All Relations between microglial cell and matrix compartment

Publication Sentence Publish Date Extraction Date Species
Dev Kumar Tripathy, Lakshmi Priya Panda, Suryanarayan Biswal, Kalpana Barhwa. Insights into the glioblastoma tumor microenvironment: current and emerging therapeutic approaches. Frontiers in pharmacology. vol 15. 2024-03-25. PMID:38523646. the tumor microenvironment is a complex network of immune components like microglia, macrophages, t cells, b cells, natural killer (nk) cells, dendritic cells and myeloid-derived suppressor cells, and non-immune components such as extracellular matrix, endothelial cells, astrocytes and neurons. 2024-03-25 2024-03-27 Not clear
Marja Koskuvi, Elina Pörsti, Tristen Hewitt, Noora Räsänen, Ying-Chieh Wu, Kalevi Trontti, Amanda McQuade, Shringaa Kalyanaraman, Ilkka Ojansuu, Olli Vaurio, Tyrone D Cannon, Jouko Lönnqvist, Sebastian Therman, Jaana Suvisaari, Jaakko Kaprio, Mathew Blurton-Jones, Iiris Hovatta, Markku Lähteenvuo, Taisia Rolova, Šárka Lehtonen, Jari Tiihonen, Jari Koistinah. Genetic contribution to microglial activation in schizophrenia. Molecular psychiatry. 2024-03-23. PMID:38519640. rna sequencing predicted downregulation of extracellular matrix structure constituent gene ontology (go) terms and hepatic fibrosis pathway activation that were shared by microglia of both affected and unaffected twins, but the upregulation of major histocompatibility complex (mhc) class ii receptors was observed only in affected twin microglia. 2024-03-23 2024-03-26 human
Marja Koskuvi, Elina Pörsti, Tristen Hewitt, Noora Räsänen, Ying-Chieh Wu, Kalevi Trontti, Amanda McQuade, Shringaa Kalyanaraman, Ilkka Ojansuu, Olli Vaurio, Tyrone D Cannon, Jouko Lönnqvist, Sebastian Therman, Jaana Suvisaari, Jaakko Kaprio, Mathew Blurton-Jones, Iiris Hovatta, Markku Lähteenvuo, Taisia Rolova, Šárka Lehtonen, Jari Tiihonen, Jari Koistinah. Genetic contribution to microglial activation in schizophrenia. Molecular psychiatry. 2024-03-23. PMID:38519640. we conclude that microglia of the patients with scz have gene expression aberrations related to inflammation response and extracellular matrix without contributing to increased microglial activation. 2024-03-23 2024-03-26 human
Assunta Virtuoso, Christos Galanis, Maximilian Lenz, Michele Papa, Andreas Vlacho. Regional Microglial Response in Entorhino-Hippocampal Slice Cultures to Schaffer Collateral Lesion and Metalloproteinases Modulation. International journal of molecular sciences. vol 25. issue 4. 2024-02-24. PMID:38397023. microglia and astrocytes are essential in sustaining physiological networks in the central nervous system, with their ability to remodel the extracellular matrix, being pivotal for synapse plasticity. 2024-02-24 2024-02-26 mouse
Stefano Stanca, Martina Rossetti, Leona Bokulic Panichi, Paolo Bongioann. The Cellular Dysfunction of the Brain-Blood Barrier from Endothelial Cells to Astrocytes: The Pathway towards Neurotransmitter Impairment in Schizophrenia. International journal of molecular sciences. vol 25. issue 2. 2024-01-27. PMID:38279249. the homeostasis of the bbb is preserved by the neurovascular unit which is constituted by ecs, astrocytes and microglia, neurons, and the extracellular matrix. 2024-01-27 2024-01-29 Not clear
Weizhuo Lu, Jiyue We. Crosstalk Among Glial Cells in the Blood-Brain Barrier Injury After Ischemic Stroke. Molecular neurobiology. 2024-01-26. PMID:38279077. ischemic stroke-induced activation of microglia and astrocytes leads to increased production of inflammatory mediators, containing chemokines, cytokines, matrix metalloproteinases (mmps), etc., which are important factors in the pathological process of bbb breakdown. 2024-01-26 2024-01-29 Not clear
