All Relations between microglial cell and hippocampus

Publication Sentence Publish Date Extraction Date Species
M J Zhang, J H Zhong, X J Y. Effect of Curcumin on Cognitive Behavior and Pathological Characteristics of the Hippocampus in Mice with Inherent Alzheimer's Disease. Bulletin of experimental biology and medicine. 2023-08-11. PMID:37566247. the distribution and the quantity of amyloid plaques and the spread of microglia in the hippocampus were determined by immunofluorescence. 2023-08-11 2023-08-16 mouse
M J Zhang, J H Zhong, X J Y. Effect of Curcumin on Cognitive Behavior and Pathological Characteristics of the Hippocampus in Mice with Inherent Alzheimer's Disease. Bulletin of experimental biology and medicine. 2023-08-11. PMID:37566247. in the hippocampus of app/ps1 mice, curcumin significantly diminished the elevated aβ levels and inhibited microglia proliferation. 2023-08-11 2023-08-16 mouse
Priyanka Mishra, Alexander Silva, Jay Sharma, Jacqueline Nguyen, Donald P Pizzo, Denise Hinz, Debashis Sahoo, Stephanie Cherqu. Rescue of Alzheimer's disease phenotype in a mouse model by transplantation of wild-type hematopoietic stem and progenitor cells. Cell reports. vol 42. issue 8. 2023-08-10. PMID:37561625. transcriptomic analysis revealed a significant decrease in gene expression related to "disease-associated microglia" in the cortex and "neurodegeneration-associated endothelial cells" in the hippocampus of the wt hspc-transplanted 5xfad mice compared with diseased controls. 2023-08-10 2023-08-16 mouse
Ya Lan Yang, Ted Weita La. Chronic Visual Stimulation with LED Light Flickering at 24, 40, or 80 Hz Failed to Reduce Amyloid β Load in the 5XFAD Alzheimer's Disease Mouse Model. eNeuro. vol 10. issue 8. 2023-08-07. PMID:37550065. as expected, 33-week-old 5xfad mice but not control wild-type mice of the same age exhibited an abundance of swollen microglia and aβ plaques in the visual cortex and hippocampus. 2023-08-07 2023-08-14 mouse
Seong Hye Kim, In Gyoung Ju, Jin Hee Kim, Hyeyoon Eo, So-Ri Son, Dae Sik Jang, Myung Sook O. Linderae Radix Ameliorates Cognitive Dysfunction by Inhibiting Neuroinflammation and Synaptic Damage in Alzheimer's Disease Models. Molecular neurobiology. 2023-08-05. PMID:37542650. furthermore, we found that microglia activation increased, and the expression of synaptic proteins decreased in the hippocampus of the aβo-injected group, which was alleviated in the lr-treated group. 2023-08-05 2023-08-14 mouse
Wataru Nagata, Mari Gotoh, Akiho Koizumi, Keiko Fukasawa, Keiichi Nakagawa, Yasushi Satoh, Toshiaki Ishizuk. Two-carba cyclic phosphatidic acid treatment promotes phenotypic switch from M1 to M2 microglia and prevents behavioral abnormalities in a mouse model of neuropsychiatric systemic lupus erythematosus. Human cell. 2023-08-04. PMID:37540445. the expression of cd68, an m1 phenotypic marker of microglia, was significantly elevated in the prefrontal cortex and hippocampus of mrl/lpr mice, which was significantly suppressed by 2ccpa treatment. 2023-08-04 2023-08-14 mouse
Tao Zhu, Bingran Chen, Han Han, Xu Lu, Zhuo Chen, Ting Ye, Hui Zhao, Meng Zheng, Chao Huan. Zymosan A produces a rapid and sustained antidepressant effect in chronically stressed mice by stimulating hippocampal microglia. Behavioural pharmacology. vol 34. issue 6. 2023-08-02. PMID:37530136. zymosan a produces a rapid and sustained antidepressant effect in chronically stressed mice by stimulating hippocampal microglia. 2023-08-02 2023-08-14 mouse
