| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eun-Jung Lee, Hyun-Myung Ko, Yeon-Hui Jeong, Eun-Mi Park, Hee-Sun Ki. β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia. Journal of neuroinflammation. vol 12. 2016-05-03. PMID:26173397. |
β-lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia. |
2016-05-03 |
2023-08-13 |
Not clear |
| Kimberleve Rolón-Reyes, Yuriy V Kucheryavykh, Luis A Cubano, Mikhail Inyushin, Serguei N Skatchkov, Misty J Eaton, Jeffrey K Harrison, Lilia Y Kucheryavyk. Microglia Activate Migration of Glioma Cells through a Pyk2 Intracellular Pathway. PloS one. vol 10. issue 6. 2016-04-27. PMID:26098895. |
in the tumor environment, microglia release factors that lead to the degradation of the extracellular matrix and stimulate signaling pathways to promote glioma cell invasion. |
2016-04-27 |
2023-08-13 |
mouse |
| Kimberleve Rolón-Reyes, Yuriy V Kucheryavykh, Luis A Cubano, Mikhail Inyushin, Serguei N Skatchkov, Misty J Eaton, Jeffrey K Harrison, Lilia Y Kucheryavyk. Microglia Activate Migration of Glioma Cells through a Pyk2 Intracellular Pathway. PloS one. vol 10. issue 6. 2016-04-27. PMID:26098895. |
in the present study, we demonstrated that microglia can promote glioma migration through a mechanism independent of extracellular matrix degradation. |
2016-04-27 |
2023-08-13 |
mouse |
| Jun Tang, Yihao Tao, Liang Tan, Liming Yang, Yin Niu, Qianwei Chen, Yunfeng Yang, Hua Feng, Zhi Chen, Gang Zh. Cannabinoid receptor 2 attenuates microglial accumulation and brain injury following germinal matrix hemorrhage via ERK dephosphorylation in vivo and in vitro. Neuropharmacology. vol 95. 2016-03-24. PMID:25963415. |
microglia accumulation plays detrimental roles in the pathology of germinal matrix hemorrhage (gmh) in the immature preterm brain. |
2016-03-24 |
2023-08-13 |
rat |
| Yirong Yang, Victor M Salayandia, Jeffrey F Thompson, Lisa Y Yang, Eduardo Y Estrada, Yi Yan. Attenuation of acute stroke injury in rat brain by minocycline promotes blood-brain barrier remodeling and alternative microglia/macrophage activation during recovery. Journal of neuroinflammation. vol 12. 2016-03-09. PMID:25889169. |
minocycline reduces reperfusion injury by inhibiting matrix metalloproteinases (mmps) and microglia activity after cerebral ischemia. |
2016-03-09 |
2023-08-13 |
rat |
| Bastian Zinnhardt, Thomas Viel, Lydia Wachsmuth, Alexis Vrachimis, Stefan Wagner, Hans-Jörg Breyholz, Andreas Faust, Sven Hermann, Klaus Kopka, Cornelius Faber, Frédéric Dollé, Sabina Pappata, Anna M Planas, Bertrand Tavitian, Michael Schäfers, Lydia M Sorokin, Michael T Kuhlmann, Andreas H Jacob. Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 11. 2016-02-16. PMID:26126867. |
multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke. |
2016-02-16 |
2023-08-13 |
Not clear |
| Bastian Zinnhardt, Thomas Viel, Lydia Wachsmuth, Alexis Vrachimis, Stefan Wagner, Hans-Jörg Breyholz, Andreas Faust, Sven Hermann, Klaus Kopka, Cornelius Faber, Frédéric Dollé, Sabina Pappata, Anna M Planas, Bertrand Tavitian, Michael Schäfers, Lydia M Sorokin, Michael T Kuhlmann, Andreas H Jacob. Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 11. 2016-02-16. PMID:26126867. |
activation of microglia and matrix metalloproteinases (mmps) is involved in positively and negatively affecting stroke outcome. |
2016-02-16 |
2023-08-13 |
Not clear |
| Yu-Huan Gu, Masato Kanazawa, Stephanie Y Hung, Xiaoyun Wang, Shunichi Fukuda, James A Koziol, Gregory J Del Zopp. Cathepsin L acutely alters microvessel integrity within the neurovascular unit during focal cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 11. 2016-02-16. PMID:26198177. |
