| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sandra L Silva, Ana R Vaz, Andreia Barateiro, Ana S Falcão, Adelaide Fernandes, Maria A Brito, Rui F M Silva, Dora Brite. Features of bilirubin-induced reactive microglia: from phagocytosis to inflammation. Neurobiology of disease. vol 40. issue 3. 2011-01-25. PMID:20727973. |
in the present study we report that microglia primary cultures stimulated by ucb react by the acquisition of a phagocytic phenotype that shifted into an inflammatory response characterized by the secretion of the pro-inflammatory cytokines tumour necrosis factor (tnf)-α, interleukin (il)-1β, and il-6, upregulation of cyclooxygenase (cox)-2 and increased matrix metalloproteinase (mmp)-2 and -9 activities. |
2011-01-25 |
2023-08-12 |
Not clear |
| Haruyuki Suzuki, Yoshihisa Sugimura, Shintaro Iwama, Hiromi Suzuki, Ozaki Nobuaki, Hiroshi Nagasaki, Hiroshi Arima, Makoto Sawada, Yutaka Ois. Minocycline prevents osmotic demyelination syndrome by inhibiting the activation of microglia. Journal of the American Society of Nephrology : JASN. vol 21. issue 12. 2011-01-07. PMID:21030598. |
il-1β, inducible nitric-oxide synthase, and tnf-α), monocyte chemoattractant protein-1, and matrix metalloproteinase-12 in microglia. |
2011-01-07 |
2023-08-12 |
rat |
| Heehong Hwang, Shinrye Lee, Won-Ha Lee, Ho-Jae Lee, Kyoungho Su. Stimulation of glucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL) induces inflammatory activation of microglia in culture. Journal of neuroscience research. vol 88. issue 10. 2010-10-26. PMID:20162721. |
using bv-2 mouse microglia cells and mouse primary microglia cultures, we have demonstrated that 1) both gitr and gitrl are expressed in microglia cells; 2) stimulation of gitrl induces inflammatory activation of microglia on the basis of production of nitric oxide (no) and expression of inducible nitric oxide synthase, cyclooxygenase-2, cd40, and matrix metalloproteinase-9; 3) gitrl-mediated microglial no production partially depends on p38 mapk, jnk, and nuclear factor-kappab pathways; and 4) gitrl stimulation also induces microglia cell death. |
2010-10-26 |
2023-08-12 |
mouse |
| Jai-Nien Tung, Tang-Yi Tsao, Shun-Liang Chen, Cheng-Jeng Tai, Shing-Chuan Shen, Ya-Wen Cheng, Ming-Chung Jian. Presence of secretory cellular apoptosis susceptibility protein in cerebrospinal fluids of patients with intracerebral hemorrhage caused by stroke and neurotrauma. Neuro endocrinology letters. vol 31. issue 3. 2010-10-08. PMID:20588233. |
matrix metalloproteinase-2 (mmp-2) produced by interferon-gamma-activated microglia (brain macrophages) is essential for disrupting the glia limitans of bbb, which is critical for lymphocytes penetration into brain capillaries in various cns disorders. |
2010-10-08 |
2023-08-12 |
Not clear |
| Eun-Jung Lee, Moon-Sook Woo, Pyong-Gon Moon, Moon-Chang Baek, In-Young Choi, Won-Ki Kim, Eunsung Junn, Hee-Sun Ki. Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1. Journal of immunology (Baltimore, Md. : 1950). vol 185. issue 1. 2010-09-01. PMID:20511551. |
alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1. |
2010-09-01 |
2023-08-12 |
rat |
| Eun-Jung Lee, Moon-Sook Woo, Pyong-Gon Moon, Moon-Chang Baek, In-Young Choi, Won-Ki Kim, Eunsung Junn, Hee-Sun Ki. Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1. Journal of immunology (Baltimore, Md. : 1950). vol 185. issue 1. 2010-09-01. PMID:20511551. |
