| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brian R Hoffmann, Yuanyuan Liu, Deane F Moshe. Modification of EGF-like module 1 of thrombospondin-1, an animal extracellular protein, by O-linked N-acetylglucosamine. PloS one. vol 7. issue 3. 2012-07-09. PMID:22403705. |
these results demonstrate that o-β-n-acetylglucosaminylation can occur on secreted extracellular matrix proteins as well as on cell surface proteins. |
2012-07-09 |
2023-08-12 |
human |
| b' Nevenka Gligorijevi\\xc4\\x87, Sandra Aran\\xc4\\x91elovi\\xc4\\x87, Lana Filipovi\\xc4\\x87, Ksenija Jakovljevi\\xc4\\x87, Radmila Jankovi\\xc4\\x87, Sanja Grguri\\xc4\\x87-\\xc5\\xa0ipka, Ivanka Ivanovi\\xc4\\x87, Sini\\xc5\\xa1a Radulovi\\xc4\\x87, Zivoslav Lj Te\\xc5\\xa1i\\xc4\\x8. Picolinate ruthenium(II)-arene complex with in vitro antiproliferative and antimetastatic properties: comparison to a series of ruthenium(II)-arene complexes with similar structure. Journal of inorganic biochemistry. vol 108. 2012-07-05. PMID:22266461.' |
regardless of their effect on cell growth, ru(ii) complexes exerted antimetastatic effect on several tumor cell lines in vitro, achieved mostly by the effect on cell adhesion, migration and angiogenesis, while picolinate ruthenium(ii)-arene additionally exerted inhibitory effect on extracellular matrix degradation. |
2012-07-05 |
2023-08-12 |
Not clear |
| Gert-Jan Bakker, Volker Andresen, Robert M Hoffman, Peter Fried. Fluorescence lifetime microscopy of tumor cell invasion, drug delivery, and cytotoxicity. Methods in enzymology. vol 504. 2012-06-19. PMID:22264531. |
by correlating specific areas in the phasor plot to the actual image, we obtained direct insight into cancer-cell invasion into a 3d collagen matrix, the differential uptake of doxorubicin by cells, and the consequences on cell invasion and apoptosis induction. |
2012-06-19 |
2023-08-12 |
Not clear |
| Yosuke Amemiya, Keiko Kawano, Michiya Matsusaki, Mitsuru Akashi, Noriyuki Nakamura, Chikashi Nakamur. Formation of nanofilms on cell surfaces to improve the insertion efficiency of a nanoneedle into cells. Biochemical and biophysical research communications. vol 420. issue 3. 2012-06-01. PMID:22450311. |
here, we have formed nanofilms composed of extracellular matrix molecules on cell surfaces and found that the formation of the nanofilms improved insertion efficiency of a nanoneedle into fibroblast and neural cells. |
2012-06-01 |
2023-08-12 |
Not clear |
| Bernice Jim, Thomas Steffen, Janet Moir, Peter Roughley, Lisbet Haglun. Development of an intact intervertebral disc organ culture system in which degeneration can be induced as a prelude to studying repair potential. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. vol 20. issue 8. 2012-05-31. PMID:21336509. |
degeneration was induced by a single trypsin injection into the center of the disc and the effect on cell viability and matrix degradation was followed. |
2012-05-31 |
2023-08-12 |
cattle |
| David A Carrino, Sam Mesiano, Nichole M Barker, William W Hurd, Arnold I Capla. Proteoglycans of uterine fibroids and keloid scars: similarity in their proteoglycan composition. The Biochemical journal. vol 443. issue 2. 2012-05-14. PMID:22257180. |
these qualitative and quantitative proteoglycan differences may play a role in the expansion of these fibroses and in their excessive matrix deposition and matrix disorganization, due to effects on cell proliferation, tgf (transforming growth factor)-β signalling and/or collagen fibril formation. |
2012-05-14 |
2023-08-12 |
human |
| Jonathan D McCanless, Judith A Cole, Steven M Slack, Joel D Bumgardner, Paul O Zamora, Warren O Haggar. Modeling nucleus pulposus regeneration in vitro: mesenchymal stem cells, alginate beads, hypoxia, bone morphogenetic protein-2, and synthetic peptide B2A. Spine. vol 36. issue 26. 2012-05-11. PMID:21311397. |
