| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sheng-Yu Zhou, Zhen-Ni Guo, Dian-Hui Zhang, Yang Qu, Hang Ji. The Role of Pericytes in Ischemic Stroke: Fom Cellular Functions to Therapeutic Targets. Frontiers in molecular neuroscience. vol 15. 2022-05-02. PMID:35493333. |
nvus are composed of neurons, endothelial cells, pericytes, astrocytes, microglia, and the extracellular matrix. |
2022-05-02 |
2023-08-13 |
Not clear |
| Guangyuan Han, Lijuan Song, Zhibin Ding, Qing Wang, Yuqing Yan, Jianjun Huang, Cungen M. The Important Double-Edged Role of Astrocytes in Neurovascular Unit After Ischemic Stroke. Frontiers in aging neuroscience. vol 14. 2022-04-25. PMID:35462697. |
in recent years, neurovascular unit (nvu) which is composed of neurons, astrocytes (ast), microglia (mg), vascular cells and extracellular matrix (ecm), has become an attractive field in ischemic stroke. |
2022-04-25 |
2023-08-13 |
Not clear |
| Ciro De Luca, Assunta Virtuoso, Michele Papa, Francesco Certo, Giuseppe Maria Vincenzo Barbagallo, Roberto Altier. Regional Development of Glioblastoma: The Anatomical Conundrum of Cancer Biology and Its Surgical Implication. Cells. vol 11. issue 8. 2022-04-23. PMID:35456027. |
in this review, we analyze the anatomical and biological basis of gliomagenesis considering neural stem cells, the spatiotemporal diversity of astrocytes, microglia, neurons and glutamate transporters, extracellular matrix and the peritumoral environment. |
2022-04-23 |
2023-08-13 |
Not clear |
| Hongmin Li, Zhaofu Sheng, Suliman Khan, Ruiyi Zhang, Yang Liu, Yan Zhang, V Wee Yong, Mengzhou Xu. Matrix Metalloproteinase-9 as an Important Contributor to the Pathophysiology of Depression. Frontiers in neurology. vol 13. 2022-04-04. PMID:35370878. |
matrix metalloproteinases (mmps) are physiologically expressed in the central nervous system in neurons, astrocytes and microglia, and their aberrant elevation contributes to a number of diseases. |
2022-04-04 |
2023-08-13 |
Not clear |
| Tracy J Berg, Alexander Pietra. Radiotherapy-induced remodeling of the tumor microenvironment by stromal cells. Seminars in cancer biology. 2022-02-10. PMID:35143991. |
we highlight the response of endothelial cells and the vasculature, macrophages and microglia, and astrocytes, as well as describing resulting changes in the extracellular matrix. |
2022-02-10 |
2023-08-13 |
Not clear |
| Saima I Machlovi, Sarah M Neuner, Brittany M Hemmer, Riana Khan, Yiyuan Liu, Min Huang, Jeffrey D Zhu, Joseph M Castellano, Dongming Cai, Edoardo Marcora, Alison M Goat. APOE4 genotype confers transcriptomic and functional alterations to primary mouse microglia. Neurobiology of disease. 2022-01-15. PMID:35031484. |
while transcriptomic profiling of myelin-challenged microglia revealed a largely overlapping response profile across genotypes, differential enrichment of genes in interferon signaling, extracellular matrix and translation-related pathways was identified in e4 versus e3 microglia both at baseline and following myelin challenge. |
2022-01-15 |
2023-08-13 |
mouse |
| Rocio A Barahona, Samuel Morabito, Vivek Swarup, Kim N Gree. Cortical diurnal rhythms remain intact with microglial depletion. Scientific reports. vol 12. issue 1. 2022-01-08. PMID:34997092. |
in the adult brain, microglia play an important role in the regulation of condensed extracellular matrix structures called perineuronal nets (pnns), and it has been suggested that pnns are also regulated in a circadian and diurnal manner. |
2022-01-08 |
2023-08-13 |
mouse |
| Jason Abbas Aramideh, Andres Vidal-Itriago, Marco Morsch, Manuel B Graebe. Cytokine Signalling at the Microglial Penta-Partite Synapse. International journal of molecular sciences. vol 22. issue 24. 2021-12-24. PMID:34947983. |
