| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyong Nyon Nam, Hoon-Ji Jung, Mi-Hyun Kim, Chulhun Kang, Woo-Sang Jung, Ki-Ho Cho, Eunjoo H Le. Chunghyuldan attenuates brain microglial inflammatory response. Canadian journal of physiology and pharmacology. vol 87. issue 6. 2010-01-28. PMID:19526039. |
chunghyuldan was effective at inhibiting lps-induced nitric oxide (no) release from rat brain microglia. |
2010-01-28 |
2023-08-12 |
rat |
| Henrik Wilms, Thorsten Schwark, Lars-Ove Brandenburg, Jobst Sievers, Reinhard Dengler, Günther Deuschl, Ralph Luciu. Regulation of activin A synthesis in microglial cells: pathophysiological implications for bacterial meningitis. Journal of neuroscience research. vol 88. issue 1. 2010-01-26. PMID:19681171. |
further studies showed that activin enhances microglial proliferation and decreases the gamma-interferon-induced synthesis of nitric oxide, one of several microglial mediators involved in the inflammatory response in microglia activation. |
2010-01-26 |
2023-08-12 |
rat |
| Jiyeon Ock, Sangseop Kim, Kyu-Yang Yi, Nak-Jung Kim, Hyung Soo Han, Je-Yoel Cho, Kyoungho Su. A novel anti-neuroinflammatory pyridylimidazole compound KR-31360. Biochemical pharmacology. vol 79. issue 4. 2010-01-19. PMID:19800321. |
since nitric oxide (no) is one of the major inflammatory mediators that are produced by activated microglia, inhibitory effects of novel synthetic compounds on microglial no production were investigated. |
2010-01-19 |
2023-08-12 |
mouse |
| Xinying Yang, Lin Du, Xuelian Tang, Suk-Yul Jung, Bing Zheng, Byoung Yul Soh, Sung-Yeon Kim, Qianqun Gu, Hyun Par. Brevicompanine E reduces lipopolysaccharide-induced production of proinflammatory cytokines and enzymes in microglia by inhibiting activation of activator protein-1 and nuclear factor-kappaB. Journal of neuroimmunology. vol 216. issue 1-2. 2010-01-11. PMID:19815299. |
we found that brevicompanine e (be), isolated from a deep ocean sediment derived fungus penicillium sp., inhibited lipopolysaccharide (lps)-induced tumor necrosis factor-alpha (tnf-alpha), interleukin-1beta (il-1beta), inducible nitric oxide (inos) and cyclooxygenase-2 (cox-2) production in microglia. |
2010-01-11 |
2023-08-12 |
Not clear |
| Yukiko Doi, Tetsuya Mizuno, Yuki Maki, Shijie Jin, Hiroyuki Mizoguchi, Masayoshi Ikeyama, Minoru Doi, Makoto Michikawa, Hideyuki Takeuchi, Akio Suzumur. Microglia activated with the toll-like receptor 9 ligand CpG attenuate oligomeric amyloid {beta} neurotoxicity in in vitro and in vivo models of Alzheimer's disease. The American journal of pathology. vol 175. issue 5. 2010-01-11. PMID:19834064. |
cpg enhanced microglial clearance of oabeta1-42 and induced higher levels of the antioxidant enzyme heme oxygenase-1 in microglia without producing neurotoxic molecules such as nitric oxide and glutamate. |
2010-01-11 |
2023-08-12 |
mouse |
| So-Young Hwang, Byong-Chul Yoo, Jae-won Jung, Eok-Soo Oh, Ji-Sun Hwang, Jin-A Shin, Song-Yi Kim, Seok-Ho Cha, Inn-Oc Ha. Induction of glioma apoptosis by microglia-secreted molecules: The role of nitric oxide and cathepsin B. Biochimica et biophysica acta. vol 1793. issue 11. 2009-12-23. PMID:19748528. |
induction of glioma apoptosis by microglia-secreted molecules: the role of nitric oxide and cathepsin b. microglia contributes significantly to brain tumor mass, particularly in astrocytic gliomas. |
2009-12-23 |
2023-08-12 |
rat |
| Isabella Napoli, Katrin Kierdorf, Harald Neuman. Microglial precursors derived from mouse embryonic stem cells. Glia. vol 57. issue 15. 2009-12-09. PMID:19455585. |
