| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael L Lehmann, Thaddeus K Weigel, Hannah A Cooper, Abdel G Elkahloun, Stacey L Kigar, Miles Herkenha. Decoding microglia responses to psychosocial stress reveals blood-brain barrier breakdown that may drive stress susceptibility. Scientific reports. vol 8. issue 1. 2019-10-22. PMID:30050134. |
microglia transcriptomes from csd-s mice were enriched for pathways associated with inflammation, phagocytosis, oxidative stress, and extracellular matrix remodeling. |
2019-10-22 |
2023-08-13 |
mouse |
| Michael L Lehmann, Thaddeus K Weigel, Hannah A Cooper, Abdel G Elkahloun, Stacey L Kigar, Miles Herkenha. Decoding microglia responses to psychosocial stress reveals blood-brain barrier breakdown that may drive stress susceptibility. Scientific reports. vol 8. issue 1. 2019-10-22. PMID:30050134. |
the results suggest that the inflammatory profile of csd-s microglia may be precipitated by extracellular matrix degradation, oxidative stress, microbleeds, and entry and phagocytosis of blood-borne substances into brain parenchyma. |
2019-10-22 |
2023-08-13 |
mouse |
| Jingsi Zhang, Zhennian Zhang, Wen Zhang, Xiangting Li, Ting Wu, Tingting Li, Min Cai, Zhonghai Yu, Jun Xiang, Dingfang Ca. Jia-Jian-Di-Huang-Yin-Zi decoction exerts neuroprotective effects on dopaminergic neurons and their microenvironment. Scientific reports. vol 8. issue 1. 2019-10-14. PMID:29959371. |
jjdhyz also protected the ultrastructure of the blood-brain barrier (bbb) and tight junction proteins by inhibiting the activation of microglia and astrocytes besides the increase in three types of matrix metalloproteinases in the substantia nigra. |
2019-10-14 |
2023-08-13 |
mouse |
| Yuan Gao, En-Jie Liu, Wei-Jin Wang, Ya-Li Wang, Xiao-Guang Li, Xin Wang, Shi-Hong Li, Shu-Juan Zhang, Meng-Zhu Li, Qiu-Zhi Zhou, Xiao-Bing Long, Hua-Qiu Zhang, Jian-Zhi Wan. Microglia CREB-Phosphorylation Mediates Amyloid-β-Induced Neuronal Toxicity. Journal of Alzheimer's disease : JAD. vol 66. issue 1. 2019-09-19. PMID:30282353. |
inhibition of microglia activation by minocycline or creb phosphorylation by h89, an inhibitor of protein kinase a (pka), abolished aβ-induced microglia creb hyperphosphorylation with restoration of neuronal function and attenuation of inflammatory response, i.e., reduced levels of interleukin-6 (il6) and pcreb binding of matrix metalloproteinase-9 (mmp9) dna. |
2019-09-19 |
2023-08-13 |
mouse |
| Youngmi Koo, Brian T Hawkins, Yeoheung Yu. Three-dimensional (3D) tetra-culture brain on chip platform for organophosphate toxicity screening. Scientific reports. vol 8. issue 1. 2019-09-13. PMID:29434277. |
here we report on a microfluidic-based three-dimensional, four-cell tissue construct consisting of 1) a blood-brain barrier that has dynamic flow and membrane-free culture of the endothelial layer, and 2) an extracellular matrix (ecm)-embedded tissue construct with neuroblastoma, microglia, and astrocytes. |
2019-09-13 |
2023-08-13 |
Not clear |
| Florian Hansmann, Ning Zhang, Vanessa Herder, Eva Leitzen, Wolfgang Baumgärtne. Delayed Astrogliosis Associated with Reduced M1 Microglia Activation in Matrix Metalloproteinase 12 Knockout Mice during Theiler's Murine Encephalomyelitis. International journal of molecular sciences. vol 20. issue 7. 2019-07-23. PMID:30959793. |
delayed astrogliosis associated with reduced m1 microglia activation in matrix metalloproteinase 12 knockout mice during theiler's murine encephalomyelitis. |
2019-07-23 |
2023-08-13 |
mouse |
| Shu-Qi Yao, Wei Yi, Rong Liu, Neng-Gui X. [Development of research on mechanisms of electroacupuncture intervention underlying improvement of cerebral ischemia rats in recent five years]. Zhen ci yan jiu = Acupuncture research. vol 44. issue 5. 2019-06-07. PMID:31155874. |
moreover, ea preconditioning also could suppress the expression of pro-apoptosis genes and proteins to relieve apoptosis, regulate activation of microglia, and down-regulate the expression of blood brain barrier integrity-related matrix metalloprotein 9. |