Nina E Baumgartner, Mandy C Biraud, Elizabeth K Luca. Sex differences in socioemotional behavior and changes in ventral hippocampal transcription across aging in C57Bl/6J mice. Neurobiology of aging. vol 130. 2023-07-31. PMID:37524006. to investigate potential neural mechanisms underlying these behavioral changes, we analyzed transcriptional neuropathology markers in the ventral hippocampus and found age-related changes in genes related to activated microglia, angiogenesis, and cytokines. 2023-07-31 2023-08-14 mouse
Jemi Feiona Vergil Andrews, Divya Bharathi Selvaraj, Akshay Kumar, Syed Aasish Roshan, Muthuswamy Anusuyadevi, Mahesh Kandasam. A Mild Dose of Aspirin Promotes Hippocampal Neurogenesis and Working Memory in Experimental Ageing Mice. Brain sciences. vol 13. issue 7. 2023-07-29. PMID:37509038. this study investigated the effect of aspirin on spatial memory in correlation with the regulation of hippocampal neurogenesis and microglia in the brains of ageing experimental mice. 2023-07-29 2023-08-14 mouse
Yan Cheng, Rachael Elizabeth Dempsey, Soheil Kazemi Roodsari, Dorela D Shuboni-Mulligan, Olivier George, Larry D Sanford, Ming-Lei Gu. Cocaine Regulates NLRP3 Inflammasome Activity and CRF Signaling in a Region- and Sex-Dependent Manner in Rat Brain. Biomedicines. vol 11. issue 7. 2023-07-29. PMID:37509440. to further characterize the effects of cocaine on microglia and neuroimmune signaling in vivo, we utilized the brains from both sexes of outbred rats with cocaine self-administration to explore the activation status of microglia, nod-, lrr-, and pyrin domain-containing protein 3 (nlrp3) inflammasome activity, corticotropin-releasing factor (crf) signaling, and nf-κb levels in the striatum and hippocampus (hp). 2023-07-29 2023-08-14 mouse
Keiichi Hiramoto, Masashi Imai, Shota Tanaka, Kazuya Oo. Dementia Is Induced via the AGEs/Iba1/iNOS Pathway in Aged KK-Ay/Tajcl Mice. Life (Basel, Switzerland). vol 13. issue 7. 2023-07-29. PMID:37511915. hippocampal levels of cc-chemokine receptor 7 and inducible nitric oxide synthase, which are from m1-type macrophages that shift from microglia, were higher in kk-ay/tajcl mice than in control mice. 2023-07-29 2023-08-14 mouse
Lulu Xie, Jiaxin Qin, Tingting Wang, Shuai Zhang, Mingcui Luo, Xuelei Cheng, Xinrui Cao, Hui Wang, Baozhen Yao, Dan Xu, Biwen Pen. Impact of Prenatal Acetaminophen Exposure for Hippocampal Development Disorder on Mice. Molecular neurobiology. 2023-07-29. PMID:37516664. in addition, pace significantly decreased the expression of genes related to synaptic development in fetal hippocampal neurons and hippocampal astrocyte and microglia were also damaged to varying degrees. 2023-07-29 2023-08-14 mouse
Juan M Tamayo, Hadley C Osman, Jared J Schwartzer, Kent Pinkerton, Paul Ashwoo. Characterizing the Neuroimmune Environment of Offspring in a Novel Model of Maternal Allergic Asthma and Particulate Matter Exposure. Research square. 2023-07-28. PMID:37503062. the combination of maa and uis exposure (maa-uis) during pregnancy resulted in an increase in microglia density in the hippocampus of offspring, as identified by iba-1 staining. 2023-07-28 2023-08-14 mouse
Liming Dong, Ning Jiang, Jie Bai, Yiman Li, Zhihui Song, Xinmin Liu, Chao Zhan. Neuroprotective Effects of Dammarane Sapogenins Against lipopolysaccharide-induced Cognitive Impairment, Neuroinflammation and Synaptic Dysfunction. Neurochemical research. 2023-07-25. PMID:37490197. ds also remarkably inhibited lps-induced neuroinflammation by suppressing microglia overactivation, pro-inflammatory cytok ine release (tnf-α and il-1β) and reducing neuronal loss in the ca1 and dg regions of the hippocampus. 2023-07-25 2023-08-14 rat