stimulation with interferon-gamma or lipopolysaccharide (lps) demonstrated upregulation of proinflammatory cytokine gene transcription including nitric oxide synthase-2, interleukin-1beta, and tumor necrosis factor-alpha at levels comparable to primary microglia. |
2009-12-09 |
2023-08-12 |
mouse |
| Min Qiao, Shuzhen Meng, Tadeusz Foniok, Ursula I Tuo. Mild cerebral hypoxia-ischemia produces a sub-acute transient inflammatory response that is less selective and prolonged after a substantial insult. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 27. issue 7. 2009-12-01. PMID:19631731. |
cerebral ischemia initiates various injurious processes including neuroinflammatory responses such as activation of microglia and increases in cytokine and nitric oxide release. |
2009-12-01 |
2023-08-12 |
Not clear |
| Youngnam Jin, In Young Choi, Chunsook Kim, Suyoung Hong, Won-Ki Ki. Excretory-secretory products from Paragonimus westermani increase nitric oxide production in microglia in PKC-dependent and -independent manners. Neuroscience research. vol 65. issue 2. 2009-11-13. PMID:19539668. |
excretory-secretory products from paragonimus westermani increase nitric oxide production in microglia in pkc-dependent and -independent manners. |
2009-11-13 |
2023-08-12 |
Not clear |
| Cinzia Dello Russo, Lucia Lisi, Giuseppe Tringali, Pierluigi Navarr. Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation. Biochemical pharmacology. vol 78. issue 9. 2009-11-10. PMID:19576187. |
microglia contribute to initiating and maintaining brain inflammation, and once activated release pro-inflammatory mediators potentially cytotoxic, like nitric oxide (no). |
2009-11-10 |
2023-08-12 |
rat |
| Ki Hyun Kim, Il Kyun Lee, Kyung Ran Kim, Sang Keun Ha, Sun Yeou Kim, Kang Ro Le. New benzamide derivatives and NO production inhibitory compounds from Limonia acidissima. Planta medica. vol 75. issue 10. 2009-11-09. PMID:19343623. |
among the isolates, 13 alpha,14 beta,17 alpha-lanosta-7,9,24-triene-3 beta,16 alpha-diol (8), 4-methoxy-1-methyl-2(1 h)-quinolinone (10), and 13 alpha,14 beta,17 alpha-lanosta-7,24-diene-3 beta,11 beta,16 alpha-triol (13) potently inhibited nitric oxide (no) production in microglia cells. |
2009-11-09 |
2023-08-12 |
Not clear |
| Hung-Ming Wu, Nian-Sheng Tzeng, Li Qian, Sung-Jen Wei, Xiaoming Hu, Shih-Heng Chen, Scott M Rawls, Patrick Flood, Jau-Shyong Hong, Ru-Band L. Novel neuroprotective mechanisms of memantine: increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial activation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 10. 2009-10-29. PMID:19536110. |
in addition, memantine also displays neuroprotective effects against lps-induced da neuronal damage through its inhibition of microglia activation showed by both ox-42 immunostaining and reduction of pro-inflammatory factor production, such as extracellular superoxide anion, intracellular reactive oxygen species, nitric oxide, prostaglandin e(2), and tumor necrosis factor-alpha. |
2009-10-29 |
2023-08-12 |
rat |
| Wen-Juan Duan, Jing-Yu Yang, Li-Xia Chen, Li-Jia Zhang, Zhi-Hu Jiang, Xu-Dong Cai, Xue Zhang, Feng Qi. Monoterpenes from Paeonia albiflora and their inhibitory activity on nitric oxide production by lipopolysaccharide-activated microglia. Journal of natural products. vol 72. issue 9. 2009-10-21. PMID:19691309. |
monoterpenes from paeonia albiflora and their inhibitory activity on nitric oxide production by lipopolysaccharide-activated microglia. |
2009-10-21 |
2023-08-12 |
Not clear |
| Wen-Juan Duan, Jing-Yu Yang, Li-Xia Chen, Li-Jia Zhang, Zhi-Hu Jiang, Xu-Dong Cai, Xue Zhang, Feng Qi. Monoterpenes from Paeonia albiflora and their inhibitory activity on nitric oxide production by lipopolysaccharide-activated microglia. Journal of natural products. vol 72. issue 9. 2009-10-21. PMID:19691309. |
