| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew J E Maksoud, Vasiliki Tellios, Wei-Yang L. Nitric oxide attenuates microglia proliferation by sequentially facilitating calcium influx through TRPV2 channels, activating NFATC2, and increasing p21 transcription. Cell cycle (Georgetown, Tex.). vol 20. issue 4. 2021-06-03. PMID:33530820. |
nitric oxide attenuates microglia proliferation by sequentially facilitating calcium influx through trpv2 channels, activating nfatc2, and increasing p21 transcription. |
2021-06-03 |
2023-08-13 |
Not clear |
| Mohammed E Choudhury, Yuka Kigami, Junya Tanak. Dual Roles of Microglia in the Basal Ganglia in Parkinson's Disease. International journal of molecular sciences. vol 22. issue 8. 2021-05-25. PMID:33918947. |
in pd, dopaminergic (daergic) neuronal degeneration in the substantia nigra pars compacta (snc) activates the microglia, which then promote daergic neuronal degeneration by releasing potentially neurotoxic factors, including nitric oxide, cytokines, and reactive oxygen species. |
2021-05-25 |
2023-08-13 |
Not clear |
| George B Stefano, Tobias Esch, Radek Ptacek, Richard M Krea. Dysregulation of Nitric Oxide Signaling in Microglia: Multiple Points of Functional Convergence in the Complex Pathophysiology of Alzheimer Disease. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:32975239. |
dysregulation of nitric oxide signaling in microglia: multiple points of functional convergence in the complex pathophysiology of alzheimer disease. |
2021-05-20 |
2023-08-13 |
Not clear |
| George B Stefano, Tobias Esch, Radek Ptacek, Richard M Krea. Dysregulation of Nitric Oxide Signaling in Microglia: Multiple Points of Functional Convergence in the Complex Pathophysiology of Alzheimer Disease. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:32975239. |
within this functional context, we hypothesize that early initiation events in the pathophysiology of ad may operationally involve a convergence of dysregulated peripheral and central constitutive nitric oxide signaling pathways resulting from a chronic state of systemic proinflammation and leading to severely dysfunctional "hyperactivated" microglia. |
2021-05-20 |
2023-08-13 |
Not clear |
| Ying Liu, ShiJi Deng, Zhi Zhang, Yue Gu, ShengNan Xia, XinYu Bao, Xiang Cao, Yun X. 6-Gingerol attenuates microglia-mediated neuroinflammation and ischemic brain injuries through Akt-mTOR-STAT3 signaling pathway. European journal of pharmacology. vol 883. 2021-05-18. PMID:32681941. |
furthermore, microglia induced pro-inflammatory cytokines, such as il-6, il-1β, incremental intercellular nitric oxide (no), as well as inos were blocked by the treatment of 6-gingerol in lipopolysaccharide (lps) stimulated microglia. |
2021-05-18 |
2023-08-13 |
Not clear |
| Jay Sibbitts, Christopher T Culbertso. Measuring stimulation and inhibition of intracellular nitric oxide production in SIM-A9 microglia using microfluidic single-cell analysis. Analytical methods : advancing methods and applications. vol 12. issue 38. 2021-05-14. PMID:32909562. |
measuring stimulation and inhibition of intracellular nitric oxide production in sim-a9 microglia using microfluidic single-cell analysis. |
2021-05-14 |
2023-08-13 |
Not clear |
| Jay Sibbitts, Christopher T Culbertso. Measuring stimulation and inhibition of intracellular nitric oxide production in SIM-A9 microglia using microfluidic single-cell analysis. Analytical methods : advancing methods and applications. vol 12. issue 38. 2021-05-14. PMID:32909562. |
under pathological conditions microglia produce inflammatory signaling molecules, such as nitric oxide (no), that can damage dna and proteins and ultimately induce neuronal apoptosis. |
