| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H M Kim, H K Rim, T Shin, J J Kim, S T Park, J M Oh, M K Choi, Y T Chung, H S Rhee, J Y Jeung, K N Lee, N S Kim, C H Ki. Human chorionic gonadotropin induces nitric oxide synthesis by murine microglia. International journal of immunopharmacology. vol 22. issue 6. 2000-06-02. PMID:10727756. |
human chorionic gonadotropin induces nitric oxide synthesis by murine microglia. |
2000-06-02 |
2023-08-12 |
human |
| T Dehmer, J Lindenau, S Haid, J Dichgans, J B Schul. Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo. Journal of neurochemistry. vol 74. issue 5. 2000-05-25. PMID:10800968. |
our results suggest that inos-derived nitric oxide produced in microglia plays an important role in the death of dopaminergic neurons but that other mechanisms contribute to the loss of dopaminergic terminals in mptp neurotoxicity. |
2000-05-25 |
2023-08-12 |
mouse |
| B A Schoneboom, J S Lee, F B Griede. Early expression of IFN-alpha/beta and iNOS in the brains of Venezuelan equine encephalitis virus-infected mice. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 20. issue 2. 2000-04-21. PMID:10714557. |
moreover, vee infection increased levels of nitric oxide (no) in resting microglial cultures but decreased no production in ifn-gamma-stimulated microglia. |
2000-04-21 |
2023-08-12 |
mouse |
| Q Si, Y Nakamura, K Kataok. A serum factor enhances production of nitric oxide and tumor necrosis factor-alpha from cultured microglia. Experimental neurology. vol 162. issue 1. 2000-04-18. PMID:10716891. |
a serum factor enhances production of nitric oxide and tumor necrosis factor-alpha from cultured microglia. |
2000-04-18 |
2023-08-12 |
rat |
| Q Si, Y Nakamura, K Kataok. A serum factor enhances production of nitric oxide and tumor necrosis factor-alpha from cultured microglia. Experimental neurology. vol 162. issue 1. 2000-04-18. PMID:10716891. |
in the present study, we found that serum also enhanced lipopolysaccharide (lps)-induced production of nitric oxide and tumor necrosis factor-alpha, which are other important neurotoxins released by activated microglia. |
2000-04-18 |
2023-08-12 |
rat |
| P J Kingham, J M Pococ. Microglial apoptosis induced by chromogranin A is mediated by mitochondrial depolarisation and the permeability transition but not by cytochrome c release. Journal of neurochemistry. vol 74. issue 4. 2000-04-11. PMID:10737601. |
treatment of primary cultures of rat brain microglia or the murine n9 microglial cell line with chromogranin a resulted in nitric oxide production, which triggered microglial apoptosis. |
2000-04-11 |
2023-08-12 |
rat |
| H K Hsieh, L T Tsao, J P Wang, C N Li. Synthesis and anti-inflammatory effect of chalcones. The Journal of pharmacy and pharmacology. vol 52. issue 2. 2000-03-29. PMID:10714946. |
almost all of the 2',5'-dialkoxychalcones exhibited potent inhibitory effects on nitric oxide (no) formation from murine microglial cell lines n9 stimulated with lipopolysaccharide (lps). |
2000-03-29 |
2023-08-12 |
rat |
| I S Matsui Lee, M Suzuki, N Hayashi, J Hu, L J Van Eldik, K Titani, M Nishikim. Copper-dependent formation of disulfide-linked dimer of S100B protein. Archives of biochemistry and biophysics. vol 374. issue 2. 2000-03-15. PMID:10666291. |
the disulfide-linked dimer markedly stimulated nitric oxide production in a microglial cell line, bv2. |
2000-03-15 |
2023-08-12 |
Not clear |
| R C van der Veen, T A Dietlin, J Dixon Gray, W Gilmor. Macrophage-derived nitric oxide inhibits the proliferation of activated T helper cells and is induced during antigenic stimulation of resting T cells. Cellular immunology. vol 199. issue 1. 2000-03-14. PMID:10675274. |
to examine how macrophage-derived nitric oxide (no) affects t helper (th) cell activity, t cell clones representing th1 and th2 subsets were activated before exposure to stimulated peritoneal macrophages or microglia. |
2000-03-14 |
2023-08-12 |
Not clear |
| Y Nakamura, Q S Si, K Kataok. Lipopolysaccharide-induced microglial activation in culture: temporal profiles of morphological change and release of cytokines and nitric oxide. Neuroscience research. vol 35. issue 2. 2000-01-21. PMID:10616913. |
to elucidate the mechanism of the microglial activation, we examined the time course of lipopolysaccharide (lps)-induced change in morphology and the release of cytokines and nitric oxide (no) in cultured microglia from neonatal rat brains. |
2000-01-21 |
2023-08-12 |
rat |
| S Chatterjee, H Noack, H Possel, G Wol. Induction of nitric oxide synthesis lowers intracellular glutathione in microglia of primary glial cultures. Glia. vol 29. issue 1. 2000-01-18. PMID:10594927. |
induction of nitric oxide synthesis lowers intracellular glutathione in microglia of primary glial cultures. |
2000-01-18 |
