All Relations between microglial cell and nitrogen monoxide

Publication Sentence Publish Date Extraction Date Species
You Jung Kang, Seung Jae Hyeon, Amanda McQuade, Jiwoon Lim, Seung Hyun Baek, Yen N Diep, Khanh V Do, Yeji Jeon, Dong-Gyu Jo, C Justin Lee, Mathew Blurton-Jones, Hoon Ryu, Hansang Ch. Neurotoxic Microglial Activation via IFNγ-Induced Nrf2 Reduction Exacerbating Alzheimer's Disease. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-03-14. PMID:38482922. the proinflammatory microglia in turn produce neurotoxic nitric oxide and proinflammatory mediators exacerbating synaptic impairment, phosphorylated-tau accumulation, and discernable neuronal loss. 2024-03-14 2024-03-16 mouse
. Retraction: NOSH-NBP, a novel nitric oxide and hydrogen sulfide- releasing hybrid, attenuates ischemic stroke-induced neuroinflammatory injury by modulating microglia polarization. Frontiers in cellular neuroscience. vol 17. 2023-12-11. PMID:38077949. retraction: nosh-nbp, a novel nitric oxide and hydrogen sulfide- releasing hybrid, attenuates ischemic stroke-induced neuroinflammatory injury by modulating microglia polarization. 2023-12-11 2023-12-17 Not clear
Sabrina de Souza, Jesús Rosario-Claudio, Jaewon Sim, Kufreobong E Inyang, Andrew Dagenais, Karli Monahan, Beenhwa Lee, Hariharan Ramakrishnan, Visha Parmar, Matan Geron, Grégory Scherrer, Joseph K Folger, Geoffroy Laume. Interleukin-10 signaling in somatosensory neurons controls CCL2 release and inflammatory response. Brain, behavior, and immunity. 2023-12-11. PMID:38081433. we showed that mice that lack il-10r1 specifically on advillin-positive neurons have exaggerated blood nitric oxide levels, spinal microglia activation, and cytokine upregulation in the spinal cord, liver, and gut compared to wild-type (wt) counterparts in response to systemic lipopolysaccharide (lps) injection. 2023-12-11 2023-12-17 mouse
Yuta Morisaki, Motoki Ohshima, Hikaru Suzuki, Hidemi Misaw. LAG-3 expression in microglia regulated by IFN-γ/STAT1 pathway and metalloproteases. Frontiers in cellular neuroscience. vol 17. 2023-12-01. PMID:38026700. furthermore, lag-3 knockdown in microglia promoted nitric oxide production by ifn-γ. 2023-12-01 2023-12-10 mouse
Noam Steinberg, Danny Galleguillos, Asifa Zaidi, Melanie Horkey, Simonetta Sipion. Naïve Huntington's disease microglia mount a normal response to inflammatory stimuli but display a partially impaired development of innate immune tolerance that can be counteracted by ganglioside GM1. Journal of neuroinflammation. vol 20. issue 1. 2023-11-25. PMID:37996924. we further show that ganglioside gm1, a glycosphingolipid with anti-inflammatory effects on wild-type microglia, not only decreases the production of pro-inflammatory cytokines and nitric oxide in activated q140 microglia, but also dramatically dampen microglia response to re-stimulation with lps in an experimental model of tolerance. 2023-11-25 2023-11-28 mouse
Meng Liy Pan, Nur Nabilah Ahmad Puzi, Yin Yin Ooi, Rajesh Ramasamy, Sharmili Vidyadara. Response Profiles of BV2 Microglia to IFN-γ and LPS Co-Stimulation and Priming. Biomedicines. vol 11. issue 10. 2023-10-30. PMID:37893022. similarly, when testing different stimulation protocols for bv2 microglia, we discovered differences in the response of the cells in terms of the production of intracellular ros (iros), nitric oxide (no), cd40 expression, and migratory capacity. 2023-10-30 2023-11-08 Not clear
