| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abraham Miranda-Páez, Sergio R Zamudio, Priscila Vázquez-León, Vicente Sandoval-Herrera, Ivan Villanueva-Becerril, Giancarlo Carl. Effect of melatonin injection into the periaqueductal gray on antinociception and tonic immobility in male rats. Hormones and behavior. vol 89. 2017-09-04. PMID:27988316. |
ti-induced antinociception can be elicited, facilitated, or increased through opioid and γ-aminobutyric acid (gaba) among other chemical mediators at several levels of the central nervous system, mainly in the periaqueductal gray (pag). |
2017-09-04 |
2023-08-13 |
rat |
| Q F Liu, L Li, Y Q Guo, X Li, Z D Mou, X Wang, G Z D. Injection of Toll-like receptor 4 siRNA into the ventrolateral periaqueductal gray attenuates withdrawal syndrome in morphine-dependent rats. Archives italiennes de biologie. vol 154. issue 4. 2017-06-19. PMID:28306133. |
we assessed the role of the toll-like receptor 4 (tlr4) gene in the ventrolateral periaqueductal gray (vlpag) region of morphine-dependent rats on attenuating withdrawal syndrome, and regulating glutamic acid decarboxylase (gad67), glutamic acid (glu), and gamma-aminobutyric acid (gaba). |
2017-06-19 |
2023-08-13 |
rat |
| Abraham Miranda-Páez, Sergio Zamudio, Priscila Vázquez-León, Carolina Campos-Rodríguez, Eduardo Ramírez-San Jua. Involvement of opioid and GABA systems in the ventrolateral periaqueductal gray on analgesia associated with tonic immobility. Pharmacology, biochemistry, and behavior. vol 142. 2016-10-31. PMID:26780595. |
involvement of opioid and gaba systems in the ventrolateral periaqueductal gray on analgesia associated with tonic immobility. |
2016-10-31 |
2023-08-13 |
rat |
| R C Almada, C M Roncon, D H Elias-Filho, N C Coimbr. Endocannabinoid signaling mechanisms in the substantia nigra pars reticulata modulate GABAergic nigrotectal pathways in mice threatened by urutu-cruzeiro venomous pit viper. Neuroscience. vol 303. 2016-05-10. PMID:26141842. |
the substantia nigra pars reticulata (snpr) is rich in γ-aminobutyric acid (gaba)-ergic neurons and connected to the mesencephalic tectum (mt) structures, such as the superior colliculus and dorsal periaqueductal gray matter. |
2016-05-10 |
2023-08-13 |
mouse |
| Ling Cheng, Peng Li, Stephanie Cheeyee Tjen-A-Looi, John Charles Longhurs. What do we understand from clinical and mechanistic studies on acupuncture treatment for hypertension? Chinese medicine. vol 10. 2015-12-02. PMID:26628909. |
the long-lasting inhibition of hypertension induced by ea was related to opioids and gaba in the rvlm, neural circuitry between the arcuate and ventrolateral periaqueductal gray, and prolongation of the increase in preproenkephalin mrna levels and enkephalin levels in the rvlm and arcuate. |
2015-12-02 |
2023-08-13 |
Not clear |
| Erin N Bobeck, QiLiang Chen, Michael M Morgan, Susan L Ingra. Contribution of adenylyl cyclase modulation of pre- and postsynaptic GABA neurotransmission to morphine antinociception and tolerance. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 9. 2015-03-02. PMID:24622471. |
opioid inhibition of presynaptic gaba release in the ventrolateral periaqueductal gray (vlpag) activates the descending antinociception pathway. |
2015-03-02 |
2023-08-12 |
rat |
| Elena E Bagle. Opioid and GABAB receptors differentially couple to an adenylyl cyclase/protein kinase A downstream effector after chronic morphine treatment. Frontiers in pharmacology. vol 5. 2014-07-10. PMID:25009497. |
a cellular hallmark of withdrawal is an opioid sensitive protein kinase a-dependent increase in gaba transporter-1 (gat-1) currents in periaqueductal gray (pag) neurons. |
2014-07-10 |
2023-08-13 |
Not clear |
| b' Petr T\\xc5\\xafma, Magdal\\xc3\\xa9na \\xc5\\xa0ustkov\\xc3\\xa1-Fi\\xc5\\xa1erov\\xc3\\xa1, Franti\\xc5\\xa1ek Opekar, V\\xc3\\xa1clav Pavl\\xc3\\xad\\xc4\\x8dek, Kl\\xc3\\xa1ra M\\xc3\\xa1lkov\\xc3\\xa. Large-volume sample stacking for in vivo monitoring of trace levels of \\xce\\xb3-aminobutyric acid, glycine and glutamate in microdialysates of periaqueductal gray matter by capillary electrophoresis with contactless conductivity detection. Journal of chromatography. A. vol 1303. 2014-01-31. PMID:23866123.' |
