| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rishika Dhapola, Subhendu Shekhar Hota, Phulen Sarma, Anusuya Bhattacharyya, Bikash Medhi, Dibbanti HariKrishna Redd. Recent advances in molecular pathways and therapeutic implications targeting neuroinflammation for Alzheimer's disease. Inflammopharmacology. vol 29. issue 6. 2021-12-08. PMID:34813026. |
various pathways like nfκb, p38 mapk, akt/mtor, caspase, nitric oxide and cox trigger microglia to release inflammatory cytokines. |
2021-12-08 |
2023-08-13 |
Not clear |
| Pan M Liy, Nur Nabilah A Puzi, Shinsmon Jose, Sharmili Vidyadara. Nitric oxide modulation in neuroinflammation and the role of mesenchymal stem cells. Experimental biology and medicine (Maywood, N.J.). vol 246. issue 22. 2021-12-07. PMID:33715528. |
within the inflamed brain, microglia and astrocytes produce large amounts of nitric oxide during inflammation. |
2021-12-07 |
2023-08-13 |
Not clear |
| Joseph Schober, Jahnavi Polina, Field Walters, Nathan Scott, Eric Lodholz, Albert Crider, Karin Sandoval, Ken Wit. NNC 26-9100 increases Aβ1-42 phagocytosis, inhibits nitric oxide production and decreases calcium in BV2 microglia cells. PloS one. vol 16. issue 7. 2021-11-30. PMID:34237100. |
nnc 26-9100 increases aβ1-42 phagocytosis, inhibits nitric oxide production and decreases calcium in bv2 microglia cells. |
2021-11-30 |
2023-08-13 |
mouse |
| Joseph Schober, Jahnavi Polina, Field Walters, Nathan Scott, Eric Lodholz, Albert Crider, Karin Sandoval, Ken Wit. NNC 26-9100 increases Aβ1-42 phagocytosis, inhibits nitric oxide production and decreases calcium in BV2 microglia cells. PloS one. vol 16. issue 7. 2021-11-30. PMID:34237100. |
herein, the compound nnc 26-9100 (nnc) was evaluated in toxicity, nitric oxide release, aβ1-42 uptake and cytosolic calcium assays during lipopolysaccharide (lps)-activated conditions using mouse bv2 microglia cells. |
2021-11-30 |
2023-08-13 |
mouse |
| Yu-Wei Wu, Jun-Yao Long, Xiao-Gang Liu, Hong-Qiao Fa. Evaluating nitric oxide produced by rat inflamed microglial cell Lline, CHME-5, under the effect of IMOD. Cellular and molecular biology (Noisy-le-Grand, France). vol 67. issue 2. 2021-11-25. PMID:34817326. |
evaluating nitric oxide produced by rat inflamed microglial cell lline, chme-5, under the effect of imod. |
2021-11-25 |
2023-08-13 |
rat |
| Yu-Wei Wu, Jun-Yao Long, Xiao-Gang Liu, Hong-Qiao Fa. Evaluating nitric oxide produced by rat inflamed microglial cell Lline, CHME-5, under the effect of IMOD. Cellular and molecular biology (Noisy-le-Grand, France). vol 67. issue 2. 2021-11-25. PMID:34817326. |
nitric oxide (no), as a free radical, is produced by inflamed microglia cells and is one of the destructive factors of the immune system and a factor in myelin degradation. |
2021-11-25 |
2023-08-13 |
rat |
| Yu-Wei Wu, Jun-Yao Long, Xiao-Gang Liu, Hong-Qiao Fa. Evaluating nitric oxide produced by rat inflamed microglial cell Lline, CHME-5, under the effect of IMOD. Cellular and molecular biology (Noisy-le-Grand, France). vol 67. issue 2. 2021-11-25. PMID:34817326. |
nitric oxide induction was performed by bacterial lipopolysaccharide (lps) in rat inflamed microglial cell line, chme-5. |
2021-11-25 |
2023-08-13 |
rat |
