All Relations between spinal cord ventral horn motor neuron alpha and cerebellum

Publication Sentence Publish Date Extraction Date Species
Haseena Sait, Arya Shambhavi, Manmohan Pandey, Deepak Ravichandran, Shubha R Phadk. T2 olivary nuclei hyperintensities: A characteristic neuroimaging finding in FIG4 related leukoencephalopathy. American journal of medical genetics. Part A. 2022-12-18. PMID:36529678. fig4 related leukoencephalopathy has recently been considered as an expanded spectrum of fig4 related disorders characterized by upper and lower motor neuron involvement, dystonia, intellectual disability, bulbar symptoms with cerebellar atrophy. 2022-12-18 2023-08-14 Not clear
Rangariroyashe H Chipika, Grainne Mulkerrin, Pierre-François Pradat, Aizuri Murad, Fabrice Ango, Cédric Raoul, Peter Bed. Cerebellar pathology in motor neuron disease: neuroplasticity and neurodegeneration. Neural regeneration research. vol 17. issue 11. 2022-05-10. PMID:35535867. the clinical picture is dominated by upper and lower motor neuron degeneration, but extra-motor pathology is increasingly recognized, including cerebellar pathology. 2022-05-10 2023-08-13 Not clear
Stacey Li Hi Shing, Aizuri Murad, Jasmin Lope, Orla Hardiman, Peter Bed. Cerebellar remodelling decades after spinal cord insult: neuroplasticity in poliomyelitis survivors. Journal of integrative neuroscience. vol 21. issue 2. 2022-04-01. PMID:35364653. the objective of this study is the systematic characterisation of cerebellar integrity metrics in a cohort of adult poliomyelitis survivors as a template condition for longstanding lower motor neuron injury. 2022-04-01 2023-08-13 Not clear
Sevim Türay, Recep Eröz, A Nazlı Başa. A novel pathogenic variant in the 3' end of the AGTPBP1 gene gives rise to neurodegeneration without cerebellar atrophy: an expansion of the disease phenotype? Neurogenetics. vol 22. issue 2. 2021-12-03. PMID:33909173. however, in our patients, no signs of cerebellar atrophy in cranial mri were present, so the acronym condca is not applicable; lower motor neuron findings were also absent. 2021-12-03 2023-08-13 Not clear
Sevim Türay, Recep Eröz, A Nazlı Başa. A novel pathogenic variant in the 3' end of the AGTPBP1 gene gives rise to neurodegeneration without cerebellar atrophy: an expansion of the disease phenotype? Neurogenetics. vol 22. issue 2. 2021-12-03. PMID:33909173. childhood-onset neurodegeneration with cerebellar atrophy (condca) is a recently described form of the large group of infantile hereditary lower motor neuron diseases (teoh et al. 2021-12-03 2023-08-13 Not clear
William Kristian Karlsson, Joan Lilja Sunnleyg Højgaard, Anna Vilhelmsen, Clarissa Crone, Birgit Andersen, Ian Law, Lisbeth Birk Møller, Troels Tolstrup Nielsen, Emilie Neerup Nielsen, Thomas Krag, Kirsten Svenstrup, Jørgen Erik Nielse. Novel Homozygous Truncating Variant Widens the Spectrum of Early-Onset Multisystemic SYNE1 Ataxia. Cerebellum (London, England). 2021-07-28. PMID:34318393. we expand the list of likely pathogenic variants in syne1 ataxia with a novel homozygous truncating variant with proximity to the c-terminus and relate it to a phenotype comprising early-onset cerebellar deficits, upper and lower motor neuron involvement and cognitive deficits. 2021-07-28 2023-08-13 Not clear
Mert Karakaya, Cem Paketci, Janine Altmueller, Holger Thiele, Irmgard Hoelker, Uluc Yis, Brunhilde Wirt. Biallelic variant in AGTPBP1 causes infantile lower motor neuron degeneration and cerebellar atrophy. American journal of medical genetics. Part A. vol 179. issue 8. 2020-07-28. PMID:31102495. biallelic variant in agtpbp1 causes infantile lower motor neuron degeneration and cerebellar atrophy. 2020-07-28 2023-08-13 Not clear
