All Relations between microglial cell and nitrogen monoxide

Publication Sentence Publish Date Extraction Date Species
Juan E Tichauer, Rommy von Bernhard. Transforming growth factor-β stimulates β amyloid uptake by microglia through Smad3-dependent mechanisms. Journal of neuroscience research. vol 90. issue 10. 2013-01-04. PMID:22715062. here we evaluated the participation of the tgfβ smad3 pathway in regulation of the expression pattern of scavenger receptors (sr) and activation of microglia through nitric oxide (no·) secretion and phagocytosis of aβ. 2013-01-04 2023-08-12 Not clear
Aditya Sunkaria, Willayat Yousuf Wani, Deep Raj Sharma, Kiran Dip Gil. Dichlorvos exposure results in activation induced apoptotic cell death in primary rat microglia. Chemical research in toxicology. vol 25. issue 8. 2012-12-26. PMID:22817663. we observed significant up-regulation of pro-inflammatory molecules like nitric oxide, tnf-α, and il-1β when microglia were treated with dichlorvos (10 μm). 2012-12-26 2023-08-12 rat
Hyo Geun Kim, Mi Sun Ju, Sang Keun Ha, Hyangsook Lee, Hyejung Lee, Sun Yeou Kim, Myung Sook O. Acacetin protects dopaminergic cells against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neuroinflammation in vitro and in vivo. Biological & pharmaceutical bulletin. vol 35. issue 8. 2012-12-21. PMID:22863927. moreover, the acacetin-treated group inhibited microglia activation, accompanied by production of inducible nitric oxide synthases and cyclooxygenase-2. 2012-12-21 2023-08-12 mouse
Yanji Cui, Jinji Wu, Sung-Cherl Jung, Gi-Ok Kim, Ryeo Kyeong Ko, Hye-Ja Lee, Eun-Sook Yoo, Hee-Kyoung Kang, Kyoungho Suk, Su-Yong Eu. Neuroprotective effect of methyl lucidone against microglia-mediated neurotoxicity. European journal of pharmacology. vol 690. issue 1-3. 2012-12-17. PMID:22683871. methyl lucidone treatment (0.1-10 μm) significantly inhibited lipopolysaccharide (lps, 100 ng/ml, 24 h)-stimulated nitric oxide (no) production in a dose-dependent manner in both primary cortical microglia and bv-2 cell line. 2012-12-17 2023-08-12 Not clear
Ben-Shmuel Sarit, Gera Lajos, Danon Abraham, Apte Ron, Fleisher-Berkovich Siga. Inhibitory role of kinins on microglial nitric oxide and tumor necrosis factor-α production. Peptides. vol 35. issue 2. 2012-11-19. PMID:22490447. brain inflammation is sustained by chronic activation of microglia and the over-production of pro-inflammatory cytokines and nitric oxide (no), which in turn can be highly neurotoxic. 2012-11-19 2023-08-12 rat
Saurabh Khasnavis, Arundhati Jana, Avik Roy, Monalisa Mazumder, Bharat Bhushan, Tony Wood, Supurna Ghosh, Richard Watson, Kalipada Paha. Suppression of nuclear factor-κB activation and inflammation in microglia by physically modified saline. The Journal of biological chemistry. vol 287. issue 35. 2012-11-19. PMID:22753407. rns60, but not normal saline, rns10.3 (tcp-modified saline without excess oxygen), and pns60 (saline containing excess oxygen without tcp modification) were found to inhibit the production of nitric oxide (no) and the expression of inducible no synthase in activated microglia. 2012-11-19 2023-08-12 human
