| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Lu, Xiaorong Li, Pingxiang Xu, Yan Zheng, Xiaomin Wan. Tenuigenin down-regulates the release of nitric oxide, matrix metalloproteinase-9 and cytokines from lipopolysaccharide-stimulated microglia. Neuroscience letters. vol 650. 2018-03-19. PMID:28392358. |
the results showed that ten can significantly decrease the release of nitric oxide (no) from lipopolysaccharide (lps)-activated rat microglia in a dose-dependent manner. |
2018-03-19 |
2023-08-13 |
rat |
| Dongdong Shi, Xiaoqiang Song, Yuanqiang Guo, Jing Xu, Yu Liu, Jingling Zhang, Chun-Ai Cui, Da-Qing Ji. Alismol, a Sesquiterpenoid Isolated from Vladimiria souliei, Suppresses Proinflammatory Mediators in Lipopolysaccharide-Stimulated Microglia. Journal of molecular neuroscience : MN. vol 62. issue 1. 2018-03-06. PMID:28474151. |
microglia activation plays an important role in the pathogenesis of various neurodegenerative diseases by producing neurotoxic factors, such as proinflammatory cytokines and nitric oxide (no); therefore, suppression of microglia activation is a potential therapeutic approach against these diseases. |
2018-03-06 |
2023-08-13 |
Not clear |
| Ran Xiao, Shan Li, Qian Cao, Xiuling Wang, Qiujin Yan, Xiaoning Tu, Ying Zhu, Fan Zh. Human endogenous retrovirus W env increases nitric oxide production and enhances the migration ability of microglia by regulating the expression of inducible nitric oxide synthase. Virologica Sinica. vol 32. issue 3. 2018-03-05. PMID:28656540. |
human endogenous retrovirus w env increases nitric oxide production and enhances the migration ability of microglia by regulating the expression of inducible nitric oxide synthase. |
2018-03-05 |
2023-08-13 |
human |
| Lindsay Joy Spielman, Deanna Lynn Gibson, Andis Klegeri. Incretin hormones regulate microglia oxidative stress, survival and expression of trophic factors. European journal of cell biology. vol 96. issue 3. 2018-03-02. PMID:28336086. |
we also show that incretins reduce oxidative stress in bv-2 microglia by inhibiting the accumulation of intracellular reactive oxygen species (ros) and release of nitric oxide (no), as well as by increasing the expression of the antioxidant glutathione peroxidase 1 (gpx1) and superoxide dismutase 1 (sod1). |
2018-03-02 |
2023-08-13 |
human |
| Richard Gordon, Neeraj Singh, Vivek Lawana, Anamitra Ghosh, Dilshan S Harischandra, Huajun Jin, Colleen Hogan, Souvarish Sarkar, Dharmin Rokad, Nikhil Panicker, Vellareddy Anantharam, Anumantha G Kanthasamy, Arthi Kanthasam. Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease. Neurobiology of disease. vol 93. 2018-02-27. PMID:27151770. |
further, shrna-mediated knockdown and genetic ablation of pkcδ in primary microglia blunted the microglial proinflammatory response elicited by the inflammogens, including ros generation, nitric oxide production, and proinflammatory cytokine and chemokine release. |
2018-02-27 |
2023-08-13 |
mouse |
| Liqing Zhang, Zhangang Zhang, Yan Fu, Pin Yang, Zhenxia Qin, Yongjun Chen, Ying X. Trans-cinnamaldehyde improves memory impairment by blocking microglial activation through the destabilization of iNOS mRNA in mice challenged with lipopolysaccharide. Neuropharmacology. vol 110. issue Pt A. 2018-02-22. PMID:27543415. |
primary microglia stimulated by lipopolysaccharide (lps) were used to evaluate the potential anti-neuroinflammatory effects of tca by examining the production of nitric oxide (no), expression of inducible nitric oxide synthase (inos), pro-inflammatory cytokines, and activation of mapks. |
2018-02-22 |
2023-08-13 |
mouse |
| Hai M Nguyen, Eva M Grössinger, Makoto Horiuchi, Kyle W Davis, Lee-Way Jin, Izumi Maezawa, Heike Wulf. Differential Kv1.3, KCa3.1, and Kir2.1 expression in "classically" and "alternatively" activated microglia. Glia. vol 65. issue 1. 2018-02-01. PMID:27696527. |
