| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard Milne. Microglial expression of alphavbeta3 and alphavbeta5 integrins is regulated by cytokines and the extracellular matrix: beta5 integrin null microglia show no defects in adhesion or MMP-9 expression on vitronectin. Glia. vol 57. issue 7. 2009-06-08. PMID:18985734. |
gel zymography revealed that beta5 integrin null microglia showed no deficiency in their expression of matrix metalloproteinase (mmp)-9 in response to vitronectin. |
2009-06-08 |
2023-08-12 |
Not clear |
| Stephen J Crocker, Ricardo F Frausto, J Lindsay Whitton, Richard Milne. A novel method to establish microglia-free astrocyte cultures: comparison of matrix metalloproteinase expression profiles in pure cultures of astrocytes and microglia. Glia. vol 56. issue 11. 2008-12-18. PMID:18449943. |
a novel method to establish microglia-free astrocyte cultures: comparison of matrix metalloproteinase expression profiles in pure cultures of astrocytes and microglia. |
2008-12-18 |
2023-08-12 |
Not clear |
| Shweta Singhal, Jean M Lawrence, Bhairavi Bhatia, James S Ellis, Anthony S Kwan, Angus Macneil, Philip J Luthert, James W Fawcett, Maria-Thereza Perez, Peng T Khaw, G Astrid Lim. Chondroitin sulfate proteoglycans and microglia prevent migration and integration of grafted Müller stem cells into degenerating retina. Stem cells (Dayton, Ohio). vol 26. issue 4. 2008-08-15. PMID:18218817. |
these observations suggest that both microglia and cspgs constitute a barrier for stem cell migration following transplantation into experimental models of retinal degeneration and that control of matrix deposition and the innate microglial response to neural retina degeneration may need to be addressed when translating cell-based therapies to treat human retinal disease. |
2008-08-15 |
2023-08-12 |
human |
| Tiina M Kauppinen, Youichirou Higashi, Sang Won Suh, Carole Escartin, Kazuki Nagasawa, Raymond A Swanso. Zinc triggers microglial activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 22. 2008-07-01. PMID:18509044. |
when stimulated by infection, tissue injury, or other signals, microglia assume an activated, "ameboid" morphology and release matrix metalloproteinases, reactive oxygen species, and other proinflammatory factors. |
2008-07-01 |
2023-08-12 |
mouse |
| Makoto Tsuda, Emika Toyomitsu, Takayuki Komatsu, Takahiro Masuda, Emiko Kunifusa, Kaoru Nasu-Tada, Schuichi Koizumi, Kimiko Yamamoto, Joji Ando, Kazuhide Inou. Fibronectin/integrin system is involved in P2X(4) receptor upregulation in the spinal cord and neuropathic pain after nerve injury. Glia. vol 56. issue 5. 2008-06-12. PMID:18240312. |
microglia cultured on dishes coated with fibronectin, an extracellular matrix molecule, expressed a higher level of p2x(4)r protein when compared with those cultured on control dishes. |
2008-06-12 |
2023-08-12 |
mouse |
| Min-Chul Seo, Sangseop Kim, Sang-Hyun Kim, Long Tai Zheng, Eui Kyun Park, Won-Ha Lee, Kyoungho Su. Discoidin domain receptor 1 mediates collagen-induced inflammatory activation of microglia in culture. Journal of neuroscience research. vol 86. issue 5. 2008-04-23. PMID:17969104. |
because collagen is one of the main components of extracellular matrix in the central nervous system, we hypothesized that collagen also induces inflammatory activation of brain microglia, and ddr1 may mediate collagen-induced microglial activation. |
2008-04-23 |
2023-08-12 |
mouse |
| Min-Chul Seo, Sangseop Kim, Sang-Hyun Kim, Long Tai Zheng, Eui Kyun Park, Won-Ha Lee, Kyoungho Su. Discoidin domain receptor 1 mediates collagen-induced inflammatory activation of microglia in culture. Journal of neuroscience research. vol 86. issue 5. 2008-04-23. PMID:17969104. |