since tetrapartite may also refer to the presence of extracellular matrix components, we propose the more precise term microglial penta-partite synapse for synapses that show a microglial cell process in close physical proximity to neuronal and astrocytic synaptic constituents. |
2021-12-24 |
2023-08-13 |
Not clear |
| Ji-Yong Liu, Jun Liao, Rui Fang, Jin-Wen Ge, Zhi-Gang Me. [Advance in mechanisms of glial scarring after stroke and intervention of traditional Chinese medicine]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 23. 2021-12-24. PMID:34951241. |
subsequently, reactive astrocytes proliferate, differentiate, and migrate around the lesion to form glial scar with the participation of microglia, neuron-glial antigen 2(ng2) glial cells, and extracellular matrix. |
2021-12-24 |
2023-08-13 |
Not clear |
| Jun Tang, Shiju Jila, Tiantian Luo, Bo Zhang, Hongping Miao, Hua Feng, Zhi Chen, Gang Zh. C3/C3aR inhibition alleviates GMH-IVH-induced hydrocephalus by preventing microglia-astrocyte interactions in neonatal rats. Neuropharmacology. 2021-12-18. PMID:34921829. |
activation of microglia and astrocytes following germinal matrix hemorrhage and intraventricular hemorrhage (gmh-ivh) plays a detrimental role in posthemorrhagic hydrocephalus (phh). |
2021-12-18 |
2023-08-13 |
rat |
| Edward R Neves, Brendan A C Harley, Sara Pedro. Microphysiological systems to study tumor-stroma interactions in brain cancer. Brain research bulletin. vol 174. 2021-12-10. PMID:34166771. |
the extensive use of these therapeutic agents requires a more profound understanding of the tumor-stroma interactions, including neural tissue, extracellular matrix, blood-brain barrier, astrocytes and microglia. |
2021-12-10 |
2023-08-13 |
human |
| Yimin Huang, Baole Zhang, Hannah Haneke, Verena Haage, Malgorzata Lubas, Yang Yuan, Pengfei Xia, Edyta Motta, Cynthia Nanvuma, Omar Dzaye, Feng Hu, Helmut Kettenman. Glial cell line-derived neurotrophic factor increases matrix metallopeptidase 9 and 14 expression in microglia and promotes microglia-mediated glioma progression. Journal of neuroscience research. vol 99. issue 4. 2021-11-30. PMID:33404121. |
glial cell line-derived neurotrophic factor increases matrix metallopeptidase 9 and 14 expression in microglia and promotes microglia-mediated glioma progression. |
2021-11-30 |
2023-08-13 |
mouse |
| Jinhan Yang, Tong Wang, Xiaoxia Jin, Gaoyang Wang, Fenghong Zhao, Yaping Ji. Roles of Crosstalk between Astrocytes and Microglia in Triggering Neuroinflammation and Brain Edema Formation in 1,2-Dichloroethane-Intoxicated Mice. Cells. vol 10. issue 10. 2021-11-25. PMID:34685627. |
the present research revealed, for the first time, that subacute intoxication with 1,2-dce might provoke the proinflammatory polarization of microglia, and pretreatment with minocycline, a specific inhibitor of microglial activation, may attenuate the enhanced protein levels of ionized calcium-binding adapter molecule1 (iba-1), cluster of differentiation 11b (cd11b), glial fibrillary acidic protein (gfap), soluble calcium-binding protein 100b (s100b), tumor necrosis factor α (tnf-α), interleukin 6 (il-6), inducible nitric oxide synthase (inos), vascular cell adhesion molecule-1 (vcam-1), intercellular adhesion molecule-1 (icam-1), matrix metalloproteinase-9 (mmp-9), toll-like receptor 4 (tlr4), myd88, and p-p65, and ameliorate the suppressed protein expression levels of occludin and claudin 5; we also observed changes in water content and made pathological observations on edema in the brains of 1,2-dce-intoxicated mice. |
