| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiz-Yuh Wang, Andrew Y C Shum, Yi-Jung Ho, Jia-Yi Wan. Oxidative neurotoxicity in rat cerebral cortex neurons: synergistic effects of H2O2 and NO on apoptosis involving activation of p38 mitogen-activated protein kinase and caspase-3. Journal of neuroscience research. vol 72. issue 4. 2003-06-06. PMID:12704812. |
microglia, activated upon neuronal injury or inflammatory stimulation, are known to release superoxide anion (*o(2) (-)), hydrogen peroxide (h(2)o(2)), and nitric oxide (no), thereby further contributing to oxidative neurotoxicity. |
2003-06-06 |
2023-08-12 |
human |
| Claudia Rozenfeld, Rodrigo Martinez, Rodrigo T Figueiredo, Marcelo T Bozza, Flávia R S Lima, Ana Lúcia Pires, Patrícia M Silva, Adriana Bonomo, Joseli Lannes-Vieira, Wanderley De Souza, Vivaldo Moura-Net. Soluble factors released by Toxoplasma gondii-infected astrocytes down-modulate nitric oxide production by gamma interferon-activated microglia and prevent neuronal degeneration. Infection and immunity. vol 71. issue 4. 2003-05-12. PMID:12654825. |
soluble factors released by toxoplasma gondii-infected astrocytes down-modulate nitric oxide production by gamma interferon-activated microglia and prevent neuronal degeneration. |
2003-05-12 |
2023-08-12 |
Not clear |
| Claudia Rozenfeld, Rodrigo Martinez, Rodrigo T Figueiredo, Marcelo T Bozza, Flávia R S Lima, Ana Lúcia Pires, Patrícia M Silva, Adriana Bonomo, Joseli Lannes-Vieira, Wanderley De Souza, Vivaldo Moura-Net. Soluble factors released by Toxoplasma gondii-infected astrocytes down-modulate nitric oxide production by gamma interferon-activated microglia and prevent neuronal degeneration. Infection and immunity. vol 71. issue 4. 2003-05-12. PMID:12654825. |
in this way, nitric oxide (no), the main toxic metabolite produced by ifn-gamma-activated microglia, may cause neuronal injury during t. gondii infection. |
2003-05-12 |
2023-08-12 |
Not clear |
| Anita Greco, Maria Antonietta Ajmone-Cat, Alessia Nicolini, Maria Gina Sciulli, Luisa Minghett. Paracetamol effectively reduces prostaglandin E2 synthesis in brain macrophages by inhibiting enzymatic activity of cyclooxygenase but not phospholipase and prostaglandin E synthase. Journal of neuroscience research. vol 71. issue 6. 2003-05-07. PMID:12605411. |
finally, none of the nsaids affected the productions of nitric oxide and tumor necrosis factor(alpha), two inflammatory mediators released by activated microglia. |
2003-05-07 |
2023-08-12 |
rat |
| S Sugama, B P Cho, L A Degiorgio, Y Shimizu, S S Kim, Y S Kim, D H Shin, B T Volpe, D J Reis, S Cho, T H Jo. Temporal and sequential analysis of microglia in the substantia nigra following medial forebrain bundle axotomy in rat. Neuroscience. vol 116. issue 4. 2003-04-30. PMID:12617934. |
in contrast to microglial expression of interleukin-1beta and inducible nitric oxide synthase at the axotomy site, nigral microglia were interleukin-1beta and inducible nitric oxide synthase-negative. |
2003-04-30 |
2023-08-12 |
rat |
| S Sugama, B P Cho, L A Degiorgio, Y Shimizu, S S Kim, Y S Kim, D H Shin, B T Volpe, D J Reis, S Cho, T H Jo. Temporal and sequential analysis of microglia in the substantia nigra following medial forebrain bundle axotomy in rat. Neuroscience. vol 116. issue 4. 2003-04-30. PMID:12617934. |
the present data support the idea that phagocytosis of axotomized neurons by activated microglia is not limited to dead neurons but includes dying neurons probably without cytotoxic effects of inflammatory substances, such as interleukin-1beta or nitric oxide. |
