| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jonathan Vinet, Ilia D Vainchtein, Carlotta Spano, Carmela Giordano, Domenico Bordini, Giulia Curia, Massimo Dominici, Hendrikus W G M Boddeke, Bart J L Eggen, Giuseppe Biagin. Microglia are less pro-inflammatory than myeloid infiltrates in the hippocampus of mice exposed to status epilepticus. Glia. vol 64. issue 8. 2018-01-04. PMID:27246930. |
myeloid infiltrates also expressed matrix metalloproteinase (mmp)-9 and 12 while microglia only expressed mmp-12, suggesting the involvement of both cell types in the bbb leakage that follows se. |
2018-01-04 |
2023-08-13 |
mouse |
| Frank Szulzewsky, Sonali Arora, Lot de Witte, Thomas Ulas, Darko Markovic, Joachim L Schultze, Eric C Holland, Michael Synowitz, Susanne A Wolf, Helmut Kettenman. Human glioblastoma-associated microglia/monocytes express a distinct RNA profile compared to human control and murine samples. Glia. vol 64. issue 8. 2018-01-04. PMID:27312099. |
in comparison to human control microglia hgams upregulated genes associated with mitotic cell cycle, cell migration, cell adhesion, and extracellular matrix organization. |
2018-01-04 |
2023-08-13 |
human |
| Frank Szulzewsky, Sonali Arora, Lot de Witte, Thomas Ulas, Darko Markovic, Joachim L Schultze, Eric C Holland, Michael Synowitz, Susanne A Wolf, Helmut Kettenman. Human glioblastoma-associated microglia/monocytes express a distinct RNA profile compared to human control and murine samples. Glia. vol 64. issue 8. 2018-01-04. PMID:27312099. |
we validated the expression of several genes associated with extracellular matrix organization in samples of human control microglia, hgams, and the hgams-depleted fraction via qpcr. |
2018-01-04 |
2023-08-13 |
human |
| Amene Saghazadeh, Carina C Ferrari, Nima Rezae. Deciphering variability in the role of interleukin-1β in Parkinson's disease. Reviews in the neurosciences. vol 27. issue 6. 2018-01-02. PMID:27166719. |
microglia and astrocytes), mitogen-activated protein kinase and nuclear factor κ light-chain-enhancer of activated b cells signaling pathways, and several mediators (including cyclooxygenase, neurotrophic factors, reactive oxygen species, caspases, heme oxygenase-1, and matrix metalloproteinases). |
2018-01-02 |
2023-08-13 |
Not clear |
| Ana S Falcão, Luís A R Carvalho, Gonçalo Lidónio, Ana R Vaz, Susana D Lucas, Rui Moreira, Dora Brite. Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation. ACS chemical neuroscience. vol 8. issue 1. 2017-10-30. PMID:27797173. |
vs also suppressed aβ-induced expression of inflammatory mediators in microglia, such as matrix metalloproteinase (mmp)-2 and mmp-9, as well as high-mobility group box protein-1 (hmgb1), nod-like receptor protein 3 (nlrp3)-inflammasome, and interleukin (il)-1β. |
2017-10-30 |
2023-08-13 |
mouse |
| Yu Young Lee, Eun-Jung Lee, Jin-Sun Park, Se-Eun Jang, Dong-Hyun Kim, Hee-Sun Ki. Anti-Inflammatory and Antioxidant Mechanism of Tangeretin in Activated Microglia. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 11. issue 2. 2017-10-18. PMID:26899309. |
additionally, we found that the activities, mrna levels, and protein levels of matrix metalloproteinase (mmp)-3 and mmp-8 were inhibited, while the expression of tissue inhibitor of metalloproteinase-2 was enhanced by tangeretin in lps-stimulated microglia. |
2017-10-18 |
2023-08-13 |
Not clear |
| Jun Tang, Hongping Miao, Bing Jiang, Qianwei Chen, Liang Tan, Yihao Tao, Jianbo Zhang, Fabao Gao, Hua Feng, Gang Zhu, Zhi Che. A selective CB2R agonist (JWH133) restores neuronal circuit after Germinal Matrix Hemorrhage in the preterm via CX3CR1 Neuropharmacology. vol 119. 2017-08-31. PMID:28153531. |