using a low cell density, hypoxic, alginate-bead culture system, the effects of bone morphogenetic protein-2 (bmp-2) and synthetic peptide b2a on cell proliferation and extracellular matrix (ecm) synthesis were assessed at days 0, 3, 5, and 7, using nucleus pulposus (np)-like differentiated mesenchymal stem cells (mscs). |
2012-05-11 |
2023-08-12 |
Not clear |
| Qingzong Tseng, Eve Duchemin-Pelletier, Alexandre Deshiere, Martial Balland, Hervé Guillou, Odile Filhol, Manuel Thér. Spatial organization of the extracellular matrix regulates cell-cell junction positioning. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 5. 2012-03-30. PMID:22307605. |
the organization of cells into epithelium depends on cell interaction with both the extracellular matrix (ecm) and adjacent cells. |
2012-03-30 |
2023-08-12 |
Not clear |
| Ming Zhao, Yohei Tominaga, Kenoki Ohuchida, Kazuhiro Mizumoto, Lin Cui, Shingo Kozono, Hayato Fujita, Ryo Maeyama, Hiroki Toma, Masao Tanak. Significance of combination therapy of zoledronic acid and gemcitabine on pancreatic cancer. Cancer science. vol 103. issue 1. 2012-02-28. PMID:21954965. |
four human pancreatic cancer cell lines were treated with zol, gem or a combination of both, and the effects of the respective drug regimens on cell proliferation, invasion and matrix metalloproteinase (mmp) expression were examined. |
2012-02-28 |
2023-08-12 |
mouse |
| Ya-li Yang, Charles Sun, Matthew E Wilhelm, Laura J Fox, Jieling Zhu, Laura J Kaufma. Influence of chondroitin sulfate and hyaluronic acid on structure, mechanical properties, and glioma invasion of collagen I gels. Biomaterials. vol 32. issue 31. 2011-12-19. PMID:21820735. |
this study is among the few efforts to differentiate structural, mechanical and biochemical effects of changes to matrix composition on cell motility in 3d. |
2011-12-19 |
2023-08-12 |
Not clear |
| Carly Lodewyks, Jose Rodriguez, Jing Yan, Betty Lerner, Jeremy Lipschitz, Charles Nfon, Julia Darlene Rempel, Julia Uhanova, Gerald Yosel Minu. GABA-B receptor activation inhibits the in vitro migration of malignant hepatocytes. Canadian journal of physiology and pharmacology. vol 89. issue 6. 2011-11-28. PMID:21762014. |
we also sought to determine whether any effects on cell migration were mediated by changes in cyclic adenosine monophosphate (camp) signaling or matrix metalloproteinase (mmp) expression. |
2011-11-28 |
2023-08-12 |
human |
| Jihye Seong, Mingxing Ouyang, Taejin Kim, Jie Sun, Po-Chao Wen, Shaoying Lu, Yue Zhuo, Nicholas M Llewellyn, David D Schlaepfer, Jun-Lin Guan, Shu Chien, Yingxiao Wan. Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer. Nature communications. vol 2. 2011-11-18. PMID:21792185. |
here we show that, on cell adhesion to extracellular matrix proteins or stimulation by platelet-derived growth factor (pdgf), the fret responses of drm-targeting fak biosensor are stronger than that at non-drm regions, suggesting that fak activation can occur at drm microdomains. |
2011-11-18 |
2023-08-12 |
Not clear |
| Su-Jeong Hwang, Sung Kwan Yoon, Gou Young Koh, Gyun Min Le. Effects of culture temperature and pH on flag-tagged COMP angiopoietin-1 (FCA1) production from recombinant CHO cells: FCA1 aggregation. Applied microbiology and biotechnology. vol 91. issue 2. 2011-11-14. PMID:21509567. |
to maximize the production of flag-tagged cartilage oligomeric matrix protein angiopoietin-1 (fca1) from chinese hamster ovary (cho) cells, the effects of culture ph and temperature on cell growth and fca1 production were investigated. |
2011-11-14 |
2023-08-12 |
Not clear |