2003-04-30 |
2023-08-12 |
rat |
| Yuxin Liu, Liya Qin, Guorong Li, Wei Zhang, Lijia An, Bin Liu, Jau-Shyong Hon. Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation. The Journal of pharmacology and experimental therapeutics. vol 305. issue 1. 2003-04-22. PMID:12649371. |
inflammation-mediated neurodegeneration involves activation of the brain's resident immune cells, the microglia, which produce proinflammatory and neurotoxic factors, including cytokines, reactive oxygen intermediates, nitric oxide, and eicosanoids that impact on neurons to induce neurodegeneration. |
2003-04-22 |
2023-08-12 |
rat |
| Kazuyuki Nakajima, Shinichi Kohsaka, Yoko Tohyama, Tadashi Kurihar. Activation of microglia with lipopolysaccharide leads to the prolonged decrease of conventional protein kinase C activity. Brain research. Molecular brain research. vol 110. issue 1. 2003-04-04. PMID:12573537. |
the activation of microglia by lipopolysaccharide (lps) results in the induction of harmful factors including nitric oxide and tumor necrosis factor alpha (tnfalpha). |
2003-04-04 |
2023-08-12 |
Not clear |
| Yoichi Nakamura, Miho Ohmaki, Koji Murakami, Yukio Yoned. Involvement of protein kinase C in glutamate release from cultured microglia. Brain research. vol 962. issue 1-2. 2003-04-01. PMID:12543462. |
to elucidate the mechanism of glutamate release, we examined the possible regulation by nitric oxide and protein kinase c. cultured microglia prepared from the whole brains of newborn rats released glutamate by the stimulation with lipopolysaccharide (lps) dose dependently. |
2003-04-01 |
2023-08-12 |
rat |
| Christian Lefebvre d'Hellencourt, Claudia N Montero-Menei, Rozenn Bernard, Dominique Coue. Vitamin D3 inhibits proinflammatory cytokines and nitric oxide production by the EOC13 microglial cell line. Journal of neuroscience research. vol 71. issue 4. 2003-04-01. PMID:12548714. |
vitamin d3 inhibits proinflammatory cytokines and nitric oxide production by the eoc13 microglial cell line. |
2003-04-01 |
2023-08-12 |
Not clear |
| Christian Lefebvre d'Hellencourt, Claudia N Montero-Menei, Rozenn Bernard, Dominique Coue. Vitamin D3 inhibits proinflammatory cytokines and nitric oxide production by the EOC13 microglial cell line. Journal of neuroscience research. vol 71. issue 4. 2003-04-01. PMID:12548714. |
this study focuses on the effect of 1,25(oh)(2)d(3) on the expression and production of inflammatory cytokines and nitric oxide (no) by the eoc13 microglial cell line. |
2003-04-01 |
2023-08-12 |
Not clear |
| Mei-Jen Wang, Wan-Wan Lin, Huan-Lian Chen, Ying-Hsin Chang, Hsio-Chung Ou, Jon-Son Kuo, Jau-Shyong Hong, Kee-Ching G Jen. Silymarin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity by inhibiting microglia activation. The European journal of neuroscience. vol 16. issue 11. 2003-03-25. PMID:12473078. |
the results showed that silymarin significantly inhibited the lps-induced activation of microglia and the production of inflammatory mediators, such as tumour necrosis factor-alpha and nitric oxide (no), and reduced the damage to dopaminergic neurons. |
2003-03-25 |
2023-08-12 |
Not clear |
| Anna Członkowska, Iwona Kurkowska-Jastrzebska, Andrzej Członkowski, Doris Peter, George B Stefan. Immune processes in the pathogenesis of Parkinson's disease - a potential role for microglia and nitric oxide. Medical science monitor : international medical journal of experimental and clinical research. vol 8. issue 8. 2003-03-21. PMID:12165754. |
