All Relations between microglial cell and nitrogen monoxide

Publication Sentence Publish Date Extraction Date Species
Lalita Subedi, Eunhee Ji, Dongyun Shin, Jongsik Jin, Joo Hong Yeo, Sun Yeou Ki. Equol, a Dietary Daidzein Gut Metabolite Attenuates Microglial Activation and Potentiates Neuroprotection In Vitro. Nutrients. vol 9. issue 3. 2017-08-17. PMID:28264445. equol inhibited the lipopolysaccharide (lps)-induced tlr4 activation, mapk activation, nf-kb-mediated transcription of inflammatory mediators, production of nitric oxide (no), release of prostaglandin e2 (pge-2), secretion of tumor necrosis factor-α (tnf-α) and interleukin 6 (il-6), in lipopolysaccharide (lps)-activated murine microglia cells. 2017-08-17 2023-08-13 Not clear
Liang-En Yu, Chiou-Lian Lai, Ching-Tien Lee, Jiz-Yuh Wan. Highly electronegative low-density lipoprotein L5 evokes microglial activation and creates a neuroinflammatory stress via Toll-like receptor 4 signaling. Journal of neurochemistry. vol 142. issue 2. 2017-08-10. PMID:28444734. we found that l5 enables the activation of microglia and elicits an inflammatory response, as evidenced by increased oxygen/nitrogen free radicals (nitric oxide, reactive oxygen species, and peroxides), elevated tumor necrosis factor-α levels, decreased basal interleukin-10 levels, and augmented production of pro-inflammatory proteins (inducible nitric oxide synthase and cyclooxygenase-2). 2017-08-10 2023-08-13 human
Tian-Ya Liu, Xiao-Ying Yang, Long-Tai Zheng, Guang-Hui Wang, Xue-Chu Zhe. Activation of Nur77 in microglia attenuates proinflammatory mediators production and protects dopaminergic neurons from inflammation-induced cell death. Journal of neurochemistry. vol 140. issue 4. 2017-07-13. PMID:27889907. nur77 over-expression or application of nur77 agonist cytosporone b suppressed the expression of proinflammatory genes, such as inducible nitric oxide nos, cyclooxygenase-2, il-1β, and tumor necrosis factor-α in the activated microglia, while silenced nur77 exaggerated the inflammatory responses in microglia. 2017-07-13 2023-08-13 mouse
Changyeol Lee, Soonok Kim, Wei Li, Sunghee Bang, Hanna Lee, Hyun-Jung Lee, Eun-Young Noh, Jung-Eun Park, Woo Young Bang, Sang Hee Shi. Bioactive secondary metabolites produced by an endophytic fungus Gaeumannomyces sp. JS0464 from a maritime halophyte Phragmites communis. The Journal of antibiotics. vol 70. issue 6. 2017-07-11. PMID:28352106. chemical investigations of extracts of js0464 led to the isolation of two glycosylated dialkylresorcinol derivatives (1-2), an anthraquinone derivative (3) and eight known compounds (4-11), which were identified by spectroscopic analyses incorporating one-dimensional/2d nmr and ms. nine compounds showed significant nitric oxide reduction activity in lipopolysaccharide-stimulated microglia bv-2 cells, seven of which did not impair cell viability. 2017-07-11 2023-08-13 Not clear
Gyun Jee Song, Youngpyo Nam, Myungjin Jo, Myungsu Jung, Ja Young Koo, Wansang Cho, Minseob Koh, Seung Bum Park, Kyoungho Su. A novel small-molecule agonist of PPAR-γ potentiates an anti-inflammatory M2 glial phenotype. Neuropharmacology. vol 109. 2017-06-19. PMID:27288982. activated microglia and astrocytes play an essential role in neuroinflammation by producing nitric oxide (no), inflammatory cytokines, chemokines, and neurotoxins. 2017-06-19 2023-08-13 mouse
Yang Jiao, Ting Xie, Lu-Hui Zou, Qian Wei, Li Qiu, Li-Xia Che. Lanostane triterpenoids from Ganoderma curtisii and their NO production inhibitory activities of LPS-induced microglia. Bioorganic & medicinal chemistry letters. vol 26. issue 15. 2017-06-19. PMID:27335254. their anti-inflammatory activities were tested by measuring their inhibitory effects on nitric oxide (no) production in bv-2 microglia cells activated by lipopolysaccharide. 2017-06-19 2023-08-13 rat
