reduce the precipitation of aβ, and the activation of microglia and astrocytes. |
2023-11-03 |
2023-11-08 |
mouse |
| Xin Tang, Ellen Walter, Eric Wohleb, Yanbo Fan, Chenran Wan. ATG5 (autophagy related 5) in microglia controls hippocampal neurogenesis in Alzheimer disease. Autophagy. 2023-11-02. PMID:37915255. |
atg5 (autophagy related 5) in microglia controls hippocampal neurogenesis in alzheimer disease. |
2023-11-02 |
2023-11-08 |
Not clear |
| Huili Jiang, Xianqi Long, Yu Wang, Xuhui Zhang, Lu Chen, Xinjing Yang, Bingcong Zhao, Ye Zhang, Yemao Chai, Tuya Ba. Acupuncture Ameliorates Depression-Like Behaviors Through Modulating the Neuroinflammation Mediated by TLR4 Signaling Pathway in Rats Exposed to Chronic Restraint Stress. Molecular neurobiology. 2023-11-02. PMID:37917302. |
the expression of activated microglia in hippocampus was detected by immunofluorescence. |
2023-11-02 |
2023-11-08 |
rat |
| Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Che. Intranasal oxytocin alleviates comorbid depressive symptoms in neuropathic pain via elevating hippocampal BDNF production in both female and male mice. Neuropharmacology. 2023-11-01. PMID:37913985. |
intranasal oxytocin not only inhibited the activation of microglia and astrocytes, but also increased the downregulated oxytocin receptor (otr) expression, reversed the elevated glun2a, and restored the decreased bdnf expression in the hippocampus. |
2023-11-01 |
2023-11-08 |
mouse |
| Hui He, Haili He, Li Mo, Zili You, Jinqiang Zhan. Priming of microglia with dysfunctional gut microbiota impairs hippocampal neurogenesis and fosters stress vulnerability of mice. Brain, behavior, and immunity. 2023-11-01. PMID:37914097. |
priming of microglia with dysfunctional gut microbiota impairs hippocampal neurogenesis and fosters stress vulnerability of mice. |
2023-11-01 |
2023-11-08 |
mouse |
| Hui He, Haili He, Li Mo, Zili You, Jinqiang Zhan. Priming of microglia with dysfunctional gut microbiota impairs hippocampal neurogenesis and fosters stress vulnerability of mice. Brain, behavior, and immunity. 2023-11-01. PMID:37914097. |
here we explored in an animal model of depression whether disruption of the gut microbiome primes hippocampal microglia, thereby impairing neurogenesis and sensitizing to stress. |
2023-11-01 |
2023-11-08 |
mouse |
| Jing Ma, Yi-Hui Hou, Zhe-Yan Liao, Zheng Ma, Xiao-Xuan Zhang, Jian-Li Wang, Yun-Bo Zhu, Hai-Lei Shan, Ping-Yue Wang, Cheng-Bo Li, Ying-Lei Lv, Yi-Lan Wei, Jie-Zhi Do. Neuroprotective Effects of Leptin on the APP/PS1 Alzheimer's Disease Mouse Model: Role of Microglial and Neuroinflammation. Degenerative neurological and neuromuscular disease. vol 13. 2023-10-31. PMID:37905186. |
the purpose of this study was to determine whether leptin affected microglia in the hippocampus of young and aged male app/ps1 mice. |
2023-10-31 |
2023-11-08 |
mouse |
| Sumit S Rathod, Yogeeta O Agrawal, Kartik T Nakhate, M F Nagoor Meeran, Shreesh Ojha, Sameer N Goya. Neuroinflammation in the Central Nervous System: Exploring the Evolving Influence of Endocannabinoid System. Biomedicines. vol 11. issue 10. 2023-10-30. PMID:37893016. |
the presence of cb2 receptors in certain brain components, like cultured cerebellar granular cells, purkinje fibers, and microglia, as well as in the areas like the cerebral cortex, hippocampus, and cerebellum is also evidenced by immunoblotting assays, radioligand binding, and autoradiography studies. |
2023-10-30 |
2023-11-08 |
Not clear |
| Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Che. Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics. Frontiers in immunology. vol 14. 2023-10-26. PMID:37881439. |
roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics. |
2023-10-26 |
2023-11-08 |
Not clear |
| Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Che. Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics. Frontiers in immunology. vol 14. 2023-10-26. PMID:37881439. |
however, the mechanisms of the crosstalk between microglia and adult hippocampal neurogenesis in depression are not yet fully understood. |
2023-10-26 |
2023-11-08 |
Not clear |
| Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Che. Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics. Frontiers in immunology. vol 14. 2023-10-26. PMID:37881439. |
therefore, in this review, we first introduce recent discoveries regarding the roles of microglia and adult hippocampal neurogenesis in the etiology of depression. |
2023-10-26 |
2023-11-08 |
Not clear |
| Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Che. Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics. Frontiers in immunology. vol 14. 2023-10-26. PMID:37881439. |
then, we systematically discuss the possible mechanisms of how microglia regulate adult hippocampal neurogenesis in depression according to recent studies, which involve toll-like receptors, microglial polarization, fractalkine-c-x3-c motif chemokine receptor 1, hypothalamic-pituitary-adrenal axis, cytokines, brain-derived neurotrophic factor, and the microbiota-gut-brain axis, etc. |
2023-10-26 |
2023-11-08 |
Not clear |