| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qinwen Wang, Michael J Rowan, Roger Anwy. Beta-amyloid-mediated inhibition of NMDA receptor-dependent long-term potentiation induction involves activation of microglia and stimulation of inducible nitric oxide synthase and superoxide. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 27. 2005-02-04. PMID:15240796. |
the study thus provides evidence that the abeta-mediated inhibition of ltp induction involves an inflammatory-type reaction in which activation of microglia results in the production of nitric oxide and superoxide and thence possibly peroxynitrite, a highly reactive oxidant. |
2005-02-04 |
2023-08-12 |
mouse |
| Jongmin Lee, Yoon-Seong Kim, Dong-Hee Choi, Moon Suk Bang, Tai Ryoon Han, Tong H Joh, Soo-Youl Ki. Transglutaminase 2 induces nuclear factor-kappaB activation via a novel pathway in BV-2 microglia. The Journal of biological chemistry. vol 279. issue 51. 2005-02-04. PMID:15471861. |
we demonstrated previously that inhibitors of tgase 2 reduce nitric oxide (no) generation in a lipopolysaccharide (lps)-treated microglial cell line. |
2005-02-04 |
2023-08-12 |
rat |
| Rommy von Bernhardi, Jaime Eugení. Microglial reactivity to beta-amyloid is modulated by astrocytes and proinflammatory factors. Brain research. vol 1025. issue 1-2. 2005-01-06. PMID:15464759. |
microglia exposed to abeta responded with reactive morphological changes, induction of inos, elevated nitric oxide production and decreased reductive metabolism. |
2005-01-06 |
2023-08-12 |
Not clear |
| Young-Joon Park, Mamoru Koketsu, Jeong Min Kim, Joo-Hong Yeo, Hideharu Ishihara, Kwang-Gill Lee, Sun Yeou Kim, Chong-Kook Ki. 1,3-selenazol-4-one derivatives inhibit inducible nitric oxide-mediated nitric oxide production in lipopolysaccharide-induced BV-2 cells. Biological & pharmaceutical bulletin. vol 26. issue 12. 2005-01-04. PMID:14646166. |
activated microglia extensively produce nitric oxide (no) by inducing expression of inducible no synthase (inos). |
2005-01-04 |
2023-08-12 |
Not clear |
| David M Thomas, Jennifer Dowgiert, Timothy J Geddes, Dina Francescutti-Verbeem, Xiuli Liu, Donald M Kuh. Microglial activation is a pharmacologically specific marker for the neurotoxic amphetamines. Neuroscience letters. vol 367. issue 3. 2004-12-17. PMID:15337264. |
because microglia are known to produce many of the reactive species (e.g., nitric oxide, superoxide, cytokines) that mediate the neurotoxicity of the amphetamine-class of drugs, their activation could represent an early and essential event in the neurotoxic cascade associated with high-dose amphetamine intoxication. |
2004-12-17 |
2023-08-12 |
Not clear |
| Key Chung Park, Kyung Cheon Chung, Yoon-Seong Kim, Jongmin Lee, Tong H Joh, Soo-Youl Ki. Transglutaminase 2 induces nitric oxide synthesis in BV-2 microglia. Biochemical and biophysical research communications. vol 323. issue 3. 2004-12-09. PMID:15381106. |
transglutaminase 2 induces nitric oxide synthesis in bv-2 microglia. |
2004-12-09 |
2023-08-12 |
Not clear |
| Katsura Takano, Yoichi Nakamura, Yukio Yoned. [Microglial cell death induced by polyamines]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 24. issue 4. 2004-11-30. PMID:15484815. |
cultured microglia prepared from the whole brains of newborn rats produced nitric oxide (no) by the stimulation with lipopolysaccharide (lps). |
2004-11-30 |
2023-08-12 |
rat |
| Heasuk Lee, Jaeyoon Jeong, Eunyung Son, Ahmed Mosa, Gyeong Jae Cho, Wan Sung Choi, Jeoung-Hee Ha, In Kyeom Kim, Maan Gee Lee, Choong-Young Kim, Kyoungho Su. Ethanol selectively modulates inflammatory activation signaling of brain microglia. Journal of neuroimmunology. vol 156. issue 1-2. 2004-11-23. PMID:15465599. |
after treatment of bv-2 mouse microglial cells or rat primary microglia cultures with various stimuli, nitric oxide (no) production was measured as an indicator of microglial activation. |
2004-11-23 |
2023-08-12 |
mouse |
| Sung-Soo Kim, Pil-Jae Kong, Bong-Seog Kim, Dong-Hyuk Sheen, Su-Youn Nam, Wanjoo Chu. Inhibitory action of minocycline on lipopolysaccharide-induced release of nitric oxide and prostaglandin E2 in BV2 microglial cells. Archives of pharmacal research. vol 27. issue 3. 2004-11-04. PMID:15089037. |
moreover, activated microglia are known to release a variety of proinflammatory cytokines and oxidants such as nitric oxide (no). |
2004-11-04 |
2023-08-12 |
Not clear |
| Weihua Zhao, Wenjie Xie, Weidong Le, David R Beers, Yi He, Jenny S Henkel, Ericka P Simpson, Albert A Yen, Qin Xiao, Stanley H Appe. Activated microglia initiate motor neuron injury by a nitric oxide and glutamate-mediated mechanism. Journal of neuropathology and experimental neurology. vol 63. issue 9. 2004-10-21. PMID:15453095. |
activated microglia initiate motor neuron injury by a nitric oxide and glutamate-mediated mechanism. |
