| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiang Zhang, Chen Chen, Jiagao Lü, Minjie Xie, Dengji Pan, Xiang Luo, Zhiyuan Yu, Qiang Dong, Wei Wan. Cell cycle inhibition attenuates microglial proliferation and production of IL-1beta, MIP-1alpha, and NO after focal cerebral ischemia in the rat. Glia. vol 57. issue 8. 2009-07-09. PMID:19115378. |
using the bv-2 microglia cell line, we showed that roscovitine not only inhibited oxygen-glucose deprivation (ogd) induced cell cycle activation by arresting the cells at g1/s and g2/m in a dose-dependent manner, but it also inhibited interleukin-1 beta (il-1beta), macrophage inflammatory protein-1alpha (mip-1alpha), and nitric oxide (no) production. |
2009-07-09 |
2023-08-12 |
rat |
| Rongtai Wei, Chiao-Mei Li. Strain-dependent inflammatory responsiveness of rat microglial cells. Journal of neuroimmunology. vol 211. issue 1-2. 2009-07-07. PMID:19356804. |
in addition, lew/n microglia exhibited enhanced secretion of tumor necrosis factor-alpha and ccl2, as well as elevated nitric oxide production. |
2009-07-07 |
2023-08-12 |
rat |
| Ana Pocivavsek, Mark P Burns, G William Rebec. Low-density lipoprotein receptors regulate microglial inflammation through c-Jun N-terminal kinase. Glia. vol 57. issue 4. 2009-07-01. PMID:18803301. |
to model glial activation, we treated primary mouse microglia and the microglial cell line bv2 with lipopolysaccharide (lps) and studied two inflammatory responses: an increase in nitric oxide production (no) and a decrease in apoe production. |
2009-07-01 |
2023-08-12 |
mouse |
| Yi Chang, Jie-Jen Lee, Cheng-Ying Hsieh, George Hsiao, Duen-Suey Chou, Joen-Rong She. Inhibitory effects of ketamine on lipopolysaccharide-induced microglial activation. Mediators of inflammation. vol 2009. 2009-06-16. PMID:19343193. |
microglia activated in response to brain injury release neurotoxic factors including nitric oxide (no) and proinflammatory cytokines such as tumor necrosis factor-alpha (tnf-alpha) and interleukin-1beta (il-1beta). |
2009-06-16 |
2023-08-12 |
Not clear |
| C-Y Wu, C Kaur, V Sivakumar, J Lu, E-A Lin. Kv1.1 expression in microglia regulates production and release of proinflammatory cytokines, endothelins and nitric oxide. Neuroscience. vol 158. issue 4. 2009-05-20. PMID:19118603. |
kv1.1 expression in microglia regulates production and release of proinflammatory cytokines, endothelins and nitric oxide. |
2009-05-20 |
2023-08-12 |
rat |
| Yachen Li, Xiaoming Hu, Yuxin Liu, Yongming Bao, Lijia A. Nimodipine protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation. Neuropharmacology. vol 56. issue 3. 2009-05-11. PMID:19049811. |
the neuroprotective effect of nimodipine was attributed to the inhibition of microglial activation, since nimodipine significantly inhibited the production of nitric oxide (no), tumor necrosis factor-alpha (tnf-alpha), interleukin-1beta (il-1beta) and prostaglandin e(2) (pge(2)) from lps-stimulated microglia. |
2009-05-11 |
2023-08-12 |
mouse |
| Jim Bartle. Could glial activation be a factor in migraine? Medical hypotheses. vol 72. issue 3. 2009-04-28. PMID:19036526. |
activated microglia and astrocytes produce and release a variety of neuroexcitatory substances including nitric oxide, excitatory amino acids and proinflammatory cytokines. |
2009-04-28 |
2023-08-12 |
Not clear |
| Y Kurauchi, A Hisatsune, Y Isohama, H Katsuk. Nitric oxide-cyclic GMP signaling pathway limits inflammatory degeneration of midbrain dopaminergic neurons: cell type-specific regulation of heme oxygenase-1 expression. Neuroscience. vol 158. issue 2. 2009-04-15. PMID:18996444. |