2021-05-14 |
2023-08-13 |
Not clear |
| Christopher T Tsui, Samantha R MacGillivray, Savannah M Weber, Lowell McAllister, Matthew A Churchward, Christopher R Dennison, Kathryn G Tod. Applying a novel 3D hydrogel cell culture to investigate activation of microglia due to rotational kinematics associated with mild traumatic brain injury. Journal of the mechanical behavior of biomedical materials. vol 114. 2021-05-14. PMID:33184015. |
however, no measurable glial cell reactivity was observed in response to the rotational kinematics through any of the chosen metrics (nitric oxide, pro-inflammatory cytokine release and proportion of amoeboid activated microglia). |
2021-05-14 |
2023-08-13 |
Not clear |
| Yoshito Mizoguchi, Masahiro Ohgidani, Yoshinori Haraguchi, Toru Murakawa-Hirachi, Takahiro A Kato, Akira Monj. ProBDNF induces sustained elevation of intracellular Ca Glia. vol 69. issue 7. 2021-05-11. PMID:33740269. |
probdnf induces sustained elevation of intracellular ca microglia are intrinsic immune cells that release factors including pro- and anti-inflammatory cytokines, nitric oxide (no) and neurotrophins following activation in the brain. |
2021-05-11 |
2023-08-13 |
Not clear |
| Shashank Kumar Maurya, Neetu Bhattacharya, Suman Mishra, Amit Bhattacharya, Pratibha Banerjee, Sabyasachi Senapati, Rajnikant Mishr. Microglia Specific Drug Targeting Using Natural Products for the Regulation of Redox Imbalance in Neurodegeneration. Frontiers in pharmacology. vol 12. 2021-05-02. PMID:33927630. |
but the same microglia starts releasing pro-inflammatory cytokines like tnf-α, ifn-γ, reactive oxygen species (ros), and nitric oxide (no), increasing neuroinflammation and redox imbalance in the brain under chronic signals. |
2021-05-02 |
2023-08-13 |
Not clear |
| Anne-Marie Howe, Aoife Cosgrave, Maitiú Ó'Murchú, Conor Britchfield, Aoife Mulvagh, Iván Fernandez-Perez, Megan Dykstra, Aimée C Jones, Derek A Costell. Characterising lipoteichoic acid as an in vitro model of acute neuroinflammation. International immunopharmacology. vol 85. 2021-04-30. PMID:32485352. |
using bv2 and n2a cells as an in vitro model, we highlight that acute exposure to lta robustly promotes inflammatory cytokine and nitric oxide (no) production in microglia but also in neurons, similar to that reported under longer-term and chronic inflammatory conditions. |
2021-04-30 |
2023-08-13 |
Not clear |
| Sam Joshva Baskar Jesudasan, Somnath J Gupta, Matthew A Churchward, Kathryn G Todd, Ian R Winshi. Inflammatory Cytokine Profile and Plasticity of Brain and Spinal Microglia in Response to ATP and Glutamate. Frontiers in cellular neuroscience. vol 15. 2021-04-24. PMID:33889075. |
the available data indicates that atp and glutamate can induce the release of pro inflammatory factors tnf (tumor necrosis factor), il-1β (interleukin 1 beta), and no (nitric oxide) from microglia. |
2021-04-24 |
2023-08-13 |
Not clear |
| Jinqiang Zhang, Hui He, Yan Qiao, Tao Zhou, Haili He, Saini Yi, Lijuan Zhang, Li Mo, Yahui Li, Weike Jiang, Zili Yo. Priming of microglia with IFN-γ impairs adult hippocampal neurogenesis and leads to depression-like behaviors and cognitive defects. Glia. vol 68. issue 12. 2021-04-06. PMID:32652855. |
chronic activation with ifn-γ induces reactive phenotypes in microglia associated with morphological changes, population expansion, mhc ii and cd68 up-regulation, and pro-inflammatory cytokine (il-1β, tnf-α, il-6) and nitric oxide (no) release. |
2021-04-06 |
2023-08-13 |
mouse |