a new variant of large-volume sample stacking injection (lvss) was used in the capillary electrophoresis with capacitively coupled contactless conductivity detection (ce/c(4)d) determination of the neurotransmitters γ-aminobutyric acid (gaba), glycine (gly) and glutamate (glu) in microdialysates of periaqueductal gray matter (pag). |
2014-01-31 |
2023-08-12 |
Not clear |
| Peng Li, Stephanie C Tjen-A-Loo. Mechanism of the inhibitory effect of electroacupuncture on experimental arrhythmias. Journal of acupuncture and meridian studies. vol 6. issue 2. 2013-10-18. PMID:23591002. |
these studies were mostly conducted in the department of physiology, shanghai medical university; recently the mechanism of acupuncture's effect on arrhythmias was analyzed in the school of medicine, university of california, irvine, which involves the following: (1)the inhibitory effect of ea on ventricular extrasystoles can be induced by hypothalamic defense area stimulation: a low-current and low-frequency stimulation of the median nerve underneath acupoints p 5 or deep peroneal nerve underneath s 36 can activate arcuate nucleus-ventral periaqueductal gray -nuclei raphe pathway and release endorphin, enkephaline, gamma-aminobutyric acid (gaba), 5-hydroxytryptamine (5-ht), etc., thus inhibiting the rostral ventrolateral medulla (rvlm), decreasing sympathetic outflow, and alleviating ventricular extrasystoles; (2) the bradycardia induced by stimulation of aortic depressor nerve can be blocked by stimulation of superficial radial nerve (underneath li 6-7) or superficial peroneal nerve (underneath g37-39): these stimulations activate the rvlm release opioids and gaba to inhibit nucleus tractus solitarius and vagal nuclei, and block vagal bradycardia. |
2013-10-18 |
2023-08-12 |
Not clear |
| Rosana L Pagano, Erich T Fonoff, Camila S Dale, Gerson Ballester, Manoel J Teixeira, Luiz R G Britt. Motor cortex stimulation inhibits thalamic sensory neurons and enhances activity of PAG neurons: possible pathways for antinociception. Pain. vol 153. issue 12. 2013-04-30. PMID:23017297. |
we have also observed a decreased zif268, δ-aminobutyric acid (gaba), and glutamic acid decarboxylase expression within the same region, suggesting an inhibition of gabaergic interneurons of the midbrain periaqueductal gray, consequently activating neurons responsible for the descending pain inhibitory control system. |
2013-04-30 |
2023-08-12 |
rat |
| Jennifer T Lamberts, Chelsea E Smith, Ming-Hua Li, Susan L Ingram, Richard R Neubig, John R Trayno. Differential control of opioid antinociception to thermal stimuli in a knock-in mouse expressing regulator of G-protein signaling-insensitive Gαo protein. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 10. 2013-04-26. PMID:23467353. |
in the hot-plate test, a measure of supraspinal nociception, morphine antinociception was increased, and this was associated with an increased ability of opioids to inhibit presynaptic gaba neurotransmission in the periaqueductal gray. |
2013-04-26 |
2023-08-12 |
mouse |
| Zhi-Liang Liu, Hongyu Ma, Ru-Xiang Xu, Yi-Wu Dai, Hong-Tian Zhang, Xue-Qin Yao, Kun Yan. Potassium channels underlie postsynaptic but not presynaptic GABAB receptor-mediated inhibition on ventrolateral periaqueductal gray neurons. Brain research bulletin. vol 88. issue 5. 2013-04-25. PMID:22634546. |
gaba receptors b subtype (gaba(b)rs) are abundantly expressed at presynaptic and postsynaptic neuronal structures in the rat ventrolateral periaqueductal gray (pag), an area related to pain regulation. |
2013-04-25 |
2023-08-12 |
rat |