in our preliminary experiments, we found that alpha-synuclein induced the expression of matrix metalloproteinases (mmps) (mmp-1, -3, -8, and -9) in rat primary cultured microglia. |
2010-09-01 |
2023-08-12 |
rat |
| Sun Mi Shin, Kyu Suk Cho, Min Sik Choi, Sung Hoon Lee, Seol-Heui Han, Young-Sun Kang, Hee Jin Kim, Jae Hoon Cheong, Chan Young Shin, Kwang Ho K. Urokinase-type plasminogen activator induces BV-2 microglial cell migration through activation of matrix metalloproteinase-9. Neurochemical research. vol 35. issue 7. 2010-08-20. PMID:20177776. |
urokinase-type plasminogen activator induces bv-2 microglial cell migration through activation of matrix metalloproteinase-9. |
2010-08-20 |
2023-08-12 |
Not clear |
| John P Frampton, Matthew R Hynd, Michael L Shuler, William Shai. Effects of glial cells on electrode impedance recorded from neuralprosthetic devices in vitro. Annals of biomedical engineering. vol 38. issue 3. 2010-06-30. PMID:20336824. |
astrocytes and microglia were cultured at various ratios within the matrix surrounding the probes, and were observed over a period of 2 weeks. |
2010-06-30 |
2023-08-12 |
Not clear |
| Christina Doverhag, Maj Hedtjärn, Françoise Poirier, Carina Mallard, Henrik Hagberg, Anna Karlsson, Karin Sävma. Galectin-3 contributes to neonatal hypoxic-ischemic brain injury. Neurobiology of disease. vol 38. issue 1. 2010-06-22. PMID:20053377. |
microglia accumulation was increased in the gal3-/- mice but accompanied by decreased levels of total matrix metalloproteinase (mmp)-9 and nitrotyrosine. |
2010-06-22 |
2023-08-12 |
mouse |
| Min Sik Choi, Kyu Suk Cho, Sun Mi Shin, Hyun Myung Ko, Kyung Ja Kwon, Chan Young Shin, Kwang Ho K. ATP induced microglial cell migration through non-transcriptional activation of matrix metalloproteinase-9. Archives of pharmacal research. vol 33. issue 2. 2010-06-14. PMID:20195827. |
atp induced microglial cell migration through non-transcriptional activation of matrix metalloproteinase-9. |
2010-06-14 |
2023-08-12 |
Not clear |
| Jiyeon Lee, Eunjin Lim, Yumi Kim, Endan Li, Seungjoon Par. Ghrelin attenuates kainic acid-induced neuronal cell death in the mouse hippocampus. The Journal of endocrinology. vol 205. issue 3. 2010-06-03. PMID:20351014. |
the inhibitory effect of ghrelin on the activation of microglia and astrocytes appears to be associated with the inhibition of matrix metalloproteinase-3 expression in damaged hippocampal neurons. |
2010-06-03 |
2023-08-12 |
mouse |
| Dashdemberel Narantuya, Atsushi Nagai, Abdullah Md Sheikh, Kiryo Wakabayashi, Yuri Shiota, Tatsuzo Watanabe, Junichi Masuda, Shotai Kobayashi, Seung U Kim, Shuhei Yamaguch. Microglia transplantation attenuates white matter injury in rat chronic ischemia model via matrix metalloproteinase-2 inhibition. Brain research. vol 1316. 2010-05-06. PMID:20036218. |
microglia transplantation attenuates white matter injury in rat chronic ischemia model via matrix metalloproteinase-2 inhibition. |
2010-05-06 |
2023-08-12 |
rat |
| Dashdemberel Narantuya, Atsushi Nagai, Abdullah Md Sheikh, Kiryo Wakabayashi, Yuri Shiota, Tatsuzo Watanabe, Junichi Masuda, Shotai Kobayashi, Seung U Kim, Shuhei Yamaguch. Microglia transplantation attenuates white matter injury in rat chronic ischemia model via matrix metalloproteinase-2 inhibition. Brain research. vol 1316. 2010-05-06. PMID:20036218. |
transplantation of both cell types reduced the level of matrix metalloproteinase (mmp)-2 mrna in microglia of the cc. |
2010-05-06 |
2023-08-12 |
rat |
