| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bijay Parajuli, Yoshifumi Sonobe, Jun Kawanokuchi, Yukiko Doi, Mariko Noda, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumur. Immunoglobulin G(1) immune complex upregulates interferon-γ-induced nitric oxide production via ERK1/2 activation in murine microglia. Journal of neuroimmunology. vol 244. issue 1-2. 2012-05-08. PMID:22306300. |
igg(1) immune complexes increased nitric oxide production in murine microglia in the presence of interferon (ifn)-γ. |
2012-05-08 |
2023-08-12 |
Not clear |
| Celia A Dodd, Nikolay M Filipo. Manganese potentiates LPS-induced heme-oxygenase 1 in microglia but not dopaminergic cells: role in controlling microglial hydrogen peroxide and inflammatory cytokine output. Neurotoxicology. vol 32. issue 6. 2012-05-02. PMID:21963524. |
in microglia, mn increases hydrogen peroxide (h(2)o(2)) release and potentiates lipopolysaccharide (lps)-induced cytokines (tnf-α, il-6) and nitric oxide (no). |
2012-05-02 |
2023-08-12 |
Not clear |
| Xian-jin Zhu, Yan-fang Song, Qiu-yu Zhang, Ying-ping Cao, Wei-qun Xu, Dong-hui S. [Effects of fractalkine on the expression of inflammatory substances in LPS-activated microglia cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 27. issue 12. 2012-03-22. PMID:22152809. |
to investigate the effect of fractalkine on the expression of the tumor necrosis factor-α(tnf-α), interleukin-1β (il-1β), and nitric oxide (no) in lps-activated murine microglia cells line n9. |
2012-03-22 |
2023-08-12 |
Not clear |
| Ki Hyun Kim, Sang Keun Ha, Sang Un Choi, Sun Yeou Kim, Kang Ro Le. Bioactive phenolic constituents from the seeds of Pharbitis nil. Chemical & pharmaceutical bulletin. vol 59. issue 11. 2012-03-01. PMID:22041085. |
in addition, compounds 11, 12 and 24 potently inhibited nitric oxide (no) production in lipopolysaccharide (lps)-activated bv-2 cells, a microglia cells with ic(50) values ranging from 14.7 to 19.9 µm. |
2012-03-01 |
2023-08-12 |
human |
| Shuxian Hu, Wen S Sheng, Robert Bryan Roc. Immunomodulatory properties of kappa opioids and synthetic cannabinoids in HIV-1 neuropathogenesis. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 6. issue 4. 2012-02-29. PMID:21850403. |
based upon findings that synthetic cannabinoids inhibit hiv-1 expression in human microglia and suppress production of inflammatory mediators such as nitric oxide (no) in human astrocytes, as well as a substantial literature demonstrating neuroprotective properties of cannabinoids in other systems, synthetic cannabinoids have also emerged as potential therapeutic agents in hiv neuropathogenesis. |
2012-02-29 |
2023-08-12 |
human |
| Satoko Yasuoka, Jun Kawanokuchi, Bijay Parajuli, Shijie Jin, Yukiko Doi, Mariko Noda, Yoshifumi Sonobe, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumur. Production and functions of IL-33 in the central nervous system. Brain research. vol 1385. 2012-02-14. PMID:21349253. |
it also enhances chemokines and nitric oxide production and phagocytosis by microglia. |
2012-02-14 |
2023-08-12 |
Not clear |
| Ludmila A Voloboueva, Rona G Giffar. Inflammation, mitochondria, and the inhibition of adult neurogenesis. Journal of neuroscience research. vol 89. issue 12. 2012-01-23. PMID:21910136. |
activated microglia produce a variety of proinflammatory factors, including interleukin-6, tumor necrosis factor-α, reactive oxygen species, and nitric oxide, all of which are antineurogenic. |
2012-01-23 |
