| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Ohtani, M Minami, M Sato. Expression of inducible nitric oxide synthase mRNA and production of nitric oxide are induced by adenosine triphosphate in cultured rat microglia. Neuroscience letters. vol 293. issue 1. 2001-02-08. PMID:11065141. |
expression of inducible nitric oxide synthase mrna and production of nitric oxide are induced by adenosine triphosphate in cultured rat microglia. |
2001-02-08 |
2023-08-12 |
rat |
| Y Ohtani, M Minami, M Sato. Expression of inducible nitric oxide synthase mRNA and production of nitric oxide are induced by adenosine triphosphate in cultured rat microglia. Neuroscience letters. vol 293. issue 1. 2001-02-08. PMID:11065141. |
the effect of adenosine triphosphate (atp) on the expression of the inducible nitric oxide synthase (inos) mrna and production of nitric oxide in cultured rat microglia was examined. |
2001-02-08 |
2023-08-12 |
rat |
| Y Ohtani, M Minami, M Sato. Expression of inducible nitric oxide synthase mRNA and production of nitric oxide are induced by adenosine triphosphate in cultured rat microglia. Neuroscience letters. vol 293. issue 1. 2001-02-08. PMID:11065141. |
the induction began within 1 h after addition of atp (100 microm) with peak expression occurring at 6 h. the release of nitric oxide to culture medium was significantly increased by the treatment with atp (100 and 1,000 microm) for 12 and 24 h. these results indicate that atp is a potential mediator to induce inos mrna expression and no production in microglia. |
2001-02-08 |
2023-08-12 |
rat |
| M Stangel, A Compsto. Polyclonal immunoglobulins (IVIg) modulate nitric oxide production and microglial functions in vitro via Fc receptors. Journal of neuroimmunology. vol 112. issue 1-2. 2001-01-18. PMID:11108934. |
ivig increased nitric oxide (no) production in a dose-dependent manner in microglia stimulated with ifngamma. |
2001-01-18 |
2023-08-12 |
rat |
| O Ogawa, H Umegaki, D Sumi, T Hayashi, A Nakamura, N K Thakur, J Yoshimura, H Endo, A Iguch. Inhibition of inducible nitric oxide synthase gene expression by indomethacin or ibuprofen in beta-amyloid protein-stimulated J774 cells. European journal of pharmacology. vol 408. issue 2. 2000-12-27. PMID:11080519. |
recent studies show that a mononuclear phagocyte lineage, including microglia, plays a possible role in the pathogenesis of alzheimer's disease through nitric oxide (no)-mediated neurotoxicity. |
2000-12-27 |
2023-08-12 |
Not clear |
| P D Drew, J A Chavi. Female sex steroids: effects upon microglial cell activation. Journal of neuroimmunology. vol 111. issue 1-2. 2000-12-22. PMID:11063824. |
activated microglia are believed to contribute to multiple sclerosis pathology, perhaps in part due to production of nitric oxide (no) and tnf-alpha, molecules which can be toxic to cells including oligodendrocytes. |
2000-12-22 |
2023-08-12 |
mouse |
| P D Drew, J A Chavi. Female sex steroids: effects upon microglial cell activation. Journal of neuroimmunology. vol 111. issue 1-2. 2000-12-22. PMID:11063824. |
the current study demonstrates that the female sex steroids estriol, beta-estradiol and progesterone inhibit lipopolysaccharide (lps) induction of nitric oxide (no) production by primary rat microglia and by the mouse n9 microglial cell line. |
2000-12-22 |
2023-08-12 |
mouse |
| H Possel, H Noack, J Putzke, G Wolf, H Sie. Selective upregulation of inducible nitric oxide synthase (iNOS) by lipopolysaccharide (LPS) and cytokines in microglia: in vitro and in vivo studies. Glia. vol 32. issue 1. 2000-11-21. PMID:10975910. |
a role for free radicals has been proposed in infectious brain disease, where resident microglia cells upregulate the inducible nitric oxide synthase isoform (inos), and thus are capable of producing nitric oxide at enhanced rates. |
2000-11-21 |
2023-08-12 |
rat |
| Y Nakamura, Q Si, K Kataok. Differential regulation of microglial NO production by protein kinase C inhibitors. Neurochemistry international. vol 38. issue 1. 2000-11-20. PMID:10913682. |
nitric oxide (no) produced by microglia has been implicated in the pathogenesis of various central nervous system diseases; however, the intracellular signal pathways for the production of no are not well known. |
2000-11-20 |
2023-08-12 |
rat |