excessive production of nitric oxide (no) by microglia is at least in part responsible for the pathogenesis of various neurodegenerative disorders including parkinson disease, but at the same time no may also play a distinct role as a signaling molecule such as an activator of soluble guanylyl cyclase. |
2009-04-15 |
2023-08-12 |
rat |
| Yuanli Duan, Christie L Sahley, Kenneth J Mulle. ATP and NO dually control migration of microglia to nerve lesions. Developmental neurobiology. vol 69. issue 1. 2009-04-15. PMID:19025930. |
previous work on the leech has shown that nitric oxide (no), generated at the lesion, is both a stop signal for microglia at the lesion and crucial for their directed migration from hundreds of micrometers away within the nerve cord, perhaps mediated by a soluble guanylate cyclase (sgc). |
2009-04-15 |
2023-08-12 |
Not clear |
| Li Jia Zhang, Chun Fu Wu, Xue Lian Meng, Dan Yuan, Xu Dong Cai, Qi Long Wang, Jing Yu Yan. Comparison of inhibitory potency of three different curcuminoid pigments on nitric oxide and tumor necrosis factor production of rat primary microglia induced by lipopolysaccharide. Neuroscience letters. vol 447. issue 1. 2009-04-14. PMID:18838107. |
comparison of inhibitory potency of three different curcuminoid pigments on nitric oxide and tumor necrosis factor production of rat primary microglia induced by lipopolysaccharide. |
2009-04-14 |
2023-08-12 |
rat |
| Li Jia Zhang, Chun Fu Wu, Xue Lian Meng, Dan Yuan, Xu Dong Cai, Qi Long Wang, Jing Yu Yan. Comparison of inhibitory potency of three different curcuminoid pigments on nitric oxide and tumor necrosis factor production of rat primary microglia induced by lipopolysaccharide. Neuroscience letters. vol 447. issue 1. 2009-04-14. PMID:18838107. |
in the present study, we found that all of the three curcuminoid pigments significantly suppressed nitric oxide (no) production by lps-activated microglia and the relative potency was dmc>bdmc>cur. |
2009-04-14 |
2023-08-12 |
rat |
| Margalida Mir, Laia Tolosa, Víctor J Asensio, Jerònia Lladó, Gabriel Olmo. Complementary roles of tumor necrosis factor alpha and interferon gamma in inducible microglial nitric oxide generation. Journal of neuroimmunology. vol 204. issue 1-2. 2009-04-09. PMID:18703234. |
proinflammatory cytokines and pathogen components activate microglia to release several substances such as nitric oxide (no) produced after the induction of type ii nitric oxide synthase (inos). |
2009-04-09 |
2023-08-12 |
mouse |
| Katrin Färber, Giselle Cheung, Daniel Mitchell, Russell Wallis, Eberhard Weihe, Wilhelm Schwaeble, Helmut Kettenman. C1q, the recognition subcomponent of the classical pathway of complement, drives microglial activation. Journal of neuroscience research. vol 87. issue 3. 2009-03-31. PMID:18831010. |
a shift toward proinflammatory microglial activation is indicated by the release of interleukin-6, tumor necrosis factor-alpha, and nitric oxide and the oxidative burst in rat primary microglial cells, an activation and differentiation process similar to the proinflammatory response of microglia to exposure to lipopolysaccharide. |
2009-03-31 |
2023-08-12 |
rat |
| Seung Hyun Kim, Sin-Duk Jang, Ki Yong Lee, Sang Hyun Sung, Young Choong Ki. Chemical constituents isolated from Polygala japonica leaves and their inhibitory effect on nitric oxide production in vitro. Journal of enzyme inhibition and medicinal chemistry. vol 24. issue 1. 2009-03-23. PMID:18825536. |
a methanolic extract of dried leaves of polygala japonica houtt (polygalaceae) significantly attenuated nitric oxide production in lipopolysaccharide-simulated bv2 microglia. |
2009-03-23 |