using bv-2 mouse microglial cells and mouse primary microglial cultures, we have demonstrated that (1) collagen induces inflammatory activation of microglia as evidenced by production of nitric oxide, expression of inducible nitric oxide synthase, cox-2, cd40, and matrix metalloproteinase-9; (2) ddr1 is expressed in microglia and is phosphorylated by collagen treatment; and (3) collagen-induced microglial activation is abrogated by ddr1 blockade but not by integrin neutralization. |
2008-04-23 |
2023-08-12 |
mouse |
| Hong Liao, Wenhui Huang, Rui Niu, Lixin Sun, Luyong Zhan. Cross-talk between the epidermal growth factor-like repeats/fibronectin 6-8 repeats domains of Tenascin-R and microglia modulates neural stem/progenitor cell proliferation and differentiation. Journal of neuroscience research. vol 86. issue 1. 2008-04-04. PMID:17803220. |
however, it remains unclear how all elements, such as astrocytes, microglia, extracellular matrix molecules, soluble factors, and their cross-talk interactions in the microenvironments, affect neural stem/progenitor cell fate. |
2008-04-04 |
2023-08-12 |
Not clear |
| Yoon-Jung Kim, So-Young Hwang, Ji-Sun Hwang, Jung-Weon Lee, Eok-Soo Oh, Inn-Oc Ha. C6 glioma cell insoluble matrix components enhance interferon-gamma-stimulated inducible nitric-oxide synthase/nitric oxide production in BV2 microglial cells. The Journal of biological chemistry. vol 283. issue 5. 2008-04-02. PMID:17981810. |
the results suggest that insoluble matrix components derived from malignant glioma cells can regulate microglia activation. |
2008-04-02 |
2023-08-12 |
rat |
| Sachiko Ito, Kenya Kimura, Masataka Haneda, Yoshiyuki Ishida, Makoto Sawada, Ken-ichi Isob. Induction of matrix metalloproteinases (MMP3, MMP12 and MMP13) expression in the microglia by amyloid-beta stimulation via the PI3K/Akt pathway. Experimental gerontology. vol 42. issue 6. 2007-12-19. PMID:17198748. |
induction of matrix metalloproteinases (mmp3, mmp12 and mmp13) expression in the microglia by amyloid-beta stimulation via the pi3k/akt pathway. |
2007-12-19 |
2023-08-12 |
Not clear |
| George C McConnell, Thomas M Schneider, D Jason Owens, Ravi V Bellamkond. Extraction force and cortical tissue reaction of silicon microelectrode arrays implanted in the rat brain. IEEE transactions on bio-medical engineering. vol 54. issue 6 Pt 1. 2007-07-03. PMID:17554828. |
in this study, we quantified the force of extraction of implanted four shank michigan electrodes in adult rat brains and investigated potential cellular and extracellular matrix contributors to tissue-electrode adhesion using immunohistochemical markers for microglia, astrocytes and extracellular matrix deposition in the immediate vicinity of the electrodes. |
2007-07-03 |
2023-08-12 |
rat |
| Qing Wang, Xian Nan Tang, Midori A Yenar. The inflammatory response in stroke. Journal of neuroimmunology. vol 184. issue 1-2. 2007-06-01. PMID:17188755. |
it will review the role of specific cell types including leukocytes, endothelium, glia, microglia, the extracellular matrix and neurons. |
2007-06-01 |
2023-08-12 |
Not clear |
| Gregory J del Zoppo, Richard Milner, Takuma Mabuchi, Stephanie Hung, Xiaoyun Wang, Greta I Berg, James A Kozio. Microglial activation and matrix protease generation during focal cerebral ischemia. Stroke. vol 38. issue 2 Suppl. 2007-04-05. PMID:17261708. |
in vitro microglia cells activate and respond to exposure to specific matrix proteins (eg, vitronectin, fibronectin) that circulate. |
2007-04-05 |
2023-08-12 |
Not clear |
