| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xin Xu, Zhiyu Li, Yue Leng, Corey P Neu, Sarah Calv. Knockdown of the pericellular matrix molecule perlecan lowers in situ cell and matrix stiffness in developing cartilage. Developmental biology. vol 418. issue 2. 2017-05-15. PMID:27578148. |
our results demonstrate that the knockdown of a spatially restricted matrix molecule can have a profound influence on cell and tissue stiffness, implicating a role for outside-in mechanical signals from the pcm in regulating the intracellular mechanisms required for the overall development of cartilage. |
2017-05-15 |
2023-08-13 |
Not clear |
| Maria M Barreca, Walter Spinello, Vincenzo Cavalieri, Giuseppina Turturici, Gabriella Sconzo, Punit Kaur, Rosaria Tinnirello, Alexzander A A Asea, Fabiana Gerac. Extracellular Hsp70 Enhances Mesoangioblast Migration via an Autocrine Signaling Pathway. Journal of cellular physiology. vol 232. issue 7. 2017-05-15. PMID:27925208. |
we further demonstrate that hsp70 has a positive role in regulating matrix metalloproteinase 2 (mmp2) and mmp9 expression and that mmp2 has a more pronounced effect on cell migration, as compared to mmp9. |
2017-05-15 |
2023-08-13 |
mouse |
| Scott C Johns, Xin Yin, Michael Jeltsch, Joseph R Bishop, Manuela Schuksz, Roland El Ghazal, Sarah A Wilcox-Adelman, Kari Alitalo, Mark M Fuste. Functional Importance of a Proteoglycan Coreceptor in Pathologic Lymphangiogenesis. Circulation research. vol 119. issue 2. 2017-05-12. PMID:27225479. |
heparan sulfate is a linear polysaccharide expressed on proteoglycan core proteins on cell membranes and matrix, playing roles in angiogenesis, although little is known about any function(s) in lymphatic remodeling in vivo. |
2017-05-12 |
2023-08-13 |
Not clear |
| Andreia M Silva, José H Teixeira, Maria Ines Almeida, Raquel M Gonçalves, Mário A Barbosa, Susana G Santo. Extracellular Vesicles: Immunomodulatory messengers in the context of tissue repair/regeneration. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 98. 2017-05-12. PMID:27644894. |
next, the impact of ev on cell proliferation and differentiation, and on extracellular matrix remodelling, key aspects of the subsequent phases of tissue repair, is addressed. |
2017-05-12 |
2023-08-13 |
human |
| Teena Bhakuni, Mohammad Farhan Ali, Irshad Ahmad, Shadabi Bano, Shoyab Ansari, Mohamad Aman Jairajpur. Role of heparin and non heparin binding serpins in coagulation and angiogenesis: A complex interplay. Archives of biochemistry and biophysics. vol 604. 2017-05-09. PMID:27372899. |
inhibitory role of serpins is modulated by binding to cofactors, specially heparin and heparan sulfate proteoglycans (hspgs) present on cell surfaces and extracellular matrix. |
2017-05-09 |
2023-08-13 |
Not clear |
| Chun-Yen Liu, Michiya Matsusaki, Mitsuru Akash. Three-Dimensional Tissue Models Constructed by Cells with Nanometer- or Micrometer-Sized Films on the Surfaces. Chemical record (New York, N.Y.). vol 16. issue 2. 2017-04-28. PMID:26924465. |
to date, we have developed a simple but unique bottom-up approach, a hierarchical cell manipulation technique, with a nanometer-sized ecm matrix consisting of fibronectin (fn) and gelatin (g) on cell surfaces. |
2017-04-28 |
2023-08-13 |
Not clear |
| Jiao Luo, Ying Wang, Bing Yu, Hongyan Qian, Yan He, Guixiu Sh. A Potential of sFasL in Preventing Gland Injury in Sjogren's Syndrome. BioMed research international. vol 2017. 2017-04-18. PMID:28326325. |
sfasl can be produced by mfasl cleaved by matrix metalloproteinases (mmp) and also reveals a role for binding to fas which is expressed on cell surface. |
2017-04-18 |
2023-08-13 |
human |