a selective cb2r agonist (jwh133) restores neuronal circuit after germinal matrix hemorrhage in the preterm via cx3cr1 microglia play dual roles after germinal matrix hemorrhage, and the neurotrophic phenotype maybe neuroprotective. |
2017-08-31 |
2023-08-13 |
Not clear |
| Wen Zhu, Karen E Carney, Victoria M Pigott, Lindsay M Falgoust, Paul A Clark, John S Kuo, Dandan Su. Glioma-mediated microglial activation promotes glioma proliferation and migration: roles of Na+/H+ exchanger isoform 1. Carcinogenesis. vol 37. issue 9. 2017-08-10. PMID:27287871. |
microglia play important roles in extracellular matrix remodeling, tumor invasion, angiogenesis, and suppression of adaptive immunity in glioma. |
2017-08-10 |
2023-08-13 |
Not clear |
| Xiaoning Han, Xi Lan, Qiang Li, Yufeng Gao, Wei Zhu, Tian Cheng, Takayuki Maruyama, Jian Wan. Inhibition of prostaglandin E2 receptor EP3 mitigates thrombin-induced brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 36. issue 6. 2017-08-09. PMID:26661165. |
ep3 receptor inhibition reduced lesion volume, neurologic deficit, cell death, matrix metalloproteinase-9 activity, neutrophil infiltration, and the number of cd68(+) microglia, but increased the number of ym-1(+) m2 microglia. |
2017-08-09 |
2023-08-13 |
mouse |
| Franciska Erdő, László Denes, Elizabeth de Lang. Age-associated physiological and pathological changes at the blood-brain barrier: A review. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 37. issue 1. 2017-08-09. PMID:27837191. |
besides the morphological alterations of the cellular elements (endothelial cells, astrocytes, pericytes, microglia, neuronal elements) of the bbb and neurovascular unit, the changes of the barrier at molecular level (tight junction proteins, adheres junction proteins, membrane transporters, basal lamina, extracellular matrix) are also summarized. |
2017-08-09 |
2023-08-13 |
human |
| C Connolly, A Magnusson-Lind, G Lu, P K Wagner, A L Southwell, M R Hayden, M Björkqvist, B R Leavit. Enhanced immune response to MMP3 stimulation in microglia expressing mutant huntingtin. Neuroscience. vol 325. 2017-06-07. PMID:27033979. |
matrix metalloprotease 3 (mmp3), an endogenous neuronal activator of microglia, also induces increased cytokine release from yac128 microglia compared to wildtype microglia. |
2017-06-07 |
2023-08-13 |
mouse |
| Kazuhide Inou. Purinergic signaling in microglia in the pathogenesis of neuropathic pain. Proceedings of the Japan Academy. Series B, Physical and biological sciences. vol 93. issue 4. 2017-04-24. PMID:28413195. |
the p2x4 receptor (p2x4r), a subtype of ionotropic atp receptors, is upregulated in spinal microglia after nerve injury by several factors, including cc chemokine receptor ccr2, the extracellular matrix protein fibronectin in the spinal cord, interferon regulatory factor 8 (irf8) and irf5. |
2017-04-24 |
2023-08-13 |
Not clear |
| Inge Van Hove, Evy Lefevere, Lies De Groef, Jurgen Sergeys, Manuel Salinas-Navarro, Claude Libert, Roosmarijn Vandenbroucke, Lieve Moon. MMP-3 Deficiency Alleviates Endotoxin-Induced Acute Inflammation in the Posterior Eye Segment. International journal of molecular sciences. vol 17. issue 11. 2017-04-10. PMID:27809288. |
matrix metalloproteinase-3 (mmp-3) is known to mediate neuroinflammatory processes by activating microglia, disrupting blood-central nervous system barriers and supporting neutrophil influx into the brain. |
2017-04-10 |
2023-08-13 |
mouse |
| L G Khaspekov, L E Frumkin. Molecular Mechanisms Mediating Involvement of Glial Cells in Brain Plastic Remodeling in Epilepsy. Biochemistry. Biokhimiia. vol 82. issue 3. 2017-03-22. PMID:28320280. |
data on the involvement of aquaporin-4 in epileptogenic plastic changes and on participation of microglia and extracellular matrix in dysregulation of synaptic transmission and plastic remodeling in epileptic brain tissue are reviewed. |