2004-10-21 |
2023-08-12 |
Not clear |
| Ananth Chandrasekaran, Gopalakrishnakone Ponnambalam, Charanjit Kau. Domoic acid-induced neurotoxicity in the hippocampus of adult rats. Neurotoxicity research. vol 6. issue 2. 2004-10-07. PMID:15325963. |
in this review article, we report the leading hypotheses in the understanding of da-induced neurotoxicity, which focus on the role of da in neuropathological manifestations, the formation of the retrograde messenger molecule nitric oxide (no) for the production of free radicals in the development of neuronal damage, the activation of glial cells (microglia and astrocytes) in response to da-induced neuronal damage and the neuroprotective role of melatonin as a free radical scavenger or antioxidant in da-induced neurotoxicity. |
2004-10-07 |
2023-08-12 |
rat |
| Seong-Soo Joo, Hee-Chul Kang, Tae-Joon Won, Do-Ik Le. Ursodeoxycholic acid inhibits pro-inflammatory repertoires, IL-1 beta and nitric oxide in rat microglia. Archives of pharmacal research. vol 26. issue 12. 2004-08-26. PMID:14723342. |
ursodeoxycholic acid inhibits pro-inflammatory repertoires, il-1 beta and nitric oxide in rat microglia. |
2004-08-26 |
2023-08-12 |
rat |
| Seong-Soo Joo, Hee-Chul Kang, Tae-Joon Won, Do-Ik Le. Ursodeoxycholic acid inhibits pro-inflammatory repertoires, IL-1 beta and nitric oxide in rat microglia. Archives of pharmacal research. vol 26. issue 12. 2004-08-26. PMID:14723342. |
in the present study, we hypothesized that udca may inhibit the production of the pro-inflammatory cytokine, il-1beta, and nitric oxide (no) in microglia. |
2004-08-26 |
2023-08-12 |
rat |
| Kyoungho Su. Minocycline suppresses hypoxic activation of rodent microglia in culture. Neuroscience letters. vol 366. issue 2. 2004-08-25. PMID:15276240. |
we have previously shown that hypoxia induces inflammatory activation of cultured microglia, and the hypoxic induction of nitric oxide production in microglia is mediated through p38 mitogen-activated protein kinase pathway. |
2004-08-25 |
2023-08-12 |
Not clear |
| Hee-Sun Kim, So-Young Whang, Moon-Sook Woo, Jin-Sun Park, Won-Ki Kim, Inn-Oc Ha. Sodium butyrate suppresses interferon-gamma-, but not lipopolysaccharide-mediated induction of nitric oxide and tumor necrosis factor-alpha in microglia. Journal of neuroimmunology. vol 151. issue 1-2. 2004-08-18. PMID:15145607. |
sodium butyrate suppresses interferon-gamma-, but not lipopolysaccharide-mediated induction of nitric oxide and tumor necrosis factor-alpha in microglia. |
2004-08-18 |
2023-08-12 |
Not clear |
| P D Koeberle, J Gauldie, A K Bal. Effects of adenoviral-mediated gene transfer of interleukin-10, interleukin-4, and transforming growth factor-beta on the survival of axotomized retinal ganglion cells. Neuroscience. vol 125. issue 4. 2004-08-02. PMID:15120851. |
nitric oxide, synthesized by reactive microglia and astrocytes has been implicated in promoting neuronal degeneration observed in many diseases and insults of the central nervous system. |
2004-08-02 |
2023-08-12 |
Not clear |
| P D Koeberle, J Gauldie, A K Bal. Effects of adenoviral-mediated gene transfer of interleukin-10, interleukin-4, and transforming growth factor-beta on the survival of axotomized retinal ganglion cells. Neuroscience. vol 125. issue 4. 2004-08-02. PMID:15120851. |
anti-inflammatory cytokines including interleukin-10 (il-10), interleukin-4 (il-4), and transforming growth factor-beta (tgf-beta) have been shown to prevent inducible nitric oxide synthase expression, and inhibit nitric oxide synthesis by microglia and astrocytes in culture. |
2004-08-02 |
2023-08-12 |
Not clear |
| Shun-Fen Tzeng, Hsin-Ying Huan. Downregulation of inducible nitric oxide synthetase by neurotrophin-3 in microglia. Journal of cellular biochemistry. vol 90. issue 2. 2004-05-27. PMID:14505339. |
downregulation of inducible nitric oxide synthetase by neurotrophin-3 in microglia. |
2004-05-27 |
2023-08-12 |
mouse |
| Shun-Fen Tzeng, Hsin-Ying Huan. Downregulation of inducible nitric oxide synthetase by neurotrophin-3 in microglia. Journal of cellular biochemistry. vol 90. issue 2. 2004-05-27. PMID:14505339. |
microglia activated after many neurological degeneration of the central nervous system (cns) act as important regulators for neuropathogenesis in the injured cns via producing proinflammatory mediators, such as nitric oxide (no), tnf-alpha, and il-1beta. |
2004-05-27 |
2023-08-12 |
mouse |
| Arthur H Neufel. Pharmacologic neuroprotection with an inhibitor of nitric oxide synthase for the treatment of glaucoma. Brain research bulletin. vol 62. issue 6. 2004-05-17. PMID:15036557. |
excessive nitric oxide, generated by inducible nos-2 in astrocytes and microglia in the optic nerve head of patients with glaucoma, may contribute to the optic neuropathy associated with the disease. |
2004-05-17 |
2023-08-12 |
rat |