| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Clotilde Lauro, Raffaela Cipriani, Myriam Catalano, Flavia Trettel, Giuseppina Chece, Valentina Brusadin, Letizia Antonilli, Nico van Rooijen, Fabrizio Eusebi, Bertil B Fredholm, Cristina Limatol. Adenosine A1 receptors and microglial cells mediate CX3CL1-induced protection of hippocampal neurons against Glu-induced death. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 7. 2010-07-09. PMID:20200508. |
cx3cl1/cx3cr1 interaction modulates the release of cytokines from microglia, reducing the level of tumor necrosis factor-alpha, interleukin-1-beta, and nitric oxide and induces the production of neurotrophic substances, both in vivo and in vitro. |
2010-07-09 |
2023-08-12 |
mouse |
| Ji Sun Kim, Jae Yeon Kim, Hwa Jin Lee, Hyo Jin Lim, Da Yeon Lee, Do Hee Kim, Jae-Ha Ry. Suppression of inducible nitric oxide synthase expression by furfuran lignans from flower buds of Magnolia fargesii in BV-2 microglial cells. Phytotherapy research : PTR. vol 24. issue 5. 2010-06-28. PMID:19943243. |
activated microglia produces diverse neurotoxic factors such as nitric oxide (no) and tumor necrosis factor-alpha that serve as apoptotic inducers resulting in various neurodegenerative diseases. |
2010-06-28 |
2023-08-12 |
Not clear |
| Moonhee Lee, Valerio Tazzari, Daniela Giustarini, Ranieri Rossi, Anna Sparatore, Piero Del Soldato, Edith McGeer, Patrick L McGee. Effects of hydrogen sulfide-releasing L-DOPA derivatives on glial activation: potential for treating Parkinson disease. The Journal of biological chemistry. vol 285. issue 23. 2010-06-24. PMID:20368333. |
the donating agents and the l-dopa hybrids reduced the release of tumor necrosis factor-alpha, interleukin-6, and nitric oxide from stimulated microglia, astrocytes as well as the thp-1 and u373 cell lines. |
2010-06-24 |
2023-08-12 |
human |
| Dan Yuan, Bin Ma, Jing-yu Yang, Yuan-yuan Xie, Li Wang, Li-jia Zhang, Yoshihiro Kano, Chun-fu W. Anti-inflammatory effects of rhynchophylline and isorhynchophylline in mouse N9 microglial cells and the molecular mechanism. International immunopharmacology. vol 9. issue 13-14. 2010-06-22. PMID:19781666. |
excessive production of nitric oxide (no) and proinflammatory cytokines from activated microglia contributes to human neurodegenerative disorders. |
2010-06-22 |
2023-08-12 |
mouse |
| David R Wallac. HIV neurotoxicity: potential therapeutic interventions. Journal of biomedicine & biotechnology. vol 2006. issue 3. 2010-06-10. PMID:17047310. |
the glutamatergic system, nitric oxide, calcium, oxidative stress, apoptosis, and microglia have all been implicated in the pathogenesis of hiv-related neuronal degeneration. |
2010-06-10 |
2023-08-12 |
human |
| Lijia Zhang, Chunfu Wu, Siqi Zhao, Dan Yuan, Guoning Lian, Xiaoxiao Wang, Lihui Wang, Jingyu Yan. Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-kappaB signaling pathways in N9 microglia induced by lipopolysaccharide. International immunopharmacology. vol 10. issue 3. 2010-06-02. PMID:20018257. |
our previous report has showed that demethoxycurcumin (dmc), a natural derivative of curcumin (cur), exhibited stronger inhibitory activity on nitric oxide (no) and tumor necrosis factor-alpha (tnf-alpha) production compared with cur in lipopolysaccharide (lps) activated rat primary microglia. |
2010-06-02 |
2023-08-12 |
rat |
| Neville N Osborn. Mitochondria: Their role in ganglion cell death and survival in primary open angle glaucoma. Experimental eye research. vol 90. issue 6. 2010-05-27. PMID:20359479. |