| A Takeuchi, O Miyaishi, K Kiuchi, K Isob. Cu/Zn- and Mn-superoxide dismutases are specifically up-regulated in neurons after focal brain injury. Journal of neurobiology. vol 45. issue 1. 2000-11-03. PMID:10992255. |
in previous studies, we have demonstrated that damaged neurons within a boundary area around necrosis fall into delayed cell death due to the cytotoxic effect of microglial nitric oxide (no), and are finally eliminated by activated microglia. |
2000-11-03 |
2023-08-12 |
rat |
| J Y Chang, L Z Li. Catecholamines inhibit microglial nitric oxide production. Brain research bulletin. vol 52. issue 6. 2000-10-16. PMID:10974492. |
these results suggest that catecholamines have the ability to block nitric oxide production by microglia, which could partially explain the impaired immune protection against viral infection in the central nervous system in stressed animals. |
2000-10-16 |
2023-08-12 |
Not clear |
| K Abe, Y Abe, H Sait. Agmatine suppresses nitric oxide production in microglia. Brain research. vol 872. issue 1-2. 2000-09-20. PMID:10924686. |
agmatine suppresses nitric oxide production in microglia. |
2000-09-20 |
2023-08-12 |
rat |
| K Abe, Y Abe, H Sait. Agmatine suppresses nitric oxide production in microglia. Brain research. vol 872. issue 1-2. 2000-09-20. PMID:10924686. |
activation of microglia by lipopolysaccharide (lps, 1 microg/ml) caused the expression of inducible nitric oxide synthase (inos) and the production of nitric oxide (no) assessed as the accumulation of nitrite in the culture supernatants. |
2000-09-20 |
2023-08-12 |
rat |
| P D Drew, J A Chavi. Inhibition of microglial cell activation by cortisol. Brain research bulletin. vol 52. issue 5. 2000-09-14. PMID:10922518. |
activated microglia produce molecules including nitric oxide (no) and tumor necrosis factor-alpha (tnf-alpha) which can also be toxic to neurons. |
2000-09-14 |
2023-08-12 |
Not clear |
| J A Edwards, F Denis, P J Talbo. Activation of glial cells by human coronavirus OC43 infection. Journal of neuroimmunology. vol 108. issue 1-2. 2000-08-25. PMID:10900340. |
this virus also modulated the activity of matrix metalloproteinases-2 and -9 and augmented nitric oxide production in both u-373mg cells and the human microglial cell line chme-5. |
2000-08-25 |
2023-08-12 |
human |
| R C Chang, C Rota, R E Glover, R P Mason, J S Hon. A novel effect of an opioid receptor antagonist, naloxone, on the production of reactive oxygen species by microglia: a study by electron paramagnetic resonance spectroscopy. Brain research. vol 854. issue 1-2. 2000-07-27. PMID:10784126. |
microglia as the first line of defensive cells in the brain produce free radicals including superoxide and nitric oxide (no), contributing to neurodegeneration. |
2000-07-27 |
2023-08-12 |
Not clear |
| C A Colton, O N Chernyshev, D L Gilbert, M P Vite. Microglial contribution to oxidative stress in Alzheimer's disease. Annals of the New York Academy of Sciences. vol 899. 2000-07-13. PMID:10863548. |
we also report that the effect of a beta peptides on superoxide anion production is not associated with a concomitant increase in nitric oxide (no) production in either human monocyte derived macrophages (mdm) or hamster microglia from primary cultures. |
2000-07-13 |
2023-08-12 |
human |
| K K Kopec, R T Carrol. Phagocytosis is regulated by nitric oxide in murine microglia. Nitric oxide : biology and chemistry. vol 4. issue 2. 2000-07-07. PMID:10835290. |
phagocytosis is regulated by nitric oxide in murine microglia. |
2000-07-07 |
2023-08-12 |
Not clear |
| K K Kopec, R T Carrol. Phagocytosis is regulated by nitric oxide in murine microglia. Nitric oxide : biology and chemistry. vol 4. issue 2. 2000-07-07. PMID:10835290. |
nitric oxide (no) is produced by inducible nitric oxide synthase (inos) in activated microglia and has been shown to participate in host defense mechanisms. |
2000-07-07 |
2023-08-12 |
Not clear |
| B Liu, L Du, J S Hon. Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation. The Journal of pharmacology and experimental therapeutics. vol 293. issue 2. 2000-06-21. PMID:10773035. |
treatment of rat mesencephalic mixed neuron-glia cultures with lipopolysaccharide (lps)-activated microglia, resident immune cells of the brain, to release proinflammatory and neurotoxic factors tumor necrosis factor-alpha, interleukin-1beta, nitric oxide, and superoxide and subsequently caused damage to midbrain neurons, including dopaminergic neurons. |
2000-06-21 |
2023-08-12 |
rat |