| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yangdong Zhang, Haiyang Wang, Lanxiang Liu, Xiaolong Mo, Dian He, Xueyi Chen, Rui Xiao, Qisheng Cheng, Madiha Fatima, Yamei Du, Peng Xi. Maternal Separation Regulates Sensitivity of Stress-Induced Depression in Mice by Affecting Hippocampal Metabolism. Physiology & behavior. 2024-03-29. PMID:38552706. |
this may be achieved by regulating the hippocampus's pantothenate and coa biosynthesis and beta alanine metabolism pathways represented by beta-alanine, l-aspartic acid, 2-aminoadipic acid, and glycine metabolites. |
2024-03-29 |
2024-04-01 |
mouse |
| Alyssa Kuang, Valentina L Kouznetsova, Santosh Kesari, Igor F Tsigeln. Diagnostics of Thyroid Cancer Using Machine Learning and Metabolomics. Metabolites. vol 14. issue 1. 2024-01-22. PMID:38248814. |
we identified seven metabolic pathways related to tc: pyrimidine metabolism, tyrosine metabolism, glycine, serine, and threonine metabolism, pantothenate and coa biosynthesis, arginine biosynthesis, phenylalanine metabolism, and phenylalanine, tyrosine, and tryptophan biosynthesis. |
2024-01-22 |
2024-01-24 |
Not clear |
| Qing Li, Xiangui Liu, Lijuan Li, Chuanlong Ge, Li Jia. A comprehensive analysis of hepatopancreas metabolomics and transcriptomics provides insights into the growth of three-year-old crabs (Eriocheir sinensis) under low temperature. Comparative biochemistry and physiology. Part D, Genomics & proteomics. vol 49. 2023-12-23. PMID:38141371. |
based on integrated transcriptomic and metabolomic analysis, the significantly difference focuses on metabolic pathways involving glycine, serine, and threonine metabolism, amino sugar and nucleotide sugar metabolism, cysteine and methionine metabolism, pantothenate and coa biosynthesis, arginine and proline metabolism, and vitamin digestion and absorption. |
2023-12-23 |
2023-12-25 |
Not clear |
| Jiedan Liao, Wenshuo Hu, Weijun Wang, Xinyan Wang, Shu Yu, Xinni Niu, Wenhui Zhu, Bolun Zhou, Yiwan Song, Weijun Zeng, Zhimin Lu, Jinding Che. Plasma metabonomics of classical swine fever virus-infected pigs. Frontiers in veterinary science. vol 10. 2023-12-22. PMID:38130437. |
thirteen metabolic pathways changed significantly in csfv-infected pigs, including tricarboxylic acid cycle, inositol phosphate metabolism, glycine, serine and threonine metabolism,lysine degradation, alanine, aspartate and glutamic acid metabolism, pantothenate and coa biosynthesis, β-alanine metabolism, lysine degradation, arginine and proline metabolism, glycerolipid metabolism, phenylalanine metabolism, arachidonic acid metabolism, linoleic acid metabolism. |
2023-12-22 |
2023-12-24 |
Not clear |
| Taixiang Gao, Rui Wang, Hongxiong Zhang, Feng Zha. Network pharmacology combined with metabolomics reveals the mechanism of Fuzi decoction against chronic heart failure in rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1210. 2022-09-05. PMID:36063700. |
a pathway enrichment analysis showed that fzd was mainly involved in glycine, serine and threonine metabolism, aminoacyl-trna biosynthesis, β-alanine metabolism, pantothenate and coa biosynthesis, glyoxylate and dicarboxylate metabolism and other metabolic pathways. |
2022-09-05 |
2023-08-14 |
rat |
| Emma Ivantsova, Andrew S Wengrovitz, Christopher L Souders, Christopher J Martyniu. Developmental and behavioral toxicity assessment of glyphosate and its main metabolite aminomethylphosphonic acid (AMPA) in zebrafish embryos/larvae. Environmental toxicology and pharmacology. 2022-05-03. PMID:35504511. |
gly increased cytochrome c oxidase subunit 4 isoform 1 and citrate synthase mrna in larvae while ampa decreased cytochrome c oxidase i and increased 3-hydroxyacyl coa dehydrogenase transcripts. |
2022-05-03 |
2023-08-13 |
zebrafish |
| Evasio Pasini, Giovanni Corsetti, Claudia Romano, Roberto Aquilani, Tiziano Scarabelli, Carol Chen-Scarabelli, Francesco S Dioguard. Management of Anaemia of Chronic Disease: Beyond Iron-Only Supplementation. Nutrients. vol 13. issue 1. 2021-09-07. PMID:33467658. |
