| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Satish Patnaik, Meenakshi Rai, Subhadra Jalali, Komal Agarwal, Akshay Badakere, Lavanya Puppala, Sushma Vishwakarma, Divya Balakrishnan, Padmaja K Rani, Ramesh Kekunnaya, Preeti Patil Chhablani, Subhabrata Chakrabarti, Inderjeet Kau. An interplay of microglia and matrix metalloproteinase MMP9 under hypoxic stress regulates the opticin expression in retina. Scientific reports. vol 11. issue 1. 2021-10-29. PMID:33811221. |
an interplay of microglia and matrix metalloproteinase mmp9 under hypoxic stress regulates the opticin expression in retina. |
2021-10-29 |
2023-08-13 |
human |
| Amin Sherafat, Friederike Pfeiffer, Akiko Nishiyam. Shaping of Regional Differences in Oligodendrocyte Dynamics by Regional Heterogeneity of the Pericellular Microenvironment. Frontiers in cellular neuroscience. vol 15. 2021-10-26. PMID:34690700. |
there are regional differences in astrocytes, microglia, the vasculature, and the composition of the extracellular matrix (ecm). |
2021-10-26 |
2023-08-13 |
Not clear |
| Zinaida S Vexler, Xian Nan Tang, Midori A Yenar. Inflammation in adult and neonatal stroke. Clinical neuroscience research. vol 6. issue 5. 2021-10-20. PMID:20300490. |
it will review the role of specific cell types and interactions among blood cells, endothelium, glia, microglia, the extracellular matrix and neurons - cumulatively called "neurovascular unit" - in stroke induction and evolution. |
2021-10-20 |
2023-08-12 |
Not clear |
| Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yu Takahashi, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihar. Pentylenetetrazol kindling induces cortical astrocytosis and increased expression of extracellular matrix molecules in mice. Brain research bulletin. vol 163. 2021-09-29. PMID:32726668. |
in this study, we investigated the effects of status epilepticus on astrocytes, microglia, and extracellular matrix (ecm) molecules in the somatosensory cortex and piriform cortex of mice. |
2021-09-29 |
2023-08-13 |
mouse |
| Kan Zhang, Lei Wu, Kana Lin, Mazhong Zhang, Weiguang Li, Xiaoping Tong, Jijian Zhen. Integrin-dependent microgliosis mediates ketamine-induced neuronal apoptosis during postnatal rat retinal development. Experimental neurology. vol 340. 2021-09-27. PMID:33640375. |
remodeling of the extracellular matrix (ecm) by matrix metalloproteinases (mmps) plays a pivotal role for microglia in developing retina. |
2021-09-27 |
2023-08-13 |
rat |
| Lifen Liu, Yutong Liu, Nana Li, Runzhi Huang, Ximing Zheng, Liang Huang, Shuangxin Hou, Qionglan Yua. Multiple inflammatory profiles of microglia and altered neuroimages in APP/PS1 transgenic AD mice. Brain research bulletin. vol 156. 2021-08-20. PMID:31931120. |
in parallel with these observations, we found that mainly clustered microglia significantly upregulated the production of proinflammatory factors including tnf-α, inos and il-1β, and anti-inflammatory cytokines including il-4, tgf-β and extracellular protecting matrix ym-1 and enzyme arginase 1 (arg1) at 6-12 months of age. |
2021-08-20 |
2023-08-13 |
mouse |
| Gen Hamanaka, Tomoya Kubo, Ryo Ohtomo, Hajime Takase, Estefania Reyes-Bricio, Shuntaro Oribe, Noriko Osumi, Josephine Lok, Eng H Lo, Ken Ara. Microglial responses after phagocytosis: Escherichia coli bioparticles, but not cell debris or amyloid beta, induce matrix metalloproteinase-9 secretion in cultured rat primary microglial cells. Glia. vol 68. issue 7. 2021-08-18. PMID:32057146. |
in this study, we tested if microglia secrete a neurovascular mediator matrix metalloproteinase-9 (mmp-9) after phagocytosis in vitro. |
2021-08-18 |
2023-08-13 |
rat |