other insults to the ganglion cells might come from substances such as glutamate, prostaglandins and nitric oxide released from astrocytes and microglia in the optic nerve head region. |
2010-05-27 |
2023-08-12 |
Not clear |
| Shuei Sugama, Takato Takenouchi, Byung P Cho, Tong H Joh, Makoto Hashimoto, Hiroshi Kitan. Possible roles of microglial cells for neurotoxicity in clinical neurodegenerative diseases and experimental animal models. Inflammation & allergy drug targets. vol 8. issue 4. 2010-05-13. PMID:19754411. |
the contribution of microglial cells to these neurodegenerative disorders is supported by findings in animal experiments: (1) microglial activation precedes the neurodegenerative changes; (2) activated microglia surround the region that undergo neurodegeneration and phagocytose the degenerating cells; (3) activated microglia release neurotoxic molecules such as interleukin(il)-1beta, il-6, tnf-alpha, nitric oxide, reactive oxygen species; (4) inhibition of microglial activation leads to the amelioration of neurodegeneration, (5) microglia derived from aged animal exert more toxicity to neurons in an age-dependent fashion, in the same way neurodegenerative disorders occur. |
2010-05-13 |
2023-08-12 |
human |
| Sun Hong Park, Jong Soon Kang, Yeo Dae Yoon, Kiho Lee, Kang-Jeon Kim, Ki Hoon Lee, Chang Woo Lee, Eun-Yi Moon, Sang-Bae Han, Bong Hee Kim, Hwan Mook Kim, Song-Kyu Par. Glabridin inhibits lipopolysaccharide-induced activation of a microglial cell line, BV-2, by blocking NF-kappaB and AP-1. Phytotherapy research : PTR. vol 24 Suppl 1. 2010-05-10. PMID:19455572. |
glabridin dose-dependently attenuated lipopolysaccharide (lps)-induced production of inflammatory mediators, including nitric oxide, tumor necrosis factor-alpha and interleukin-1beta, in bv-2 cells, a murine microglia cell line. |
2010-05-10 |
2023-08-12 |
Not clear |
| Ki Hyun Kim, Jung Wook Choi, Sang Keun Ha, Sun Yeou Kim, Kang Ro Le. Neolignans from Piper kadsura and their anti-neuroinflammatory activity. Bioorganic & medicinal chemistry letters. vol 20. issue 1. 2010-05-06. PMID:19900811. |
the anti-neuroinflammatory activities of these compounds were evaluated by assessing nitric oxide (no) production in lps-activated bv-2 cells, a microglia cell line. |
2010-05-06 |
2023-08-12 |
Not clear |
| Yiner Wang, Harald Neuman. Alleviation of neurotoxicity by microglial human Siglec-11. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 9. 2010-05-05. PMID:20203208. |
stimulation of siglec-11 by cross-linking suppressed the lipopolysaccharides (lps)-induced gene transcription of the proinflammatory mediators interleukin-1beta and nitric oxide synthase-2 in microglia. |
2010-05-05 |
2023-08-12 |
human |
| D Nayak, Y Huo, W X T Kwang, P N Pushparaj, S D Kumar, E-A Ling, S T Dhee. Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia. Neuroscience. vol 166. issue 1. 2010-05-04. PMID:20036321. |
sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia. |
2010-05-04 |
2023-08-12 |
mouse |
| D Nayak, Y Huo, W X T Kwang, P N Pushparaj, S D Kumar, E-A Ling, S T Dhee. Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia. Neuroscience. vol 166. issue 1. 2010-05-04. PMID:20036321. |
in this study, we demonstrate that sphingosine kinase1 (sphk1), a key enzyme of the sphingolipid metabolic pathway, and its receptors are expressed in the mouse bv2 microglial cells and sphk1 alters the expression and production of proinflammatory cytokines and nitric oxide in microglia treated with lipopolysaccharide (lps). |