a novel ex vivo assay showed that cathepsin l released from microglia during ischemia degrades microvessel matrix, and interacts with mmp activity. |
2016-02-16 |
2023-08-13 |
human |
| Setsuya Fujit. 50 years of research on the phenomena and epigenetic mechanism of neurogenesis. Neuroscience research. vol 86. 2015-07-17. PMID:24703934. |
following the stage of pure matrix cell proliferation (stage i), stage of neuron production (stage ii) ensues, and when stage ii is over, stage of gliogenesis (stage iii) follows immediately; first, glioblasts, then astrocytes, oligodendrocytes and microglia differentiate, in sequence.as for the mechanism of the switching, recent progress in molecular research on dynamism of the chromatin and transcription-factors revealed the irreversible epigenetic changes controlling the switch. |
2015-07-17 |
2023-08-13 |
Not clear |
| Ping Hu, Jeffrey S Thinschmidt, Sergio Caballero, Samuel Adamson, Louise Cole, Tailoi Chan-Ling, Maria B Gran. Loss of survival factors and activation of inflammatory cascades in brain sympathetic centers in type 1 diabetic mice. American journal of physiology. Endocrinology and metabolism. vol 308. issue 8. 2015-06-19. PMID:25714673. |
furthermore, levels of matrix metalloproteinase-2 (mmp-2), nucleoside triphosphate diphosphohydrolase-1 (cd39), and ionized calcium-binding adaptor molecule 1 (iba-1) were utilized to assess inflammatory changes in astrocytes, microglia, and blood vessels. |
2015-06-19 |
2023-08-13 |
mouse |
| Fangyuan Shi, Shuangyan Duan, Jihong Cui, Xingrong Yan, Hongmin Li, Yingjuan Wang, Fulin Chen, Lihua Zhang, Jun Liu, Xin Xi. Induction of matrix metalloproteinase-3 (MMP-3) expression in the microglia by lipopolysaccharide (LPS) via upregulation of glycoprotein nonmetastatic melanoma B (GPNMB) expression. Journal of molecular neuroscience : MN. vol 54. issue 2. 2015-05-28. PMID:24682924. |
induction of matrix metalloproteinase-3 (mmp-3) expression in the microglia by lipopolysaccharide (lps) via upregulation of glycoprotein nonmetastatic melanoma b (gpnmb) expression. |
2015-05-28 |
2023-08-12 |
Not clear |
| Fangyuan Shi, Shuangyan Duan, Jihong Cui, Xingrong Yan, Hongmin Li, Yingjuan Wang, Fulin Chen, Lihua Zhang, Jun Liu, Xin Xi. Induction of matrix metalloproteinase-3 (MMP-3) expression in the microglia by lipopolysaccharide (LPS) via upregulation of glycoprotein nonmetastatic melanoma B (GPNMB) expression. Journal of molecular neuroscience : MN. vol 54. issue 2. 2015-05-28. PMID:24682924. |
in this study, we used rt-pcr and western blotting to detect gpnmb and matrix metalloproteinase-3 (mmp-3) expressions in activated microglia. |
2015-05-28 |
2023-08-12 |
Not clear |
| Randy Tatt Yhew Haw, Chih Kong Tong, Andrew Yew, Han Chung Lee, James B Phillips, Sharmili Vidyadara. A three-dimensional collagen construct to model lipopolysaccharide-induced activation of BV2 microglia. Journal of neuroinflammation. vol 11. 2015-03-30. PMID:25074682. |
by culturing microglia within a matrix, we aim to emulate the physical state of microglia embedded within parenchyma. |
2015-03-30 |
2023-08-13 |
Not clear |
| Mareike Caesar, Sandra Felk, Susanne Zach, Gunnar Brønstad, Jan O Aasly, Thomas Gasser, Frank Gillardo. Changes in matrix metalloprotease activity and progranulin levels may contribute to the pathophysiological function of mutant leucine-rich repeat kinase 2. Glia. vol 62. issue 7. 2015-01-02. PMID:24652679. |
furthermore, medium levels of matrix metalloprotease (mmp) 2 increased, whereas mmp 9 decreased in lrrk2(r1441g) mutant microglia. |
2015-01-02 |
2023-08-12 |
mouse |