| Byungwook Kim, Ju-Young Park, Duk-Yeon Cho, Hyun Myung Ko, Sung-Hwa Yoon, Dong-Kug Cho. 2-(5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)-N-(2-hydroxyethyl)-2-oxoacetamide (CDMPO) has anti-inflammatory properties in microglial cells and prevents neuronal and behavioral deficits in MPTP mouse model of Parkinson's disease. Neuropharmacology. vol 166. 2021-04-02. PMID:31887307. |
cdmpo and its parent compound, rimonabant, significantly attenuated nitric oxide (no) production in lps-stimulated primary microglia and bv2 cells. |
2021-04-02 |
2023-08-13 |
mouse |
| Nika Zharichenko, Dolores B Njok. The Role of Pro-Inflammatory and Regulatory Signaling by IL-33 in the Brain and Liver: A Focused Systematic Review of Mouse and Human Data and Risk of Bias Assessment of the Literature. International journal of molecular sciences. vol 21. issue 11. 2021-03-31. PMID:32486265. |
il-33 was produced by astrocytes and endothelial cells while il-33 receptors were expressed by microglia and astrocytes, demonstrating that these cells are first responders for il-33; however, in the cns, il-33 seems to induce th1 cytokines such as il-1β and tnf-α chemokines such as rantes, mcp-1, mip-1α, and ip-10, as well as nitric oxide. |
2021-03-31 |
2023-08-13 |
mouse |
| Jing-Shuai Wu, Qin-Yu Meng, Xiao-Hui Shi, Lu-Xin Liu, Zhen-Kun Zhang, Hua-Shi Guan, Chang-Lun Shao, Chang-Yun Wan. The oxygenated products of cryptotanshinone by biotransformation with Cunninghamella elegans exerting anti-neuroinflammatory effects by inhibiting TLR 4-mediated MAPK signaling pathway. Bioorganic chemistry. vol 104. 2021-03-29. PMID:32911197. |
all of the biotransformation products (2-4) were found to inhibit significantly lipopolysaccharide-induced nitric oxide production in bv2 microglia cells with the ic |
2021-03-29 |
2023-08-13 |
Not clear |
| In Jun Yeo, Jaesuk Yun, Dong Ju Son, Sang-Bae Han, Jin Tae Hon. Antifungal drug miconazole ameliorated memory deficits in a mouse model of LPS-induced memory loss through targeting iNOS. Cell death & disease. vol 11. issue 8. 2021-03-25. PMID:32796824. |
excessive cytokines can stimulate inos in microglia and astroglia and overproduce nitric oxide, which can be toxic to neurons. |
2021-03-25 |
2023-08-13 |
mouse |
| Ji Ae Lee, Hye Ri Kim, Hyo Jin Son, Nari Shin, Se Hee Han, Chan Seong Cheong, Dong Jin Kim, Onyou Hwan. A novel pyrazolo [3,4-d] pyrimidine, KKC080106, activates the Nrf2 pathway and protects nigral dopaminergic neurons. Experimental neurology. vol 332. 2021-03-09. PMID:32580013. |
in addition, in lipopolysaccharide-activated microglia, kkc080106 suppressed the generation of the proinflammatory markers, such as il-1β, tnf-α, cyclooxygenase-2, inducible nitric oxide synthase, and nitric oxide, and inhibited the phosphorylation of kinases known to be involved in inflammatory signaling, such as iκb kinase, p38, jnk, and erk. |
2021-03-09 |
2023-08-13 |
mouse |
| Shi Wei Tan, Daud Ahmad Bin Israf Ali, Huzwah Khaza'ai, Jia Woei Wong, Sharmili Vidyadara. Cellular uptake and anti-inflammatory effects of palm oil-derived delta (δ)-tocotrienol in microglia. Cellular immunology. vol 357. 2021-03-09. PMID:32979761. |
it was previously shown that δ-tocotrienol derived from palm oil reduced nitric oxide released by bv2 microglia as early as 18 h after lipopolysaccharide stimulation. |
2021-03-09 |
2023-08-13 |
Not clear |
| Yihai Wang, Yanqiong Lei, Yuying Huang, Zhe Wang, Jingwen Xu, Xiangjiu H. Jasmonates from Chinese acorns (Quercus serrata var. brevipetiolata) exert pronounced anti-neuroinflammatory activities. Bioorganic chemistry. vol 103. 2021-03-02. PMID:32750609. |
the isolated jasmonates were evaluated for anti-neuroinflammatory activity, and some showed pronounced inhibitory effects on the production of nitric oxide (no) induced by lipopolysaccharide (lps) in bv-2 microglia cells. |
2021-03-02 |
2023-08-13 |
Not clear |