All Relations between 5-ht system and serotonin

Reference Sentence Publish Date Extraction Date Species
Mauricio Sepulveda, Elizabeth E Manning, Andrea Gogos, Matthew Hale, Maarten van den Buus. Long-term effects of young-adult methamphetamine on dorsal raphe serotonin systems in mice: Role of brain-derived neurotrophic factor. Brain research vol 1762 issue 2022 33737066 To assess the long-term effects of chronic adolescent methamphetamine (METH) treatment on the serotonin system in the brain, we used serotonin-1A receptor (5-HT 2022-01-06 2022-01-09 mouse
N Haddjeri, C Ortemann, C de Montigny, P Blie. Effect of sustained administration of the 5-HT1A receptor agonist flesinoxan on rat 5-HT neurotransmission. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology vol 9 issue 5 1999 10523050 At the postsynaptic level, long-term treatment with flesinoxan (5 mg/kg/day x 14 days) did not modify the responsiveness of dorsal hippocampus CA3 pyramidal neurons to microiontophoretic applications of 5-HT and flesinoxan nor to endogenous 5-HT released by the electrical stimulation of the ascending 5-HT pathway, indicating an unchanged sensitivity of postsynaptic 5-HT1A receptors. 1999-11-22 2022-01-08 rat
H K Kramer, J C Poblete, E C Azmiti. Characterization of the translocation of protein kinase C (PKC) by 3,4-methylenedioxymethamphetamine (MDMA/ecstasy) in synaptosomes: evidence for a presynaptic localization involving the serotonin transporter (SERT). Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol 19 issue 4 1998 9718590 3, 4-methylenedioxymethamphetamine (MDMA or Ecstasy) is a substituted amphetamine whose acute and long-term effects on the serotonin system are dependent on an interaction with the 5-HT uptake transporter (SERT). 1998-11-25 2022-01-08 Not clear
A Mosner, G Kuhlman, C Roehm, W H Voge. Serotonergic receptors modify the voluntary intake of alcohol and morphine but not of cocaine and nicotine by rats. Pharmacology vol 54 issue 4 1997 9211564 These results suggest: (1) selective stimulation of 5-HT1A receptors reduces alcohol preference, (2) stimulation of all 5-HT receptors has no effect on alcohol intake, indicating the presence of inhibitory receptors, (3) stimulation of the serotonergic system in general stimulates morphine preference, (4) the serotonin system does not affect nicotine or cocaine preference and (5) the serotonergic system is not involved in the voluntary consumption of all, but-only of some drugs/chemicals of abuse. 1997-09-03 2022-01-08 rat
E H Cook, B L Leventha. The serotonin system in autism. Current opinion in pediatrics vol 8 issue 4 1997 9053096 The serotonin system has been implicated as a factor in some cases of autism since the finding in 1961 of elevated serotonin (5-hydroxytryptamine) levels in the blood of patients with autism. 1997-03-07 2022-01-07 human
G Pi\\xc3\\xb1eyro, C de Montigny, M Weiss, P Blie. Autoregulatory properties of dorsal raphe 5-HT neurons: possible role of electrotonic coupling and 5-HT1D receptors in the rat brain. Synapse (New York, N.Y.) vol 22 issue 1 1996 8822478 The 5-HT pathway was electrically stimulated at the level of the ventromedial tegmentum and the ensuing action potentials, recorded in the dorsal raphe, met all criteria for antidromic invasion of 5-HT neurons. 1996-11-08 2022-01-07 Not clear
P Blier, A Lista, C De Montign. Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: II. Effect of pertussis and cholera toxins. The Journal of pharmacology and experimental therapeutics vol 265 issue 1 1993 8474003 The effectiveness of the stimulation of the ascending 5-HT pathway in suppressing the firing activity of the same neurons, which results from the release of 5-HT at the level of their dendritic tree, was also markedly decreased in the cholera toxin-treated rats, but intriguingly not in the pertussis toxin-treated rats. 1993-05-18 2022-01-07 rat