| Philipp Ulbrich, Mahsima Khoshneviszadeh, Solveig Jandke, Stefanie Schreiber, Alexander Dityate. Interplay between perivascular and perineuronal extracellular matrix remodelling in neurological and psychiatric diseases. The European journal of neuroscience. vol 53. issue 12. 2021-08-13. PMID:32594588. |
vascular damage, central nervous system (cns) injury, seizure or even psychological stress may trigger activation of microglia and infiltration of other immune cells, accompanied by high levels of expression and activity of extracellular proteases, such as matrix metalloproteinases (mmps), and degradation/remodelling of the perivascular and perineuronal extracellular matrix (ecm). |
2021-08-13 |
2023-08-13 |
Not clear |
| Marie Frühauf, Ulrike Zeitschel, Corinna Höfling, Franziska Ullm, Friederike V Rabiger, Gottfried Alber, Tilo Pompe, Uwe Müller, Steffen Roßne. Construction of a 3D brain extracellular matrix model to study the interaction between microglia and T cells in co-culture. The European journal of neuroscience. vol 53. issue 12. 2021-08-13. PMID:32954591. |
construction of a 3d brain extracellular matrix model to study the interaction between microglia and t cells in co-culture. |
2021-08-13 |
2023-08-13 |
Not clear |
| Ana Freitas, Miguel Aroso, António Barros, Miriam Fernández, Eduardo Conde-Sousa, Marina Leite, Eva Daniela Carvalho, Cristina C Ribeiro, Rita Ferreira, Ana Paula Pêgo, Rui Vitorino, Maria Gomez-Lazar. Characterization of the Striatal Extracellular Matrix in a Mouse Model of Parkinson's Disease. Antioxidants (Basel, Switzerland). vol 10. issue 7. 2021-08-09. PMID:34356328. |
to uncover the effects of these changes on brain cells, we morphologically characterized the primary microglia used to repopulate this matrix and further quantified the effects on cellular mechanical stress by an intracellular fluorescence resonance energy transfer (fret)-mechanosensor using the u-2 os cell line. |
2021-08-09 |
2023-08-13 |
mouse |
| Ana Freitas, Miguel Aroso, António Barros, Miriam Fernández, Eduardo Conde-Sousa, Marina Leite, Eva Daniela Carvalho, Cristina C Ribeiro, Rita Ferreira, Ana Paula Pêgo, Rui Vitorino, Maria Gomez-Lazar. Characterization of the Striatal Extracellular Matrix in a Mouse Model of Parkinson's Disease. Antioxidants (Basel, Switzerland). vol 10. issue 7. 2021-08-09. PMID:34356328. |
our data suggest changes in microglia survival and morphology, and a decrease in cytoskeletal tension in response to the modified matrix from both hemispheres of 6-hydroxydopamine (6-ohda)-lesioned animals. |
2021-08-09 |
2023-08-13 |
mouse |
| Giuseppe Nicolò Fanelli, Dario Grassini, Valerio Ortenzi, Francesco Pasqualetti, Nicola Montemurro, Paolo Perrini, Antonio Giuseppe Naccarato, Cristian Scaten. Decipher the Glioblastoma Microenvironment: The First Milestone for New Groundbreaking Therapeutic Strategies. Genes. vol 12. issue 3. 2021-07-30. PMID:33804731. |
gbm's microenvironment is multifaceted and is made up of soluble factors, extracellular matrix components, tissue-resident cell types (e.g., neurons, astrocytes, endothelial cells, pericytes, and fibroblasts) together with resident (e.g., microglia) or recruited (e.g., bone marrow-derived macrophages) immune cells. |
2021-07-30 |
2023-08-13 |
Not clear |
| Stoyan Stoyanov, Weilun Sun, Henning Peter Düsedau, Carla Cangalaya, Ilseob Choi, Hadi Mirzapourdelavar, David Baidoe-Ansah, Rahul Kaushik, Jens Neumann, Ildiko Rita Dunay, Alexander Dityate. Attenuation of the extracellular matrix restores microglial activity during the early stage of amyloidosis. Glia. vol 69. issue 1. 2021-07-28. PMID:32865286. |