the limiting step of heme synthesis is d-amino-levulinic acid (d-ala), whose availability and synthesis require glycine and succinil-coenzyme a (coa) as precursor substrates. |
2021-09-07 |
2023-08-13 |
human |
| J B Delaye, D Lanznaster, C Veyrat-Durebex, A Fontaine, G Bacle, A Lefevre, R Hergesheimer, J C Lecron, P Vourc'h, C R Andres, F Maillot, P Corcia, P Emond, H Blasc. Behavioral, Hormonal, Inflammatory, and Metabolic Effects Associated with FGF21-Pathway Activation in an ALS Mouse Model. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 18. issue 1. 2021-07-30. PMID:33021723. |
at 16 weeks, metabolomics analyses revealed a clear discrimination (cv-anova = 0.0086) according to the treatment and the most discriminant pathways, including sphingolipid metabolism, butanoate metabolism, pantothenate and coa biosynthesis, and the metabolism of amino acids like tyrosine, arginine, proline, glycine, serine, alanine, aspartate, and glutamate. |
2021-07-30 |
2023-08-13 |
mouse |
| Solange D Sousa, Luigi Lucini, Paolo Ajmone-Marsan, Maurício F van Tilburg, Arlindo A Mour. Untargeted metabolomic profiling of accessory sex gland fluid from Morada Nova rams. Molecular reproduction and development. vol 87. issue 4. 2021-05-20. PMID:32202367. |
meaningful pathways associated with agf metabolites included glycine, serine and threonine metabolism; pantothenate and coa biosynthesis; galactose metabolism; glutamate metabolism and phenylalanine metabolism, and so forth. |
2021-05-20 |
2023-08-13 |
human |
| Qisong Zhang, Zhuoru He, Zhongqiu Liu, Lingzhi Gon. Integrated plasma and liver gas chromatography mass spectrometry and liquid chromatography mass spectrometry metabolomics to reveal physiological functions of sodium taurocholate cotransporting polypeptide (NTCP) with an Ntcp knockout mouse model. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1165. 2021-05-13. PMID:33545502. |
pathway analysis revealed that the metabolism of tyrosine, glycine, taurine, fatty acid and glycerophospholipid as well as the biosynthesis of tryptophan, pantothenate and coa were significantly dysregulated in the ntcp ko mice, indicating that ntcp is closely involved in these metabolic pathways. |
2021-05-13 |
2023-08-13 |
mouse |
| Xinying Zhao, Alimire Abulikemu, Songqing Lv, Yi Qi, Junchao Duan, Jie Zhang, Rui Chen, Caixia Guo, Yanbo Li, Zhiwei Su. Oxidative stress- and mitochondrial dysfunction-mediated cytotoxicity by silica nanoparticle in lung epithelial cells from metabolomic perspective. Chemosphere. vol 275. 2021-05-13. PMID:33662726. |
five metabolic pathways were significantly perturbed, in particular, oxidative stress- and mitochondrial dysfunction-related gsh metabolism and pantothenate and coenzyme a (coa) biosynthesis, where the identified metabolites glutathione (gsh), glycine, beta-alanine, cysteine, cysteinyl-glycine and pantothenic acid were included. |
2021-05-13 |
2023-08-13 |
Not clear |
| Xin Tian, Lina Wu, Min Jiang, Zhenyong Zhang, Rong Wu, Jianing Miao, Caigang Liu, Song Ga. Downregulation of GLYAT Facilitates Tumor Growth and Metastasis and Poor Clinical Outcomes Through the PI3K/AKT/Snail Pathway in Human Breast Cancer. Frontiers in oncology. vol 11. 2021-05-13. PMID:33968740. |
the glycine n-acyltransferase (glyat) gene encodes a protein that catalyzes the transfer of acyl groups from acyl coa to glycine, resulting in acyl glycine and coenzyme a. aberrant glyat expression is associated with several malignant tumors, but its clinical importance in human breast cancer (bc), has yet to be fully addressed. |
2021-05-13 |
2023-08-13 |
human |
| Johann M Rohwer, Chantelle Schutte, Rencia van der Slui. Functional Characterisation of Three Glycine International journal of molecular sciences. vol 22. issue 6. 2021-04-21. PMID:33803916. |