P Blier, A Lista, C De Montign. Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: I. Effect of spiperone. The Journal of pharmacology and experimental therapeutics vol 265 issue 1 1993 8474032 and a third one immediately before the experiment, the responsiveness of CA3 pyramidal neurons to 5-HT applied by microiontophoresis and to that released by the electrical stimulation of the ascending 5-HT pathway was markedly reduced. 1993-05-18 2022-01-07 Not clear
Y Chaput, C de Montigny, P Blie. Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments. An in vivo electrophysiologic study in the rat. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol 5 issue 4 1992 1839498 Repeated electroconvulsive shocks (ECS; administered every other day for 14 days) as well as the sustained 21-day administration of the tricyclic antidepressant imipramine (10 mg/kg/day) and of the selective 5-hydroxytryptamine (5-HT) reuptake blocker paroxetine (5 mg/kg/day), increased the suppressant effect of the electrical stimulation of the afferent 5-HT pathway on the firing activity of CA3 hippocampus pyramidal neurons. 1992-05-05 2022-01-07 rat
R Godbout, Y Chaput, P Blier, C de Montign. Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission. Neuropharmacology vol 30 issue 7 1991 1681446 The sustained administration of tandospirone for 14 days (10 mg/kg/day, s.c.) altered neither the effectiveness of microiontophoretically-applied 5-HT and tandospirone nor that of endogenous 5-HT, released by the electrical simulation of the afferent 5-HT pathway, in suppressing the firing activity of pyramidal neurones in the hippocampus, suggesting that postsynaptic 5-HT1A receptors had not desensitized. 1991-11-04 2022-01-07 rat
Y Chaput, P Lesieur, C de Montign. Effects of short-term serotonin depletion on the efficacy of serotonin neurotransmission: electrophysiological studies in the rat central nervous system. Synapse (New York, N.Y.) vol 6 issue 4 1991 1962911 The effect of afferent 5-HT pathway stimulation was reduced in only 40% of treated rats, whereas the sensitivity of CA3 pyramidal neurons to microiontophoretic 5-HT was not modified. 1991-03-25 2022-01-07 rat
Y Chaput, P Lesieur, C de Montign. Effects of short-term serotonin depletion on the efficacy of serotonin neurotransmission: electrophysiological studies in the rat central nervous system. Synapse (New York, N.Y.) vol 6 issue 4 1991 1962911 The effects of short-term serotonin (5-HT) depletion by p-chlorophenylalanine (PCPA) on the firing activity of dorsal raphe nucleus 5-HT neurons, on the responsiveness of dorsal hippocampus pyramidal neurons to microiontophoretically applied 5-HT and on the efficacy of the electrical stimulation of the ascending 5-HT pathway in suppressing the firing activity of CA3 dorsal hippocampus pyramidal neurons were assessed in chloral hydrate-anesthetized rats. 1991-03-25 2022-01-07 rat
Y Chaput, P Lesieur, C de Montign. Effects of short-term serotonin depletion on the efficacy of serotonin neurotransmission: electrophysiological studies in the rat central nervous system. Synapse (New York, N.Y.) vol 6 issue 4 1991 1962911 The present results showing that the 350 mg/kg/day regimen of PCPA, but not the 250 mg/kg/day regimen, reduced the efficacy of the stimulation of the ascending 5-HT pathway suggest that a greater than 90% depletion is required to affect 5-HT neurotransmission significantly. 1991-03-25 2022-01-07 rat
P Gambardella, A M Greco, R Sticchi, D D'Apont. Circadian rhythm variations in the adult rat induced by low and high protein diets administered at various stages of development. Chronobiology international vol 7 issue 1 1990 1695553 The rhythm of the serotonin system was significantly altered by a low protein diet: decreased 5-HT amplitude (low protein diet in the fetal stage and suckling), decreased 5-HT amplitude and deranged 5-HIAA rhythm (low protein in the post-lactation period), deranged 5-HIAA rhythm (low protein diet throughout the experiment). 1990-08-28 2022-01-07 rat