Mert Karakaya, Cem Paketci, Janine Altmueller, Holger Thiele, Irmgard Hoelker, Uluc Yis, Brunhilde Wirt. Biallelic variant in AGTPBP1 causes infantile lower motor neuron degeneration and cerebellar atrophy. American journal of medical genetics. Part A. vol 179. issue 8. 2020-07-28. PMID:31102495. likewise, a novel phenotype, childhood-onset neurodegeneration with cerebellar atrophy (condca) has been described recently in individuals with lower motor neuron disorder and cerebellar atrophy due to biallelic loss-of-function variants in agtpbp1 that encodes cytosolic carboxypeptidase 1 (ccp1). 2020-07-28 2023-08-13 Not clear
Milos Stanojlovic, Xiaosha Pang, Yifeng Lin, Sarrabeth Stone, Marija Cvetanovic, Wensheng Li. Inhibition of Vascular Endothelial Growth Factor Receptor 2 Exacerbates Loss of Lower Motor Neurons and Axons during Experimental Autoimmune Encephalomyelitis. PloS one. vol 11. issue 7. 2017-08-02. PMID:27466819. interestingly, we found that treatment with su5416, a selective vegfr2 inhibitor, starting after the onset of eae clinical symptoms exacerbated lower motor neuron loss and axon loss in the lumbar spinal cord of mice undergoing eae, but did not alter purkinje neuron loss in the cerebellum or upper motor neuron loss in the cerebral cortex. 2017-08-02 2023-08-13 mouse
Yu-sheng Li, Cheng-yuan Mao, Chang-he Shi, Bo Song, Jun Wu, Jie Qin, Yan Ji, Hui-xia Niu, Hai-yang Luo, Dan-dan Shang, Shi-lei Sun, Yu-ming X. Exome sequencing reveals novel SPG11 mutation in hereditary spastic paraplegia with complicated phenotypes. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 22. issue 7. 2016-04-20. PMID:26003865. we used a combined approach of whole-exome sequencing and candidate mutation validation to identify the disease-causing gene in a hereditary spastic paraplegia (hsp) patient with lower motor neuron involvement, mild cerebellar signs and dysgenesis of the corpus callosum. 2016-04-20 2023-08-13 Not clear
Yu-sheng Li, Cheng-yuan Mao, Chang-he Shi, Bo Song, Jun Wu, Jie Qin, Yan Ji, Hui-xia Niu, Hai-yang Luo, Dan-dan Shang, Shi-lei Sun, Yu-ming X. Exome sequencing reveals novel SPG11 mutation in hereditary spastic paraplegia with complicated phenotypes. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 22. issue 7. 2016-04-20. PMID:26003865. our finding suggests that these novel compound heterozygous mutations in spg11 are associated with hsp and lower motor neuron involvement, mild cerebellar signs and dysgenesis of the corpus callosum. 2016-04-20 2023-08-13 Not clear
S Sveinbjornsdottir, G Einarsso. [Disorders of stance and gait: a review.]. Laeknabladid. vol 83. issue 9. 2015-10-26. PMID:19679901. the clinical symptoms of gait disturbances associated with upper and lower motor neuron dysfunction, extrapyramidal disorders, sensory, cerebellar and other neurological conditions as well as diseases of the skeleton are described. 2015-10-26 2023-08-12 Not clear
C Bettencourt, J L López-Sendón, J García-Caldentey, P Rizzu, I M C Bakker, O Shomroni, B Quintáns, J R Dávila, M R Bevova, M-J Sobrido, P Heutink, J G de Yébene. Exome sequencing is a useful diagnostic tool for complicated forms of hereditary spastic paraplegia. Clinical genetics. vol 85. issue 2. 2015-03-30. PMID:23438842. whole-exome sequencing was performed in two spanish siblings with a neurodegenerative syndrome including upper and lower motor neuron, ocular and cerebellar signs. 2015-03-30 2023-08-12 Not clear