| Alicja Lerner, Anto Bagic, Janine M Simmons, Zoltan Mari, Omer Bonne, Ben Xu, Diane Kazuba, Peter Herscovitch, Richard E Carson, Dennis L Murphy, Wayne C Drevets, Mark Hallet. Widespread abnormality of the γ-aminobutyric acid-ergic system in Tourette syndrome. Brain : a journal of neurology. vol 135. issue Pt 6. 2012-07-27. PMID:22577221. |
in addition, the gaba(a) receptor binding was increased in the bilateral substantia nigra, left periaqueductal grey, right posterior cingulate cortex and bilateral cerebellum. |
2012-07-27 |
2023-08-12 |
Not clear |
| Il-Sung Jan. GABAA receptors facilitate spontaneous glutamate release in rat periaqueductal gray neurons. Neuroreport. vol 22. issue 16. 2012-07-23. PMID:21934537. |
the functional role of presynaptic γ-aminobutyric acid (gaba)(a) receptors in excitatory glutamatergic transmission was examined in rat periaqueductal gray neurons recorded using a conventional whole-cell patch clamp technique. |
2012-07-23 |
2023-08-12 |
rat |
| Il-Sung Jan. GABAA receptors facilitate spontaneous glutamate release in rat periaqueductal gray neurons. Neuroreport. vol 22. issue 16. 2012-07-23. PMID:21934537. |
the results suggest that the activation of presynaptic gaba(a) receptors directly depolarizes glutamatergic terminals resulting in the facilitation of spontaneous glutamate release, and that presynaptic gaba(a) receptors play an important role in the regulation of various physiological functions mediated by the periaqueductal gray. |
2012-07-23 |
2023-08-12 |
rat |
| Stephanie M Miller, Joseph S Lonstei. Autoradiographic analysis of GABAA receptor binding in the neural anxiety network of postpartum and non-postpartum laboratory rats. Brain research bulletin. vol 86. issue 1-2. 2012-04-04. PMID:21664440. |
we here examined autoradiographic binding of [(3)h]muscimol to measure the total population of gaba(a) receptors and [(3)h]flunitrazepam to assess density of benzodiazepine sites in the medial prefrontal cortex, bed nucleus of the stria terminalis, amygdala, hippocampus, and periaqueductal gray of female rats sacrificed on day 7 postpartum, day 10 of pregnancy, or as diestrous virgins. |
2012-04-04 |
2023-08-12 |
rat |
| Thatiane de Oliveira Sergio, Valquiria Camin de Bortoli, Helio Zangross. Serotonin-2A receptor regulation of panic-like behavior in the rat dorsal periaqueductal gray matter: the role of GABA. Psychopharmacology. vol 218. issue 4. 2012-03-26. PMID:21660445. |
serotonin-2a receptor regulation of panic-like behavior in the rat dorsal periaqueductal gray matter: the role of gaba. |
2012-03-26 |
2023-08-12 |
rat |
| C Dea. Cannabinoid and GABA modulation of sympathetic nerve activity and blood pressure in the dorsal periaqueductal gray of the rat. American journal of physiology. Regulatory, integrative and comparative physiology. vol 301. issue 6. 2012-02-14. PMID:21940402. |
cannabinoid and gaba modulation of sympathetic nerve activity and blood pressure in the dorsal periaqueductal gray of the rat. |
2012-02-14 |
2023-08-12 |
rat |
| Elena E Bagley, Jennifer Hacker, Vladimir I Chefer, Christophe Mallet, Gavan P McNally, Billy C H Chieng, Julie Perroud, Toni S Shippenberg, MacDonald J Christi. Drug-induced GABA transporter currents enhance GABA release to induce opioid withdrawal behaviors. Nature neuroscience. vol 14. issue 12. 2012-01-20. PMID:22037500. |
we found that gaba transporter 1 (gat-1) cation currents directly increased gabaergic neuronal excitability and synaptic gaba release in the periaqueductal gray (pag) during opioid withdrawal in rodents. |
2012-01-20 |
2023-08-12 |
Not clear |
| E Stone, J H Coote, J Allard, T A Lovic. GABAergic control of micturition within the periaqueductal grey matter of the male rat. The Journal of physiology. vol 589. issue Pt 8. 2011-08-09. PMID:21486804. |
microinjection of the gaba agonist muscimol (250 pmol) into the caudal ventrolateral periaqueductal grey (pag), but not at other sites in the pag, either depressed reflex voiding frequency (-60%, n = 7) and tonic eus emg activity (-38%, n = 6) or completely inhibited voiding (four sites). |
2011-08-09 |
2023-08-12 |
rat |