| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan-Chen Liu, Na Feng, Wei-Wei Li, Peng-Fei Tu, Jian-Ping Chen, Jing-Yan Han, Ke-Wu Zen. Costunolide Plays an Anti-Neuroinflammation Role in Lipopolysaccharide-Induced BV2 Microglial Activation by Targeting Cyclin-Dependent Kinase 2. Molecules (Basel, Switzerland). vol 25. issue 12. 2021-02-18. PMID:32575562. |
in this study, we found that ctl significantly inhibited the production of inflammatory mediators including nitric oxide, il-6, tnf-α, and pge2 in lipopolysaccharide (lps)-stimulated bv2 microglia. |
2021-02-18 |
2023-08-13 |
Not clear |
| Chih-Cheng Wu, Cheng-Yi Chang, Kuei-Chung Shih, Chih-Jen Hung, Ya-Yu Wang, Shih-Yi Lin, Wen-Ying Chen, Yu-Hsiang Kuan, Su-Lan Liao, Wen-Yi Wang, Chun-Jung Che. β-Funaltrexamine Displayed Anti-inflammatory and Neuroprotective Effects in Cells and Rat Model of Stroke. International journal of molecular sciences. vol 21. issue 11. 2021-02-16. PMID:32485857. |
β-funaltrexamine shifted the polarization of microglia towards the anti-inflammatory phenotype, as evidenced by decreased nitric oxide, tumor necrosis factor-α, interleukin-1β, and prostaglandin e2, along with increased cd163 and arginase 1. |
2021-02-16 |
2023-08-13 |
rat |
| Sandra Gegunde, Amparo Alfonso, Eva Alonso, Rebeca Alvariño, Luis M Botan. Gracilin-Derivatives as Lead Compounds for Anti-inflammatory Effects. Cellular and molecular neurobiology. vol 40. issue 4. 2020-12-28. PMID:31729596. |
to carry out the experiments, microglia cells were pre-treated with compounds for 1 h and then stimulated with lipopolysaccharide for 24 h to determine reactive oxygen species production, mitochondrial membrane potential, the release of nitric oxide, interleukin-6 and tumor necrosis factor-α and the expression of nuclear factor-erythroid 2-related factor 2, nuclear factor-κb, the inducible nitric oxide synthase, and the cyclophilin a. |
2020-12-28 |
2023-08-13 |
Not clear |
| Matthew J E Maksoud, Vasiliki Tellios, Yun-Yan Xiang, Wei-Yang L. Nitric oxide signaling inhibits microglia proliferation by activation of protein kinase-G. Nitric oxide : biology and chemistry. vol 94. 2020-12-21. PMID:31759970. |
nitric oxide signaling inhibits microglia proliferation by activation of protein kinase-g. microglia population is primarily determined by a finely-regulated proliferation process during early development of the central nervous system (cns). |
2020-12-21 |
2023-08-13 |
Not clear |
| Yongxin Mai, Zhe Wang, Yihai Wang, Jingwen Xu, Xiangjiu H. Anti-neuroinflammatory triterpenoids from the seeds of Quercus serrata Thunb. Fitoterapia. vol 142. 2020-12-18. PMID:32092529. |
meanwhile, the inhibitory effects on nitric oxide (no) production induced by lipopolysaccharide (lps) in microglia cells (bv-2) of the identified triterpenoids were evaluated. |
2020-12-18 |
2023-08-13 |
Not clear |
| Tatsuhiro Akaishi, Shohei Yamamoto, Kazuho Ab. The Synthetic Curcumin Derivative CNB-001 Attenuates Thrombin-Stimulated Microglial Inflammation by Inhibiting the ERK and p38 MAPK Pathways. Biological & pharmaceutical bulletin. vol 43. issue 1. 2020-11-09. PMID:31902919. |
we have recently found that the synthetic curcumin derivative cnb-001 suppresses lipopolysaccharide (lps)-induced nitric oxide (no) production in cultured microglia, demonstrating that it exerts anti-neuroinflammatory effects by regulating microglial activation. |
2020-11-09 |
2023-08-13 |
rat |