Chung Sub Kim, Lalita Subedi, Oh Wook Kwon, Hyun Bong Park, Sun Yeou Kim, Sang Un Choi, Kang Ro Le. Wasabisides A-E, Lignan Glycosides from the Roots of Wasabia japonica. Journal of natural products. vol 79. issue 10. 2017-06-16. PMID:27700070. all isolated compounds (1-9) were evaluated for their potential neuroprotective effects through induction of nerve growth factor in c6 glioma cells, for their effects on nitric oxide levels in lipopolysaccharide-stimulated murine microglia bv2 cells, and for their cytotoxicity against four human tumor cell lines (a549, sk-ov-3, sk-mel-2, and bt549). 2017-06-16 2023-08-13 human
Yachao Xing, Ning Li, Di Zhou, Gang Chen, Kun Jiao, Wenli Wang, Yingying Si, Yue Ho. Sesquiterpene Coumarins from Ferula sinkiangensis Act as Neuroinflammation Inhibitors. Planta medica. vol 83. issue 1-02. 2017-05-22. PMID:27420353. to identify novel natural neuroinflammation inhibitors, a bioactivity-guided phytochemical research was performed on the traditional chinese medicine "awei", that exhibited a significant inhibitory effect on nitric oxide production in over-activated microglia cells. 2017-05-22 2023-08-13 Not clear
Leihua Weng, He Zhang, Xiaoxi Li, Hui Zhan, Fan Chen, Lijuan Han, Yun Xu, Xiang Ca. Ampelopsin attenuates lipopolysaccharide-induced inflammatory response through the inhibition of the NF-κB and JAK2/STAT3 signaling pathways in microglia. International immunopharmacology. vol 44. 2017-05-12. PMID:27998743. we found that pre-treatment of microglia cells with amp before lps with a non-cytotoxic concentration range decreased the production of nitric oxide (no) and prostaglandin e2 (pge2). 2017-05-12 2023-08-13 Not clear
Wen-Jun Xu, Rui-Jun Li, Olga Quasie, Ming-Hua Yang, Ling-Yi Kong, Jun Lu. Polyprenylated Tetraoxygenated Xanthones from the Roots of Hypericum monogynum and Their Neuroprotective Activities. Journal of natural products. vol 79. issue 8. 2017-05-02. PMID:27525351. compounds 1 and 2 exhibited neuroprotective effects against corticosterone (cort)-induced lesions of pc12 cells at concentrations of 6.25, 12.50, and 25.00 μm, with cell viability greater than 75%, as well as inhibitory effects on nitric oxide production in lipopolysaccharide-induced bv2 microglia cells, with ic50 values of 7.47 ± 0.65 and 9.60 ± 0.12 μm, respectively. 2017-05-02 2023-08-13 Not clear
Chi-Su Yoon, Dong-Cheol Kim, Tran Hong Quang, Jungwon Seo, Dae Gill Kang, Ho Sub Lee, Hyuncheol Oh, Youn-Chul Ki. A Prenylated Xanthone, Cudratricusxanthone A, Isolated from Cudrania tricuspidata Inhibits Lipopolysaccharide-Induced Neuroinflammation through Inhibition of NF-κB and p38 MAPK Pathways in BV2 Microglia. Molecules (Basel, Switzerland). vol 21. issue 9. 2017-04-17. PMID:27649130. cudratricusxanthone a (1) suppressed the expression of inducible nitric oxide synthase (inos) and cyclooxygenase (cox)-2 enzymes and decreased the production of inos-derived nitric oxide and cox-2-derived prostaglandin e2 in lps-stimulated mouse bv2 microglia. 2017-04-17 2023-08-13 mouse
Yu Jin Kim, Hye-Sun Lim, Jun Lee, Soo-Jin Jeon. Quantitative Analysis of Psoralea corylifolia Linne and its Neuroprotective and Anti-Neuroinflammatory Effects in HT22 Hippocampal Cells and BV-2 Microglia. Molecules (Basel, Switzerland). vol 21. issue 8. 2017-04-14. PMID:27548120. angelicin, isobavachalcone, and bakuchiol suppressed lipopolysaccharide (lps)-stimulated nitric oxide production in lps-treated bv-2 microglia more significantly than did the other components. 2017-04-14 2023-08-13 Not clear
Jie Ma, Chuang-Jun Li, Jing-Zhi Yang, Yan Li, Xiu-Qi Bao, Nai-Hong Chen, Dong-Ming Zhan. Three new coumarin glycosides from the stems of Hydrangea paniculata. Journal of Asian natural products research. vol 19. issue 4. 2017-04-12. PMID:28367637. in addition, compounds 1-3 were screened for their neuroprotective effects against serum deprivation-induced pc12 cell damage, hepatoprotective activities against dl-galactosamine-induced toxicity in hl-7702 cells and their ability to inhibit lps-induced nitric oxide production in the murine microglia bv2 cell line, but they were inactive. 2017-04-12 2023-08-13 Not clear