2017-03-22 |
2023-08-13 |
Not clear |
| K M Koss, M A Churchward, A T Nguyen, J Y Yager, K G Todd, L D Unswort. Brain biocompatibility and microglia response towards engineered self-assembling (RADA)4 nanoscaffolds. Acta biomaterialia. vol 35. 2016-12-26. PMID:26850147. |
evidence suggests that cultured microglia phagocytise the matrix whilst remaining ramified and viable, as shown visually and metabolically (mtt). |
2016-12-26 |
2023-08-13 |
Not clear |
| Tomoji Maeda, Manato Inagaki, Yu Fujita, Takehiro Kimoto, Chiaki Tanabe-Fujimura, Kun Zou, Junjun Liu, Shuyu Liu, Hiroto Koman. ATP increases the migration of microglia across the brain endothelial cell monolayer. Bioscience reports. vol 36. issue 2. 2016-12-13. PMID:26934979. |
an inhibitor of matrix metalloproteinases (mmps) decreased the transmigration of microglia in our system, indicating that mmps play a role in microglial chemotaxis. |
2016-12-13 |
2023-08-13 |
mouse |
| Jerry J Flores, Damon Klebe, William B Rolland, Tim Lekic, Paul R Krafft, John H Zhan. PPARγ-induced upregulation of CD36 enhances hematoma resolution and attenuates long-term neurological deficits after germinal matrix hemorrhage in neonatal rats. Neurobiology of disease. vol 87. 2016-10-20. PMID:26739391. |
we evaluated if upregulating cd36 scavenger receptor expression in microglia and macrophages through pparγ stimulation, which was effective in experimental adult cerebral hemorrhage models and is being evaluated clinically, will enhance hematoma resolution and ameliorate long-term brain sequelae using a neonatal rat germinal matrix hemorrhage model. |
2016-10-20 |
2023-08-13 |
rat |
| Barbara Fazi, Armando Felsani, Luigi Grassi, Anna Moles, Daniel D'Andrea, Nicola Toschi, Daria Sicari, Pasquale De Bonis, Carmelo Anile, Maria Giovanna Guerrisi, Emilia Luca, Maria Giulia Farace, Giulio Maira, Silvia Anna Ciafré, Annunziato Mangiol. The transcriptome and miRNome profiling of glioblastoma tissues and peritumoral regions highlights molecular pathways shared by tumors and surrounding areas and reveals differences between short-term and long-term survivors. Oncotarget. vol 6. issue 26. 2016-09-27. PMID:26188123. |
here we present deep sequencing data showing that peritumoral (p) areas differ from healthy white matter, but share with their respective frankly tumoral (c) samples, a number of mrnas and micrornas representative of extracellular matrix remodeling, tgfβ and signaling, of the involvement of cell types different from tumor cells but contributing to tumor growth, such as microglia or reactive astrocytes. |
2016-09-27 |
2023-08-13 |
Not clear |
| T A Volden, C D Reyelts, T A Hoke, J Arikkath, S J Bonaser. Validation of Flow Cytometry and Magnetic Bead-Based Methods to Enrich CNS Single Cell Suspensions for Quiescent Microglia. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 10. issue 4. 2016-09-15. PMID:26260923. |
microglia are resident mononuclear phagocytes within the cns parenchyma that intimately interact with neurons and astrocytes to remodel synapses and extracellular matrix. |
2016-09-15 |
2023-08-13 |
mouse |
| Lin Li, Yihao Tao, Jun Tang, Qianwei Chen, Yang Yang, Zhou Feng, Yujie Chen, Liming Yang, Yunfeng Yang, Gang Zhu, Hua Feng, Zhi Che. A Cannabinoid Receptor 2 Agonist Prevents Thrombin-Induced Blood-Brain Barrier Damage via the Inhibition of Microglial Activation and Matrix Metalloproteinase Expression in Rats. Translational stroke research. vol 6. issue 6. 2016-08-11. PMID:26376816. |
jwh-133 also decreased the number of p44/p42(+)/iba-1(+) microglia, lowered evans blue extravasation, and inhibited the elevated matrix metallopeptidase (mmp)-9 and matrix metallopeptidase (mmp)-12 activities. |
2016-08-11 |
2023-08-13 |
rat |