M B Youdim, N Drigues, S Mande. Oxidative stress indices in Parkinson's disease : biochemical determination. Methods in molecular medicine. vol 62. 2012-10-02. PMID:21318773. table 1 biochemical alterations in substantia nigra of parkinson's disease indicating oxidative stress elevated decreased iron (in microglia, astrocytes, oligodendrocytes, and melanized dopamine neurons and mitochondria) gsh (gssg unchanged); gsh/gssg ratio decreased mitochondrial complex i ferritin calcium binding protein (calbindin 28) mitochondrial monoamine oxidase b transferrin and transferrin receptor lipofuscin vitamins e and c ubiquitin copper cu/zn-superoxide dismutase cytotoxic cytokines (tnf-a, il-1, il-6) inflammatory transcription factor nfkb heme oxygenase-1 ratio of oxidized to reduced glutathione (gssg/gsh) nitric oxide neuromelanin. 2012-10-02 2023-08-12 Not clear
M M Gree. Inflammation and the pathophysiology of Alzheimer's disease. Dialogues in clinical neuroscience. vol 2. issue 3. 2012-09-10. PMID:22034457. this paper discusses the evidence for inflammation in ad, and describes the mechanism whereby microglia generate neurotoxic cytokines, reactive oxygen species, and nitric oxide. 2012-09-10 2023-08-12 Not clear
Yan Hua Mou, Jing Yu Yang, Nan Cui, Ji Ming Wang, Yue Hou, Shuang Song, Chun Fu W. Effects of cobalt chloride on nitric oxide and cytokines/chemokines production in microglia. International immunopharmacology. vol 13. issue 1. 2012-09-04. PMID:22472292. effects of cobalt chloride on nitric oxide and cytokines/chemokines production in microglia. 2012-09-04 2023-08-12 mouse
Feng Zhang, Hui Zhou, Belinda C Wilson, Jing-Shan Shi, Jau-Shyong Hong, Hui-Ming Ga. Fluoxetine protects neurons against microglial activation-mediated neurotoxicity. Parkinsonism & related disorders. vol 18 Suppl 1. 2012-08-27. PMID:22166439. fluoxetine significantly inhibited lps-induced activation of microglia and subsequent release of multiple pro-inflammatory and cytotoxic factors including tumor necrosis factor-α, interleukin-1β, nitric oxide, and reactive oxygen species. 2012-08-27 2023-08-12 rat
Jagadeesh S Rao, Matthew Kellom, Hyung-Wook Kim, Stanley I Rapoport, Edmund A Rees. Neuroinflammation and synaptic loss. Neurochemical research. vol 37. issue 5. 2012-08-20. PMID:22311128. in neuroinflammation, activated microglia and astrocytes release cytokines and chemokines as well as nitric oxide, which in turn activate many signal transduction pathways. 2012-08-20 2023-08-12 Not clear
Yuh-Lit Chow, Ka-Heng Lee, Sharmili Vidyadaran, Nordin Haji Lajis, M Nadeem Akhtar, Daud Ahmad Israf, Ahmad Syahid. Cardamonin from Alpinia rafflesiana inhibits inflammatory responses in IFN-γ/LPS-stimulated BV2 microglia via NF-κB signalling pathway. International immunopharmacology. vol 12. issue 4. 2012-08-07. PMID:22306767. in this investigation, cardamonin shows promising anti-inflammatory activity in microglial cell line bv2 by inhibiting the secretion of pro-inflammatory mediators including nitric oxide (no), prostaglandin e(2) (pge(2)), tumour necrosis factor-α (tnf-α), interleukin-1β (il-1β) and interleukin-6 (il-6). 2012-08-07 2023-08-12 Not clear
A M Scarf, C Luus, E Da Pozzo, S Selleri, C Guarino, C Martini, L M Ittner, M Kassio. Evidence for complex binding profiles and species differences at the translocator protein (TSPO) (18 kDa). Current molecular medicine. vol 12. issue 4. 2012-08-03. PMID:22348617. when tested for their effects on pregnenolone production in rat c6 glioma cells, nitric oxide release in murine microglia, and cell proliferation in human mcf-7 breast cancer cells, the pyrrolobenzoxazepines (40 μm) displayed functional effects which did not correlate to the binding trend observed in competition assays. 2012-08-03 2023-08-12 human
