| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yongyi Li, Mingwei Zhu, Wen-Xiong Chen, Jing Luo, Xin Li, Yangyang Cao, Meng Zheng, Shanshan Ma, Zhilan Xiao, Yani Zhang, Linyan Jiang, Xiumin Wang, Ting Tan, Xia Li, Qian Gong, Xiaoli Xiong, Jun Wang, Mingxi Tang, Mingtao Li, Ya-Ping Tan. A novel mutation in intron 1 of Wnt1 causes developmental loss of dopaminergic neurons in midbrain and ASD-like behaviors in rats. Molecular psychiatry. 2023-09-01. PMID:37658228. |
our results for the first time documented that the developmental loss of daergic neurons in the midbrain underlies the pathogenesis of asd, and that the abnormal progenitor cell patterning is a cellular underpinning for this developmental daergic neuronal loss. |
2023-09-01 |
2023-09-07 |
rat |
| Lin Feng, Da Li, Yao Tian, Chengshun Zhao, Yun Sun, Xiaolong Kou, Jun Wu, Liu Wang, Qi Gu, Wei Li, Jie Hao, Baoyang Hu, Yukai Wan. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation Neural regeneration research. vol 19. issue 2. 2023-07-25. PMID:37488911. |
these beads allow midbrain dopaminergic progenitor cell differentiation and cryopreservation without digestion, effectively maintaining axonal integrity in vitro. |
2023-07-25 |
2023-08-14 |
human |
| Lin Feng, Da Li, Yao Tian, Chengshun Zhao, Yun Sun, Xiaolong Kou, Jun Wu, Liu Wang, Qi Gu, Wei Li, Jie Hao, Baoyang Hu, Yukai Wan. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation Neural regeneration research. vol 19. issue 2. 2023-07-25. PMID:37488911. |
overall, our findings show that these midbrain dopaminergic progenitor cell beads enhance the effectiveness of neuronal cell transplantation. |
2023-07-25 |
2023-08-14 |
human |
| Lin Feng, Da Li, Yao Tian, Chengshun Zhao, Yun Sun, Xiaolong Kou, Jun Wu, Liu Wang, Qi Gu, Wei Li, Jie Hao, Baoyang Hu, Yukai Wan. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation Neural regeneration research. vol 19. issue 2. 2023-07-25. PMID:37488911. |
one-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation numerous studies have shown that cell replacement therapy can replenish lost cells and rebuild neural circuitry in animal models of parkinson's disease. |
2023-07-25 |
2023-08-14 |
human |
| Lin Feng, Da Li, Yao Tian, Chengshun Zhao, Yun Sun, Xiaolong Kou, Jun Wu, Liu Wang, Qi Gu, Wei Li, Jie Hao, Baoyang Hu, Yukai Wan. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation Neural regeneration research. vol 19. issue 2. 2023-07-25. PMID:37488911. |
importantly, midbrain dopaminergic progenitor cell bead grafts showed increased survival and only mild immunoreactivity in vivo compared with suspended midbrain dopaminergic progenitor cell grafts. |
2023-07-25 |
2023-08-14 |
human |
| Aaron C Ta, Lin-Chien Huang, Caroline R McKeown, Jennifer E Bestman, Kendall Van Keuren-Jensen, Hollis T Clin. Temporal and Spatial Transcriptomic Dynamics across Brain Development in Xenopus laevis tadpoles. G3 (Bethesda, Md.). 2021-11-09. PMID:34751375. |
we found that genes pertaining to positive regulation of neural progenitor cell proliferation as well as known progenitor cell markers were upregulated in the midbrain prior to metamorphic climax; concurrently, expression of cell cycle timing regulators decreased across this period, supporting the notion that cell cycle lengthening contributes to a decrease in proliferation by the end of metamorphosis. |
2021-11-09 |
2023-08-13 |
mouse |
| Loksum Wong, Cameron J Weadick, Claire Kuo, Belinda S W Chang, Vincent Tropep. Duplicate dmbx1 genes regulate progenitor cell cycle and differentiation during zebrafish midbrain and retinal development. BMC developmental biology. vol 10. 2011-02-28. PMID:20860823. |
duplicate dmbx1 genes regulate progenitor cell cycle and differentiation during zebrafish midbrain and retinal development. |
2011-02-28 |
2023-08-12 |
mouse |
| B Xu, J S Goldman, V V Rymar, C Forget, P S Lo, S J Bull, E Vereker, P A Barker, L E Trudeau, A F Sadikot, T E Kenned. Critical roles for the netrin receptor deleted in colorectal cancer in dopaminergic neuronal precursor migration, axon guidance, and axon arborization. Neuroscience. vol 169. issue 2. 2010-11-23. PMID:20493932. |