| Jia Chen, Dan Zhang, Qin Li, Dan Yang, Zengjie Fan, Dongyang Ma, Liling Re. Effect of different cell sheet ECM microenvironment on the formation of vascular network. Tissue & cell. vol 48. issue 5. 2017-03-22. PMID:27561623. |
the prefabrication of vascular network based on cell sheet technique brings a promising potential for sufficient vascularization due to rich extracellular matrix (ecm) of cell sheets. |
2017-03-22 |
2023-08-13 |
human |
| Valentina Belli, Daniela Guarnieri, Marco Biondi, Francesca Della Sala, Paolo A Nett. Dynamics of nanoparticle diffusion and uptake in three-dimensional cell cultures. Colloids and surfaces. B, Biointerfaces. vol 149. 2017-02-24. PMID:27710850. |
this study aims at elucidating the effect of three-dimensional (3d) extracellular matrix on cell behaviour and nanoparticle (np) diffusion and its consequences on np cellular uptake mechansims. |
2017-02-24 |
2023-08-13 |
human |
| Joanna Rosińczuk, Jakub Taradaj, Robert Dymarek, Mirosław Sope. Mechanoregulation of Wound Healing and Skin Homeostasis. BioMed research international. vol 2016. 2017-02-13. PMID:27413744. |
the study describes the influence of rigidity of extracellular matrix and special restrictions on cell physiology. |
2017-02-13 |
2023-08-13 |
Not clear |
| Yona Nadir, Benjamin Brenne. Heparanase procoagulant activity in cancer progression. Thrombosis research. vol 140 Suppl 1. 2017-01-09. PMID:27067977. |
heparanase is an endo-β-d-glucuronidase that is capable of cleaving heparan sulfate side chains of heparan sulfate proteoglycans on cell surfaces and the extracellular matrix. |
2017-01-09 |
2023-08-13 |
mouse |
| Huanxin Xie, Yongbin Jing, Jingjun Xia, Xintao Wang, Changcheng You, Jinglong Ya. Aquaporin 3 protects against lumbar intervertebral disc degeneration via the Wnt/β-catenin pathway. International journal of molecular medicine. vol 37. issue 3. 2016-12-19. PMID:26820815. |
the objective of the present study was to investigate the effect of aqp3 on cell proliferation and extracellular matrix (ecm) degradation in human nucleus pulposus cells (hnpcs) using gain-of-function and loss-of-function experiments, and to determine whether wnt/β-catenin signaling is involved in the effect of aqp3 on ivd degeneration. |
2016-12-19 |
2023-08-13 |
human |
| Ping Du, Muhammad Suhaeri, Ramesh Subbiah, Se Young Van, Jimin Park, Sang Heon Kim, Kwideok Park, Kangwon Le. Elasticity Modulation of Fibroblast-Derived Matrix for Endothelial Cell Vascular Morphogenesis and Mesenchymal Stem Cell Differentiation. Tissue engineering. Part A. vol 22. issue 5-6. 2016-12-13. PMID:26786806. |
as for hmscs multilineage differentiation, adipogenesis is improved on natural fdm that with lower matrix elasticity, while osteogenesis is accelerated on physically modified fdms that with higher matrix elasticity, these results further confirm the crucial role of matrix elasticity on cell fate determination. |
2016-12-13 |
2023-08-13 |
human |
| Ying-Hui Zhang, Juan-Juan Wang, Min Li, Han-Xi Zheng, Lan Xu, You-Guo Che. Matrix Metallopeptidase 14 Plays an Important Role in Regulating Tumorigenic Gene Expression and Invasion Ability of HeLa Cells. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 26. issue 3. 2016-12-13. PMID:26825836. |
the objectives of this study were to investigate the functional effect of matrix metallopeptidase 14 (mmp14) on cell invasion in cervical cancer cells (hela line) and to study the underlying molecular mechanisms. |
2016-12-13 |
2023-08-13 |
Not clear |
| Li Wang, Rui-Zhi Tan, Yue Chen, Hong-Lian Wang, Yu-Hang Liu, Dan Wen, Jun-Ming Fa. CagA promotes proliferation and secretion of extracellular matrix by inhibiting signaling pathway of apoptosis in rat glomerular mesangial cells. Renal failure. vol 38. issue 3. 2016-12-13. PMID:26837331. |