| Naser-Aldin Lashgari, Nazanin Momeni Roudsari, Saeideh Momtaz, Thozhukat Sathyapalan, Amir Hossein Abdolghaffari, Amirhossein Sahebka. The involvement of JAK/STAT signaling pathway in the treatment of Parkinson's disease. Journal of neuroimmunology. vol 361. 2021-11-24. PMID:34739911. |
stimulation of microglial cell with aggregated α-syn results in production of nitric oxide (no), tumor necrosis factor (tnf)-α, and il-1β in pd. |
2021-11-24 |
2023-08-13 |
Not clear |
| Joseph A Nicolazzo, Yijun Pan, Ilenia Di Stefano, Kwok H C Choy, Sanjeevini Babu Reddiar, Yi Ling Low, Dorothy C C Wai, Raymond S Norton, Liang Ji. Blockade of Microglial Kv1.3 Potassium Channels by the Peptide HsTX1[R14A] Attenuates Lipopolysaccharide-mediated Neuroinflammation. Journal of pharmaceutical sciences. 2021-11-24. PMID:34767826. |
in lps-treated primary mouse microglia, the levels of tnf-α and nitric oxide were also attenuated by hstx1[r14a] (26.1 and 20.4%, respectively). |
2021-11-24 |
2023-08-13 |
mouse |
| Zihnil A I Mazrad, Baptiste Schelle, Joseph A Nicolazzo, Meike N Leiske, Kristian Kemp. Nitrile-Functionalized Poly(2-oxazoline)s as a Versatile Platform for the Development of Polymer Therapeutics. Biomacromolecules. vol 22. issue 11. 2021-11-15. PMID:34647734. |
in addition, ao-functionalized pox were shown to release nitric oxide intracellularly in bv-2 microglia. |
2021-11-15 |
2023-08-13 |
Not clear |
| You Jung Kang, Hsih-Yin Tan, Charles Y Lee, Hansang Ch. An Air Particulate Pollutant Induces Neuroinflammation and Neurodegeneration in Human Brain Models. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 8. issue 21. 2021-11-11. PMID:34561961. |
finally, it is observed that additional proinflammatory mediators and nitric oxide released from the m1 microglia exacerbate neuronal damages, such as synaptic impairment, phosphoric tau accumulation, and neuronal death. |
2021-11-11 |
2023-08-13 |
human |
| Dong Gil Lee, Bo Ra Nam, Jae-Won Huh, Dong-Seok Le. Isoliquiritigenin Reduces LPS-Induced Inflammation by Preventing Mitochondrial Fission in BV-2 Microglial Cells. Inflammation. vol 44. issue 2. 2021-11-09. PMID:33150538. |
excessive microglial cell activation in the brain can lead to the production of various neurotoxic factors (e.g., pro-inflammatory cytokines, nitric oxide) which can, in turn, initiate neurodegenerative processes. |
2021-11-09 |
2023-08-13 |
Not clear |
| Tong Wang, Qi Sun, Jinhan Yang, Gaoyang Wang, Fenghong Zhao, Yuhua Chen, Yaping Ji. Reactive astrocytes induced by 2-chloroethanol modulate microglia polarization through IL-1β, TNF-α, and iNOS upregulation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 157. 2021-11-01. PMID:34517076. |
interleukin-1β (il-1β), tumor necrosis factor-α (tnf-α), and inducible nitric oxide synthase (inos) expressions were upregulated in 2-ce-induced reactive astrocytes, enhancing il-1β, tnf-α, and nitric oxide (no) excretions, which stimulated microglia polarization. |
2021-11-01 |
2023-08-13 |
mouse |
| Hyun-Min Yoon, Kyung-Jun Jang, Min Seok Han, Jin-Woo Jeong, Gi Young Kim, Jai-Heon Lee, Yung Hyun Cho. Ganoderma lucidum ethanol extract inhibits the inflammatory response by suppressing the NF-κB and toll-like receptor pathways in lipopolysaccharide-stimulated BV2 microglial cells. Experimental and therapeutic medicine. vol 5. issue 3. 2021-10-21. PMID:23408713. |