immune processes in the pathogenesis of parkinson's disease - a potential role for microglia and nitric oxide. |
2003-03-21 |
2023-08-12 |
Not clear |
| Jaewon Lee, Sic L Chan, Mark P Mattso. Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain. Neuromolecular medicine. vol 2. issue 1. 2003-02-06. PMID:12230303. |
adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain. |
2003-02-06 |
2023-08-12 |
mouse |
| Sun Young Park, Heasuk Lee, Jinyoung Hur, Sun Yeou Kim, Hocheol Kim, Jae-Hoon Park, Sanghoon Cha, Sang Soo Kang, Gyeong Jae Cho, Wan Sung Choi, Kyoungho Su. Hypoxia induces nitric oxide production in mouse microglia via p38 mitogen-activated protein kinase pathway. Brain research. Molecular brain research. vol 107. issue 1. 2003-02-06. PMID:12414118. |
hypoxia induces nitric oxide production in mouse microglia via p38 mitogen-activated protein kinase pathway. |
2003-02-06 |
2023-08-12 |
mouse |
| Sun Young Park, Heasuk Lee, Jinyoung Hur, Sun Yeou Kim, Hocheol Kim, Jae-Hoon Park, Sanghoon Cha, Sang Soo Kang, Gyeong Jae Cho, Wan Sung Choi, Kyoungho Su. Hypoxia induces nitric oxide production in mouse microglia via p38 mitogen-activated protein kinase pathway. Brain research. Molecular brain research. vol 107. issue 1. 2003-02-06. PMID:12414118. |
nitric oxide (no), which is known to be produced by activated microglia, may participate in this process. |
2003-02-06 |
2023-08-12 |
mouse |
| Soichi Maekawa, Mayuki Aibiki, Qiu-Shang Si, Yoichi Nakamura, Yoichi Shirakawa, Kiyoshi Kataok. Differential effects of lowering culture temperature on mediator release from lipopolysaccharide-stimulated neonatal rat microglia. Critical care medicine. vol 30. issue 12. 2003-01-24. PMID:12483061. |
we examined the effects of culture temperature changes from 37 degrees c to 33 degrees c or 30 degrees c on mediator release, including nitric oxide, interleukin-6, and tumor necrosis factor-alpha from lipopolysaccharide-stimulated microglia harvested from neonatal rats. |
2003-01-24 |
2023-08-12 |
rat |
| Refik Pul, Dan Nguyen, Ulrike Schmitz, Peter Marx, Martin Stange. Comparison of intravenous immunoglobulin preparations on microglial function in vitro: more potent immunomodulatory capacity of an IgM/IgA-enriched preparation. Clinical neuropharmacology. vol 25. issue 5. 2003-01-13. PMID:12410056. |
we have compared five commercially available ivig preparations on their capacity to modulate tumor necrosis factor (tnf)-alpha secretion and nitric oxide production in cultured microglia. |
2003-01-13 |
2023-08-12 |
Not clear |
| Miao Chuai, Tadanori Ogata, Tadao Morino, Hideo Okumura, Haruyasu Yamamoto, Peter Schuber. Prostaglandin E1 analog inhibits the microglia function: suppression of lipopolysaccharide-induced nitric oxide and TNF-alpha release. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 20. issue 6. 2003-01-03. PMID:12472236. |
prostaglandin e1 analog inhibits the microglia function: suppression of lipopolysaccharide-induced nitric oxide and tnf-alpha release. |
2003-01-03 |
2023-08-12 |
rat |
| Miao Chuai, Tadanori Ogata, Tadao Morino, Hideo Okumura, Haruyasu Yamamoto, Peter Schuber. Prostaglandin E1 analog inhibits the microglia function: suppression of lipopolysaccharide-induced nitric oxide and TNF-alpha release. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 20. issue 6. 2003-01-03. PMID:12472236. |
the cultured microglia were exposed to lipopolysaccharide (lps) (100 ng/ml), an endotoxin, for 24 h, then the released nitric oxide and tnf-alpha in the culture media was analyzed. |
2003-01-03 |
2023-08-12 |
rat |