in the present study, cck8 assay, enzyme-linked immunosorbent assay, and immunohistochemistry were performed to investigate the effect of caga on cell proliferation and extracellular matrix secretion in rat glomerular mesangial cells. |
2016-12-13 |
2023-08-13 |
rat |
| Joséphine Lantoine, Thomas Grevesse, Agnès Villers, Geoffrey Delhaye, Camille Mestdagh, Marie Versaevel, Danahe Mohammed, Céline Bruyère, Laura Alaimo, Stéphanie P Lacour, Laurence Ris, Sylvain Gabriel. Matrix stiffness modulates formation and activity of neuronal networks of controlled architectures. Biomaterials. vol 89. 2016-12-13. PMID:26946402. |
here we designed robust and reproducible laminin-polylysine grid micropatterns on cell culture substrates that have similar biochemical properties but a 100-fold difference in young's modulus to investigate the role of the matrix rigidity on the formation and activity of cortical neuronal networks. |
2016-12-13 |
2023-08-13 |
Not clear |
| Merry L Lindsey, Rugmani Padmanabhan Iyer, Mira Jung, Kristine Y DeLeon-Pennell, Yonggang M. Matrix metalloproteinases as input and output signals for post-myocardial infarction remodeling. Journal of molecular and cellular cardiology. vol 91. 2016-11-11. PMID:26721597. |
while mmps process cytokine and extracellular matrix (ecm) substrates to regulate the inflammatory and fibrotic components of the wound healing response to mi, mmps also serve as upstream signaling initiators with direct actions on cell signaling cascades. |
2016-11-11 |
2023-08-13 |
Not clear |
| Fan Zhang, Qingxin Song, Xuan Huang, Fengning Li, Kun Wang, Yixing Tang, Canglong Hou, Hongxing She. A Novel High Mechanical Property PLGA Composite Matrix Loaded with Nanodiamond-Phospholipid Compound for Bone Tissue Engineering. ACS applied materials & interfaces. vol 8. issue 2. 2016-10-21. PMID:26646188. |
as a novel matrix supporting human osteoblast (hfob1.19) growth, ndpc50-pfs with different amounts of ndpc50 demonstrated no negative effects on cell proliferation and osteogenic differentiation. |
2016-10-21 |
2023-08-13 |
mouse |
| C Magliaro, A Tirella, G Mattei, A Pirone, A Ahluwali. HisTOOLogy: an open-source tool for quantitative analysis of histological sections. Journal of microscopy. vol 260. issue 3. 2016-10-17. PMID:26258893. |
in addition, to demonstrate how the tool can be employed to obtain quantitative information on biological tissues, the effect of different hepatic tissue decellularization protocols on cell removal and matrix preservation was assessed through image analysis using histoology and compared with conventional dna and total protein content assays. |
2016-10-17 |
2023-08-13 |
Not clear |
| Jiaying Zhao, Yuankun Cai, Chenqing Yin, You Lv, Wanmin Wei, Xin Wang, Zong Hao, Chenxia Shen, Huipeng Wang, Jun Che. Study on the inhibition of hyperthermic CO₂ pneumoperitoneum on the proliferation and migration of colon cancer cells and its mechanism. Oncology reports. vol 35. issue 2. 2016-10-17. PMID:26718327. |
the growth and morphology of cells were observed under a microscope, the inhibition on cell proliferation was measured using wst-8 test, cell apoptosis and the cell cycle were monitored using fluorescence-activated cell sorting analysis, the migration of cells was tested using the scratch assay, and the expression of hsp-70, caspase-3, hypoxia-inducible factor-1α (hif-1α) and matrix metalloproteinase-9 (mmp-9) proteins and genes was investigated using western blotting and reverse transcription polymerase chain reaction. |
2016-10-17 |
2023-08-13 |
Not clear |