Yulin Liu, Junjie Zhang, Yabei Li, Yuxiang Zhao, Shuake Kuermanbayi, Jian Zhuang, Hua Zhang, Feng Xu, Fei L. Matrix stiffness-dependent microglia activation in response to inflammatory cues: Chemical science. vol 15. issue 1. 2023-12-22. PMID:38131065. matrix stiffness-dependent microglia activation in response to inflammatory cues: microglia play a crucial role in maintaining the homeostasis of the central nervous system (cns) by sensing and responding to mechanical and inflammatory cues in their microenvironment. 2023-12-22 2023-12-24 Not clear
Philip Regan, Katriona L Hole, Julia Sero, Robert J William. Epigallocatechin Gallate Modulates Microglia Phenotype to Suppress Pro-inflammatory Signalling Cues and Inhibit Phagocytosis. Molecular neurobiology. 2023-12-14. PMID:38095777. egcg was broadly anti-inflammatory, reducing cytokine release and downregulating transcription, particularly of components of the microglia extracellular matrix such as mmp3 and serpinb2. 2023-12-14 2023-12-17 Not clear
b' Mengqin Zhou, Peng Su, Jingyan Liang, \\xe5\\xa4\\xa9 \\xe5\\xba\\x86 \\xe7\\x86\\x8. Research progress on the roles of neurovascular unit in stroke-induced immunosuppression. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 52. issue 5. 2023-10-30. PMID:37899404.' the neurovascular unit (nvu) is a complex multi-cellular structure consisting of neurons, endothelial cells, pericyte, astrocyte, microglia and extracellular matrix, etc. 2023-10-30 2023-11-08 Not clear
Rayane Rahmani, Naiomi Rambarack, Jaijeet Singh, Andrew Constanti, Afia B Al. Age-Dependent Sex Differences in Perineuronal Nets in an International journal of molecular sciences. vol 24. issue 19. 2023-10-14. PMID:37834366. perineuronal nets (pnns) are important components of the extracellular matrix with a critical role in synaptic stabilisation and have been shown to be influenced by microglia, which enter an activated state during ad. 2023-10-14 2023-10-15 Not clear
Björn F Vahsen, Sumedha Nalluru, Georgia R Morgan, Lucy Farrimond, Emily Carroll, Yinyan Xu, Kaitlyn M L Cramb, Benazir Amein, Jakub Scaber, Antigoni Katsikoudi, Ana Candalija, Mireia Carcolé, Ruxandra Dafinca, Adrian M Isaacs, Richard Wade-Martins, Elizabeth Gray, Martin R Turner, Sally A Cowley, Kevin Talbo. C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9. Nature communications. vol 14. issue 1. 2023-09-22. PMID:37736756. specifically, lps-primed c9orf72 hre mutant microglia show consistently increased expression and release of matrix metalloproteinase-9 (mmp9). 2023-09-22 2023-10-07 human
Haixiang Wu, Fangcheng Xu, Yunfang Luo, Yibao Zhang, Min Tan. 3D bioprinted endothelial cell-microglia coculture for diabetic retinopathy modeling. Biofabrication. 2023-09-19. PMID:37725996. this study used digital light processing bioprinting to construct a 3d coculture model of endothelial cells (ecs) and microglia under varying glucose conditions, with a hydrogel stiffness of 4.6-7.1 kpa to mimic the extracellular matrix property of retina plexiform. 2023-09-19 2023-10-07 Not clear
Marissa A Smail, Brittany L Smith, Rammohan Shukla, Khaled Alganem, Hunter M Eby, Justin L Bollinger, Ria K Parikh, James B Chambers, James K Reigle, Rachel D Moloney, Nawshaba Nawreen, Eric S Wohleb, Harry Pantazopoulos, Robert E McCullumsmith, James P Herma. Molecular neurobiology of loss: a role for basolateral amygdala extracellular matrix. Molecular psychiatry. 2023-08-29. PMID:37644175. a comprehensive multi-omics investigation of the bla, spanning multiple cohorts, platforms, and analyses, revealed alterations in microglia and the extracellular matrix (ecm). 2023-08-29 2023-09-07 rat