at this age, there are neither aβ plaques, nor activation of microglia, nor dysregulation in the expression of genes encoding major extracellular matrix (ecm) molecules or extracellular proteases in the rsc. |
2021-07-28 |
2023-08-13 |
mouse |
| Tcs Costa, E Fernandez-Villalba, V Izura, A M Lucas-Ochoa, N J Menezes-Filho, R C Santana, M D de Oliveira, F M Araújo, C Estrada, Vda Silva, S L Costa, M T Herrer. Combined 1-Deoxynojirimycin and Ibuprofen Treatment Decreases Microglial Activation, Phagocytosis and Dopaminergic Degeneration in MPTP-Treated Mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 16. issue 2. 2021-06-18. PMID:32564332. |
the central role of microglia in neuroinflammation has been studied as a target for potential neuroprotective drugs for pd, for example nonsteroidal anti-inflammatory drugs (nsaids) and matrix metalloproteinases (mmp) inhibitors that regulates microglial activation and migration. |
2021-06-18 |
2023-08-13 |
mouse |
| Tung-Tai Kuo, Vicki Wang, Jui-Sheng Wu, Yuan-Hao Chen, Kuan-Yin Tsen. Post-stroke Delivery of Valproic Acid Promotes Functional Recovery and Differentially Modifies Responses of Peri-Infarct Microglia. Frontiers in molecular neuroscience. vol 14. 2021-06-15. PMID:34122007. |
the decreases in the expression of both il-6 and galectin-3 might influence the morphological characteristics and transcriptional profiles of microglia and extracellular matrix remodeling, which could contribute to the improved recovery. |
2021-06-15 |
2023-08-13 |
rat |
| Daniel Manrique-Castano, Egor Dzyubenko, Mina Borbor, Paraskevi Vasileiadou, Christoph Kleinschnitz, Lars Roll, Andreas Faissner, Dirk M Herman. Tenascin-C preserves microglia surveillance and restricts leukocyte and, more specifically, T cell infiltration of the ischemic brain. Brain, behavior, and immunity. vol 91. 2021-05-27. PMID:33122023. |
as an endogenous activator of toll-like receptor-4 (tlr4), the extracellular matrix glycoprotein tenascin-c (tnc) regulates chemotaxis, phagocytosis and proinflammatory cytokine production in microglia. |
2021-05-27 |
2023-08-13 |
Not clear |
| Rashmi Das, Subashchandrabose Chinnathamb. Actin-mediated Microglial Chemotaxis via G-Protein Coupled Purinergic Receptor in Alzheimer's Disease. Neuroscience. vol 448. 2021-05-14. PMID:32941933. |
activated microglia undergoes actin remodeling by forming lamellipodia and filopodia, which directs the migratory axis while podosomes formed are involved in extracellular matrix degradation for invasion. |
2021-05-14 |
2023-08-13 |
Not clear |
| Myriam Cayre, Marie Falque, Océane Mercier, Karine Magalon, Pascale Durbe. Myelin Repair: From Animal Models to Humans. Frontiers in cellular neuroscience. vol 15. 2021-05-04. PMID:33935649. |
we will also highlight the conditions known to limit endogenous repair, such as aging, chronic inflammation, and the production of extracellular matrix proteins, and the role of astrocytes and microglia in these processes. |
2021-05-04 |
2023-08-13 |
Not clear |
| Patrick T Ronaldson, Thomas P Davi. Regulation of blood-brain barrier integrity by microglia in health and disease: A therapeutic opportunity. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 40. issue 1_suppl. 2021-03-23. PMID:32928017. |
microvascular endothelial cells require support from astrocytes, pericytes, microglia, neurons, and constituents of the extracellular matrix. |
2021-03-23 |
2023-08-13 |
Not clear |
| Yosif Zaki, Denise J Ca. Creating Space for Synaptic Formation-A New Role for Microglia in Synaptic Plasticity. Cell. vol 182. issue 2. 2021-03-22. PMID:32707091. |
demonstrate a novel role for microglia in regulating synaptic formation by clearing extracellular matrix proteins that embed neurons. |
2021-03-22 |
2023-08-13 |
Not clear |