| Ling-Hsuan Wu, Bor-Ren Huang, Sheng-Wei Lai, Chingju Lin, Hsiao-Yun Lin, Liang-Yo Yang, Dah-Yuu L. SIRT1 activation by minocycline on regulation of microglial polarization homeostasis. Aging. vol 12. issue 18. 2020-11-04. PMID:33021962. |
in the present study, sirt1 overexpression by genetic modification or treatment with sirt1 activators significantly inhibited the secretion of nitric oxide and expression of inducible nitric oxide synthase, cyclooxygenase 2, and proinflammatory mediator-interleukin 1β-in microglia. |
2020-11-04 |
2023-08-13 |
mouse |
| Jaclyn Iannucci, Haripriya Vittal Rao, Paula Gramma. High Glucose and Hypoxia-Mediated Damage to Human Brain Microvessel Endothelial Cells Induces an Altered, Pro-Inflammatory Phenotype in BV-2 Microglia In Vitro. Cellular and molecular neurobiology. 2020-11-02. PMID:33136275. |
alterations in microglia phenotype were assessed through measurement of nitric oxide (no), cytokine production, microglial activation state markers, and microglial phagocytosis. |
2020-11-02 |
2023-08-13 |
human |
| Jing Ji, Pengjun Xiang, Tingting Li, Li Lan, Xiaole Xu, Guo Lu, Hui Ji, Yihua Zhang, Yunman L. NOSH-NBP, a Novel Nitric Oxide and Hydrogen Sulfide- Releasing Hybrid, Attenuates Ischemic Stroke-Induced Neuroinflammatory Injury by Modulating Microglia Polarization. Frontiers in cellular neuroscience. vol 11. 2020-10-01. PMID:28603491. |
nosh-nbp, a novel nitric oxide and hydrogen sulfide- releasing hybrid, attenuates ischemic stroke-induced neuroinflammatory injury by modulating microglia polarization. |
2020-10-01 |
2023-08-13 |
Not clear |
| Francesca Gullo, Michela Ceriani, Alessia D'Aloia, Enzo Wanke, Andrew Constanti, Barbara Costa, Marzia Lecch. Plant Polyphenols and Exendin-4 Prevent Hyperactivity and TNF-α Release in LPS-Treated Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28932183. |
microglia are essential mediators of neuroinflammation and can regulate a broad spectrum of cellular responses by releasing reactive oxygen intermediates, nitric oxide, proteases, excitatory amino acids, and cytokines. |
2020-10-01 |
2023-08-13 |
Not clear |
| Nootchanat Mairuae, Poonlarp Cheepsunthor. Valproic acid attenuates nitric oxide and interleukin-1β production in lipopolysaccharide-stimulated iron-rich microglia. Biomedical reports. vol 8. issue 4. 2020-10-01. PMID:29541456. |
valproic acid attenuates nitric oxide and interleukin-1β production in lipopolysaccharide-stimulated iron-rich microglia. |
2020-10-01 |
2023-08-13 |
Not clear |
| Keren Asraf, Nofar Torika, Ron N Apte, Sigal Fleisher-Berkovic. Microglial Activation Is Modulated by Captopril: Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:29765306. |
captopril decreased lps-induced nitric oxide (no) release from primary mixed glial cells as well as regulating inducible no synthase (inos) expression, no, tumor necrosis factor-α (tnf-α) and induced interleukin-10 (il-10) production by bv2 microglia. |
2020-10-01 |
2023-08-13 |
mouse |
| Jordan A McKenzie, Andis Klegeri. Modulation of microglial functions by methyl jasmonate. Neural regeneration research. vol 13. issue 7. 2020-10-01. PMID:30028341. |
mj also selectively upregulated phagocytic activity of murine bv-2 microglia, but had no effect on nitric oxide secretion by these cells. |
2020-10-01 |
2023-08-13 |
mouse |
| Björn-Ole Bast, Uta Rickert, Janna Schneppenheim, François Cossais, Henrik Wilms, Philipp Arnold, Ralph Luciu. Aldosterone exerts anti-inflammatory effects on LPS stimulated microglia. Heliyon. vol 4. issue 10. 2020-10-01. PMID:30302409. |