2023-08-12 |
Not clear |
| Seung Hyun Kim, Sin-Duk Jang, Ki Yong Lee, Sang Hyun Sung, Young Choong Ki. Chemical constituents isolated from Polygala japonica leaves and their inhibitory effect on nitric oxide production in vitro. Journal of enzyme inhibition and medicinal chemistry. vol 24. issue 1. 2009-03-23. PMID:18825536. |
among them, compounds 1-4, 6 and 7 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in bv2 microglia at the concentrations ranging from 1.0 to 100.0 microm. |
2009-03-23 |
2023-08-12 |
Not clear |
| Han-Qing Chen, Zheng-Yu Jin, Xi-Jin Wang, Xue-Ming Xu, Li Deng, Jian-Wei Zha. Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation. Neuroscience letters. vol 448. issue 2. 2009-02-27. PMID:18952146. |
moreover, luteolin also significantly inhibited lps-induced activation of microglia and excessive production of tumor necrosis factor-alpha, nitric oxide and superoxide in mesencephalic neuron-glia cultures and microglia-enriched cultures. |
2009-02-27 |
2023-08-12 |
Not clear |
| Soyong Jang, Jae-Chul Jung, Dong Hyun Kim, Jong Hoon Ryu, Yongnam Lee, Mankil Jung, Seikwan O. The neuroprotective effects of benzylideneacetophenone derivatives on excitotoxicity and inflammation via phosphorylated Janus tyrosine kinase 2/phosphorylated signal transducer and activator of transcription 3 and mitogen-activated protein K pathways. The Journal of pharmacology and experimental therapeutics. vol 328. issue 2. 2009-02-23. PMID:18984655. |
all compounds (jc1-jc6) showed considerable effect on free radical scavenging, the inhibition of glutamate-induced neurotoxicity in cortical cells, and the suppression of lipopolysaccharide (lps)-induced nitric oxide (no) generation in microglia. |
2009-02-23 |
2023-08-12 |
mouse |
| Beata Sacha, Susanna Zierler, Seija Lehnardt, Joerg R Weber, Hubert H Kerschbau. Heterogeneous effects of distinct tocopherol analogues on NO release, cell volume, and cell death in microglial cells. Journal of neuroscience research. vol 86. issue 16. 2009-02-19. PMID:18709655. |
in primary murine microglial cells and in the microglial cell line bv-2, alpha-, gamma-, and delta-tocopherol and alpha-tocopherol acid succinate, respectively, promote nitric oxide (no) release. |
2009-02-19 |
2023-08-12 |
Not clear |
| Won-Kyo Jung, Young-Wook Ahn, Sang-Hoon Lee, Yung Hyun Choi, Se-Kwon Kim, Sung Su Yea, Inhak Choi, Sae-Gwang Park, Su-Kil Seo, Soo-Woong Lee, Il-Whan Cho. Ecklonia cava ethanolic extracts inhibit lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in BV2 microglia via the MAP kinase and NF-kappaB pathways. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 47. issue 2. 2009-02-19. PMID:19111593. |
our results indicate that ec inhibits lps-induced nitric oxide (no) and prostaglandin e(2) (pge(2)) production in a concentration-dependent manner and inhibits inducible nitric oxide (inos) and cyclooxygenase (cox)-2 in bv2 microglia without significant cytotoxicity. |
2009-02-19 |
2023-08-12 |
Not clear |
| David L Carbone, Katriana A Popichak, Julie A Moreno, Stephen Safe, Ronald B Tjalken. Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nitric-oxide synthase 2 expression in astrocytes by a novel diindolylmethane analog protects striatal neurons against apoptosis. Molecular pharmacology. vol 75. issue 1. 2009-01-26. PMID:18840677. |
long-term inflammatory activation of microglia and astrocytes plays a central role in the progression of pd and is characterized by activation of the nuclear factor-kappab (nf-kappab) signaling cascade and subsequent overproduction of inflammatory cytokines and nitric oxide (no). |
2009-01-26 |
2023-08-12 |
Not clear |