All Relations between spinal cord ventral horn motor neuron and serotonin

Reference Sentence Publish Date Extraction Date Species
Justin J Kavanagh, Janet L Taylo. Voluntary activation of muscle in humans: does serotonergic neuromodulation matter? The Journal of physiology vol issue 2022 35864781 we firstly outline structural and functional characteristics of the serotonergic system, and then describe how motoneurone discharge can be facilitated and suppressed depending on the 5-ht receptor subtype that is activated. 2022-07-22 2022-07-25 Not clear
Jacob R Thorstensen, Janet L Taylor, Justin J Kavanag. 5-HT The European journal of neuroscience vol issue 2022 35445439 5-ht the intrinsic electrical properties of motoneurons strongly affect motoneuron excitability to fast-acting excitatory ionotropic inputs. 2022-04-21 2022-04-25 Not clear
Jacob R Thorstensen, Janet L Taylor, Justin J Kavanag. 5-HT The European journal of neuroscience vol issue 2022 35445439 serotonin (5-ht) is a neurochemical that alters the intrinsic properties of motoneurons, whereby animal models and in vitro experiments indicate that 5-ht increases motoneuron excitability by activating 5-ht 2022-04-21 2022-04-25 Not clear
Mark M Rich, Stephen N Housley, Paul Nardelli, Randall K Powers, Timothy C Cop. Imbalanced Subthreshold Currents Following Sepsis and Chemotherapy: A Shared Mechanism Offering a New Therapeutic Target? The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry vol issue 2021 33345706 activation of serotonin (5ht) receptors in a rat model of sepsis restores the normal balance of subthreshold currents and normal motoneuron firing. 2021-06-22 2022-01-13 Not clear
Fredrik Piehl, Ulf Arvidsson, Hans Johnson, Staffan Cullheim, Marcelo Villar, Ake Dagerlind, Lars Terenius, Tomas H\\xc3\\xb6kfelt, Brun Ulfhak. Calcitonin Gene-related Peptide (CGRP)-like Immunoreactivity and CGRP mRNA in Rat Spinal Cord Motoneurons after Different Types of Lesions. The European journal of neuroscience vol 3 issue 8 2019 12106460 however, treatment with 5,7-dht, which lesions 5-ht neurons, including those giving rise to the bulbospinal serotoninergic pathway, did not cause any dramatic changes in motor behaviour but induced an increase in both motoneuron content of cgrp-li and expression of cgrp mrna. 2019-11-20 2022-01-11 Not clear
Gabriella A Horvath, Lorelyn Meisner, Kathryn Selby, Robert Stowe, Bruce Carleto. Improved strength on 5-hydroxytryptophan and carbidopa in spinal cord atrophy. Journal of the neurological sciences vol 378 issue 2018 28566180 there is ample evidence of an important role of descending serotonergic projections in modulating spinal motor neuron activation and firing, and experimental studies suggest that 5-ht receptor stimulation can improve motor function after spinal cord injury; however, relevant clinical data is sorely lacking. 2018-03-14 2022-01-13 Not clear
Yongzhi Xia, Dan Chen, Haijian Xia, Zhengbu Liao, Wenyuan Tang, Yi Ya. Serotonergic projections to lumbar levels and its plasticity following spinal cord injury. Neuroscience letters vol 649 issue 2018 28396282 additionally, the 5-ht innervation of these two areas evolved progressively from a diffuse network to a more restricted pattern, particularly at the ventral horn within the motoneuron area from p21 to adulthood. 2018-03-08 2022-01-13 Not clear
Jean-Fran\\xc3\\xa7ois Perrier, Florence Cote. Serotonergic modulation of spinal motor control. Current opinion in neurobiology vol 33 issue 2016 25553359 recent findings suggest that moderate release of 5-ht facilitates locomotion and promotes the excitability of motoneurons, while stronger release inhibits rhythmic activity and motoneuron firing. 2016-04-21 2022-01-12 Not clear
Robert Maratta, Keith K Fenrich, Ethan Zhao, Monica S Neuber-Hess, P Ken Ros. Distribution and density of contacts from noradrenergic and serotonergic boutons on the dendrites of neck flexor motoneurons in the adult cat. The Journal of comparative neurology vol 523 issue 11 2016 25728799 the number of 5-ht and na contacts per motoneuron ranged, respectively, from 381 to 1,430 and from 642 to 1,382, which is 2.3- and 1.4-fold less than neck extensor motoneurons (montague et al., j comp neurol 2013;521:638-656). 2016-02-24 2022-01-12 Not clear
Jeremy W Chopek, Patricia C Sheppard, Kalan Gardiner, Phillip F Gardine. Serotonin receptor and KCC2 gene expression in lumbar flexor and extensor motoneurons posttransection with and without passive cycling. Journal of neurophysiology vol 113 issue 5 2015 25505109 of interest here is the regulation of serotonin (5-ht) receptors (r), glutamate receptor, metabotropic 1 (mglur1), and potassium-chloride cotransporter (kcc2), which mediate motoneuron excitability, locomotor recovery, and spasticity posttransection. 2015-12-01 2022-01-12 Not clear