therefore, we assessed the levels of nitric oxide (no), inos, il-6, il-1β, tnf-α and cox-2 in untreated, lps-treated and lps/aldosterone-treated microglia cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jong Hee Choi, Minhee Jang, Joon-Il Lee, Won-Seok Chung, Ik-Hyun Ch. Neuroprotective Effects of a Traditional Multi-Herbal Medicine Kyung-Ok-Ko in an Animal Model of Parkinson's Disease: Inhibition of MAPKs and NF-κB Pathways and Activation of Keap1-Nrf2 Pathway. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30618742. |
these positive effects of kok were related to inhibition of loss of tyrosine hydroxylase-positive neurons, reduction of mitosox activity, increased apoptotic cells, microglia activation, and upregulation of inflammatory factors [interleukin (il)-1β, il-6, cyclooxygenase-2, and inducible nitric oxide], and reduced blood-brain barrier (bbb) disruption in the substantia nigra pars compacta (snpc) and/or striatum after mptp intoxication. |
2020-10-01 |
2023-08-13 |
mouse |
| Elvira R Akhmetzyanova, Yana O Mukhamedshina, Margarita N Zhuravleva, Luisa R Galieva, Alexander A Kostennikov, Ekaterina E Garanina, Albert A Rizvano. Transplantation of Microglia in the Area of Spinal Cord Injury in an Acute Period Increases Tissue Sparing, but Not Functional Recovery. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30631265. |
when activated microglia clear the cellular debris and release anti- and proinflammatory cytokines and chemokines, nitric oxide, neurotrophins, and antioxidants capable of producing both neurotoxic and neuroprotective effects. |
2020-10-01 |
2023-08-13 |
rat |
| Shelby L Johnson, Riley D Kirk, Nicholas A DaSilva, Hang Ma, Navindra P Seeram, Matthew J Berti. Polyphenol Microbial Metabolites Exhibit Gut and Blood⁻Brain Barrier Permeability and Protect Murine Microglia against LPS-Induced Inflammation. Metabolites. vol 9. issue 4. 2020-10-01. PMID:31010159. |
the lignan-derived pmms, equol and enterolactone, exhibited protective effects against nitric oxide production, as well as against pro-inflammatory cytokines (il-6 and tnf-α) in bv-2 microglia. |
2020-10-01 |
2023-08-13 |
human |
| Yoshito Mizoguchi, Akira Monj. Microglial Intracellular Ca Frontiers in cellular neuroscience. vol 11. 2020-09-30. PMID:28367116. |
microglia are resident innate immune cells which release many factors including proinflammatory cytokines, nitric oxide (no) and brain-derived neurotrophic factor (bdnf) when they are activated in response to immunological stimuli. |
2020-09-30 |
2023-08-13 |
Not clear |
| Siyuan Shao, Yanan Yang, Ziming Feng, Jianshuang Jiang, Peicheng Zhan. New triacetic acid lactone glycosides from the fruits of Forsythia suspensa and their nitric oxide production inhibitory activity. Carbohydrate research. vol 488. 2020-09-29. PMID:31927345. |
compound 1 exhibited inhibitory activity against the lipopolysaccharide (lps)-induced nitric oxide (no) production in microglia bv2 cells with the inhibition rate of 69.40%. |
2020-09-29 |
2023-08-13 |
Not clear |
| Jung-Hee Jang, Seung Hoon Lee, Kyungsook Jung, Horyong Yoo, Gunhyuk Par. Inhibitory Effects of Myricetin on Lipopolysaccharide-Induced Neuroinflammation. Brain sciences. vol 10. issue 1. 2020-09-28. PMID:31935983. |
we found that myricetin significantly downregulated several markers of the neuroinflammatory response in lps-induced activated microglia, including inducible nitric oxide (no) synthase (inos), cyclooxygenase-2 (cox-2), and proinflammatory modulators and cytokines such as prostaglandin e2 (pge |
2020-09-28 |
2023-08-13 |
Not clear |