Zhiwei Xue, Lei Ye, Jianwei Ge, Zhen Lan, Xinxin Zou, Chenglu Mao, Xinyu Bao, Linjie Yu, Yun Xu, Xiaolei Zh. Wwl70-induced ABHD6 inhibition attenuates memory deficits and pathological phenotypes in APPswe/PS1dE9 mice. Pharmacological research. 2023-07-22. PMID:37480972. furthermore, wwl70 significantly decreased the aβ levels and neuroinflammation in the hippocampus of ad mice, and enhanced aβ phagocytized by microglia. 2023-07-22 2023-08-14 mouse
Inez Koopman, Bart J van Dijk, Nicolaas P A Zuithoff, Jacqueline A Sluijs, Marije J van der Kamp, Zelonna A V Baldew, Catharina J M Frijns, Gabriel J E Rinkel, Elly M Hol, Mervyn D I Vergouwe. Glial cell response and microthrombosis in aneurysmal subarachnoid hemorrhage patients: An autopsy study. Journal of neuropathology and experimental neurology. 2023-07-21. PMID:37478478. in a second study, we investigated the correlation between microthrombosis and microglia by studying the microglial surface area around vessels with and without microthrombosis in the frontal cortex and hippocampus of 8 other asah patients. 2023-07-21 2023-08-14 Not clear
Miao Sun, Yang Li, Min Liu, Qingxiao Li, Likai Shi, Xianghan Ruan, Yuting Huo, Zhikang Zhou, Xiaoying Zhang, Yulong Ma, Weidong M. Insulin alleviates lipopolysaccharide-induced cognitive impairment via inhibiting neuroinflammation and ferroptosis. European journal of pharmacology. 2023-07-21. PMID:37479016. insulin treatment could also inhibit the lps-induced activation of microglia and astrocytes, and the release of tumor necrosis factor-α (tnf-α) and interleukin-1β (il-1β) in the hippocampus. 2023-07-21 2023-08-14 Not clear
Ziyang Yu, Huize Pang, Yifan Yang, Doudou Luo, Haiping Zheng, Zicheng Huang, Mingxia Zhang, Ke Re. Microglia dysfunction drives disrupted hippocampal amplitude of low frequency after acute kidney injury. CNS neuroscience & therapeutics. 2023-07-20. PMID:37469216. microglia dysfunction drives disrupted hippocampal amplitude of low frequency after acute kidney injury. 2023-07-20 2023-08-14 Not clear
Ying He, Man-Shu Zou, Ting-Ting Ren, Ping Li, Yang Liu, Yuan-Shan Ha. [Therapeutic effect and mechanism of Xiaoyao Kangai Jieyu Recipe on mice with breast cancer related depression through regulating COX pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 14. 2023-07-20. PMID:37475079. immunofluorescence was performed to detect the mean fluorescence intensity of cd11b, a marker of hippocampal microglia activation. 2023-07-20 2023-08-14 mouse
Ying He, Man-Shu Zou, Ting-Ting Ren, Ping Li, Yang Liu, Yuan-Shan Ha. [Therapeutic effect and mechanism of Xiaoyao Kangai Jieyu Recipe on mice with breast cancer related depression through regulating COX pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 14. 2023-07-20. PMID:37475079. the experimental results indicated that compared with the normal group, the model group had reduced glucose consumption and lowered number of total activities in open field test(p<0.05, p<0.01), prolonged first feeding latency in no-velty-suppressed feeding test(p<0.01), and significant depression-like behavior; the contents of il-1β, il-18, cox-2, and eprs in hippocampus were increased(p<0.05, p<0.01), with hippocampal microglia activation and obvious neuronal damage. 2023-07-20 2023-08-14 mouse