2021-11-25 |
2023-08-13 |
mouse |
| Saumya Mishra, Charul Rajput, Mahendra Pratap Sing. Cypermethrin Induces the Activation of Rat Primary Microglia and Expression of Inflammatory Proteins. Journal of molecular neuroscience : MN. vol 71. issue 6. 2021-11-23. PMID:33230707. |
cypermethrin augmented the protein kinase c-δ (pkc-δ), inducible nitric oxide synthase (inos), phosphorylated mitogen-activated protein kinase (mapk) p38 and p42/44, matrix metalloproteinase (mmp)-3, and mmp-9 levels in the cell lysate and tumour necrosis factor-α (tnf-α) and interleukin-1β (il-1β) levels in the microglia conditioned media. |
2021-11-23 |
2023-08-13 |
rat |
| Xingmei Luo, Jing Wu, Guofeng W. PPARγ activation suppresses the expression of MMP9 by downregulating NF-κB post intracerebral hemorrhage. Neuroscience letters. vol 752. 2021-11-22. PMID:33636289. |
we have previously reported that rosiglitazone, an agonist of pparγ, was effective to prevent microglia from apoptosis and ameliorate neuronal injuries post intracerebral hemorrhage (ich) with suppression of matrix metalloproteinase-9 (mmp9) expression. |
2021-11-22 |
2023-08-13 |
Not clear |
| Luisa Strackeljan, Ewa Baczynska, Carla Cangalaya, David Baidoe-Ansah, Jakub Wlodarczyk, Rahul Kaushik, Alexander Dityate. Microglia Depletion-Induced Remodeling of Extracellular Matrix and Excitatory Synapses in the Hippocampus of Adult Mice. Cells. vol 10. issue 8. 2021-11-15. PMID:34440631. |
microglia depletion-induced remodeling of extracellular matrix and excitatory synapses in the hippocampus of adult mice. |
2021-11-15 |
2023-08-13 |
mouse |
| Gisela Nilsson, Ana A Baburamani, Mary A Rutherford, Changlian Zhu, Carina Mallard, Henrik Hagberg, Regina Vontell, Xiaoyang Wan. White matter injury but not germinal matrix hemorrhage induces elevated osteopontin expression in human preterm brains. Acta neuropathologica communications. vol 9. issue 1. 2021-11-05. PMID:34654477. |
in conclusion, preterm brain injury induces elevated opn expression in microglia and astrocytes, and this increase is found in sites closely related to injury in the white matter regions but not with the hemorrhage site in the germinal matrix. |
2021-11-05 |
2023-08-13 |
human |
| Joshua D Crapser, Miguel A Arreola, Kate I Tsourmas, Kim N Gree. Microglia as hackers of the matrix: sculpting synapses and the extracellular space. Cellular & molecular immunology. vol 18. issue 11. 2021-10-31. PMID:34413489. |
microglia as hackers of the matrix: sculpting synapses and the extracellular space. |
2021-10-31 |
2023-08-13 |
Not clear |
| Joshua D Crapser, Miguel A Arreola, Kate I Tsourmas, Kim N Gree. Microglia as hackers of the matrix: sculpting synapses and the extracellular space. Cellular & molecular immunology. vol 18. issue 11. 2021-10-31. PMID:34413489. |
as it relates to synapses, microglia are reported to modify the perisynaptic matrix, which is the diffuse matrix that surrounds dendritic and axonal terminals, as well as perineuronal nets (pnns), specialized reticular formations of compact ecm that enwrap neuronal subsets and stabilize proximal synapses. |
2021-10-31 |
2023-08-13 |
Not clear |
| Joshua D Crapser, Miguel A Arreola, Kate I Tsourmas, Kim N Gree. Microglia as hackers of the matrix: sculpting synapses and the extracellular space. Cellular & molecular immunology. vol 18. issue 11. 2021-10-31. PMID:34413489. |
the interconnected relationship between synapses and the ecm in which they are embedded suggests that alterations in one structure necessarily affect the dynamics of the other, and microglia may need to sculpt the matrix to modify the synapses within. |
2021-10-31 |
2023-08-13 |
Not clear |