Van-Tinh Nguyen, Seok-Chun Ko, Gun-Woo Oh, Seong-Yeong Heo, You-Jin Jeon, Won Sun Park, Il-Whan Choi, Sung-Wook Choi, Won-Kyo Jun. Anti-inflammatory effects of sodium alginate/gelatine porous scaffolds merged with fucoidan in murine microglial BV2 cells. International journal of biological macromolecules. vol 93. issue Pt B. 2017-04-07. PMID:27234497. following stimulation with 0.5μg/ml lps, microglia cultured in porous sagfu decreased their expression of nitric oxide (no), prostaglandin e2 (pge2), and reactive oxygen species (ros). 2017-04-07 2023-08-13 Not clear
Hu-Nan Sun, Ying-Hao Han, Li Feng, Cheng-Hao Jin, Bing Han, Lei Liu, Dong-Soek Lee, Tea-Ho Kwon, Le-Gong Li, Wen-Zhong Ge, Yu-Dong Cu. 16α, 17α-epoxypregnenolone-20-oxime inhibits NO and IL-6 production in LPS-treated RAW264.7 cells. Molecular medicine reports. vol 13. issue 6. 2017-04-06. PMID:27082161. it has previously been reported that 16α, 17α-epoxypregnenolone-20-oxime (eprego) exerts an inhibitory effect on nitric oxide (no) production and inducible no synthase (inos) expression in microglia. 2017-04-06 2023-08-13 Not clear
Nguyen Thi Thanh Ngan, Tran Hong Quang, Kwan-Woo Kim, Hye Jin Kim, Jae Hak Sohn, Dae Gill Kang, Ho Sub Lee, Youn-Chul Kim, Hyuncheol O. Anti-inflammatory effects of secondary metabolites isolated from the marine-derived fungal strain Penicillium sp. SF-5629. Archives of pharmacal research. vol 40. issue 3. 2017-04-04. PMID:28074397. evaluation of the anti-inflammatory activity of these metabolites showed that 4 inhibited nitric oxide and prostaglandin e2 production in lipopolysaccharide-stimulated bv2 microglia, with ic 2017-04-04 2023-08-13 Not clear
Fei Li, Jie Ma, Chuang-Jun Li, Jing-Zhi Yang, Dan Zhang, Xiao-Guang Chen, Dong-Ming Zhan. Bioactive isopimarane diterpenoids from the stems of Euonymus oblongifolius. Phytochemistry. vol 135. 2017-03-16. PMID:28003047. all of the isolated compounds were evaluated for their ability to inhibit lps-induced nitric oxide production in the murine microglia bv2 cell line, and for their cytotoxic activity against five human cancer cell lines. 2017-03-16 2023-08-13 human
Fei Li, Jie Ma, Chuang-Jun Li, Jing-Zhi Yang, Dan Zhang, Xiao-Guang Chen, Dong-Ming Zhan. Bioactive isopimarane diterpenoids from the stems of Euonymus oblongifolius. Phytochemistry. vol 135. 2017-03-16. PMID:28003047. euonymusisopimaric acids a, e and f inhibited lps-induced nitric oxide production in the murine microglia bv2 cell line, with ic 2017-03-16 2023-08-13 human
Li-Long Pan, Peng Xu, Xiao-Ling Luo, Li-Jun Wang, Si-Yu Liu, Yi-Zhun Zhu, Jin-Feng Hu, Xin-Hua Li. Shizukaol B, an active sesquiterpene from Chloranthus henryi, attenuates LPS-induced inflammatory responses in BV2 microglial cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 88. 2017-03-14. PMID:28178617. our data showed that shizukaol b concentration-dependently suppressed expression of inducible nitric oxide synthase (inos) and cyclooxygenase-2 (cox-2), production of nitric oxide (no), tumor necrosis factor-α (tnf-α), and interleukin-1β (il-1β) in lps-stimulated bv2 microglia. 2017-03-14 2023-08-13 Not clear
Tae-Shin Park, Young-Kyoung Ryu, Hye-Yeon Park, Jae Yun Kim, Jun Go, Jung-Ran Noh, Yong-Hoon Kim, Jung Hwan Hwang, Dong-Hee Choi, Won-Keun Oh, Chul-Ho Lee, Kyoung-Shim Ki. Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model. International journal of molecular medicine. vol 39. issue 1. 2017-03-06. PMID:28004107. our results revealed that hj significantly decreased the mrna and protein expression levels of tumor necrosis factor-α (tnf‑α), interleukin (il)-1β, il-6 and inducible nitric oxide synthase (inos) induced by lipopolysaccharide in the microglial cell line. 2017-03-06 2023-08-13 mouse