I Inoue, T Shimizu, T Saheki, T Noda, T Fukud. Serotonin- and catecholamine-related substances in the brain of ornithine transcarbamylase-deficient Sparse-fur mice in the hyperammonemic state: comparison of two procedures for obtaining brain extract, decapitation and microwave irradiation. Biochemical medicine and metabolic biology vol 42 issue 3 1990 2597437 Increased flux through the 5-HT pathway during hyperammonemia was indicated by a significant positive correlation between Gln concentration and the ratio of 5-HIAA to 5-HT in the brain of spf mice taken after microwave irradiation to prevent postmortem changes in metabolites. 1990-02-02 2022-01-07 mouse
P Blier, C de Montigny, D Tardi. Short-term lithium treatment enhances responsiveness of postsynaptic 5-HT1A receptors without altering 5-HT autoreceptor sensitivity: an electrophysiological study in the rat brain. Synapse (New York, N.Y.) vol 1 issue 3 1989 2850622 In the first part of the present study, the effect of lithium on the function of terminal 5-HT autoreceptors was assessed by comparing in controls and lithium-treated rats the differential effect of two frequencies of stimulation (0.8 and 5 Hz) and that of methiothepin, a terminal 5-HT autoreceptor antagonist, on the effectiveness of the electrical activation of the ascending 5-HT pathway in suppressing dorsal hippocampus pyramidal neuron firing activity. 1989-02-21 2022-01-07 rat
P Blier, C de Montigny, Y Chapu. Electrophysiological assessment of the effects of antidepressant treatments on the efficacy of 5-HT neurotransmission. Clinical neuropharmacology vol 11 Suppl 2 issue 1988 2846168 The acute administration of 5-HT reuptake blockers does not enhance the efficacy of the stimulation of the 5-HT pathway. 1988-12-20 2022-01-07 Not clear
P Blier, Y Chaput, C de Montign. Long-term 5-HT reuptake blockade, but not monoamine oxidase inhibition, decreases the function of terminal 5-HT autoreceptors: an electrophysiological study in the rat brain. Naunyn-Schmiedeberg's archives of pharmacology vol 337 issue 3 1988 3260661 The function of the terminal 5-HT autoreceptors was assessed by comparing the effectiveness of the electrical stimulation of the ascending 5-HT pathway on the firing activity of hippocampus pyramidal neurons prior to, and following, the administration of methiothepin, an antagonist of the terminal 5-HT autoreceptor, and, by determining the ratio of effectiveness of 0.8 Hz (S1) and 5 Hz (S2) stimulations. 1988-08-22 2022-01-07 rat
Y Chaput, C de Montign. Effects of the 5-hydroxytryptamine receptor antagonist, BMY 7378, on 5-hydroxytryptamine neurotransmission: electrophysiological studies in the rat central nervous system. The Journal of pharmacology and experimental therapeutics vol 246 issue 1 1988 2839669 To assess whether endogenous 5-HT also could be antagonized, the response of pyramidal neurons to electrical activation of the 5-HT pathway was determined before and after i.v. 1988-08-17 2022-01-07 rat
Y Chaput, C de Montigny, P Blie. Effects of a selective 5-HT reuptake blocker, citalopram, on the sensitivity of 5-HT autoreceptors: electrophysiological studies in the rat brain. Naunyn-Schmiedeberg's archives of pharmacology vol 333 issue 4 1986 3022157 for 14 days, the suppression of firing activity of CA3 hippocampal pyramidal neurons produced by microiontophoretically-applied 5-HT and by the electrical activation of the ascending 5-HT pathway was measured. 1986-12-12 2022-01-07 rat
Y Chaput, P Blier, C de Montign. In vivo electrophysiological evidence for the regulatory role of autoreceptors on serotonergic terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 6 issue 10 1986 3020184 Methiothepin significantly increased the duration of the suppression of firing activity of these neurons by the electrical stimulation of the 5-HT pathway, without modifying their responsiveness to microiontophoretically applied 5-HT. 1986-11-12 2022-01-07 Not clear
Y Chaput, P Blier, C de Montign. In vivo electrophysiological evidence for the regulatory role of autoreceptors on serotonergic terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 6 issue 10 1986 3020184 In a second series of experiments, further evidence for the activation of terminal 5-HT autoreceptors by 5-HT released by the electrical stimulation was sought by assessing the effectiveness of 2 series of stimulations of the ascending 5-HT pathway delivered at different frequencies while recording the same postsynaptic neuron. 1986-11-12 2022-01-07 Not clear