Hyo Won Jung, Tae Woo Oh, Jin Ki Jung, Je-Hyun Lee, Gil Jo Shin, Yong-Ki Par. Inhibitory effects of the methylene chloride fraction of JP05 on the production of inflammatory mediators in LPS-activated BV2 microglia. Inflammation. vol 35. issue 1. 2012-07-31. PMID:21505811. excessive production of inflammatory mediators such as nitric oxide (no) and proinflammatory cytokines from activated microglia in the central nervous system contributes to uncontrolled inflammation in neurodegenerative disorders. 2012-07-31 2023-08-12 mouse
Yukihisa Yoshino, Shinichi Yamamoto, Shinichi Kohsaka, Satoru Oshiro, Kazuyuki Nakajim. Superoxide anion contributes to the induction of tumor necrosis factor alpha (TNFα) through activation of the MKK3/6-p38 MAPK cascade in rat microglia. Brain research. vol 1422. 2012-07-31. PMID:21981804. stimulation of rat microglia with lipopolysaccharide (lps) in vitro induces production of the inflammatory/cytotoxic cytokine tumor necrosis factor alpha (tnfα) along with superoxide anion (o(2)(-)) and nitric oxide (no). 2012-07-31 2023-08-12 rat
Yu-Ting Tseng, Ya-Yun Hsu, Yu-Tzu Shih, Yi-Ching L. Paeonol attenuates microglia-mediated inflammation and oxidative stress-induced neurotoxicity in rat primary microglia and cortical neurons. Shock (Augusta, Ga.). vol 37. issue 3. 2012-06-19. PMID:22089194. in lps-treated microglia, paeonol attenuated the overexpression of inducible nitric oxide synthase and cyclooxygenase 2, leading to the decrease in nitric oxide and prostaglandin e2 production, respectively. 2012-06-19 2023-08-12 rat
Min Song, Jia-xiang Xiong, Yan-yan Wang, Jun Tang, Bo Zhang, Yun Ba. VIP enhances phagocytosis of fibrillar beta-amyloid by microglia and attenuates amyloid deposition in the brain of APP/PS1 mice. PloS one. vol 7. issue 2. 2012-06-11. PMID:22328918. in addition, vip suppressed the release of tumor necrosis factor alpha (tnf-α) and nitric oxide (no) from microglia activated by combined treatment with fibrillar aβ42 and low dose interferon-γ (ifn-γ). 2012-06-11 2023-08-12 mouse
Namki Cho, Jungmoo Huh, Heejung Yang, Eun Ju Jeong, Young Choong Kim, Jinwoong Kim, Sang Hyun Sun. Chemical constituents of Polygala tenuifolia roots and their inhibitory activity on lipopolysaccharide-induced nitric oxide production in BV2 microglia. Journal of enzyme inhibition and medicinal chemistry. vol 27. issue 1. 2012-05-29. PMID:21740104. chemical constituents of polygala tenuifolia roots and their inhibitory activity on lipopolysaccharide-induced nitric oxide production in bv2 microglia. 2012-05-29 2023-08-12 Not clear
Namki Cho, Jungmoo Huh, Heejung Yang, Eun Ju Jeong, Young Choong Kim, Jinwoong Kim, Sang Hyun Sun. Chemical constituents of Polygala tenuifolia roots and their inhibitory activity on lipopolysaccharide-induced nitric oxide production in BV2 microglia. Journal of enzyme inhibition and medicinal chemistry. vol 27. issue 1. 2012-05-29. PMID:21740104. a methanolic extract of the roots of polygala tenuifolia (polygalaceae) significantly attenuated nitric oxide (no) production in lipopolysaccharide (lps)-stimulated bv2 microglia cells. 2012-05-29 2023-08-12 Not clear
Bijay Parajuli, Yoshifumi Sonobe, Jun Kawanokuchi, Yukiko Doi, Mariko Noda, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumur. Immunoglobulin G(1) immune complex upregulates interferon-γ-induced nitric oxide production via ERK1/2 activation in murine microglia. Journal of neuroimmunology. vol 244. issue 1-2. 2012-05-08. PMID:22306300. immunoglobulin g(1) immune complex upregulates interferon-γ-induced nitric oxide production via erk1/2 activation in murine microglia. 2012-05-08 2023-08-12 Not clear