Pam Enderb. Disorders of communication: dysarthria. Handbook of clinical neurology. vol 110. 2013-08-06. PMID:23312647. there are six major types of dysarthria: flaccid dysarthria associated with lower motor neuron impairment, spastic dysarthria associated with damaged upper motor neurons linked to the motor areas of the cerebral cortex, ataxic dysarthria primarily caused by cerebellar dysfunction, and hyperkinetic dysarthria and hypokinetic dysarthria, which are related to a disorder of the extrapyramidal system. 2013-08-06 2023-08-12 Not clear
Takahisa Tateishi, Toshihiro Hokonohara, Ryo Yamasaki, Shiro Miura, Hitoshi Kikuchi, Akiko Iwaki, Hiroshi Tashiro, Hirokazu Furuya, Yuko Nagara, Yasumasa Ohyagi, Nobuyuki Nukina, Toru Iwaki, Yasuyuki Fukumaki, Jun-ichi Kir. Multiple system degeneration with basophilic inclusions in Japanese ALS patients with FUS mutation. Acta neuropathologica. vol 119. issue 3. 2012-01-11. PMID:19967541. neuropathological study of one autopsied case with the fus mutation revealed multiple system degeneration in addition to upper and lower motor neuron involvement: the globus pallidus, thalamus, substantia nigra, cerebellum, inferior olivary nucleus, solitary nucleus, intermediolateral horn, clarke's column, onuf's nucleus, central tegmental tract, medial lemniscus, medial longitudinal fasciculus, superior cerebellar peduncle, posterior column, and spinocerebellar tract were all degenerated. 2012-01-11 2023-08-12 Not clear
C C S Delnooz, D J Lefeber, S M C Langemeijer, S Hoffjan, G Dekomien, M J Zwarts, B G M Van Engelen, R A Wevers, H J Schelhaas, B P C van de Warrenbur. New cases of adult-onset Sandhoff disease with a cerebellar or lower motor neuron phenotype. Journal of neurology, neurosurgery, and psychiatry. vol 81. issue 9. 2010-09-16. PMID:20798201. new cases of adult-onset sandhoff disease with a cerebellar or lower motor neuron phenotype. 2010-09-16 2023-08-12 Not clear
N Chakraborty, T Roy, A Hazra, A Biswas, K Bhattachary. Dysarthric Bengali speech: a neurolinguistic study. Journal of postgraduate medicine. vol 54. issue 4. 2009-05-07. PMID:18953144. dysarthria affects linguistic domains such as respiration, phonation, articulation, resonance and prosody due to upper motor neuron, lower motor neuron, cerebellar or extrapyramidal tract lesions. 2009-05-07 2023-08-12 Not clear
Szymon Skoczeń, Walentyna Balwierz, Sławomir Kroczka, Bozena Bańdo, Marek Kacińsk. [Late neurological complications after termination of treatment of acute lymphoblastic leukemia in children]. Przeglad lekarski. vol 61 Suppl 2. 2005-04-13. PMID:15686052. abnormalities in neurological examination were found in 33 (18%) including abnormalities of: lower motor neuron in 16 (9%), pyramidal system in 6 (3%), cerebellum in 1 (0.6%), epilepsy in 8 (5%), encephalopathy in 5 (3%). 2005-04-13 2023-08-12 Not clear
G Gatti, S Simsek, A Kurne, S Zurrida, P Naninato, P Veronesi, A Frasson, E Millen, J Rososchansky, A Luin. Paraneoplastic neurological disorders in breast cancer. Breast (Edinburgh, Scotland). vol 12. issue 3. 2004-02-04. PMID:14659327. the neurological paraneoplastic syndromes that are mainly associated with breast cancer are subacute cerebellar degeneration, paraneoplastic retinopathy, opsoclonus-myoclonus syndrome, lower motor neuron diseases and stiff-man syndrome. 2004-02-04 2023-08-12 Not clear
J L Contreras-Vidal, S Grossberg, D Bulloc. A neural model of cerebellar learning for arm movement control: cortico-spino-cerebellar dynamics. Learning & memory (Cold Spring Harbor, N.Y.). vol 3. issue 6. 1999-09-09. PMID:10456112. excitation of alpha motoneuron pools, combined with inhibition of their renshaw cells by the cerebellum, facilitate movement initiation and optimal execution. 1999-09-09 2023-08-12 Not clear