| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yong-Ki Park, Yoo Sun Chung, Yoon Seong Kim, O-Yoon Kwon, Tong H Jo. Inhibition of gene expression and production of iNOS and TNF-alpha in LPS-stimulated microglia by methanol extract of Phellodendri cortex. International immunopharmacology. vol 7. issue 7. 2007-10-04. PMID:17499198. |
we sought to investigate whether phellodendri cortex (pc) that has been used for centuries in chinese traditional medicine for the treatment of various inflammatory conditions, inhibits production of anti-inflammatory cytokines and nitric oxide (no) in microglia, and further studied the molecular and cellular mechanisms that govern these anti-inflammatory effects. |
2007-10-04 |
2023-08-12 |
mouse |
| A M M Silva, A R Silva, A M Pinheiro, S R V B Freitas, V D A Silva, C S Souza, J B Hughes, R S El-Bachá, M F D Costa, E S Velozo, M Tardy, S L Cost. Alkaloids from Prosopis juliflora leaves induce glial activation, cytotoxicity and stimulate NO production. Toxicon : official journal of the International Society on Toxinology. vol 49. issue 5. 2007-09-26. PMID:17241650. |
morphological changes and glial cells activation were investigated through rosenfeld's staining, by immunocytochemistry for the protein ox-42, specific of activated microglia, by immunocytochemistry and western immunoblot for gfap, the marker of reactive and mature astrocytes, and by the production of nitric oxide (no). |
2007-09-26 |
2023-08-12 |
rat |
| Mi Kyeong Lee, Hee Young Jeon, Ki Yong Lee, Seung Hyun Kim, Choong Je Ma, Sang Hyun Sung, Heum-Sook Lee, Mi Jung Park, Young Choong Ki. Inhibitory constituents of Euscaphis japonica on lipopolysaccharide-induced nitric oxide production in BV2 microglia. Planta medica. vol 73. issue 8. 2007-09-20. PMID:17611931. |
inhibitory constituents of euscaphis japonica on lipopolysaccharide-induced nitric oxide production in bv2 microglia. |
2007-09-20 |
2023-08-12 |
Not clear |
| Li-ping Yang, Ying Li, Xiu-an Zhu, Mark O M Ts. Minocycline delayed photoreceptor death in rds mice through iNOS-dependent mechanism. Molecular vision. vol 13. 2007-09-04. PMID:17653052. |
to elucidate the role of activated microglia and nitric oxide (no) in photoreceptor apoptosis in rds mice, and to investigate the effect of minocycline treatment on rds mice. |
2007-09-04 |
2023-08-12 |
mouse |
| Emmanuel Mbaku Ngu, Christie L Sahley, Kenneth J Mulle. Reduced axon sprouting after treatment that diminishes microglia accumulation at lesions in the leech CNS. The Journal of comparative neurology. vol 503. issue 1. 2007-08-15. PMID:17480028. |
microglia accumulate at lesions where they act as immune cells and phagocytize debris, and they may secrete neurotrophins, but they also produce molecules that can be cytotoxic, like nitric oxide (no). |
2007-08-15 |
2023-08-12 |
Not clear |
| Suhayl Dhib-Jalbu. Pathogenesis of myelin/oligodendrocyte damage in multiple sclerosis. Neurology. vol 68. issue 22 Suppl 3. 2007-08-09. PMID:17548563. |
the cd4(+) th1 cell, in particular, has been implicated, but it is abetted by a variety of other cell types (cd8(+) cells, b cells, macrophages, and microglia) and soluble products (proteases, cytokines, and nitric oxide [no]) that act both outside of and within the cns. |
2007-08-09 |
2023-08-12 |
human |
| SangMi Han, KwangGill Lee, JooHong Yeo, HaeYong Kweon, SoonOk Woo, MyeongLyeol Lee, HaJu Baek, SunYeou Kim, KwanKyu Par. Effect of honey bee venom on microglial cells nitric oxide and tumor necrosis factor-alpha production stimulated by LPS. Journal of ethnopharmacology. vol 111. issue 1. 2007-07-27. PMID:17166679. |
results showed that venom (kbv) produced and purified in korea regulated lipopolysaccharides (lps)-induced nitric oxide (no) and tumor necrosis factor-alpha (tnf-alpha) in the murine microglia, bv-2 cell line. |
2007-07-27 |
2023-08-12 |
bee |
| Han-Qing Chen, Zheng-Yu Jin, Guan-Hong L. Biochanin A protects dopaminergic neurons against lipopolysaccharide-induced damage through inhibition of microglia activation and proinflammatory factors generation. Neuroscience letters. vol 417. issue 2. 2007-07-25. PMID:17399896. |
moreover, biochanin a also significantly inhibited lps-induced activation of microglia and production of tumor necrosis factor-alpha, nitric oxide and superoxide in mesencephalic neuron-glia cultures and microglia-enriched cultures. |
2007-07-25 |
2023-08-12 |
rat |
| Aiste Jekabsone, Palwinder K Mander, Anna Tickler, Martyn Sharpe, Guy C Brow. Fibrillar beta-amyloid peptide Abeta1-40 activates microglial proliferation via stimulating TNF-alpha release and H2O2 derived from NADPH oxidase: a cell culture study. Journal of neuroinflammation. vol 3. 2007-07-20. PMID:16959029. |
fibrillar abeta can activate microglia, resulting in production of toxic and inflammatory mediators like hydrogen peroxide, nitric oxide, and cytokines. |
2007-07-20 |
2023-08-12 |
Not clear |
| Hiroaki Matsumoto, Yoshiaki Kumon, Hideaki Watanabe, Takanori Ohnishi, Masachika Shudou, Chisato Ii, Hisaaki Takahashi, Yoshinori Imai, Junya Tanak. Antibodies to CD11b, CD68, and lectin label neutrophils rather than microglia in traumatic and ischemic brain lesions. Journal of neuroscience research. vol 85. issue 5. 2007-07-18. PMID:17265469. |