2023-08-12 |
Not clear |
| Q Cao, C Kaur, C-Y Wu, J Lu, E-A Lin. Nuclear factor-kappa β regulates Notch signaling in production of proinflammatory cytokines and nitric oxide in murine BV-2 microglial cells. Neuroscience. vol 192. 2012-01-18. PMID:21729740. |
we reported previously that enhanced notch-1 expression in activated microglia modulates production of proinflammatory cytokines and nitric oxide (no). |
2012-01-18 |
2023-08-12 |
Not clear |
| Hirokazu Hara, Yoko Nakamura, Masayuki Ninomiya, Ryosuke Mochizuki, Tetsuro Kamiya, Elias Aizenman, Mamoru Koketsu, Tetsuo Adach. Inhibitory effects of chalcone glycosides isolated from Brassica rapa L. 'hidabeni' and their synthetic derivatives on LPS-induced NO production in microglia. Bioorganic & medicinal chemistry. vol 19. issue 18. 2012-01-10. PMID:21856162. |
activation of microglia induces the production of various inflammatory mediators including nitric oxide (no), leading to neurodegeneration in many central nervous system diseases. |
2012-01-10 |
2023-08-12 |
rat |
| Ki Hyun Kim, Ho Kyung Kim, Sang Un Choi, Eunjung Moon, Sun Yeou Kim, Kang Ro Le. Bioactive lignans from the rhizomes of Acorus gramineus. Journal of natural products. vol 74. issue 10. 2012-01-09. PMID:21936523. |
moreover, compounds 1-12 were evaluated for their inhibitory activities on nitric oxide production in an activated murine microglial cell line. |
2012-01-09 |
2023-08-12 |
Not clear |
| Helisoa Razafimanjato, Amal Benzaria, Nadira Taïeb, Xiao-Jun Guo, Nicolas Vidal, Coralie Di Scala, Karine Varini, Marc Maresc. The ribotoxin deoxynivalenol affects the viability and functions of glial cells. Glia. vol 59. issue 11. 2012-01-06. PMID:21748807. |
thus, don caused a biphasic effect on the neuroinflammatory response of microglia to lipopolysaccharide (lps), while sublethal doses of don increased the lps-induced secretion of tnf-α and nitric oxide, toxic doses inhibited it. |
2012-01-06 |
2023-08-12 |
human |
| Vlad A Ionescu, Erika B Villanueva, Sadayuki Hashioka, Manpreet Bahniwal, Andis Klegeri. Cultured adult porcine astrocytes and microglia express functional interferon-γ receptors and exhibit toxicity towards SH-SY5Y cells. Brain research bulletin. vol 84. issue 3. 2012-01-03. PMID:21185917. |
upon such stimulation with lipopolysaccharide (lps) and interferon-γ (ifn-γ), adult porcine microglia, but not astrocytes, secrete tumor necrosis factor-α (tnf-α) while both cell types do not secrete detectable levels of nitric oxide (no). |
2012-01-03 |
2023-08-12 |
human |
| Andrew D Kraft, G Jean Harr. Features of microglia and neuroinflammation relevant to environmental exposure and neurotoxicity. International journal of environmental research and public health. vol 8. issue 7. 2011-12-19. PMID:21845170. |
in culture, microglia have been shown to be capable of releasing several potentially cytotoxic substances, such as reactive oxygen intermediates, nitric oxide, proteases, arachidonic acid derivatives, excitatory amino acids, and cytokines; however, they also produce various neurotrophic factors and quench damage from free radicals and excitotoxins. |
2011-12-19 |
2023-08-12 |
Not clear |
| Shi Wei Tan, Rajesh Ramasamy, Maha Abdullah, Sharmili Vidyadara. Inhibitory effects of palm α-, γ- and δ-tocotrienol on lipopolysaccharide-induced nitric oxide production in BV2 microglia. Cellular immunology. vol 271. issue 2. 2011-12-02. PMID:21839427. |
