| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David Wegrzyn, Nadja Freund, Andreas Faissner, Georg Jucke. Poly I:C Activated Microglia Disrupt Perineuronal Nets and Modulate Synaptic Balance in Primary Hippocampal Neurons Frontiers in synaptic neuroscience. vol 13. 2021-03-13. PMID:33708102. |
poly i:c activated microglia disrupt perineuronal nets and modulate synaptic balance in primary hippocampal neurons perineuronal nets (pnns) are specialized, reticular structures of the extracellular matrix (ecm) that can be found covering the soma and proximal dendrites of a neuronal subpopulation. |
2021-03-13 |
2023-08-13 |
Not clear |
| Julien Saint-Pol, Fabien Gosselet, Sophie Duban-Deweer, Gwënaël Pottiez, Yannis Karamano. Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles. Cells. vol 9. issue 4. 2021-02-25. PMID:32244730. |
indeed, the neuro-vascular unit (nvu) that corresponds to the assembly of extracellular matrix, pericytes, astrocytes, oligodendrocytes, microglia and neurons have the ability to influence bbb physiology. |
2021-02-25 |
2023-08-13 |
human |
| Diana O Perkins, Clark D Jeffries, Kim Q D. Potential Roles of Redox Dysregulation in the Development of Schizophrenia. Biological psychiatry. vol 88. issue 4. 2021-02-18. PMID:32560962. |
in a rodent schizophrenia model characterized by impaired glutathione synthesis, the gclm knockout mouse, oxidative stress activated mmp9 (matrix metalloprotease 9) via its redox-responsive regulatory sites, causing a cascade of molecular events leading to microglia activation, perineural net degradation, and impaired nmda receptor function. |
2021-02-18 |
2023-08-13 |
mouse |
| Hiroshi Nakanish. Cathepsin regulation on microglial function. Biochimica et biophysica acta. Proteins and proteomics. vol 1868. issue 9. 2020-10-26. PMID:32526473. |
cathepsin s secreted from microglia induces the diurnal variation of spine density of cortical neurons though proteolytic modification of peri-synaptic extracellular matrix molecules. |
2020-10-26 |
2023-08-13 |
Not clear |
| Xiao Zhao, Rujing Chen, Mei Liu, Jianfang Feng, Jun Chen, Kaili H. Remodeling the blood-brain barrier microenvironment by natural products for brain tumor therapy. Acta pharmaceutica Sinica. B. vol 7. issue 5. 2020-10-01. PMID:28924548. |
the bbb microenvironment contains numerous cell types, including endothelial cells, astrocytes, peripheral cells and microglia, and extracellular matrix (ecm). |
2020-10-01 |
2023-08-13 |
Not clear |
| Rahul Kaushik, Evgeny Morkovin, Jenny Schneeberg, Alessandro D Confettura, Michael R Kreutz, Oleg Senkov, Alexander Dityate. Traditional Japanese Herbal Medicine Yokukansan Targets Distinct but Overlapping Mechanisms in Aged Mice and in the 5xFAD Mouse Model of Alzheimer's Disease. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:30631278. |
further analyses of the brain tissue from these animals indicated that in aged mice, this improvement was associated with a reduction in astrogliosis, microglia activation and downregulation of the extracellular matrix (ecm), whereas in 5xfad mice, none of these mechanisms were evident. |
2020-10-01 |
2023-08-13 |
mouse |
| Diana Matias, Joana Balça-Silva, Grazielle C da Graça, Caroline M Wanjiru, Lucy W Macharia, Carla Pires Nascimento, Natalia R Roque, Juliana M Coelho-Aguiar, Cláudia M Pereira, Marcos F Dos Santos, Luciana S Pessoa, Flavia R S Lima, Alberto Schanaider, Valéria P Ferrer, Vivaldo Moura-Net. Microglia/Astrocytes-Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30123112. |
in the present review, we summarize the most important mechanisms and functions of the molecular factors involved in the microglia or astrocytes-gb interactions, which is particularly the alterations that occur in the cell's extracellular matrix and the cytoskeleton. |
2020-09-30 |
2023-08-13 |
Not clear |
| Ciro De Luca, Anna Maria Colangelo, Lilia Alberghina, Michele Pap. Neuro-Immune Hemostasis: Homeostasis and Diseases in the Central Nervous System. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30534057. |
neurons, glial cells (astrocytes and microglia) and the extracellular matrix play a crucial function in a "tetrapartite" synaptic model. |
2020-09-30 |
2023-08-13 |
Not clear |
| Ji Won U. Roles of Glial Cells in Sculpting Inhibitory Synapses and Neural Circuits. Frontiers in molecular neuroscience. vol 10. 2020-09-29. PMID:29180953. |
nevertheless, studies have indicated that both astrocytes and microglia shape inhibitory synaptic connections through various mechanisms, including release of regulatory molecules, direct contact with synaptic terminals, and utilization of mediators in the extracellular matrix. |
2020-09-29 |
2023-08-13 |
Not clear |
| Christine Tschoe, Cheryl D Bushnell, Pamela W Duncan, Martha A Alexander-Miller, Stacey Q Wolf. Neuroinflammation after Intracerebral Hemorrhage and Potential Therapeutic Targets. Journal of stroke. vol 22. issue 1. 2020-09-28. PMID:32027790. |
after cerebral insult, inflammation is initially driven by the m1 microglia, secreting cytokines (e.g., interleukin-1β [il-1β] and tumor necrosis factor-α) that are involved in the breakdown of the extracellular matrix, cellular integrity, and the blood brain barrier. |