resident quiescent microglia have been thought to respond rapidly to various pathologic events in the brain by proliferating and producing many bioactive substances, including proinflammatory cytokines and nitric oxide (no). |
2007-07-18 |
2023-08-12 |
rat |
| Francis C Lau, Donna F Bielinski, James A Josep. Inhibitory effects of blueberry extract on the production of inflammatory mediators in lipopolysaccharide-activated BV2 microglia. Journal of neuroscience research. vol 85. issue 5. 2007-07-18. PMID:17265471. |
results indicated that treatments with blueberry extract inhibited the production of the inflammatory mediator nitric oxide (no) as well as the cytokines interleukin-1beta and tumor necrosis factor-alpha, in cell conditioned media from lipopolysaccharide (lps)-activated bv2 microglia. |
2007-07-18 |
2023-08-12 |
Not clear |
| Brandy L Wilkinson, Gary E Landret. The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease. Journal of neuroinflammation. vol 3. 2007-07-05. PMID:17094809. |
the induction of reactive oxygen species, as well as nitric oxide, from activated microglia can enhance the production of more potent free radicals such as peroxynitrite. |
2007-07-05 |
2023-08-12 |
Not clear |
| Takahiro Kato, Akira Monji, Sadayuki Hashioka, Shigenobu Kanb. Risperidone significantly inhibits interferon-gamma-induced microglial activation in vitro. Schizophrenia research. vol 92. issue 1-3. 2007-07-03. PMID:17363222. |
microglia has recently been regarded to be a mediator of neuroinflammation via the release of proinflammatory cytokines, nitric oxide (no) and reactive oxygen species (ros) in the central nervous system (cns). |
2007-07-03 |
2023-08-12 |
Not clear |
| Takahiro Kato, Akira Monji, Sadayuki Hashioka, Shigenobu Kanb. Risperidone significantly inhibits interferon-gamma-induced microglial activation in vitro. Schizophrenia research. vol 92. issue 1-3. 2007-07-03. PMID:17363222. |
in the present study, we thus investigated the effects of risperidone on the generation of nitric oxide, inducible no synthase (inos) expression and inflammatory cytokines: interleukin (il)-1beta, il-6 and tumor necrosis factor (tnf)-alpha by ifn-gamma-activated microglia by using griess assay, western blotting and elisa, respectively. |
2007-07-03 |
2023-08-12 |
Not clear |
| Seung Hyun Kim, Young Pyo Jang, Sang Hyun Sung, Young Choong Ki. Inhibitory activity of phenolic glycosides from the fruits of Idesia polycarpa on lipopolysaccharide-induced nitric oxide production in BV2 microglia. Planta medica. vol 73. issue 2. 2007-06-29. PMID:17128390. |
inhibitory activity of phenolic glycosides from the fruits of idesia polycarpa on lipopolysaccharide-induced nitric oxide production in bv2 microglia. |
2007-06-29 |
2023-08-12 |
Not clear |
| Seung Hyun Kim, Young Pyo Jang, Sang Hyun Sung, Young Choong Ki. Inhibitory activity of phenolic glycosides from the fruits of Idesia polycarpa on lipopolysaccharide-induced nitric oxide production in BV2 microglia. Planta medica. vol 73. issue 2. 2007-06-29. PMID:17128390. |
all six compounds significantly inhibited lipopolysaccharide-induced nitric oxide production in bv2 microglia at concentrations from 1 microm to 100 microm. |
2007-06-29 |
2023-08-12 |
Not clear |
| Rebecca Widmer, Martina Engels, Peter Voss, Tilman Grun. Postanoxic damage of microglial cells is mediated by xanthine oxidase and cyclooxygenase. Free radical research. vol 41. issue 2. 2007-06-27. PMID:17364940. |
in this study, we investigated the anoxia/reoxygenation caused damage to a microglial cell line via determination of energy metabolism, free radical production by dichlorofluorescein fluorescence and nitric oxide production by griess reagent. |
2007-06-27 |
2023-08-12 |
human |
| Mi-Jin Sohn, Hyun-Jeong Noh, Ick-Dong Yoo, Won-Gon Ki. Protective effect of radicicol against LPS/IFN-gamma-induced neuronal cell death in rat cortical neuron-glia cultures. Life sciences. vol 80. issue 18. 2007-05-22. PMID:17337278. |
radicicol inhibited the lps/ifn-gamma-induced expression of inducible nitric oxide synthase (inos) and production of nitric oxide (no) in microglia. |
2007-05-22 |
2023-08-12 |
rat |
| Claudie Hooper, Jennifer M Pococ. Chromogranin A activates diverse pathways mediating inducible nitric oxide expression and apoptosis in primary microglia. Neuroscience letters. vol 413. issue 3. 2007-04-24. PMID:17267111. |
chromogranin a activates diverse pathways mediating inducible nitric oxide expression and apoptosis in primary microglia. |
2007-04-24 |
2023-08-12 |
rat |
| Claudie Hooper, Jennifer M Pococ. Chromogranin A activates diverse pathways mediating inducible nitric oxide expression and apoptosis in primary microglia. Neuroscience letters. vol 413. issue 3. 2007-04-24. PMID:17267111. |
in primary rat microglia, cga-mediated inducible nitric oxide (inos) expression, nitric oxide (no) production, mitochondrial depolarisation and apoptosis were inhibited by pp2 (src kinase inhibitor). |
2007-04-24 |
2023-08-12 |
rat |