the inhibitory effects of the isolated compounds on nitric oxide production by lipopolysaccharide (lps)-activated n9 microglia were evaluated. |
2009-10-21 |
2023-08-12 |
Not clear |
| Heather Klintworth, Gwenn Garden, Zhengui Xi. Rotenone and paraquat do not directly activate microglia or induce inflammatory cytokine release. Neuroscience letters. vol 462. issue 1. 2009-10-07. PMID:19559752. |
microglia activation was analyzed by morphological changes and release of nitric oxide and inflammatory cytokines. |
2009-10-07 |
2023-08-12 |
Not clear |
| Katrine Kjaer, Dorte Strøbaek, Palle Christophersen, Lars Christian Biilmann Røn. Chloride channel blockers inhibit iNOS expression and NO production in IFNgamma-stimulated microglial BV2 cells. Brain research. vol 1281. 2009-09-30. PMID:19446535. |
among other factors, activated microglia produce nitric oxide (no), which is toxic to neurons and excessive microglial activation and no production contribute to the pathology of neurodegenerative diseases. |
2009-09-30 |
2023-08-12 |
Not clear |
| Guo Nan Yin, Hyejin Jeon, Shinrye Lee, Ho Won Lee, Je-Yoel Cho, Kyoungho Su. Role of soluble CD14 in cerebrospinal fluid as a regulator of glial functions. Journal of neuroscience research. vol 87. issue 11. 2009-09-21. PMID:19360901. |
soluble cd14 inhibited lipopolysaccharide (lps)- or lps/interferon-gamma-induced nitric oxide production and cell death of microglia and astrocytes. |
2009-09-21 |
2023-08-12 |
human |
| Hiroshi Katsuki, Emi Kurimoto, Sachiko Takemori, Yuki Kurauchi, Akinori Hisatsune, Yoichiro Isohama, Yasuhiko Izumi, Toshiaki Kume, Koichi Shudo, Akinori Akaik. Retinoic acid receptor stimulation protects midbrain dopaminergic neurons from inflammatory degeneration via BDNF-mediated signaling. Journal of neurochemistry. vol 110. issue 2. 2009-07-31. PMID:19457078. |
am80 protected dopaminergic neurons in rat midbrain slice culture from injury mediated by lipopolysaccharide-activated microglia, without affecting production of nitric oxide, a key mediator of cell injury. |
2009-07-31 |
2023-08-12 |
mouse |
| Henrik Wilms, Boris Schwabedissen, Jobst Sievers, Ralph Luciu. Erythropoietin does not attenuate cytokine production and inflammation in microglia--implications for the neuroprotective effect of erythropoietin in neurological diseases. Journal of neuroimmunology. vol 212. issue 1-2. 2009-07-31. PMID:19464738. |
since this pathology is associated with glial cell activation and release of cytotoxic molecules, we investigated the expression of epo receptors (epo-r) and effects of erythropoietin on microglial cell functions in vitro using rt-pcr, western immunoblotting, nitric oxide measurement, tumor necrosis factor-alpha-(tnf-alpha)-elisa and gel shift assay analyses. |
2009-07-31 |
2023-08-12 |
rat |
| Hyo Won Jung, Cheol-Ho Yoon, Kwon Moo Park, Hyung Soo Han, Yong-Ki Par. Hexane fraction of Zingiberis Rhizoma Crudus extract inhibits the production of nitric oxide and proinflammatory cytokines in LPS-stimulated BV2 microglial cells via the NF-kappaB pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 47. issue 6. 2009-07-16. PMID:19233241. |
excessive production of inflammatory mediators such as nitric oxide (no), prostaglandin e(2) (pge2), and proinflammatory cytokines, including tumor necrosis factor-alpha (tnf-alpha) and interleukin-1beta (il-1beta) from activated microglia contributes to uncontrolled inflammation in neurodegenerative diseases. |
2009-07-16 |
2023-08-12 |
mouse |