| Hung-Chi Lin, Tuzz-Ying Song, Miao-Lin H. S-Adenosylhomocysteine promotes the invasion of C6 glioma cells via increased secretion of matrix metalloproteinase-2 in murine microglial BV2 cells. Toxicological sciences : an official journal of the Society of Toxicology. vol 112. issue 2. 2010-01-25. PMID:19770485. |
in this study, we examined the hypothesis that sah may indirectly enhance the invasion of c6 glioma cells by induction of matrix metalloproteinase-2 (mmp-2) secreted from the murine microglia bv2 cells. |
2010-01-25 |
2023-08-12 |
Not clear |
| Yuri Cho, Hyo Jin Son, Eun-Mee Kim, Ji Hyun Choi, Sung Tae Kim, In Jung Ji, Dong Hee Choi, Tong H Joh, Yoon Seong Kim, Onyou Hwan. Doxycycline is neuroprotective against nigral dopaminergic degeneration by a dual mechanism involving MMP-3. Neurotoxicity research. vol 16. issue 4. 2010-01-22. PMID:19582534. |
we have recently obtained evidence that matrix metalloproteinase (mmp)-3 plays a crucial role in the apoptotic signal in daergic cells as well as activation of microglia. |
2010-01-22 |
2023-08-12 |
Not clear |
| Minho Moon, Hyo Geun Kim, Lakkyong Hwang, Ji-Hyung Seo, Sehee Kim, Sunyoung Hwang, Soonyong Kim, Dahm Lee, Hyunju Chung, Myung Sook Oh, Kyung-Tae Lee, Seungjoon Par. Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease by blocking microglial activation. Neurotoxicity research. vol 15. issue 4. 2010-01-11. PMID:19384567. |
the inhibitory effect of ghrelin on the activation of microglia appears to be indirect by suppressing matrix metalloproteinase-3 (mmp-3) expression in stressed dopaminergic neurons because ghs-r1a is not expressed in snpc microglial cells. |
2010-01-11 |
2023-08-12 |
mouse |
| Ken-ichi Isobe, Naomi Nishio, Sachiko It. [Age-related decline of immune function and age-related diseases]. Nihon rinsho. Japanese journal of clinical medicine. vol 67. issue 7. 2009-09-03. PMID:19591280. |
the ox-ldl or a-beta induces macrophages or microglia to produce inflammatory cytokines, chemokines and matrix metalloproteinases. |
2009-09-03 |
2023-08-12 |
Not clear |
| Seonghan Kim, Seo-Hyun Cho, Ka Young Kim, Ki Young Shin, Hye-Sun Kim, Cheol-Hyoung Park, Keun-A Chang, Sang Hyung Lee, Daeho Cho, Yoo-Hun Su. Alpha-synuclein induces migration of BV-2 microglial cells by up-regulation of CD44 and MT1-MMP. Journal of neurochemistry. vol 109. issue 5. 2009-06-15. PMID:19457162. |
these concurrent inductions increased the generation of soluble cd44 to liberate microglia from the surrounding extracellular matrix for migration. |
2009-06-15 |
2023-08-12 |
mouse |
| Richard Milne. Microglial expression of alphavbeta3 and alphavbeta5 integrins is regulated by cytokines and the extracellular matrix: beta5 integrin null microglia show no defects in adhesion or MMP-9 expression on vitronectin. Glia. vol 57. issue 7. 2009-06-08. PMID:18985734. |
microglial expression of alphavbeta3 and alphavbeta5 integrins is regulated by cytokines and the extracellular matrix: beta5 integrin null microglia show no defects in adhesion or mmp-9 expression on vitronectin. |
2009-06-08 |
2023-08-12 |
Not clear |
| Richard Milne. Microglial expression of alphavbeta3 and alphavbeta5 integrins is regulated by cytokines and the extracellular matrix: beta5 integrin null microglia show no defects in adhesion or MMP-9 expression on vitronectin. Glia. vol 57. issue 7. 2009-06-08. PMID:18985734. |
the extracellular matrix (ecm) protein vitronectin is a strong inducer of microglial activation, switching microglia from a resting into an activated potentially destructive phenotype. |
2009-06-08 |
2023-08-12 |
Not clear |