Y Chaput, P Blier, C de Montign. In vivo electrophysiological evidence for the regulatory role of autoreceptors on serotonergic terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 6 issue 10 1986 3020184 In a first series of experiments, the effect of the electrical activation of the ascending 5-HT pathway on the firing activity of CA3 hippocampal pyramidal neurons was measured before and after the intravenous administration of methiothepin, a terminal 5-HT autoreceptor antagonist. 1986-11-12 2022-01-07 Not clear
S Finklestein, A Campbell, R J Baldessarini, K L Moya, S N Habe. Late changes in cerebral monoamine metabolism following focal ventrolateral cerebrocortical lesions in rats. Brain research vol 344 issue 2 1985 2412650 The changes of greatest magnitude and anatomical extent were found in the serotonin system: 5-HT was generally increased, and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) and the 5-HIAA:5-HT ratio were decreased throughout the cerebral hemispheres ipsilateral to lesions. 1985-11-20 2022-01-07 rat
P Blier, C De Montign. Short-term lithium administration enhances serotonergic neurotransmission: electrophysiological evidence in the rat CNS. European journal of pharmacology vol 113 issue 1 1985 2995061 The responsiveness to 5-HT and NE was not modified whereas the effect of activation of the ascending 5-HT pathway was increased two-fold by the lithium treatment. 1985-11-12 2022-01-07 rat
H Fujiwara, M Uemoto, C Tanak. Stimulation of the rat dorsal raphe in vivo releases labeled serotonin from the parietal cortex. Brain research vol 216 issue 2 1981 7248780 These findings are a direct demonstration of the in vivo release of [3H]5-HT from the parietal cortex with stimulation of the dorsal raphe, particularly the rostral two-thirds of the nucleus and provide the neurochemical evidence for the dorsal raphe-cortical 5-HT pathway via the lateral 5-HT bundle. 1981-09-25 2022-01-07 rat
T Yamamoto, S Uek. The role of central serotonergic mechanisms on head-twitch and backward locomotion induced by hallucinogenic drugs. Pharmacology, biochemistry, and behavior vol 14 issue 1 1981 6258178 These results suggest that 5-HT receptors innervated with the ascending 5-HT pathway originating in the m-R play a vital role in the manifestation of hallucinogen-induced head-twitch. 1981-04-24 2022-01-07 Not clear
R Y Wang, C de Montigny, B I Gold, R H Roth, G K Aghajania. Denervation supersensitivity to serotonin in rat forebrain: single cell studies. Brain research vol 178 issue 2-3 1980 509215 5-HT projections to the vLGN and the AMYG were destroyed by 5,7-dihydroxytryptamine (5,7-DHT, a relatively selective toxin for 5-HT neurons) injected directly into the lateral ventricle or the ascending 5-HT pathway in the ventromedial tegmentum area. 1980-02-15 2022-01-07 Not clear
R Y Wang, G K Aghajania. Inhibiton of neurons in the amygdala by dorsal raphe stimulation: mediation through a direct serotonergic pathway. Brain research vol 120 issue 1 1977 137766 The evidence may be briefly summarized as follows:(1) on the same amygdaloid cells, both iontophoresis of serotonin (5-HT) and electrical stimulation of the DRN markedly inhibited spontaneous single unit activities; (2) the latency of DRN-induced inhibition was relatively short and is compatible with the conduction velocities (which were determined by antidromic activation of the 5-HT pathway) of unmyelinated 5-HT fibers; (3) destruction of 5-HT projections by 5,7-dihydroxytryptamine (5,7-DHT) or pharmacological depletion of 5-HT by parachlorophenylalanine (PCPA) prevented the inhibitory responsed to DRN stimulation in the great majority of cells studied; (4) in PCPA-pretreated animals, injection of 5-hydroxytryptophan (5-HTP) reversed the PCPA effect, restoring the responses of amygdaloid cells to DRN stimulation. 1977-03-15 2022-01-07 Not clear
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