elevated levels of nitric oxide (no), prostaglandin e(2) (pge(2)) and pro-inflammatory cytokine production were detected in bv2 microglia following lps stimulation. |
2021-10-21 |
2023-08-12 |
Not clear |
| Avik Roy, Kalipada Paha. Myelin Basic Protein-primed T Helper 2 Cells Suppress Microglial Activation via AlphaVBeta3 Integrin: Implications for Multiple Sclerosis. Journal of clinical & cellular immunology. vol 7. 2021-10-21. PMID:24575330. |
after polarization of mbp-primed th1 cells to th2 by gemfibrozil and other drugs, we observed that mbp-primed th2 cells dose dependently inhibited the production of interleukin-1β (il-1β) and nitric oxide (no) in lps-stimulated microglia via cell-to-cell contact. |
2021-10-21 |
2023-08-12 |
human |
| Jessica R Lowry, Nick Marshall, Tyler J Wenzel, Taryn E Murray, Andis Klegeri. The dietary fatty acids α-linolenic acid (ALA) and linoleic acid (LA) selectively inhibit microglial nitric oxide production. Molecular and cellular neurosciences. vol 109. 2021-10-15. PMID:33161065. |
however, in ad, microglia can become adversely activated, causing them to release increased levels of cytotoxins and inflammatory mediators, including nitric oxide (no) and monocyte-chemoattractant protein (mcp)-1. |
2021-10-15 |
2023-08-13 |
mouse |
| Amir Saeed Khan, Anne Wolf, Thomas Langman. The AhR ligand 2, 2'-aminophenyl indole (2AI) regulates microglia homeostasis and reduces pro-inflammatory signaling. Biochemical and biophysical research communications. vol 579. 2021-10-13. PMID:34583190. |
2ai also diminished lps-induced nitric oxide (no) release, their neurotoxic activity on photoreceptor cells, phagocytosis, and migration in murine bv-2 cells as important functional microglia parameters. |
2021-10-13 |
2023-08-13 |
human |
| Xuehua Sun, Xinyou Li, Youfei Zhou, Yufei Wang, Xiaochen Li. Up-regulating TIPE2 alleviates inflammatory pain by suppressing microglial activation-mediated inflammatory response via inhibiting Rac1/NF-κB pathway. Experimental cell research. vol 404. issue 1. 2021-09-29. PMID:33933441. |
overexpression of tipe2 mitigated lps-medicated microglial activation via decreasing nitric oxide (no) generation and the expression of microglia marker iba-1. |
2021-09-29 |
2023-08-13 |
mouse |
| Yaling Xu, Lijia Yu, Ying Liu, Xiaohui Tang, Xijin Wan. Lipopolysaccharide-Induced Microglial Neuroinflammation: Attenuation by FK866. Neurochemical research. vol 46. issue 5. 2021-09-27. PMID:33713324. |
in the present study, we observed that fk866 (a specific noncompetitive nampt inhibitor) dose-dependently inhibited lipopolysaccharide (lps)-induced proinflammatory mediator (interleukin (il)-6, il-1β, inducible nitric oxide synthase, nitric oxide and reactive species) level increase in bv2 microglia cultures. |
2021-09-27 |
2023-08-13 |
Not clear |
| Andrea Lewen, Thuy-Truc Ta, Tiziana Cesetti, Jan-Oliver Hollnagel, Ismini E Papageorgiou, Bruno Chausse, Oliver Kan. Neuronal gamma oscillations and activity-dependent potassium transients remain regular after depletion of microglia in postnatal cortex tissue. Journal of neuroscience research. vol 98. issue 10. 2021-09-17. PMID:32638411. |
the slice cultures featured well-preserved hippocampal cytoarchitecture and parvalbumin-positive interneuron networks, microglia with ramified morphology, and low basal levels of il-6, tnf-α, and nitric oxide (no). |
2021-09-17 |
2023-08-13 |
rat |