Luying Qiu, Yaxuan Wang, Yuye Wang, Fang Liu, Shumin Deng, Weishuang Xue, Yanzhe Wan. Ursolic Acid Ameliorated Neuronal Damage by Restoring Microglia-Activated MMP/TIMP Imbalance in vitro. Drug design, development and therapy. vol 17. 2023-08-28. PMID:37637267. excessively activated microglia produce pro-inflammatory mediators such as matrix metalloproteinases [mmps] and their specific inhibitors, tissue inhibitors of metalloproteinases [timps], causing neuronal damage. 2023-08-28 2023-09-07 rat
Clara Manesco, Oscar Saavedra-Villanueva, Marta Martin, Joshua de Lizaraga, Béla Varga, Thierry Cloitre, Yannick Nicolas Gerber, Florence Evelyne Perrin, Csilla Gergel. Organization of collagen fibers and tissue hardening: Markers of fibrotic scarring after spinal cord injury in mice revealed by multiphoton-atomic force microscopy imaging. Nanomedicine : nanotechnology, biology, and medicine. 2023-08-12. PMID:37572769. the scarring process involves microglia, astrocytes and extracellular matrix components, such as collagen, constructing the fibrotic component of the scar. 2023-08-12 2023-08-16 mouse
Zhengrong Zhang, Kaiwen Yu, Yang You, Peizhou Jiang, Zhiping Wu, Michael A DeTure, Dennis W Dickson, Seiko Ikezu, Junmin Peng, Tsuneya Ikez. Comprehensive characterization of human brain-derived extracellular vesicles using multiple isolation methods: Implications for diagnostic and therapeutic applications. Journal of extracellular vesicles. vol 12. issue 8. 2023-08-11. PMID:37563857. in contrast, mage samples were more enriched in molecules related to lipoproteins, cell-substrate junction and microglia, whereas sec samples were highly enriched in molecules related to extracellular matrix, alzheimer's disease and astrocytes. 2023-08-11 2023-08-16 human
Jerry Flores, Jiping Tan. Role of N-formyl peptide receptor 2 in germinal matrix hemorrhage: an intrinsic review of a hematoma resolving pathway. Neural regeneration research. vol 19. issue 2. 2023-07-25. PMID:37488889. scavenger receptor cd36 plays a vital role in microglia phagocytic blood clot clearance after germinal matrix hemorrhage. 2023-07-25 2023-08-14 Not clear
Ping-Long Fan, Sha-Sha Wang, Shi-Feng Chu, Nai-Hong Che. Time-dependent dual effect of microglia in ischemic stroke. Neurochemistry international. 2023-07-16. PMID:37454817. the traditional concept that ischemic stroke is solely a vascular occlusion disorder has been expanded to include the dynamic interaction between microglia, astrocytes, neurons, vascular cells, and matrix components forming the "neurovascular unit." 2023-07-16 2023-08-14 Not clear
Adnan H Khan, Itay Chowers, Andrew J Loter. Beyond the Complement Cascade: Insights into Systemic Immunosenescence and Inflammaging in Age-Related Macular Degeneration and Current Barriers to Treatment. Cells. vol 12. issue 13. 2023-07-14. PMID:37443742. the chronic inflammatory state in amd is complex, with contributions from cells of the innate and adaptive branches of the immune system, sometimes with overlapping features, and the interaction of their secretory products with retinal cells such as microglia and retinal pigment epithelium (rpe), extracellular matrix and choroidal vascular endothelial cells. 2023-07-14 2023-08-14 Not clear
Akari Hashimoto, Nanami Kawamura, Etsuko Tarusawa, Ikuko Takeda, Yuki Aoyama, Nobuhiko Ohno, Mio Inoue, Mai Kagamiuchi, Daisuke Kato, Mami Matsumoto, Yoshihiro Hasegawa, Junichi Nabekura, Anne Schaefer, Andrew J Moorhouse, Takeshi Yagi, Hiroaki Wak. Microglia enable cross-modal plasticity by removing inhibitory synapses. Cell reports. 2023-04-22. PMID:37086724. the enhanced cross-modal response is mediated by selective removal of inhibitory synapse terminals on pyramidal neurons by the microglia in the v2l via matrix metalloproteinase 9 signaling. 2023-04-22 2023-08-14 Not clear