2020-09-28 |
2023-08-13 |
Not clear |
| Federico N Soria, Chiara Paviolo, Evelyne Doudnikoff, Marie-Laure Arotcarena, Antony Lee, Noémie Danné, Amit Kumar Mandal, Philippe Gosset, Benjamin Dehay, Laurent Groc, Laurent Cognet, Erwan Bezar. Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling. Nature communications. vol 11. issue 1. 2020-08-31. PMID:32651387. |
these animals display a degraded hyaluronan matrix in areas close to reactive microglia. |
2020-08-31 |
2023-08-13 |
mouse |
| Petra Schwarzer, Despina Kokona, Andreas Ebneter, Martin S Zinkernage. Effect of Inhibition of Colony-Stimulating Factor 1 Receptor on Choroidal Neovascularization in Mice. The American journal of pathology. vol 190. issue 2. 2020-05-04. PMID:31783006. |
several inflammatory modulators, such as chemokine (c-c motif) ligand 9, granulocyte-macrophage colony-stimulating factor, soluble tumor necrosis factor receptor-i, il-1α, and matrix metallopeptidase-2, were elevated in the acute phase of the disease when microglia were ablated with plx5622, whereas other cytokines (eg, interferon-γ, il-4, and il-10) were reduced. |
2020-05-04 |
2023-08-13 |
mouse |
| Sophie Marie-Thérèse Smolders, Sofie Kessels, Tim Vangansewinkel, Jean-Michel Rigo, Pascal Legendre, Bert Brôn. Microglia: Brain cells on the move. Progress in neurobiology. vol 178. 2020-04-27. PMID:30954517. |
we elaborate on the extracellular matrix and the respective integrin receptors on microglia and we discuss the purinergic and molecular signalling in microglial mobility. |
2020-04-27 |
2023-08-13 |
Not clear |
| Xiang Zhou, Shalaka Wahane, Marie-Sophie Friedl, Michael Kluge, Caroline C Friedel, Kleopatra Avrampou, Venetia Zachariou, Lei Guo, Bin Zhang, Xijing He, Roland H Friedel, Hongyan Zo. Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2. Nature neuroscience. vol 23. issue 3. 2020-04-13. PMID:32112058. |
mechanistically, plexin-b2 promotes microglia motility, steers iams away from colliding cells and facilitates matrix compaction. |
2020-04-13 |
2023-08-13 |
Not clear |
| Lumei Liu, Youngmi Koo, Chukwuma Akwitti, Teal Russell, Elaine Gay, Daniel T Laskowitz, Yeoheung Yu. Three-dimensional (3D) brain microphysiological system for organophosphates and neurochemical agent toxicity screening. PloS one. vol 14. issue 11. 2020-03-18. PMID:31703066. |
this platform consists of neuronal tissue with extracellular matrix (ecm)-embedded neuroblastoma cells, microglia, and astrocytes, and vascular tissue with dynamic flow and membrane-free culture of the endothelial layer. |
2020-03-18 |
2023-08-13 |
Not clear |
| Xu Zhang, Hai-Hua Zhao, Dan Li, Hong-Peng L. Neuroprotective effects of matrix metalloproteinases in cerebral ischemic rats by promoting activation and migration of astrocytes and microglia. Brain research bulletin. vol 146. 2020-03-10. PMID:30445183. |
neuroprotective effects of matrix metalloproteinases in cerebral ischemic rats by promoting activation and migration of astrocytes and microglia. |
2020-03-10 |
2023-08-13 |
rat |
| Tomohiko Ozaki, Hajime Nakamura, Haruhiko Kishim. Therapeutic strategy against ischemic stroke with the concept of neurovascular unit. Neurochemistry international. vol 126. 2019-12-10. PMID:30946849. |
this concept emphasizes the importance not just of neurons but of the interactions between neurons, endothelial cells, astroglia, microglia and associated tissue matrix proteins to investigate the pathological condition of ischemic stroke. |
2019-12-10 |
2023-08-13 |
Not clear |
| Richard L Jayaraj, Rami Beiram, Sheikh Azimullah, Mohamed Fizur Nagoor Meeran, Shreesh K Ojha, Abdu Adem, Fakhreya Yousuf Jala. Lycopodium Attenuates Loss of Dopaminergic Neurons by Suppressing Oxidative Stress and Neuroinflammation in a Rat Model of Parkinson's Disease. Molecules (Basel, Switzerland). vol 24. issue 11. 2019-11-28. PMID:31185705. |
however, rotenone-injected rats that were orally treated with lycopodium (50 mg/kg) were protected against dopaminergic neuronal loss by diminishing the expression of matrix metalloproteinase-3 (mmp-3) and mmp-9, as well as reduced activation of microglia and astrocytes. |
2019-11-28 |
2023-08-13 |
rat |
| Eun-Jung Lee, Min-Ji Choi, Gyeongjin Lee, Bhakta Prasad Gaire, Ji Woong Choi, Hee-Sun Ki. Regulation of neuroinflammation by matrix metalloproteinase-8 inhibitor derivatives in activated microglia and astrocytes. Oncotarget. vol 8. issue 45. 2019-11-20. PMID:29108257. |
regulation of neuroinflammation by matrix metalloproteinase-8 inhibitor derivatives in activated microglia and astrocytes. |
2019-11-20 |
2023-08-13 |
mouse |
| Zhanhui Feng, Lan Ye, Damon Klebe, Yan Ding, Zhen-Ni Guo, Jerry J Flores, Cheng Yin, Jiping Tang, John H Zhan. Anti-inflammation conferred by stimulation of CD200R1 via Dok1 pathway in rat microglia after germinal matrix hemorrhage. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 39. issue 1. 2019-11-04. PMID:28792282. |
anti-inflammation conferred by stimulation of cd200r1 via dok1 pathway in rat microglia after germinal matrix hemorrhage. |
2019-11-04 |
2023-08-13 |
rat |