D R De Paula, M S França, L K R Leão, A A Maciel, T A A Moura, S A S de Moraes, C P Bahia, R S Borges, E J O Batista, A C F Passos, K R H M Oliveira, A M Herculan. Total rupture of Achilles tendon induces inflammatory response and glial activation on the spinal cord of mice. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 56. 2023-10-21. PMID:37851789. this phenomenon was accompanied by overexpression of cyclooxygenase-2 (cox-2) and inducible nitric oxide synthase-2 (nos-2) as well as hyperactivation of astrocytes and microglia in nociceptive areas of l5 spinal cord as evidenced by intense gfap and iba-1 immunostaining, respectively. 2023-10-21 2023-11-08 mouse
Laura Meleady, Morgan Towriss, Jennifer Kim, Vince Bacarac, Vivien Dang, Megan E Rowland, Annie Vogel Cierni. Histone deacetylase 3 regulates microglial function through histone deacetylation. Epigenetics. vol 18. issue 1. 2023-07-28. PMID:37506371. hdac3 inhibition enhanced neuroprotective functions of microglia in response to lps through reduced nitric oxide release and increased phagocytosis. 2023-07-28 2023-08-14 Not clear
Lara-Jasmin Schröder, Hauke Thiesler, Lina Gretenkort, Thiemo Malte Möllenkamp, Martin Stangel, Viktoria Gudi, Herbert Hildebrand. Polysialic acid promotes remyelination in cerebellar slice cultures by Siglec-E-dependent modulation of microglia polarization. Frontiers in cellular neuroscience. vol 17. 2023-07-26. PMID:37492129. unlike dp8-14, treatment with dp24-30 significantly improved remyelination, increased arginase-1-positive microglia ratios, and reduced the production of nitric oxide in wildtype, but not in siglec-e-deficient slice cultures. 2023-07-26 2023-08-14 Not clear
Kimberly Barber, Patricia Mendonca, Jasmine A Evans, Karam F A Solima. Antioxidant and Anti-Inflammatory Mechanisms of Cardamonin through Nrf2 Activation and NF-kB Suppression in LPS-Activated BV-2 Microglial Cells. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446045. the chronic activation of microglia cells leads to the overproduction of several substances, including nitric oxide and reactive oxygen species, which can induce neurodegeneration. 2023-07-14 2023-08-14 Not clear
Zisong Bai, Yingjie Wang, Qingqi Meng, Libin Xu, Gang Chen, Di Zhou, Bin Lin, Yue Hou, Ning L. Potential inhibitors of microglial activation from the roots of Wikstroemia lichiangensis W. W. Sm. Phytochemistry. 2023-06-22. PMID:37348747. has a remarkable inhibitory effect on nitric oxide production in overactivated microglia. 2023-06-22 2023-08-14 Not clear
Zeng-Hui Wei, Jagadish Koya, Nikita Acharekar, Jesus Trejos, Xing-Duo Dong, Francis A Schanne, Charles R Ashby, Sandra E Rezni. N,N-dimethylacetamide targets neuroinflammation in Alzheimer's disease in in-vitro and ex-vivo models. Scientific reports. vol 13. issue 1. 2023-05-01. PMID:37127686. we show that dma significantly suppresses the production of inflammatory mediators, such as reactive oxygen species (ros), nitric oxide (no) and various cytokines and chemokines, as well as amyloid-β (aβ), in cultured microglia and organotypic hippocampal slices induced by lipopolysaccharide (lps). 2023-05-01 2023-08-14 Not clear
Li-Hua Zhang, Wen-Ke Gao, Shi-Wei Li, Xiao-Yan Song, Hong-Hua Wu, Hai-Feng Wang, Gang Chen, Shao-Xia Wang, Yue-Hu Pe. Santalane-type sesquiterpenoids and isobenzofuranones from cultures of Paraconiothyrium sporulosum YK-03. Phytochemistry. 2023-04-26. PMID:37100221. additionally, the anti-neuroinflammatory activities of parasantalenoic acids a-c were investigated by evaluating their inhibitory effects on nitric oxide (no) production in lipopolysaccharide (lps)-stimulated bv-2 microglia cells. 2023-04-26 2023-08-14 Not clear