inhibitory effects of palm α-, γ- and δ-tocotrienol on lipopolysaccharide-induced nitric oxide production in bv2 microglia. |
2011-12-02 |
2023-08-12 |
Not clear |
| Shi Wei Tan, Rajesh Ramasamy, Maha Abdullah, Sharmili Vidyadara. Inhibitory effects of palm α-, γ- and δ-tocotrienol on lipopolysaccharide-induced nitric oxide production in BV2 microglia. Cellular immunology. vol 271. issue 2. 2011-12-02. PMID:21839427. |
here, we screened palm α-, γ- and δ-tocotrienol isoforms and tocomin® 50% (contains spectrum of tocotrienols and tocopherols) for their ability to limit nitric oxide (no) production by bv2 microglia. |
2011-12-02 |
2023-08-12 |
Not clear |
| Wei Zhang, Kester Phillips, Albert R Wielgus, Jie Liu, Alberto Albertini, Fabio A Zucca, Rudolph Faust, Steven Y Qian, David S Miller, Colin F Chignell, Belinda Wilson, Vernice Jackson-Lewis, Serge Przedborski, Danielle Joset, John Loike, Jau-Shyong Hong, David Sulzer, Luigi Zecc. Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease. Neurotoxicity research. vol 19. issue 1. 2011-11-08. PMID:19957214. |
although nm particles are phagocytized and degraded by microglia within minutes in vitro, extracellular nm particles induce microglial activation and ensuing production of superoxide, nitric oxide, hydrogen peroxide (h₂o₂), and pro-inflammatory factors. |
2011-11-08 |
2023-08-12 |
mouse |
| Hoon-Ji Jung, Kyong Nyon Nam, Min-Sook Son, Hee Kang, Joung-Woo Hong, Jong Woo Kim, Eunjoo H Le. Indirubin-3'-oxime inhibits inflammatory activation of rat brain microglia. Neuroscience letters. vol 487. issue 2. 2011-11-08. PMID:20946938. |
indirubin-3'-oxime was shown to effectively inhibit lipopolysaccharide (lps)-induced nitric oxide release from cultured rat brain microglia. |
2011-11-08 |
2023-08-12 |
rat |
| Takahiro A Kato, Akira Monji, Keiji Yasukawa, Yoshito Mizoguchi, Hideki Horikawa, Yoshihiro Seki, Sadayuki Hashioka, Youn-Hee Han, Mina Kasai, Noriyuki Sonoda, Eiichi Hirata, Yasutaka Maeda, Toyoshi Inoguchi, Hideo Utsumi, Shigenobu Kanb. Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: implication for antioxidative psychotropic actions via microglia. Schizophrenia research. vol 129. issue 2-3. 2011-10-13. PMID:21497059. |
we previously demonstrated that atypical antipsychotics including aripiprazole significantly inhibited the release of nitric oxide and proinflammatory cytokines from interferon-γ-stimulated microglia in vitro. |
2011-10-13 |
2023-08-12 |
Not clear |
| Adam C Vana, Shihe Li, Rachel Ribeiro, Flaubert Tchantchou, Yumin Zhan. Arachidonyl trifluoromethyl ketone ameliorates experimental autoimmune encephalomyelitis via blocking peroxynitrite formation in mouse spinal cord white matter. Experimental neurology. vol 231. issue 1. 2011-10-13. PMID:21683698. |
aacocf3 significantly attenuated inos induction, nitric oxide production and the generation of reactive oxygen species in reactive microglia. |
2011-10-13 |
2023-08-12 |
mouse |
| T A Kato, A Monji, Y Mizoguchi, S Hashioka, H Horikawa, Y Seki, M Kasai, H Utsumi, S Kanb. Anti-Inflammatory properties of antipsychotics via microglia modulations: are antipsychotics a 'fire extinguisher' in the brain of schizophrenia? Mini reviews in medicinal chemistry. vol 11. issue 7. 2011-10-06. PMID:21699487. |
microglia, major sources of various inflammatory cytokines and free radicals such as superoxide and nitric oxide (no) in the cns, play a crucial role in a variety of neurodegenerative diseases such as dementia. |
2011-10-06 |
2023-08-12 |
Not clear |