the pathway consists of a mitochondrial xenobiotic/medium-chain fatty acid: coenzyme a (coa) ligase (acsm2b) and glycine |
2021-04-21 |
2023-08-13 |
Not clear |
| Lon J Van Winkle, Rebecca Ryzna. One-Carbon Metabolism Regulates Embryonic Stem Cell Fate Through Epigenetic DNA and Histone Modifications: Implications for Transgenerational Metabolic Disorders in Adults. Frontiers in cell and developmental biology. vol 7. 2020-10-01. PMID:31824950. |
thr is converted to glycine and acetyl coa, and the glycine is metabolized specifically to regulate trimethylation of lysine (lys) residue 4 in histone h3 (h3k4me3). |
2020-10-01 |
2023-08-13 |
mouse |
| Lijie Zhang, Yanli Cao, Jianan Tong, Yan X. An Alkylpyrazine Synthesis Mechanism Involving l-Threonine-3-Dehydrogenase Describes the Production of 2,5-Dimethylpyrazine and 2,3,5-Trimethylpyrazine by Bacillus subtilis. Applied and environmental microbiology. vol 85. issue 24. 2020-08-21. PMID:31585995. |
2-amino-3-ketobutyrate coenzyme a (coa) ligase (kbl) catalyzes the cleavage of l-2-amino-acetoacetate, the product of tdh, into glycine and acetyl-coa in the presence of coa. |
2020-08-21 |
2023-08-13 |
Not clear |
| Katell Peoc'h, Gaël Nicolas, Caroline Schmitt, Arienne Mirmiran, Raed Daher, Thibaud Lefebvre, Laurent Gouya, Zoubida Karim, Hervé Pu. Regulation and tissue-specific expression of δ-aminolevulinic acid synthases in non-syndromic sideroblastic anemias and porphyrias. Molecular genetics and metabolism. vol 128. issue 3. 2020-06-29. PMID:30737140. |
decreased alas2 activity results either directly from loss-of-function alas2 mutations as seen in x-linked sideroblastic anemia (xlsa) or from defect in the availability of one of its two mitochondrial substrates: glycine in slc25a38 mutations and succinyl coa in glrx5 mutations. |
2020-06-29 |
2023-08-13 |
human |
| Rencia van der Slui. Analyses of the genetic diversity and protein expression variation of the acyl: CoA medium-chain ligases, ACSM2A and ACSM2B. Molecular genetics and genomics : MGG. vol 293. issue 5. 2018-10-22. PMID:29948332. |
xenobiotics are first activated to an acyl-coa by the mitochondrial xenobiotic/medium-chain fatty acid: coa ligases (acsms) and subsequently conjugated to glycine by glycine n-acyltransferase (glyat). |
2018-10-22 |
2023-08-13 |
Not clear |
| Rencia van der Slui. Analyses of the genetic diversity and protein expression variation of the acyl: CoA medium-chain ligases, ACSM2A and ACSM2B. Molecular genetics and genomics : MGG. vol 293. issue 5. 2018-10-22. PMID:29948332. |
this confirmed an earlier hypothesis that the glycine conjugation pathway is highly conserved and essential for life as it maintains the coa and glycine homeostasis in the liver mitochondria. |
2018-10-22 |
2023-08-13 |
Not clear |
| Nathan A Styles, Erin M Shonsey, Josie L Falany, Amber L Guidry, Stephen Barnes, Charles N Falan. Carboxy-terminal mutations of bile acid CoA:N-acyltransferase alter activity and substrate specificity. Journal of lipid research. vol 57. issue 7. 2017-08-24. PMID:27230263. |
bile acid coa:amino acid n-acyltransferase (baat) is the terminal enzyme in the synthesis of bile salts from cholesterol and catalyzes the conjugation of taurine or glycine to bile acid coa thioesters to form bile acid n-acylamidates. |
2017-08-24 |
2023-08-13 |
rabbit |
| Fuqiang Li, Xiang Li, Yunjie Miao, Chenxiao Shan, Fei Yuan, Chengyao Ma, Qiwen Wang, Jianwei Chen, Yong Che. UHPLC-MS-based metabolomics analysis on mice bearing neoplasm (H22) for hispidulin. Journal of pharmaceutical and biomedical analysis. vol 125. 2017-04-11. PMID:27077962. |
these pathways include pantothenate and coa biosynthesis; glycine, serine and threonine metabolism; nicotinate and nicotinamide metabolism; steroid hormone biosynthesis; pyrimidine metabolism; and glyoxylate and dicarboxylate metabolism. |
2017-04-11 |
2023-08-13 |
mouse |