2019-06-07 |
2023-08-13 |
rat |
| Sivan Izraely, Shlomit Ben-Menachem, Orit Sagi-Assif, Alona Telerman, Inna Zubrilov, Ofir Ashkenazi, Tsipi Meshel, Shelly Maman, Javier I J Orozco, Matthew P Salomon, Diego M Marzese, Metsada Pasmanik-Chor, Eli Pikarski, Marcelo Ehrlich, Dave S B Hoon, Isaac P Wit. The metastatic microenvironment: Melanoma-microglia cross-talk promotes the malignant phenotype of melanoma cells. International journal of cancer. vol 144. issue 4. 2019-05-24. PMID:29992556. |
moreover, melanoma cells exerted significant morphological changes on microglia cells, enhanced proliferation, induced matrix metalloproteinase-2 (mmp-2) activation, and cell migration. |
2019-05-24 |
2023-08-13 |
Not clear |
| Yangjin Kim, Hyunji Kang, Gibin Powathil, Hyeongi Kim, Dumitru Trucu, Wanho Lee, Sean Lawler, Mark Chaplai. Role of extracellular matrix and microenvironment in regulation of tumor growth and LAR-mediated invasion in glioblastoma. PloS one. vol 13. issue 10. 2019-03-22. PMID:30286133. |
glycosylated chondroitin sulfate proteoglycans (cspgs), a major component of the extracellular matrix (ecm) in the brain, contribute to the physical structure of the local brain microenvironment but also induce or inhibit glioma invasion by regulating the dynamics of the cspg receptor lar as well as the spatiotemporal activation status of resident astrocytes and tumor-associated microglia. |
2019-03-22 |
2023-08-13 |
Not clear |
| Marie E Burns, Beth Steven. Report on the National Eye Institute's Audacious Goals Initiative: Creating a Cellular Environment for Neuroregeneration. eNeuro. vol 5. issue 2. 2019-01-11. PMID:29766041. |
in doing so, the group identified the areas of (1) retinal and optic nerve glia, (2) microglia and inflammation, and the (3) extracellular matrix (ecm) and retinal vasculature as key to advancing our understanding and manipulation of the retinal microenvironments. |
2019-01-11 |
2023-08-13 |
Not clear |
| Jessica Maiuolo, Micaela Gliozzi, Vincenzo Musolino, Miriam Scicchitano, Cristina Carresi, Federica Scarano, Francesca Bosco, Saverio Nucera, Stefano Ruga, Maria Caterina Zito, Rocco Mollace, Ernesto Palma, Massimo Fini, Carolina Muscoli, Vincenzo Mollac. The "Frail" Brain Blood Barrier in Neurodegenerative Diseases: Role of Early Disruption of Endothelial Cell-to-Cell Connections. International journal of molecular sciences. vol 19. issue 9. 2018-12-24. PMID:30201915. |
the main neurovascular unit of the blood brain barrier (bbb) consists of a cellular component, which includes endothelial cells, astrocytes, pericytes, microglia, neurons, and oligodendrocytes as well as a non-cellular component resulting from the extracellular matrix. |
2018-12-24 |
2023-08-13 |
Not clear |
| Jonathan Vinet, Anna-Maria Costa, Manuel Salinas-Navarro, Giuseppina Leo, Lieve Moons, Lutgarde Arckens, Giuseppe Biagin. A Hydroxypyrone-Based Inhibitor of Metalloproteinase-12 Displays Neuroprotective Properties in Both International journal of molecular sciences. vol 19. issue 8. 2018-11-20. PMID:30044455. |
a hydroxypyrone-based inhibitor of metalloproteinase-12 displays neuroprotective properties in both recently, we showed that matrix metalloproteinase-12 (mmp-12) is highly expressed in microglia and myeloid infiltrates, which are presumably involved in blood⁻brain barrier (bbb) leakage and subsequent neuronal cell death that follows |
2018-11-20 |
2023-08-13 |
Not clear |
| Masato Kanazawa, Minami Miura, Masafumi Toriyabe, Misaki Koyama, Masahiro Hatakeyama, Masanori Ishikawa, Takashi Nakajima, Osamu Onodera, Tetsuya Takahashi, Masatoyo Nishizawa, Takayoshi Shimohat. Microglia preconditioned by oxygen-glucose deprivation promote functional recovery in ischemic rats. Scientific reports. vol 7. 2018-11-05. PMID:28195185. |