examining newborn dcc null mice, we report that loss of dcc function results in profound alterations of da circuitry, including da progenitor cell migration defects, reduced numbers of da cells in midbrain nuclei, an anomalous da ventral commissure, malformed da innervation of the ventral striatum, and reduced da innervation of the cerebral cortex. |
2010-11-23 |
2023-08-12 |
mouse |
| Hyun-Jung Kim, Erin McMillan, Fabin Han, Clive N Svendse. Regionally specified human neural progenitor cells derived from the mesencephalon and forebrain undergo increased neurogenesis following overexpression of ASCL1. Stem cells (Dayton, Ohio). vol 27. issue 2. 2009-08-06. PMID:19008346. |
we show here that hnpc derived from the developing cortex (hnpc(ctx)) and ventral midbrain (hnpc(vm)) have similar morphological characteristics and express the progenitor cell marker nestin. |
2009-08-06 |
2023-08-12 |
human |
| Beibei Wang, Xifeng Zou, Haiyan Zhang, Deyi Duan, Lili Ju, Xiaohua Jiang, Xiaohong Sun, Chunli Zhao, Huanying Zhao, Jin Guo, Changlei Xu, Erjing Gao, Qunyuan X. Establishment of an immortalized GABAergic neuronal progenitor cell line from embryonic ventral mesencephalon in the rat. Brain research. vol 1210. 2008-08-26. PMID:18407253. |
establishment of an immortalized gabaergic neuronal progenitor cell line from embryonic ventral mesencephalon in the rat. |
2008-08-26 |
2023-08-12 |
rat |
| Beibei Wang, Xifeng Zou, Haiyan Zhang, Deyi Duan, Lili Ju, Xiaohua Jiang, Xiaohong Sun, Chunli Zhao, Huanying Zhao, Jin Guo, Changlei Xu, Erjing Gao, Qunyuan X. Establishment of an immortalized GABAergic neuronal progenitor cell line from embryonic ventral mesencephalon in the rat. Brain research. vol 1210. 2008-08-26. PMID:18407253. |
in the present study, a thermally controlled immortalized gabaergic neuronal progenitor cell line (rmne6) was established from e13 rat ventral mesencephalon cells immortalized using the temperature-sensitive mutant of sv40 large t antigen (ts-tag). |
2008-08-26 |
2023-08-12 |
rat |
| Anja Badde, Dorothea Schult. A role for receptor protein tyrosine phosphatase lambda in midbrain development. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 24. 2008-07-10. PMID:18550757. |
overexpression of rptplambda suppressed the activity of a beta-catenin responsive promoter in the midbrain and reduced progenitor cell proliferation. |
2008-07-10 |
2023-08-12 |
Not clear |
| Jonna Saarimäki-Vire, Paula Peltopuro, Laura Lahti, Thorsten Naserke, Alexandra A Blak, Daniela M Vogt Weisenhorn, Kai Yu, David M Ornitz, Wolfgang Wurst, Juha Partane. Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 32. 2007-08-29. PMID:17687036. |
we propose a model for regulation of progenitor cell self-renewal and neuronal differentiation by combinatorial intercellular signals in the ventral midbrain. |
2007-08-29 |
2023-08-12 |
mouse |
| Naixin Li, Amata Hornbruch, Ruth Klafke, Barbara Katzenberger, Andrea Wizenman. Specification of dorsoventral polarity in the embryonic chick mesencephalon and its presumptive role in midbrain morphogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. vol 233. issue 3. 2005-10-27. PMID:15906380. |
hence, our results suggest that progressive specification of the midbrain dv axis is accompanied by progressively reduced cell mixing between dorsal and ventral precursors, leading to a partial regionalization of midbrain tissue into autonomous units of precursor cell populations. |
2005-10-27 |
2023-08-12 |
chicken |
| J Santa-Olalla, L Covarrubia. Basic fibroblast growth factor promotes epidermal growth factor responsiveness and survival of mesencephalic neural precursor cells. Journal of neurobiology. vol 40. issue 1. 1999-08-03. PMID:10398068. |
we have previously described two neural precursor cell populations from 13.5 days postcoitium (dpc) mesencephalon, one forming colonies in response to egf, present in the ventral mesencephalon, and other forming colonies in response to egf + bfgf, mainly present in the dorsal mesencephalon. |
1999-08-03 |
2023-08-12 |
Not clear |