lipopolysaccharide (lps) and interferon-γ (ifn-γ) promote differentiation into classically activated m1-like microglia, which produce high levels of pro-inflammatory cytokines and nitric oxide and are thought to contribute to neurological damage in ischemic stroke and alzheimer's disease. |
2018-02-01 |
2023-08-13 |
Not clear |
| Joyce K Y Ts. Gut Microbiota, Nitric Oxide, and Microglia as Prerequisites for Neurodegenerative Disorders. ACS chemical neuroscience. vol 8. issue 7. 2018-01-30. PMID:28640632. |
gut microbiota, nitric oxide, and microglia as prerequisites for neurodegenerative disorders. |
2018-01-30 |
2023-08-13 |
Not clear |
| J-Y Wang, C-T Lee, J-Y Wan. Nitric oxide plays a dual role in the oxidative injury of cultured rat microglia but not astroglia. Neuroscience. vol 281. 2018-01-26. PMID:25280787. |
nitric oxide plays a dual role in the oxidative injury of cultured rat microglia but not astroglia. |
2018-01-26 |
2023-08-13 |
human |
| Kenji Kawabe, Katsura Takano, Mitsuaki Moriyama, Yoichi Nakamur. Amphotericin B Increases Transglutaminase 2 Expression Associated with Upregulation of Endocytotic Activity in Mouse Microglial Cell Line BV-2. Neurochemical research. vol 42. issue 5. 2018-01-09. PMID:28224343. |
amphotericin b (amb), a polyene antibiotic, is reported to cause the microglial activation to induce nitric oxide (no) production and proinflammatory cytokines expression, and change neurotrophic factors expression in cultured microglia (motoyoshi et al. |
2018-01-09 |
2023-08-13 |
mouse |
| Alba Rossi-George, Chang-Jiang Gu. Copper disrupts S-nitrosothiol signaling in activated BV2 microglia. Neurochemistry international. vol 99. 2018-01-03. PMID:27216010. |
microglia, the primary resident immune cells of the central nervous system (cns), responds rapidly to pathogens and injury by secreting immune mediators including nitric oxide (no). |
2018-01-03 |
2023-08-13 |
Not clear |
| Hiromi Higaki, Mohammed Emamussalehin Choudhury, Chisato Kawamoto, Keisuke Miyamoto, Afsana Islam, Yurika Ishii, Kazuya Miyanishi, Haruna Takeda, Naoto Seo, Kana Sugimoto, Hisaaki Takahashi, Hajime Yano, Junya Tanak. The hypnotic bromovalerylurea ameliorates 6-hydroxydopamine-induced dopaminergic neuron loss while suppressing expression of interferon regulatory factors by microglia. Neurochemistry international. vol 99. 2018-01-03. PMID:27392596. |
in the present study, we found that bu suppressed mrna expression of proinflammatory factors and nitric oxide release in lipopolysaccharide (lps)-treated rat primary microglial cell cultures. |
2018-01-03 |
2023-08-13 |
rat |
| Chun-Hsien Chu, Shijun Wang, Chia-Ling Li, Shih-Heng Chen, Chih-Fen Hu, Yi-Lun Chung, Shiou-Lan Chen, Qingshan Wang, Ru-Band Lu, Hui-Ming Gao, Jau-Shyong Hon. Neurons and astroglia govern microglial endotoxin tolerance through macrophage colony-stimulating factor receptor-mediated ERK1/2 signals. Brain, behavior, and immunity. vol 55. 2017-12-29. PMID:27132056. |
endotoxin-tolerant microglia in neuron-glia cultures displayed m2-like polarized phenotypes, as shown by upregulation of m2 marker arg-1, elevated production of anti-inflammatory cytokine interleukin 10, and decreased secretion of pro-inflammatory mediators (tumor necrosis factor α, nitric oxide, prostaglandin e2 and interleukin 1β). |
2017-12-29 |
2023-08-13 |
Not clear |
| Yuval Nash, Eran Schmukler, Dorit Trudler, Ronit Pinkas-Kramarski, Dan Frenke. DJ-1 deficiency impairs autophagy and reduces alpha-synuclein phagocytosis by microglia. Journal of neurochemistry. vol 143. issue 5. 2017-12-07. PMID:28921554. |