| Gregory J del Zoppo, Richard Milner, Takuma Mabuchi, Stephanie Hung, Xiaoyun Wang, Greta I Berg, James A Kozio. Microglial activation and matrix protease generation during focal cerebral ischemia. Stroke. vol 38. issue 2 Suppl. 2007-04-05. PMID:17261708. |
other studies underway suggest the hypothesis that microglial cell activation and pro-mmp-9 generation during focal cerebral ischemia is promoted in part by matrix proteins in the circulation that extravasate into the neuropil when the blood-brain barrier is compromised. |
2007-04-05 |
2023-08-12 |
Not clear |
| Gregory J del Zoppo, Richard Milner, Takuma Mabuchi, Stephanie Hung, Xiaoyun Wang, Greta I Berg, James A Kozio. Microglial activation and matrix protease generation during focal cerebral ischemia. Stroke. vol 38. issue 2 Suppl. 2007-04-05. PMID:17261708. |
these matrix proteins are known to activate microglia through their specific cell surface matrix receptors. |
2007-04-05 |
2023-08-12 |
Not clear |
| Marinella Clerico, Giulia Contessa, Luca Durell. Interferon-beta1a for the treatment of multiple sclerosis. Expert opinion on biological therapy. vol 7. issue 4. 2007-04-04. PMID:17373904. |
the beneficial effect of ifn-beta in multiple sclerosis (ms) probably results from different mechanisms of action, such as a direct effect on plasma cells modulating igg synthesis, an increase of interleukin (il)-10 levels, the inhibition of il-1beta and tumour necrosis factor alpha, the stimulation of il-1 receptor antagonist production, the inhibition of proliferation of leukocytes, a decreased antigen presentation in microglia, a reduction of t cell migration into the brain by inhibition of the activity of t cell matrix metalloproteinases, and a downregulation of adhesion molecules. |
2007-04-04 |
2023-08-12 |
human |
| Yoon-Jung Kim, So-Young Hwang, Inn-Oc Ha. Insoluble matrix components of glioma cells suppress LPS-mediated iNOS/NO induction in microglia. Biochemical and biophysical research communications. vol 347. issue 3. 2006-09-13. PMID:16843440. |
insoluble matrix components of glioma cells suppress lps-mediated inos/no induction in microglia. |
2006-09-13 |
2023-08-12 |
rat |
| Yoon-Jung Kim, So-Young Hwang, Inn-Oc Ha. Insoluble matrix components of glioma cells suppress LPS-mediated iNOS/NO induction in microglia. Biochemical and biophysical research communications. vol 347. issue 3. 2006-09-13. PMID:16843440. |
this study examines the influence of insoluble matrix components of glioma (astrocytoma) cells on lps-mediated inducible nitric oxide (no)/no synthase (inos) induction in microglia cells. |
2006-09-13 |
2023-08-12 |
rat |
| Yoon-Jung Kim, So-Young Hwang, Inn-Oc Ha. Insoluble matrix components of glioma cells suppress LPS-mediated iNOS/NO induction in microglia. Biochemical and biophysical research communications. vol 347. issue 3. 2006-09-13. PMID:16843440. |
our results indicate that activation of microglia can be regulated by various cellular and pathological environmental conditions, not only through cell-cell contact or soluble factors, but also via insoluble matrix components. |
2006-09-13 |
2023-08-12 |
rat |
| Douglas G Walker, John Link, Lih-Fen Lue, Jessica E Dalsing-Hernandez, Barry E Boye. Gene expression changes by amyloid beta peptide-stimulated human postmortem brain microglia identify activation of multiple inflammatory processes. Journal of leukocyte biology. vol 79. issue 3. 2006-05-02. PMID:16365156. |
the results demonstrated that abeta activation of microglia induced a large alteration in gene transcription including activation of many proinflammatory cytokines and chemokines, most notably, interleukin (il)-1beta, il-8, and matrix metalloproteinases (mmp), including mmp1, mmp3, mmp9, mmp10, and mmp12. |
2006-05-02 |
2023-08-12 |
human |