| Alejandro M S Mayer, Mary L Hall, Michael Holland, Cristina De Castro, Antonio Molinaro, Monica Aldulescu, Jeffrey Frenkel, Lauren Ottenhoff, David Rowley, Jan Powel. Vibrio vulnificus MO6-24/O lipopolysaccharide stimulates superoxide anion, thromboxane B₂, matrix metalloproteinase-9, cytokine and chemokine release by rat brain microglia in vitro. Marine drugs. vol 12. issue 4. 2014-12-09. PMID:24675728. |
vibrio vulnificus mo6-24/o lipopolysaccharide stimulates superoxide anion, thromboxane b₂, matrix metalloproteinase-9, cytokine and chemokine release by rat brain microglia in vitro. |
2014-12-09 |
2023-08-12 |
human |
| Alejandro M S Mayer, Mary L Hall, Michael Holland, Cristina De Castro, Antonio Molinaro, Monica Aldulescu, Jeffrey Frenkel, Lauren Ottenhoff, David Rowley, Jan Powel. Vibrio vulnificus MO6-24/O lipopolysaccharide stimulates superoxide anion, thromboxane B₂, matrix metalloproteinase-9, cytokine and chemokine release by rat brain microglia in vitro. Marine drugs. vol 12. issue 4. 2014-12-09. PMID:24675728. |
priming of rat microglia by v. vulnificus mo6-24/o lps in vitro yielded a bell-shaped dose-response curve for pma (phorbol 12-myristate 13-acetate)-stimulated o₂⁻ generation: (1) 0.1-1 ng/ml v. vulnificus lps enhanced o₂⁻ generation significantly but with limited inflammatory mediator generation; (2) 10-100 ng/ml v. vulnificus lps maximized o₂⁻ generation with concomitant release of thromboxane b2 (txb2), matrix metalloproteinase-9 (mmp-9), and several cytokines and chemokines; (3) 1000-100,000 ng/ml v. vulnificus lps, with the exception of txb2, yielded both attenuated o₂⁻ production, and a progressive decrease in mmp-9, cytokines and chemokines investigated. |
2014-12-09 |
2023-08-12 |
human |
| Eun-Jung Lee, Pyong-Gon Moon, Moon-Chang Baek, Hee-Sun Ki. Comparison of the Effects of Matrix Metalloproteinase Inhibitors on TNF-α Release from Activated Microglia and TNF-α Converting Enzyme Activity. Biomolecules & therapeutics. vol 22. issue 5. 2014-11-21. PMID:25414771. |
comparison of the effects of matrix metalloproteinase inhibitors on tnf-α release from activated microglia and tnf-α converting enzyme activity. |
2014-11-21 |
2023-08-13 |
Not clear |
| Justin P Rodriguez, Michael Coulter, Jill Miotke, Ronald L Meyer, Ken-Ichi Takemaru, Joel M Levin. Abrogation of β-catenin signaling in oligodendrocyte precursor cells reduces glial scarring and promotes axon regeneration after CNS injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 31. 2014-09-29. PMID:25080590. |
this scar contains reactive astrocytes, activated microglia, macrophages and other myeloid cells, meningeal cells, proliferating oligodendrocyte precursor cells (opcs), and a dense extracellular matrix. |
2014-09-29 |
2023-08-13 |
mouse |
| Karin Sävman, Melvyn P Heyes, Pernilla Svedin, Anna Karlsso. Microglia/macrophage-derived inflammatory mediators galectin-3 and quinolinic acid are elevated in cerebrospinal fluid from newborn infants after birth asphyxia. Translational stroke research. vol 4. issue 2. 2014-08-18. PMID:23807898. |
matrix metalloproteinase-9 (mmp-9) is a tissue-degrading protease expressed by activated microglia in the immature brain after hi. |
2014-08-18 |
2023-08-12 |
Not clear |
| Takeshi Kanaumi, Ivan Milenkovic, Homa Adle-Biassette, Eleonora Aronica, Gabor G Kovac. Non-neuronal cell responses differ between normal and Down syndrome developing brains. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 31. issue 8. 2014-07-23. PMID:24113258. |
we evaluated immunoreactivity for cd68 (macrophage), hla-dr (microglia), olig2 and tppp/p25 (oligodendroglia), and gfap (astroglia) in the germinal matrix (gm), temporal lobe white matter (tewm) and hippocampus from 14 weeks of gestations to newborn in 28 ds patients and 30 age-matched controls. |
2014-07-23 |
2023-08-12 |
Not clear |