here, we discovered that α-syn significantly induced elevated secretion of the proinflammatory cytokines il-6 and il-1β and a significant dose-dependent elevation in the production of nitric oxide in dj-1 kd microglia, compared to control microglia. |
2017-12-07 |
2023-08-13 |
Not clear |
| Shun Kawasaki, Naoki Abe, Fumito Ohtake, Afsana Islam, Mohammed Emamussalehin Choudhury, Ryo Utsunomiya, Satoshi Kikuchi, Tasuku Nishihara, Jun Kuwabara, Hajime Yano, Yuji Watanabe, Mayuki Aibiki, Toshihiro Yorozuya, Junya Tanak. Effects of hypnotic bromovalerylurea on microglial BV2 cells. Journal of pharmacological sciences. vol 134. issue 2. 2017-11-16. PMID:28645489. |
bu suppressed nitric oxide (no) release and proinflammatory cytokine expression by lipopolysaccharide (lps)-treated bv2 cells, a murine microglial cell line. |
2017-11-16 |
2023-08-13 |
Not clear |
| Nofar Torika, Keren Asraf, Ella Roasso, Abraham Danon, Sigal Fleisher-Berkovic. Angiotensin Converting Enzyme Inhibitors Ameliorate Brain Inflammation Associated with Microglial Activation: Possible Implications for Alzheimer's Disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 11. issue 4. 2017-10-18. PMID:27562846. |
our in vitro study investigated the effect of both aceis on nitric oxide (no), tumor necrosis factor- α (tnf-α) release and inducible no synthase (inos) expression in lipopolysaccharide (lps)-induced bv2 microglia. |
2017-10-18 |
2023-08-13 |
mouse |
| Ravikumar Aalinkeel, Courtney S Mangum, Eliane Abou-Jaoude, Jessica L Reynolds, Maixian Liu, Karin Sundquist, Neil U Parikh, Lee D Chaves, Manoj J Mammen, Stanley A Schwartz, Supriya D Mahaja. Galectin-1 Reduces Neuroinflammation via Modulation of Nitric Oxide-Arginase Signaling in HIV-1 Transfected Microglia: a Gold Nanoparticle-Galectin-1 "Nanoplex" a Possible Neurotherapeutic? Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 12. issue 1. 2017-10-18. PMID:28028734. |
we have previously shown that galectin-1 treatment decreased oxidative stress in microglia and hypothesize that the mechanism underlying this phenomenon is the cross regulatory interactions between nitric oxide (no) and arginase i activity in microglia. |
2017-10-18 |
2023-08-13 |
human |
| David B Kurland, Volodymyr Gerzanich, Jason K Karimy, Seung Kyoon Woo, Rudi Vennekens, Marc Freichel, Bernd Nilius, Joseph Bryan, J Marc Simar. The Sur1-Trpm4 channel regulates NOS2 transcription in TLR4-activated microglia. Journal of neuroinflammation. vol 13. issue 1. 2017-10-10. PMID:27246103. |
harmful effects of activated microglia are due, in part, to the formation of peroxynitrite radicals, which is attributable to the upregulation of inducible nitric oxide (no) synthase (nos2). |
2017-10-10 |
2023-08-13 |
Not clear |
| Yu Zhang, Ruinan Gu, Jia Jia, Tingjun Hou, Long Tai Zheng, Xuechu Zhe. Inhibition of macrophage migration inhibitory factor (MIF) tautomerase activity suppresses microglia-mediated inflammatory responses. Clinical and experimental pharmacology & physiology. vol 43. issue 11. 2017-09-12. PMID:27543936. |
our results demonstrate that z-590 significantly decreases the production of nitric oxide (no), tumour necrosis factor-alpha (tnf-α), interleukin (il)-6, il-1β, cyclooxygenase (cox-2), inducible nitric oxide synthase (inos) as well as reactive oxygen species (ros) involved in inhibiting makps signalling pathway in lps-stimulated microglia cells. |
2017-09-12 |
2023-08-13 |
Not clear |
| Jianing Wang, Chunshu Yang, Qi Zhao, Ziwei Zhu, Yujia Li, Pingting Yan. Microglia activation induced by serum of SLE patients. Journal of neuroimmunology. vol 310. 2017-08-22. PMID:28778438. |
exposure to sle patient sera resulted in morphological changes in the microglia, an increase in mhc ii and cd86 protein expression, and an obvious release of nitric oxide and proinflammatory cytokines. |
2017-08-22 |
2023-08-13 |
Not clear |