2023-08-12 |
Not clear |
| S Mirzoeva, T Koppal, T V Petrova, T J Lukas, D M Watterson, L J Van Eldi. Screening in a cell-based assay for inhibitors of microglial nitric oxide production reveals calmodulin-regulated protein kinases as potential drug discovery targets. Brain research. vol 844. issue 1-2. 1999-12-10. PMID:10536268. |
a high-throughput screening (hts) assay for inhibitors of nitric oxide (no) production by activated microglia was developed and used to compare the relative activities of various anti-inflammatory compounds and cell-permeable protein kinase inhibitors. |
1999-12-10 |
2023-08-12 |
Not clear |
| N R Bhat, K K Sharm. Microglial activation by the small heat shock protein, alpha-crystallin. Neuroreport. vol 10. issue 13. 1999-11-02. PMID:10511455. |
exposure of microglia to alpha-crystallin resulted in an increased production of nitric oxide (no) and the expression of the inducible no synthase (inos) as determined by western blot and reverse transcriptase-polymerase chain reaction (rt-pcr) analyses. |
1999-11-02 |
2023-08-12 |
rat |
| A Suzumura, A Ito, M Yoshikawa, M Sawad. Ibudilast suppresses TNFalpha production by glial cells functioning mainly as type III phosphodiesterase inhibitor in the CNS. Brain research. vol 837. issue 1-2. 1999-10-21. PMID:10434004. |
although it required 10 microm or higher concentrations to effectively suppress tnfalpha production in vitro, the combination of ibudilast with other subtypes of pde inhibitors synergistically suppressed tnfalpha and nitric oxide production by microglia at 1 microm, a similar concentration that could be obtained in vivo at usual therapeutic dose. |
1999-10-21 |
2023-08-12 |
Not clear |
| D Galimberti, P Baron, L Meda, E Prat, E Scarpini, R Delgado, A Catania, J M Lipton, G Scarlat. Alpha-MSH peptides inhibit production of nitric oxide and tumor necrosis factor-alpha by microglial cells activated with beta-amyloid and interferon gamma. Biochemical and biophysical research communications. vol 263. issue 1. 1999-10-21. PMID:10486285. |
we tested the influence of alpha-msh[1-13] and of alpha-msh[11-13] in a cultured murine microglia cell line known to produce nitric oxide (no(-)(2)) and tumor necrosis factor (tnfalpha) when stimulated with beta-amyloid protein (abeta). |
1999-10-21 |
2023-08-12 |
Not clear |
| J W Fawcett, R A Ashe. The glial scar and central nervous system repair. Brain research bulletin. vol 49. issue 6. 1999-10-18. PMID:10483914. |
oligodendrocytes produce ni250, myelin-associated glycoprotein (mag), and tenascin-r, oligodendrocyte precursors produce ng2 dsd-1/phosphacan and versican, astrocytes produce tenascin, brevican, and neurocan, and can be stimulated to produce ng2, meningeal cells produce ng2 and other proteoglycans, and activated microglia produce free radicals, nitric oxide, and arachidonic acid derivatives. |
1999-10-18 |
2023-08-12 |
Not clear |
| F Casamenti, C Prosperi, C Scali, L Giovannelli, M A Colivicchi, M S Faussone-Pellegrini, G Pepe. Interleukin-1beta activates forebrain glial cells and increases nitric oxide production and cortical glutamate and GABA release in vivo: implications for Alzheimer's disease. Neuroscience. vol 91. issue 3. 1999-10-08. PMID:10391466. |
inducible nitric oxide synthase-positive cells were identified, by double staining immunohistochemistry, in the reactive microglial cells and, by electron microscope examination, in the perineuronal subpopulation of resident activated microglia. |
1999-10-08 |
2023-08-12 |
rat |
| T Pazmany, L Mechtler, T B Tomasi, J P Kosa, A Turoczi, Z Urbany. Differential regulation of major histocompatibility complex class II expression and nitric oxide release by beta-amyloid in rat astrocyte and microglia. Brain research. vol 835. issue 2. 1999-09-28. PMID:10415376. |
differential regulation of major histocompatibility complex class ii expression and nitric oxide release by beta-amyloid in rat astrocyte and microglia. |
1999-09-28 |
2023-08-12 |
rat |
| E Polazzi, G Levi, L Minghett. Human immunodeficiency virus type 1 Tat protein stimulates inducible nitric oxide synthase expression and nitric oxide production in microglial cultures. Journal of neuropathology and experimental neurology. vol 58. issue 8. 1999-08-30. PMID:10446807. |
we found that the exposure of microglia to tat led to a dose dependent expression of the inducible isoform of nitric oxide (inos) and no production. |
1999-08-30 |
2023-08-12 |
human |
| Z Y Du, X Y L. Inhibitory effects of indomethacin on interleukin-1 and nitric oxide production in rat microglia in vitro. International journal of immunopharmacology. vol 21. issue 3. 1999-07-30. PMID:10348371. |
inhibitory effects of indomethacin on interleukin-1 and nitric oxide production in rat microglia in vitro. |
1999-07-30 |
2023-08-12 |
rat |