2010-05-04 |
2023-08-12 |
mouse |
| D Nayak, Y Huo, W X T Kwang, P N Pushparaj, S D Kumar, E-A Ling, S T Dhee. Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia. Neuroscience. vol 166. issue 1. 2010-05-04. PMID:20036321. |
suppression of sphk1 by its inhibitor, n, n dimethylsphingosine (dms), or sirna resulted in decreased mrna expression of tnf-alpha, il-1beta, and inos and release of tnf-alpha and nitric oxide (no) in lps-activated microglia. |
2010-05-04 |
2023-08-12 |
mouse |
| Hyunsu Bae, Hye-Jeoung Kim, Minkyu Shin, Hyejung Lee, Chang Shik Yin, Jehyeon Ra, Jinju Ki. Inhibitory effect of Agrimoniae Herba on lipopolysaccharide-induced nitric oxide and proinflammatory cytokine production in BV2 microglial cells. Neurological research. vol 32 Suppl 1. 2010-04-29. PMID:20034446. |
nitric oxide and proinflammatory cytokines produced by activated microglia may be a possible etiological factor of neurodegenerative disorders. |
2010-04-29 |
2023-08-12 |
Not clear |
| Dan Yuan, Yuan-Yuan Xie, Xue Bai, Xia Wu, Jing-Yu Yang, Chun-Fu W. Inhibitory activity of isoflavones of Pueraria flowers on nitric oxide production from lipopolysaccharide-activated primary rat microglia. Journal of Asian natural products research. vol 11. issue 6. 2010-03-23. PMID:20183278. |
inhibitory activity of isoflavones of pueraria flowers on nitric oxide production from lipopolysaccharide-activated primary rat microglia. |
2010-03-23 |
2023-08-12 |
rat |
| Dan Yuan, Yuan-Yuan Xie, Xue Bai, Xia Wu, Jing-Yu Yang, Chun-Fu W. Inhibitory activity of isoflavones of Pueraria flowers on nitric oxide production from lipopolysaccharide-activated primary rat microglia. Journal of Asian natural products research. vol 11. issue 6. 2010-03-23. PMID:20183278. |
compounds 3-5 substantially inhibited the lipopolysaccharide-induced nitric oxide release from primary cultured rat cortical microglia (ic50: 1.3-9.3 microm). |
2010-03-23 |
2023-08-12 |
rat |
| Tsung-Kuei Kao, Yen-Chuan Ou, Shue-Ling Raung, Ching-Yi Lai, Su-Lan Liao, Chun-Jung Che. Inhibition of nitric oxide production by quercetin in endotoxin/cytokine-stimulated microglia. Life sciences. vol 86. issue 9-10. 2010-03-18. PMID:20060843. |
inhibition of nitric oxide production by quercetin in endotoxin/cytokine-stimulated microglia. |
2010-03-18 |
2023-08-12 |
Not clear |
| Sadanand Gaikwad, Sergey Larionov, Yiner Wang, Holger Dannenberg, Takashi Matozaki, Alon Monsonego, Dietmar R Thal, Harald Neuman. Signal regulatory protein-beta1: a microglial modulator of phagocytosis in Alzheimer's disease. The American journal of pathology. vol 175. issue 6. 2010-02-25. PMID:19893026. |
activation of sirpbeta1 on cultured microglia by cross-linking antibodies induced reorganization of the cytoskeleton protein beta-actin and suppressed lipopolysaccharide-induced gene transcription of tumor necrosis factor-alpha and nitric oxide synthase-2. |
2010-02-25 |
2023-08-12 |
mouse |
| Ping Zhang, Kyle M Lokuta, Deanne E Turner, Bin Li. Synergistic dopaminergic neurotoxicity of manganese and lipopolysaccharide: differential involvement of microglia and astroglia. Journal of neurochemistry. vol 112. issue 2. 2010-02-05. PMID:19895668. |
mncl2 and lps were more effective in inducing the formation of reactive oxygen species and nitric oxide in microglia than in astroglia. |
2010-02-05 |
2023-08-12 |
rat |