next, we demonstrated that administration of primary microglia preconditioned by 18 hours of ogd at 7 days prompted functional recovery at 28 days after focal cerebral ischemia compared to control therapies by marked secretion of remodelling factors such as vascular endothelial growth factor, matrix metalloproteinase-9, and transforming growth factor-β polarized to m2 microglia in vitro/vivo. |
2018-11-05 |
2023-08-13 |
rat |
| Su-Hua Zhu, Bing-Qian Liu, Mao-Juan Hao, Yi-Xin Fan, Cheng Qian, Peng Teng, Xiao-Wei Zhou, Liang Hu, Wen-Tao Liu, Zhi-Lan Yuan, Qing-Ping L. Paeoniflorin Suppressed High Glucose-Induced Retinal Microglia MMP-9 Expression and Inflammatory Response via Inhibition of TLR4/NF-κB Pathway Through Upregulation of SOCS3 in Diabetic Retinopathy. Inflammation. vol 40. issue 5. 2018-08-15. PMID:28639050. |
evidence has accumulated indicating that microglia inflammation within the retina plays a critical role in dr. microglial matrix metalloproteinase 9 (mmp-9) has an important role in the destruction of the integrity of the blood-retinal barrier (brb) associated with the development of dr. mmp-9 was also considered important for regulating inflammatory responses. |
2018-08-15 |
2023-08-13 |
mouse |
| Rebecca M Ruddy, Cindi M Morshea. Home sweet home: the neural stem cell niche throughout development and after injury. Cell and tissue research. vol 371. issue 1. 2018-08-10. PMID:28776186. |
we discuss changes that occur within the neural stem and progenitor cell populations, the vasculature, extracellular matrix, microglia, and secreted proteins through aging which impact cell behavior within the neurogenic niches. |
2018-08-10 |
2023-08-13 |
Not clear |
| Ciro De Luca, Assunta Virtuoso, Nicola Maggio, Michele Pap. Neuro-Coagulopathy: Blood Coagulation Factors in Central Nervous System Diseases. International journal of molecular sciences. vol 18. issue 10. 2018-05-30. PMID:29023416. |
these specific functions modulate neuronal networks, acting both on resident (neurons, astrocytes, and microglia) as well as circulating immune system cells and the extracellular matrix. |
2018-05-30 |
2023-08-13 |
Not clear |
| Shuai Yang, Huijuan Jin, Yiyi Zhu, Yan Wan, Elvis Nana Opoku, Lingqiang Zhu, Bo H. Diverse Functions and Mechanisms of Pericytes in Ischemic Stroke. Current neuropharmacology. vol 15. issue 6. 2018-04-23. PMID:28088914. |
recently more researchers embrace the concept of the neurovascular unit (nvu), which encompasses neurons, endothelial cells (ecs), pericytes, astrocyte, microglia, and the extracellular matrix. |
2018-04-23 |
2023-08-13 |
Not clear |
| Li Lu, Xiaorong Li, Pingxiang Xu, Yan Zheng, Xiaomin Wan. Tenuigenin down-regulates the release of nitric oxide, matrix metalloproteinase-9 and cytokines from lipopolysaccharide-stimulated microglia. Neuroscience letters. vol 650. 2018-03-19. PMID:28392358. |
tenuigenin down-regulates the release of nitric oxide, matrix metalloproteinase-9 and cytokines from lipopolysaccharide-stimulated microglia. |
2018-03-19 |
2023-08-13 |
rat |
| Li Lu, Xiaorong Li, Pingxiang Xu, Yan Zheng, Xiaomin Wan. Tenuigenin down-regulates the release of nitric oxide, matrix metalloproteinase-9 and cytokines from lipopolysaccharide-stimulated microglia. Neuroscience letters. vol 650. 2018-03-19. PMID:28392358. |
additionally, ten can significantly decrease the secretion and mrna levels of matrix metalloproteinase-9 (mmp-9) and pro-inflammatory cytokines (tnf-α/il-1β) in activated microglia. |
2018-03-19 |
2023-08-13 |
rat |
| Azizul Haque, Swapan K Ray, April Cox, Naren L Bani. Neuron specific enolase: a promising therapeutic target in acute spinal cord injury. Metabolic brain disease. vol 31. issue 3. 2018-01-12. PMID:26847611. |
cell-surface expression of enolase is often detected on activated macrophages, microglia/macrophages, microglia, and astrocytes, promoting extracellular matrix degradation, production of pro-inflammatory cytokines/chemokines, and invasion of inflammatory cells in the sites of injury and inflammation. |
2018-01-12 |
2023-08-13 |
Not clear |