Lucia Scipioni, Daniel Tortolani, Francesca Ciaramellano, Federico Fanti, Thais Gazzi, Manuel Sergi, Marc Nazaré, Sergio Oddi, Mauro Maccarron. Aβ Chronic Exposure Promotes an Activation State of Microglia through Endocannabinoid Signalling Imbalance. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047663. dysfunctional phenotype of microglia, the primary brain immune cells, may aggravate alzheimer's disease (ad) pathogenesis by releasing proinflammatory factors, such as nitric oxide (no). 2023-04-13 2023-08-14 Not clear
Shi Yi Chia, Boon-Keat Khor, Yi Juin Tay, Kok Fui Liew, Chong-Yew Le. Discovery of blood-brain barrier permeant amine-functionalized aurones as inhibitors of activated microglia. Bioorganic chemistry. vol 135. 2023-04-08. PMID:37030107. evaluation of the ability of the aurones to inhibit lipopolysaccharide (lps)-stimulated nitric oxide (no) secretion by murine bv-2 microglia has identified several inhibitors showing significant no reduction at 1 to 10 µm. 2023-04-08 2023-08-14 Not clear
Swarupa Pahan, Sumita Raha, Sridevi Dasarathi, Kalipada Paha. Cinnamein Inhibits the Induction of Nitric Oxide and Proinflammatory Cytokines in Macrophages, Microglia and Astrocytes. Journal of clinical & experimental immunology. vol 8. issue 1. 2023-02-27. PMID:36848307. cinnamein inhibits the induction of nitric oxide and proinflammatory cytokines in macrophages, microglia and astrocytes. 2023-02-27 2023-08-14 mouse
Sigal Fleisher-Berkovich, Yvonne Ventura, Maya Amoyal, Arik Dahan, Valeria Feinshtein, Leenor Alfahel, Adrian Israelson, Nirit Bernstein, Jonathan Gorelick, Shimon Ben-Shaba. Therapeutic Potential of Phytocannabinoid Cannabigerol for Multiple Sclerosis: Modulation of Microglial Activation In Vitro and In Vivo. Biomolecules. vol 13. issue 2. 2023-02-25. PMID:36830745. microglia play a crucial role in the pathogenesis of ms via the release of cytokines and reactive oxygen species, e.g., nitric oxide. 2023-02-25 2023-08-14 mouse
Sigal Fleisher-Berkovich, Yvonne Ventura, Maya Amoyal, Arik Dahan, Valeria Feinshtein, Leenor Alfahel, Adrian Israelson, Nirit Bernstein, Jonathan Gorelick, Shimon Ben-Shaba. Therapeutic Potential of Phytocannabinoid Cannabigerol for Multiple Sclerosis: Modulation of Microglial Activation In Vitro and In Vivo. Biomolecules. vol 13. issue 2. 2023-02-25. PMID:36830745. cannabigerol attenuated the microglial production of nitric oxide in bv2 microglia and primary glial cells; concomitant treatment of the cells with cannabigerol and telmisartan (a neuroprotective angiotensin receptor blocker) decreased nitric oxide production additively. 2023-02-25 2023-08-14 mouse
Mai Sakai, Zhiqian Yu, Masayuki Taniguchi, Rosanne Picotin, Nanami Oyama, David Stellwagen, Chiaki Ono, Yoshie Kikuchi, Ko Matsui, Miharu Nakanishi, Hatsumi Yoshii, Tomoyuki Furuyashiki, Takaaki Abe, Hiroaki Tomit. N-Acetylcysteine Suppresses Microglial Inflammation and Induces Mortality Dose-Dependently via Tumor Necrosis Factor-α Signaling. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36835209. this study aimed to investigate the beneficial and deleterious effects of nac on microglia and stress-induced behavior abnormalities in mice, and its association with microglial tnf-α and nitric oxide (no) production. 2023-02-25 2023-08-14 mouse
Ya-Jen Chiu, Chih-Hsin Lin, Chung-Yin Lin, Pei-Ning Yang, Yen-Shi Lo, Yu-Chieh Chen, Chiung-Mei Chen, Yih-Ru Wu, Ching-Fa Yao, Kuo-Hsuan Chang, Guey-Jen Lee-Che. Investigating Therapeutic Effects of Indole Derivatives Targeting Inflammation and Oxidative Stress in Neurotoxin-Induced Cell and Mouse Models of Parkinson's Disease. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36768965. in pd brains, the activated microglia release inflammatory factors such as interleukin (il)-β, il-6, tumor necrosis factor (tnf)-α, and nitric oxide (no), which increase oxidative stress and mediate neurodegeneration. 2023-02-11 2023-08-14 mouse