| Menemşe Gümüşderelioğlu, Sevcan Dalkıranoğlu, R Seda Tığlı Aydın, Soner Cakma. A novel dermal substitute based on biofunctionalized electrospun PCL nanofibrous matrix. Journal of biomedical materials research. Part A. vol 98. issue 3. 2011-11-10. PMID:21661095. |
human dermal keratinocytes (hs2) were cultivated on both neat and egf immobilized pcl and pcl/collagen matrices to investigate the effects of matrix chemical composition and presence of egf on cell proliferation and differentiation. |
2011-11-10 |
2023-08-12 |
human |
| Yaqin Liu, Yesen Li, Yuhong X. Inhibitory effects of novel integrin-targeting peptides on angiogenesis activity in HUVEC cells in vitro. Cell biochemistry and function. vol 29. issue 5. 2011-11-09. PMID:21590697. |
there was no significant effect on cell invasion, indicating the importance of extracellular matrix degradation in modulating the anti-invasive effect of human umbilical vein endothelial cells (huvecs). |
2011-11-09 |
2023-08-12 |
human |
| Takafumi Iida, Takayuki Kawato, Hideki Tanaka, Natsuko Tanabe, Kumiko Nakai, Ning Zhao, Naoto Suzuki, Kuniyasu Ochiai, Masao Maen. Sodium butyrate induces the production of cyclooxygenases and prostaglandin E₂ in ROS 17/2.8 osteoblastic cells. Archives of oral biology. vol 56. issue 7. 2011-11-02. PMID:21281931. |
we examined the effects of ba and/or indomethacin on cell proliferation, the expression of cyclooxygenases (coxs), prostaglandin (pg) receptors (ep1-4), extracellular matrix proteins, such as type i collagen and osteopontin, and pge(2) production, using ros17/2.8 cells as osteoblasts. |
2011-11-02 |
2023-08-12 |
Not clear |
| Paula J Williams, Judith N Bulmer, Barbara A Innes, Fiona Broughton Pipki. Possible roles for folic acid in the regulation of trophoblast invasion and placental development in normal early human pregnancy. Biology of reproduction. vol 84. issue 6. 2011-09-26. PMID:21349824. |
in addition, an array was performed on cell culture supernatants to examine a range of matrix metalloproteinases (mmps) and tissue inhibitors of mmps (timps). |
2011-09-26 |
2023-08-12 |
human |
| Guak-Kim Tan, Donna Lee M Dinnes, Peter T Myers, Justin J Cooper-Whit. Effects of biomimetic surfaces and oxygen tension on redifferentiation of passaged human fibrochondrocytes in 2D and 3D cultures. Biomaterials. vol 32. issue 24. 2011-09-23. PMID:21592565. |
we thus have further evaluated the effects of the c6s surface, alongside a number of other tailored surfaces, on cell adhesion, proliferation, matrix synthesis and relevant marker gene expression (collagen i, -ii, aggrecan and sox-9 etc) of passaged human fibrochondrocytes in 2d (coated glass coverslips) and 3d (surface-modified polymeric scaffolds) environments. |
2011-09-23 |
2023-08-12 |
human |
| Michael A Tolino, Ethan R Block, Jes K Klarlun. Brief treatment with heparin-binding EGF-like growth factor, but not with EGF, is sufficient to accelerate epithelial wound healing. Biochimica et biophysica acta. vol 1810. issue 9. 2011-09-19. PMID:21640162. |
heparin-binding egf-like growth factor (hb-egf) contains, in contrast to egf, a domain that binds to negatively charged glycans on cell surfaces and in extracellular matrix. |
2011-09-19 |
2023-08-12 |
Not clear |
| Yue-Hui Zhang, Chang-Qing Zhao, Lei-Sheng Jiang, Li-Yang Da. Substrate stiffness regulates apoptosis and the mRNA expression of extracellular matrix regulatory genes in the rat annular cells. Matrix biology : journal of the International Society for Matrix Biology. vol 30. issue 2. 2011-08-22. PMID:21055467. |
here we studied the influence of substrate stiffness on cell morphology, apoptosis and extracellular matrix (ecm) metabolism of the rat annulus fibrosus (af) cells which are known to be mechanosensitive cells. |
2011-08-22 |
2023-08-12 |
rat |