Raffaele Nardone, Yvonne H\\xc3\\xb6ller, Aljoscha Thomschewski, Peter H\\xc3\\xb6ller, Piergiorgio Lochner, Stefan Golaszewski, Francesco Brigo, Eugen Trink. Serotonergic transmission after spinal cord injury. Journal of neural transmission (Vienna, Austria : 1996) vol 122 issue 2 2015 24866695 5-ht denervation supersensitivity is one of the key mechanisms underlying the increased motoneuron excitability that occurs after sci, and this hyperexcitability has been demonstrated to underlie the pathogenesis of spasticity after sci. 2015-09-25 2022-01-12 Not clear
J E Koschnitzky, K A Quinlan, T J Lukas, E Kajtaz, E J Kocevar, W F Mayers, T Siddique, C J Heckma. Effect of fluoxetine on disease progression in a mouse model of ALS. Journal of neurophysiology vol 111 issue 11 2015 24598527 fluoxetine increases synaptic serotonin (5-ht) levels, which is known to increase spinal motoneuron excitability. 2015-01-24 2022-01-12 Not clear
J E Koschnitzky, K A Quinlan, T J Lukas, E Kajtaz, E J Kocevar, W F Mayers, T Siddique, C J Heckma. Effect of fluoxetine on disease progression in a mouse model of ALS. Journal of neurophysiology vol 111 issue 11 2015 24598527 we confirmed that 5-ht increases spinal motoneuron excitability during this neonatal time period and therefore hypothesized that antagonizing 5-ht receptors during the same time period would improve disease outcome. 2015-01-24 2022-01-12 Not clear
Yaqing Li, Lisa Li, Marilee J Stephens, Dwight Zenner, Katherine C Murray, Ian R Winship, Romana Vavrek, Glen B Baker, Karim Fouad, David J Bennet. Synthesis, transport, and metabolism of serotonin formed from exogenously applied 5-HTP after spinal cord injury in rats. Journal of neurophysiology vol 111 issue 1 2014 24068759 in contrast, when we applied exogenous 5-htp (in vitro or in vivo), aadc-containing vessels and neurons synthesized 5-ht, which contributed to increased motoneuron activity and muscle spasms (long-lasting reflexes, llrs), by acting on 5-ht2 receptors (sb206553 sensitive) located on motoneurons (ttx resistant). 2014-08-11 2022-01-12 Not clear
L-Q Ren, J Wienecke, M Chen, M M\\xc3\\xb8ller, H Hultborn, M Zhan. The time course of serotonin 2C receptor expression after spinal transection of rats: an immunohistochemical study. Neuroscience vol 236 issue 2013 23337537 serotonin 2a receptor and serotonin 2c receptor (5-ht2a and 2c receptors) are likely the most important 5-ht receptors for enhancing the motoneuron excitability by facilitating the persistent inward current (pic), and thus play an important role for the pathogenesis of spasticity after spinal cord injury. 2013-08-26 2022-01-12 Not clear
Matvey Roshchin, Pavel M Balaba. Neural control of olfaction and tentacle movements by serotonin and dopamine in terrestrial snail. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology vol 198 issue 2 2012 22076462 5ht applications decreased cineole-evoked responses recorded in the olfactory nerve and hyperpolarized the identified tentacle retractor muscle motoneuron mtc3, while da applications led to the opposite changes. 2012-10-09 2022-01-12 Not clear
Matvey Roshchin, Pavel M Balaba. Neural control of olfaction and tentacle movements by serotonin and dopamine in terrestrial snail. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology vol 198 issue 2 2012 22076462 our data suggest that 5ht and da affect the peripheral (sensory epithelium and tentacular ganglion), the central (procerebrum), and the single motor neuron (withdrawal motoneuron mtc3) level of the snail's nervous system. 2012-10-09 2022-01-12 Not clear
Tyler W Dunn, Carole A Farah, Wayne S Sossi. Inhibitory responses in Aplysia pleural sensory neurons act to block excitability, transmitter release, and PKC Apl II activation. Journal of neurophysiology vol 107 issue 1 2012 21994260 expression of the 5-ht(1apl(a)) receptor in aplysia pleural sensory neurons inhibited 5-ht-mediated translocation of the novel pkc apl ii in sensory neurons and prevented pkc-dependent synaptic facilitation at sensory to motoneuron synapses (nagakura et al. 2012-04-19 2022-01-12 Not clear
Katherine C Murray, Marilee J Stephens, Michelle Rank, Jessica D'Amico, Monica A Gorassini, David J Bennet. Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. Journal of neurophysiology vol 106 issue 2 2012 21653728 our results demonstrate that 5-ht(1b/1f) agonists, such as zolmitriptan, can restore inhibition of sensory transmission after sci without affecting general motoneuron function and thus may serve as a novel class of antispastic drugs. 2012-03-26 2022-01-12 Not clear
X-Y Kong, J Wienecke, M Chen, H Hultborn, M Zhan. The time course of serotonin 2A receptor expression after spinal transection of rats: an immunohistochemical study. Neuroscience vol 177 issue 2012 21211552 serotonin (5-ht) denervation supersensitivity is one of the mechanisms underlying this increased motoneuron excitability. 2012-01-19 2022-01-13 Not clear
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